eISSN  2234-2443
pISSN  2234-2400
Special Issue Articles of IDEN 2012
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Clin Endosc. 2012 September;45(3):220-223.
     doi:http://dx.doi.org/10.5946/ce.2012.45.3.220
Copyright ⓒ 2012 Clinical Endoscopy
Management of Non-Variceal Upper Gastrointestinal Bleeding
Seung Young Kim, Jong Jin Hyun, Sung Woo Jung and Sang Woo Lee
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
Corresponding Author: Sang Woo Lee , Tel: +82-31-412-5580 , Fax: +82-31-412-5582 , Email: leesw@kumc.or.kr
ABSTRACT
Upper gastrointestinal bleeding (UGIB) is a critical condition that demands a quick and effective medical management. Non-variceal UGIB, especially peptic ulcer bleeding is the most significant cause. Appropriate assessment and treatment have a major influence on the prognosis of patients with UGIB. Initial fluids resuscitation and/or transfusion of red blood cells are necessary in patients with clinical evidence of intravascular volume depletion. Endoscopy is essential for diagnosis and treatment of UGIB, and should be provided within 24 hours after presentation of UGIB. Pre-endoscopic use of intravenous proton pump inhibitor (PPI) can downstage endoscopic signs of hemorrhage. Post-endoscopic use of high-dose intravenous PPI can reduce the risk of rebleeding and further interventions such as repeated endoscopy and surgery. Eradication of Helicobacter pylori and withdrawal of non-steroidal anti-inflammatory drugs are recommended to prevent recurrent bleeding.
Keywords: Gastrointestinal hemorrhage; Peptic ulcer hemorrhage; Gastrointestinal endoscopy; Disease management
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