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Alanna Ebigbo 3 Articles
Endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma: long-term follow-up in a Western center
Andreas Probst, Alanna Ebigbo, Stefan Eser, Carola Fleischmann, Tina Schaller, Bruno Märkl, Stefan Schiele, Bernd Geissler, Gernot Müller, Helmut Messmann
Clin Endosc 2023;56(1):55-64.   Published online January 13, 2023
AbstractAbstract PDFPubReaderePub
/Aims: Endoscopic submucosal dissection (ESD) has been established as a treatment modality for superficial esophageal squamous cell carcinoma (ESCC). Long-term follow-up data are lacking in Western countries. The aim of this study was to analyze long-term survival in a Western center.
Patients undergoing ESD for ESCC were included. The analysis was performed retrospectively using a prospectively collected database.
R0 resection rate was 96.7% (59/61 lesions in 58 patients). Twenty-seven patients (46.6%) fulfilled the curative resection criteria (M1/M2) (group A), 11 patients (19.0%) had M3 lesions without lymphovascular invasion (LVI) (group B), and 20 patients (34.5%) had lesions with submucosal invasion or LVI (group C). Additional treatment was recommended after non-curative resection. It was not performed in 20/31 patients (64.5%), mainly because of comorbidities (75%). Twenty-nine out of 58 (50.0%) patients died during a mean follow-up of 3.7 years. Death was related to ESCC in 17.2% (5/29) of patients. The disease-specific survival rate after curative resection was 100%. Overall survival rates after 5 years were 61.5%, 63.6% and 28.1% for groups A, B, and C, respectively. The overall survival was significantly worse after non-curative resection (p=0.038).
Non-curative resection is frequent after ESD for ESCC in Western patients. The long-term prognosis is limited and mainly determined by comorbidity. Early diagnosis and pre-interventional assessments need to be improved.


Citations to this article as recorded by  
  • Endoscopic submucosal dissection for early esophageal squamous cell carcinoma: long-term results from a Western cohort
    Ilse N. Beaufort, Charlotte N. Frederiks, Anouk Overwater, Lodewijk A.A. Brosens, Arjun D. Koch, Roos E. Pouw, Jacques J.G.H.M. Bergman, Bas L.A.M. Weusten
    Endoscopy.2024; 56(05): 325.     CrossRef
  • Endoscopic Submucosal Dissection for Esophageal Cancer: Current and Future
    Yuki Okubo, Ryu Ishihara
    Life.2023; 13(4): 892.     CrossRef
  • 2,283 View
  • 138 Download
  • 2 Web of Science
  • 2 Crossref
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Role of artificial intelligence in diagnosing Barrett’s esophagus-related neoplasia
Michael Meinikheim, Helmut Messmann, Alanna Ebigbo
Clin Endosc 2023;56(1):14-22.   Published online January 17, 2023
AbstractAbstract PDFPubReaderePub
Barrett’s esophagus is associated with an increased risk of adenocarcinoma. Thorough screening during endoscopic surveillance is crucial to improve patient prognosis. Detecting and characterizing dysplastic or neoplastic Barrett’s esophagus during routine endoscopy are challenging, even for expert endoscopists. Artificial intelligence-based clinical decision support systems have been developed to provide additional assistance to physicians performing diagnostic and therapeutic gastrointestinal endoscopy. In this article, we review the current role of artificial intelligence in the management of Barrett’s esophagus and elaborate on potential artificial intelligence in the future.


Citations to this article as recorded by  
  • Endoskopische Therapie von Barrett-Neoplasien und Magenfrühkarzinomen
    Florian Berreth, Jan Peveling-Oberhag, Jörg G. Albert
    best practice onkologie.2024; 19(1-2): 28.     CrossRef
  • The Role of Screening and Early Detection in Upper Gastrointestinal Cancers
    Jin Woo Yoo, Monika Laszkowska, Robin B. Mendelsohn
    Hematology/Oncology Clinics of North America.2024; 38(3): 693.     CrossRef
  • Artificial intelligence in gastroenterology: where are we and where are we going?
    Laurence B Lovat
    Gastrointestinal Nursing.2024; 22(Sup3): S6.     CrossRef
  • As how artificial intelligence is revolutionizing endoscopy
    Jean-Francois Rey
    Clinical Endoscopy.2024; 57(3): 302.     CrossRef
  • Screening and Diagnostic Advances of Artificial Intelligence in Endoscopy
    Muhammed Yaman Swied, Mulham Alom, Obada Daaboul, Abdul Swied
    Innovations in Digital Health, Diagnostics, and Biomarkers.2024; 4(2024): 31.     CrossRef
  • Endoskopische Therapie von Barrett-Neoplasien und Magenfrühkarzinomen
    Florian Berreth, Jan Peveling-Oberhag, Jörg G. Albert
    Die Gastroenterologie.2023; 18(3): 186.     CrossRef
  • 2,443 View
  • 248 Download
  • 2 Web of Science
  • 6 Crossref
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Methods that Assist Traction during Endoscopic Submucosal Dissection of Superficial Gastrointestinal Cancers: A Systematic Literature Review
Georgios Tziatzios, Alanna Ebigbo, Stefan Karl Gölder, Andreas Probst, Helmut Messmann
Clin Endosc 2020;53(3):286-301.   Published online January 9, 2020
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Endoscopic submucosal dissection (ESD) is a well-established method for the treatment of early-stage gastrointestinal neoplasms. Adequate submucosal exposure is one of the most significant factors related to an effective and safe dissection. The aim of this systematic review was to evaluate the effcacy and safety of various methods that assist traction during ESD of precancerous and earlystage neoplastic lesions of the gastrointestinal tract. We performed an electronic search of the MEDLINE and the Cochrane Controlled Trials Register databases for relevant studies published up to May 2019. Trials exclusively recruiting patients undergoing ESD for superficial gastrointestinal cancer were considered eligible for inclusion. Thirty-three articles including 3,134 patients met the inclusion criteria. The studies evaluated different approaches for widening the endoscopic view, including magnetic anchor-guided ESD (3 studies), use of a second endoscope (5 studies), clip-involving technique (21 studies), and miscellaneous methods (4 studies). Among them, only 6 were randomized controlled trials evaluating different approaches. Overall, the implementation of methods that assist traction during ESD significantly improved the operating time and R0 resection rate and decreased the rate of complications (bleeding and perforation). Interventions that assist traction seem effcacious in improving tissue traction, thus facilitating ESD performance.


Citations to this article as recorded by  
  • The Impact of Traction Methods on Endoscopic Submucosal Dissection Efficacy for Gastric Neoplasia: A Systematic Review and Meta-analysis
    Chengu Niu, Jing Zhang, Saarwaani Vallabhajosyula, Bryan E-Xin, Mahesh Napel, Patrick I. Okolo
    Journal of Gastrointestinal Cancer.2024; 55(1): 129.     CrossRef
  • Facilitating endoscopic full‐thickness resection for gastric submucosal tumors with a novel snare traction method (with video)
    Lei Gu, Xiaotong Wang, Miao Ouyang, Fujun Li, Yu Wu, Xiaowei Liu
    Journal of Gastroenterology and Hepatology.2024; 39(3): 535.     CrossRef
  • Endoscopic Resection of Malignancies in the Upper GI Tract: A Clinical Algorithm
    Ulrike Walburga Denzer
    Visceral Medicine.2024; 40(3): 116.     CrossRef
  • Building the Toolbox of Devices to Optimize a Practice in Submucosal Endoscopy
    Rahil H. Shah, Sunil Amin
    Gastrointestinal Endoscopy Clinics of North America.2023; 33(1): 15.     CrossRef
  • Error-Correcting Mean-Teacher: Corrections instead of consistency-targets applied to semi-supervised medical image segmentation
    Robert Mendel, David Rauber, Luis A. de Souza, João P. Papa, Christoph Palm
    Computers in Biology and Medicine.2023; 154: 106585.     CrossRef
  • Endoscopic submucosal dissection techniques and technology: European Society of Gastrointestinal Endoscopy (ESGE) Technical Review
    Diogo Libânio, Pedro Pimentel-Nunes, Barbara Bastiaansen, Raf Bisschops, Michael J. Bourke, Pierre H. Deprez, Gianluca Esposito, Arnaud Lemmers, Philippe Leclercq, Roberta Maselli, Helmut Messmann, Oliver Pech, Mathieu Pioche, Michael Vieth, Bas L.A.M. We
    Endoscopy.2023; 55(04): 361.     CrossRef
  • Multi-loop traction device facilitates gastric endoscopic submucosal dissection: ex vivo pilot study and an inaugural clinical experience
    Hiroaki Matsui, Naoto Tamai, Toshiki Futakuchi, Shunsuke Kamba, Akira Dobashi, Kazuki Sumiyama
    BMC Gastroenterology.2022;[Epub]     CrossRef
  • Novel Colorectal Endoscopic Submucosal Dissection With Double-Endoscope and Snare-Based Traction
    Chu-Kuang Chou, Kun-Feng Tsai, Cheng-Hao Tseng, Ching-Tai Lee, Kuo-Hsin Yang, Min-Chi Chang, Chao-Wen Hsu
    Diseases of the Colon & Rectum.2022; 65(7): 936.     CrossRef
  • Novel articulating through-the-scope traction device
    Cem Simsek, Christopher C. Thompson, Khaled J. Alkhateeb, Sebastian A. Jofre, Hiroyuki Aihara
    VideoGIE.2022; 7(10): 353.     CrossRef
  • “String-to-ring” traction technique for endoscopic submocosal dissection in the treatment of rectal tumors
    A. A. Mitrakov, S. S. Pirogov, N. N. Mitrakova, S. V. Gamayunov, M. V. Timoshchenko, R. A. Gagaev
    Experimental and Clinical Gastroenterology.2022; (5): 97.     CrossRef
  • Combination of endoscopic submucosal dissection techniques, a practical solution for difficult cases
    Dong-Hoon Yang
    Clinical Endoscopy.2022; 55(5): 626.     CrossRef
  • A novel training model to simulate thread traction in colorectal endoscopic submucosal dissection – a video vignette
    Shih‐Feng Huang, Chao‐Wen Hsu
    Colorectal Disease.2021; 23(4): 1012.     CrossRef
  • Endoscopic diagnosis and treatment of gastric dysplasia and early cancer: Current evidence and what the future may hold
    Edward Young, Hamish Philpott, Rajvinder Singh
    World Journal of Gastroenterology.2021; 27(31): 5126.     CrossRef
  • Double-endoscope assisted endoscopic submucosal dissection for treating tumors in rectum and distal colon by expert endoscopists: a feasibility study
    A. Ebigbo, G. Tziatzios, S. K. Gölder, A. Probst, H. Messmann
    Techniques in Coloproctology.2020; 24(12): 1293.     CrossRef
  • 6,462 View
  • 269 Download
  • 11 Web of Science
  • 14 Crossref
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