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Jong Jin Hyun 9 Articles
Development of a predictive model for hypoxia due to sedatives in gastrointestinal endoscopy: a prospective clinical study in Korea
Jung Wan Choe, Jong Jin Hyun, Seong-Jin Son, Seung-Hak Lee
Clin Endosc 2024;57(4):476-485.   Published online April 12, 2024
DOI: https://doi.org/10.5946/ce.2023.198
Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReaderePub
Background
/Aims: Sedation has become a standard practice for patients undergoing gastrointestinal (GI) endoscopy. However, considering the serious cardiopulmonary adverse events associated with sedatives, it is important to identify patients at high risk. Machine learning can generate reasonable prediction for a wide range of medical conditions. This study aimed to evaluate the risk factors associated with sedation during GI endoscopy and develop a predictive model for hypoxia during endoscopy under sedation.
Methods
This prospective observational study enrolled 446 patients who underwent sedative endoscopy at the Korea University Ansan Hospital. Clinical data were used as predictor variables to construct predictive models using the random forest method that is a machine learning algorithm.
Results
Seventy-two of the 446 patients (16.1%) experienced life-threatening hypoxia requiring immediate medical intervention. Patients who developed hypoxia had higher body weight, body mass index (BMI), neck circumference, and Mallampati scores. Propofol alone and higher initial and total dose of propofol were significantly associated with hypoxia during sedative endoscopy. Among these variables, high BMI, neck circumference, and Mallampati score were independent risk factors for hypoxia. The area under the receiver operating characteristic curve for the random forest-based predictive model for hypoxia during sedative endoscopy was 0.82 (95% confidence interval, 0.79–0.86) and displayed a moderate discriminatory power.
Conclusions
High BMI, neck circumference, and Mallampati score were independently associated with hypoxia during sedative endoscopy. We constructed a model with acceptable performance for predicting hypoxia during sedative endoscopy.
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Do Patients with Pancreatic Hyperenzymemia without Abnormal Imaging Need Additional Endoscopic Ultrasound?
Jung Wan Choe, Jong Jin Hyun
Clin Endosc 2019;52(2):97-99.   Published online March 14, 2019
DOI: https://doi.org/10.5946/ce.2019.044
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Education and Training Guidelines for the Board of the Korean Society of Gastrointestinal Endoscopy
Hee Seok Moon, Eun Kwang Choi, Ji Hyun Seo, Jeong Seop Moon, Ho June Song, Kyoung Oh Kim, Jong Jin Hyun, Sung Kwan Shin, Beom Jae Lee, Sang Heon Lee
Clin Endosc 2017;50(4):345-356.   Published online July 31, 2017
DOI: https://doi.org/10.5946/ce.2017.106
AbstractAbstract PDFPubReaderePub
The Korean Society of Gastrointestinal Endoscopy (KSGE) developed a gastrointestinal (GI) endoscopy board in 1995 and related regulations. Although the KSGE has acquired many specialists since then, the education and training aims and guidelines were insufficient. During GI fellowship training, obtaining sufficient exposure to some types of endoscopic procedures is difficult. Fellows should acquire endoscopic skills through supervised endoscopic procedures during GI fellowship training. Thus, the KSGE requires training guidelines for fellowships that allow fellows to perform independent endoscopic procedures without supervision. This document is intended to provide principles that the Committee of Education and Training of the KSGE can use to develop practical guidelines for granting privileges to perform accurate GI endoscopy safely. The KSGE will improve the quality of GI endoscopy by providing guidelines for fellowships and supervisors.

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  • Endoscopic retrograde cholangiopancreatography training and education
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    Digestive Endoscopy.2024; 36(1): 74.     CrossRef
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    JGH Open.2023; 7(12): 928.     CrossRef
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    Journal of Innovative Medical Technology.2023; 1(1): 24.     CrossRef
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    Ji Min Jang, Su Bee Park, Jin Young Yoon, Min Seob Kwak, Jae Myung Cha
    Medicine.2022; 101(19): e29266.     CrossRef
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    Journal of Korean Medical Science.2022;[Epub]     CrossRef
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    Gastrointestinal Endoscopy.2021; 93(5): 1152.     CrossRef
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    Expert Review of Gastroenterology & Hepatology.2021; 15(6): 675.     CrossRef
  • Colonoscopy quality in community hospitals and nonhospital facilities in Korea
    Jae Gon Lee, Dong Soo Han, Young-Eun Joo, Dae-Seong Myung, Dong Il Park, Seul Ki Kim, Yunho Jung, Won Hyun Lee, Eun Soo Kim, Joon Seok Yoon, Chang Soo Eun
    The Korean Journal of Internal Medicine.2021; 36(Suppl 1): S35.     CrossRef
  • Guidelines for accreditation of endoscopy units: quality measures from the Korean Society of Coloproctology
    Rumi Shin, Seongdae Lee, Kyung-Su Han, Dae Kyung Sohn, Sang Hui Moon, Dong Hyun Choi, Bong-Hyeon Kye, Hae-Jung Son, Sun Il Lee, Sumin Si, Won-Kyung Kang
    Annals of Surgical Treatment and Research.2021; 100(3): 154.     CrossRef
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    The Korean Journal of Pancreas and Biliary Tract.2021; 26(4): 211.     CrossRef
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    Dong Wook Lee, Byoung Kwan Son
    The Korean Journal of Pancreas and Biliary Tract.2020; 25(1): 1.     CrossRef
  • Impact of Hospital Volume and the Experience of Endoscopist on Adverse Events Related to Endoscopic Retrograde Cholangiopancreatography: A Prospective Observational Study
    Hyun Jik Lee, Chang Min Cho, Jun Heo, Min Kyu Jung, Tae Nyeun Kim, Kook Hyun Kim, Hyunsoo Kim, Kwang Bum Cho, Ho Gak Kim, Jimin Han, Dong Wook Lee, Yoon Suk Lee
    Gut and Liver.2020; 14(2): 257.     CrossRef
  • Quality indicators in diagnostic upper gastrointestinal endoscopy
    Wladyslaw Januszewicz, Michal F. Kaminski
    Therapeutic Advances in Gastroenterology.2020;[Epub]     CrossRef
  • Optimized diagnosis ofHelicobacter pyloriand tailored eradication therapy for preventing gastric cancer: a proposal for SHAKE strategy
    Jun-Hyung Cho, So-Young Jin
    Expert Review of Gastroenterology & Hepatology.2020; 14(7): 553.     CrossRef
  • Endoscopy training in Korea
    Joon Sung Kim, Byung-Wook Kim
    The Korean Journal of Internal Medicine.2019; 34(2): 237.     CrossRef
  • Current Korean Medical Specialty and Subspecialty System for Preparation of Privileging and Credentialing of ERCP Subspecialty
    Eun Kwang Choi
    The Korean Journal of Pancreas and Biliary Tract.2019; 24(2): 47.     CrossRef
  • Accredited Endoscopy Unit Program of Korea: Overview and Qualification
    Jung-Wook Kim, Yu Kyung Cho, Jin-Oh Kim, Jae-Young Jang
    Clinical Endoscopy.2019; 52(5): 426.     CrossRef
  • ERCP practice beyond the training period – bridging the gap between guidelines and real-life practice: a single operator experience of 679 procedures
    Theodor Voiosu, Andrei Voiosu, Andreea Benguş, Bogdan Mateescu
    Romanian Journal of Internal Medicine.2019; 57(2): 151.     CrossRef
  • Basic training in digestive endoscopy for resident physicians in gastroenterology. Recommendations by the Sociedad Española de Endoscopia Digestiva (SEED)
    Álvaro Brotons, Angels Vilella, Cristina Sánchez-Montes, Catalina Garau, Albert Vila, Vicente Pons Beltrán, Carlos Dolz Abadía
    Revista Española de Enfermedades Digestivas.2018;[Epub]     CrossRef
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Experimental Models of Pancreatitis
Jong Jin Hyun, Hong Sik Lee
Clin Endosc 2014;47(3):212-216.   Published online May 31, 2014
DOI: https://doi.org/10.5946/ce.2014.47.3.212
AbstractAbstract PDFPubReaderePub

Acute pancreatitis is an inflammatory disease characterized by interstitial edema, inflammatory cell infiltration, and acinar cell necrosis, depending on its severity. Regardless of the extent of tissue injury, acute pancreatitis is a completely reversible process with evident normal tissue architecture after recovery. Its pathogenic mechanism has been known to be closely related to intracellular digestive enzyme activation. In contrast to acute pancreatitis, chronic pancreatitis is characterized by irreversible tissue damage such as acinar cell atrophy and pancreatic fibrosis that results in exocrine and endocrine insufficiency. Recently, many studies of chronic pancreatitis have been prompted by the discovery of the pancreatic stellate cell, which has been identified and distinguished as the key effector cell of pancreatic fibrosis. However, investigations into the pathogenesis and treatment of pancreatitis face many obstacles because of its anatomical location and disparate clinical course. Due to these difficulties, most of our knowledge on pancreatitis is based on research conducted using experimental models of pancreatitis. In this review, several experimental models of pancreatitis will be discussed in terms of technique, advantages, and limitations.

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    Journal of Cancer Prevention.2019; 24(4): 233.     CrossRef
  • Phytoceuticals in Acute Pancreatitis: Targeting the Balance between Apoptosis and Necrosis
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    Pancreatology.2018; 18(5): 516.     CrossRef
  • Plasticity of differentiated cells in wound repair and tumorigenesis, part I: stomach and pancreas
    Joseph Burclaff, Jason C. Mills
    Disease Models & Mechanisms.2018;[Epub]     CrossRef
  • TSG-6 secreted by human adipose tissue-derived mesenchymal stem cells ameliorates severe acute pancreatitis via ER stress downregulation in mice
    Qiang Li, Woo-Jin Song, Min-Ok Ryu, Aryung Nam, Ju-Hyun An, Jin-Ok Ahn, Dong Ha Bhang, Yun Chan Jung, Hwa-Young Youn
    Stem Cell Research & Therapy.2018;[Epub]     CrossRef
  • Increased heat shock protein 70 expression attenuates pancreatic fibrosis induced by dibutyltin dichloride
    Jae Min Lee, Kwang Gyun Lee, Hyuk Soon Choi, Eun Sun Kim, Bora Keum, Yeon Seok Seo, Yoon Tae Jeen, Hoon Jai Chun, Hong Sik Lee, Soon Ho Um, Chang Duck Kim
    Scandinavian Journal of Gastroenterology.2018; 53(10-11): 1404.     CrossRef
  • Murine Models of Pancreatitis Leading to the Development of Pancreatic Cancer
    Ana S. Leal, Karen T. Liby
    Current Protocols in Pharmacology.2018;[Epub]     CrossRef
  • Loss of Sirt2 increases and prolongs a caerulein-induced pancreatitis permissive phenotype and induces spontaneous oncogenic Kras mutations in mice
    Songhua Quan, Daniel R. Principe, Angela E. Dean, Seong-Hoon Park, Paul J. Grippo, David Gius, Nobuo Horikoshi
    Scientific Reports.2018;[Epub]     CrossRef
  • Genetically inducedvs.classical animal models of chronic pancreatitis: a critical comparison
    Sarah Klauss, Stephan Schorn, Steffen Teller, Hendrik Steenfadt, Helmut Friess, Güralp O. Ceyhan, Ihsan Ekin Demir
    The FASEB Journal.2018; 32(11): 5778.     CrossRef
  • High-fat diet modifies cytokine gene expression and exacerbates the effects of acute pancreatitis in the liver of rats
    Ahmed Abdelsadik
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Acute Duodenal Ischemia and Periampullary Intramural Hematoma after an Uneventful Endoscopic Retrograde Cholangiopancreatography in a Patient with Primary Myelofibrosis
Chang Ho Jung, Jong Jin Hyun, Dae Hoe Gu, Eul Sun Moon, Jae Seon Kim, Hong Sik Lee, Chang Duck Kim
Clin Endosc 2014;47(3):270-274.   Published online May 31, 2014
DOI: https://doi.org/10.5946/ce.2014.47.3.270
AbstractAbstract PDFPubReaderePub

Acute duodenal ischemia and periampullary intramural hematoma are rare complications after endoscopic retrograde cholangiopancreatography (ERCP). A 77-year-old man with splenomegaly complained of abdominal pain caused by common bile duct (CBD) stone. After successful removal of the CBD stone without immediate complications, the patient developed intramural hematoma around the ampulla of Vater along with diffuse duodenal edema. The findings were compatible with acute intestinal ischemia, and further evaluation revealed that he had underlying primary myelofibrosis. Myeloproliferative diseases are known to be significantly associated with an increased risk of thrombohemorrhagic complications. Therefore, particular attention should be given to this group of patients when a high-risk procedure such as ERCP is performed.

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    Yuki Tanisaka, Akashi Fujita, Shomei Ryozawa
    Digestive Endoscopy.2022; 34(6): 1264.     CrossRef
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    Eric Weiss, Madeline Tadley, Pak S. Leung, Mark Kaplan
    ACG Case Reports Journal.2017; 4(1): e70.     CrossRef
  • 6,634 View
  • 67 Download
  • 2 Web of Science
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Preparation and Patient Evaluation for Safe Gastrointestinal Endoscopy
Seong Hee Kang, Jong Jin Hyun
Clin Endosc 2013;46(3):212-218.   Published online May 31, 2013
DOI: https://doi.org/10.5946/ce.2013.46.3.212
AbstractAbstract PDFPubReaderePub

Patient evaluation and preparation is the first and mandatory step to ensure safety and quality of endoscopic procedures. This begins and ends with identifying the patient, procedure type, and indication. Every patient has the right to be fully informed about risks and benefits of what is to be performed on them, and the medical personnel should respect the decision made by the patients. Thoroughly performed history taking and physical examination will guide the endoscopists to better stratify risk and plan sedation. Special attention should be given to higher-risk patients with higher-risk condition undergoing higher-risk procedures. Making preparations to monitor the patients and being ready to handle emergency situations throughout the endoscopic procedure are sine qua non to warrant safe endoscopy.

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    Šćepan Sinanović, Tanja Prodović, Olivera Milovanović, Saša Bubanj, Miljan Krstović, Srećko Potić, Jelena Sekulić, Danilo Jeremić
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    Chih-Wei Yang, Yueng-Hsiang Chu, Hsin-Chien Chen, Wei-Chen Huang, Peng-Jen Chen, Wei-Kuo Chang
    Frontiers in Oncology.2022;[Epub]     CrossRef
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    Chih-Ming Ou Yang, Yu-Tong Yen, Chai-Hock Chua, Chin-Chu Wu, Kuan-En Chu, Tsung-I Hung
    World Journal of Clinical Cases.2019; 7(20): 3276.     CrossRef
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    Jung Min Lee, Geeho Min, Bora Keum, Jae Min Lee, Seung Han Kim, Hyuk Soon Choi, Eun Sun Kim, Yeon Seok Seo, Yoon Tae Jeen, Hoon Jai Chun, Hong Sik Lee, Soon Ho Um, Chang Duck Kim
    Gut and Liver.2019; 13(6): 649.     CrossRef
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    Allyson H. Wexler, Megan A. Rech
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    Jung Min Lee, Geeho Min, Jae Min Lee, Seung Han Kim, Hyuk Soon Choi, Eun Sun Kim, Bora Keum, Yoon Tae Jeen, Hoon Jai Chun, Hong Sik Lee, Chang Duck Kim, Jong-Jae Park, Beom Jae Lee, Seong Ji Choi, Woojung Kim
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    Ben Da, James Buxbaum
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    Seung-Hwa Lee, Young-Kyu Park, Sung-Min Cho, Joon-Koo Kang, Duck-Joo Lee
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    Tae Hoon Lee, Chang Kyun Lee
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    Somchai Amornyotin
    World Journal of Gastrointestinal Endoscopy.2013; 5(11): 527.     CrossRef
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Feasibility of Obtaining Quantitative 3-Dimensional Information Using Conventional Endoscope: A Pilot Study
Jong Jin Hyun, Hoon Jai Chun, Bora Keum, Yeon Seok Seo, Yong Sik Kim, Yoon Tae Jeen, Hong Sik Lee, Soon Ho Um, Chang Duck Kim, Ho Sang Ryu, Jong-Wook Lim, Dong-Gi Woo, Young-Joong Kim, Myo-Taeg Lim
Clin Endosc 2012;45(3):182-188.   Published online August 22, 2012
DOI: https://doi.org/10.5946/ce.2012.45.3.182
AbstractAbstract PDFPubReaderePub
Background/Aims

Three-dimensional (3D) imaging is gaining popularity and has been partly adopted in laparoscopic surgery or robotic surgery but has not been applied to gastrointestinal endoscopy. As a first step, we conducted an experiment to evaluate whether images obtained by conventional gastrointestinal endoscopy could be used to acquire quantitative 3D information.

Methods

Two endoscopes (GIF-H260) were used in a Borrmann type I tumor model made of clay. The endoscopes were calibrated by correcting the barrel distortion and perspective distortion. Obtained images were converted to gray-level image, and the characteristics of the images were obtained by edge detection. Finally, data on 3D parameters were measured by using epipolar geometry, two view geometry, and pinhole camera model.

Results

The focal length (f) of endoscope at 30 mm was 258.49 pixels. Two endoscopes were fixed at predetermined distance, 12 mm (d12). After matching and calculating disparity (v2-v1), which was 106 pixels, the calculated length between the camera and object (L) was 29.26 mm. The height of the object projected onto the image (h) was then applied to the pinhole camera model, and the result of H (height and width) was 38.21 mm and 41.72 mm, respectively. Measurements were conducted from 2 different locations. The measurement errors ranged from 2.98% to 7.00% with the current Borrmann type I tumor model.

Conclusions

It was feasible to obtain parameters necessary for 3D analysis and to apply the data to epipolar geometry with conventional gastrointestinal endoscope to calculate the size of an object.

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Management of Non-Variceal Upper Gastrointestinal Bleeding
Seung Young Kim, Jong Jin Hyun, Sung Woo Jung, Sang Woo Lee
Clin Endosc 2012;45(3):220-223.   Published online August 22, 2012
DOI: https://doi.org/10.5946/ce.2012.45.3.220
AbstractAbstract PDFPubReaderePub

Upper gastrointestinal bleeding (UGIB) is a critical condition that demands a quick and effective medical management. Non-variceal UGIB, especially peptic ulcer bleeding is the most significant cause. Appropriate assessment and treatment have a major influence on the prognosis of patients with UGIB. Initial fluids resuscitation and/or transfusion of red blood cells are necessary in patients with clinical evidence of intravascular volume depletion. Endoscopy is essential for diagnosis and treatment of UGIB, and should be provided within 24 hours after presentation of UGIB. Pre-endoscopic use of intravenous proton pump inhibitor (PPI) can downstage endoscopic signs of hemorrhage. Post-endoscopic use of high-dose intravenous PPI can reduce the risk of rebleeding and further interventions such as repeated endoscopy and surgery. Eradication of Helicobacter pylori and withdrawal of non-steroidal anti-inflammatory drugs are recommended to prevent recurrent bleeding.

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    Il Ju Choi
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Comparison on the Efficacy of Disinfectants Used in Automated Endoscope Reprocessors: PHMB-DBAC versus Orthophthalaldehyde
Sun Young Kim, Hong Sik Lee, Jong Jin Hyun, Min Ho Seo, Sun Young Yim, Ha Young Oh, Hye Sook Kim, Bora Keum, Yeon Seok Seo, Yong Sik Kim, Yoon Tae Jeen, Hoon Jai Chun, Soon Ho Um, Chang Duck Kim, Ho Sang Ryu
Clin Endosc 2011;44(2):109-115.   Published online December 31, 2011
DOI: https://doi.org/10.5946/ce.2011.44.2.109
AbstractAbstract PDFPubReaderePub
Background/Aims

Since endoscopes are reusable apparatus classified as semicritical item, thorough reprocessing to achieve high-level disinfection is of utmost importance to prevent spread of infection. To improve disinfection efficacy and safety, disinfectants and endoscope reprocessors are continuously evolving. This study aimed to compare the efficacy of the combination of polyhexamethylenebiguanide hydrochloride-alkyldimethylbenzylammonium chloride (PHMB-DBAC) and orthophthalaldehyde (OPA) used respectively in ultrasonographic cleaning incorporated automated endoscope reprocessors: COOLENDO (APEX Korea) or OER-A (Olympus Optical).

Methods

A total of 86 flexible upper endoscopes were randomly reprocessed with either COOLENDO/PHMB-DBAC or OER-A/OPA. Culture samplings were done at two sites (endoscope tip and working channel) which were later incubated on blood agar plate. Bacterial colonies were counted and identified.

Results

The culture-positive rate at the endoscope tip and working channel was 0% and 2.33% for COOLENDO/PHMB-DBAC and 4.65% and 0% for OER-A/OPA. Staphylococcus hominis was cultured from one endoscope reprocessed with COOLENDO/PHMB-DBAC and Pseudomonas putida was isolated from two endoscopes reprocessed with OER-A/OPA.

Conclusions

The reprocessing efficacy of COOLENDO/PHMB-DBAC was non-inferior to that of OER-A/OPA (p=0.032; confidence interval, -0.042 to 0.042). During the study period, significant side effect of PHMB-DBAC was not observed.

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    Hyun Il Seo, Dae Sung Lee, Eun Mi Yoon, Min-Jung Kwon, Hyosoon Park, Yoon Suk Jung, Jung Ho Park, Chong Il Sohn, Dong Il Park
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    Kyong Hee Hong, Yun Jeong Lim
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    Yong Kook Lee, Jeong Bae Park
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    N. Govindji, P. Wills, M. Upton, N. Tirelli, S. Yeates, M. Webb
    Journal of Applied Microbiology.2013; 114(5): 1285.     CrossRef
  • 8,535 View
  • 68 Download
  • 8 Crossref
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