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Colorectal carcinoma and chronic inflammatory demyelinating polyneuropathy: is there a possible paraneoplastic association?
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Adnan Malik, Faisal Inayat, Muhammad Hassan Naeem Goraya, Gul Nawaz, Ahmad Mehran, Atif Aziz, Saad Saleem
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Clin Endosc 2023;56(2):245-251. Published online July 28, 2021
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DOI: https://doi.org/10.5946/ce.2021.076
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 Abstract
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- A plethora of paraneoplastic syndromes have been reported as remote effects of colorectal carcinoma (CRC). However, there is a dearth of data pertaining to the association of this cancer with demyelinating neuropathies. Herein, we describe the case of a young woman diagnosed with chronic inflammatory demyelinating polyneuropathy (CIDP). Treatment with intravenous immunoglobulins and prednisone did not improve her condition, and her neurological symptoms worsened. Subsequently, she was readmitted with exertional dyspnea, lightheadedness, malaise, and black stools. Colonoscopy revealed a necrotic mass in the ascending colon, which directly invaded the second part of the duodenum. Pathologic results confirmed the diagnosis of locally advanced CRC. Upon surgical resection of the cancer, her CIDP showed dramatic resolution without any additional therapy. Patients with CRC may develop CIDP as a type of paraneoplastic syndrome. Clinicians should remain cognizant of this potential association, as it is of paramount importance for the necessary holistic clinical management.
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Citations
Citations to this article as recorded by  - Cutaneous Paraneoplastic Syndromes in Colorectal Cancer Patients
Vlad Alexandru Ionescu, Gina Gheorghe, Teodor Florin Georgescu, Vlad Buica, Mihai-Stefan Catanescu, Iris-Andreea Cercel, Beatrice Budeanu, Mihail Budan, Ancuta Nastac, Ninel Iacobus Antonie, Daniel O. Costache, Raluca Simona Costache, Nicolae Bacalbasa, L
Gastrointestinal Disorders.2025; 7(1): 8. CrossRef - A case of MOGAD with rectal adenocarcinoma: Comorbidity or paraneoplastic neurological syndrome?
Yiyi Luo, Gang Peng, Jiahua Liang, Xuwei Song, Jiayu Tang
Brain, Behavior, & Immunity - Health.2025; 45: 100985. CrossRef - Polineuropatía crónica inflamatoria desmielinizante: caso clínico
Maira Alexandra Quisnia Amaguaya, Prissila Banesa Calderón Guaraca, Rodrigo Jose Mendoza Rivas
Anatomía Digital.2024; 7(3.3): 52. CrossRef
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