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Na Young Han 3 Articles
Molecular Imaging for Theranostics in Gastroenterology: One Stone to Kill Two Birds
Kwang Hyun Ko, Chang-Il Kown, Jong Min Park, Hoo Geun Lee, Na Young Han, Ki Baik Hahm
Clin Endosc 2014;47(5):383-388.   Published online September 30, 2014
DOI: https://doi.org/10.5946/ce.2014.47.5.383
AbstractAbstract PDFPubReaderePub

Molecular imaging in gastroenterology has become more feasible with recent advances in imaging technology, molecular genetics, and next-generation biochemistry, in addition to advances in endoscopic imaging techniques including magnified high-resolution endoscopy, narrow band imaging or autofluorescence imaging, flexible spectral imaging color enhancement, and confocal laser endomicroscopy. These developments have the potential to serve as "red flag" techniques enabling the earlier and accurate detection of mucosal abnormalities (such as precancerous lesions) beyond biomarkers, virtual histology of detected lesions, and molecular targeted therapy-the strategy of "one stone to kill two or three birds"; however, more effort should be done to be "blue ocean" benefit. This review deals with the introduction of Raman spectroscopy endoscopy, imaging mass spectroscopy, and nanomolecule development for theranostics. Imaging of molecular pathological changes in cells/tissues/organs might open the "royal road" to either convincing diagnosis of diseases that otherwise would only be detected in the advanced stages or novel therapeutic methods targeted to personalized medicine.

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  • A supramolecular colloidal system based on folate-conjugated β-cyclodextrin polymer and indocyanine green for enhanced tumor-targeted cell imaging in 2D culture and 3D tumor spheroids
    Yuting Wen, Jianfeng Wang, Wei Zheng, Jingling Zhu, Xia Song, Taili Chen, Miao Zhang, Zhiwei Huang, Jun Li
    Journal of Colloid and Interface Science.2024; 667: 259.     CrossRef
  • ESR Position Paper on Imaging Biobanks

    Insights into Imaging.2015; 6(4): 403.     CrossRef
  • International Digestive Endoscopy Network 2014: Turnpike to the Future
    Eun Young Kim, Kwang An Kwon, Il Ju Choi, Ji Kon Ryu, Ki Baik Hahm
    Clinical Endoscopy.2014; 47(5): 371.     CrossRef
  • 8,665 View
  • 72 Download
  • 3 Web of Science
  • 3 Crossref
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Recent Advances in Molecular Imaging of Premalignant Gastrointestinal Lesions and Future Application for Early Detection of Barrett Esophagus
Kwang Hyun Ko, Na Young Han, Chang Il Kwon, Hoo Keun Lee, Jong Min Park, Eun Hee Kim, Ki Baik Hahm
Clin Endosc 2014;47(1):7-14.   Published online January 24, 2014
DOI: https://doi.org/10.5946/ce.2014.47.1.7
AbstractAbstract PDFPubReaderePub

Recent advances in optical molecular imaging allow identification of morphologic and biochemical changes in tissues associated with gastrointestinal (GI) premalignant lesions earlier and in real-time. This focused review series introduces high-resolution imaging modalities that are being evaluated preclinically and clinically for the detection of early GI cancers, especially Barrett esophagus and esophageal adenocarcinoma. Although narrow band imaging, autofluorescence imaging, and chromoendoscopy are currently applied for this purpose in the clinic, further adoptions of probe-based confocal laser endomicroscopy, high-resolution microendoscopy, optical coherence tomography, and metabolomic imaging, as well as imaging mass spectrometry, will lead to detection at the earliest and will guide predictions of the clinical course in the near future in a manner that is beyond current advancements in optical imaging. In this review article, the readers will be introduced to sufficient information regarding this matter with which to enjoy this new era of high technology and to confront science in the field of molecular medical imaging.

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  • Fluorescence imaging-guided surgery: current status and future directions
    Zia Ullah, Shubham Roy, Saz Muhammad, Chen Yu, Haiyan Huang, Dongxiang Chen, Haodong Long, Xiulan Yang, Xuelian Du, Bing Guo
    Biomaterials Science.2024;[Epub]     CrossRef
  • Pivotal Role of Peptides in Gastric Carcinoma: Diagnosis and Therapy
    Sajjad Ahmadpour, Fatemeh Khodadust, Ahmad Hormati, Karim Eivaziatashbeik
    International Journal of Peptide Research and Therapeutics.2021; 27(1): 503.     CrossRef
  • High-resolution proteomics and metabolomics in thyroid cancer: Deciphering novel biomarkers
    Diana Navas-Carrillo, José Manuel Rodriguez, Silvia Montoro-García, Esteban Orenes-Piñero
    Critical Reviews in Clinical Laboratory Sciences.2017; 54(7-8): 446.     CrossRef
  • hERG1 behaves as biomarker of progression to adenocarcinoma in Barrett's esophagus and can be exploited for a novel endoscopic surveillance
    Elena Lastraioli, Tiziano Lottini, Jessica Iorio, Giancarlo Freschi, Marilena Fazi, Claudia Duranti, Laura Carraresi, Luca Messerini, Antonio Taddei, Maria Novella Ringressi, Marianna Salemme, Vincenzo Villanacci, Carla Vindigni, Anna Tomezzoli, Roberta L
    Oncotarget.2016; 7(37): 59535.     CrossRef
  • Imaging Mass Spectrometry in Papillary Thyroid Carcinoma for the Identification and Validation of Biomarker Proteins
    Kyueng-Whan Min, Joo-Young Bang, Kwang Pyo Kim, Wan-Seop Kim, Sang Hwa Lee, Selina Rahman Shanta, Jeong Hwa Lee, Ji Hye Hong, So Dug Lim, Young-Bum Yoo, Chan-Hyun Na
    Journal of Korean Medical Science.2014; 29(7): 934.     CrossRef
  • Molecular Imaging for Theranostics in Gastroenterology: One Stone to Kill Two Birds
    Kwang Hyun Ko, Chang-Il Kown, Jong Min Park, Hoo Geun Lee, Na Young Han, Ki Baik Hahm
    Clinical Endoscopy.2014; 47(5): 383.     CrossRef
  • 6,713 View
  • 63 Download
  • 7 Web of Science
  • 6 Crossref
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Application of Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Imaging Mass Spectrometry (MALDI-TOF IMS) for Premalignant Gastrointestinal Lesions
Kwang Hyun Ko, Chang Il Kwon, So Hye Park, Na Young Han, Hoo Keun Lee, Eun Hee Kim, Ki Baik Hahm
Clin Endosc 2013;46(6):611-619.   Published online November 19, 2013
DOI: https://doi.org/10.5946/ce.2013.46.6.611
AbstractAbstract PDFPubReaderePub

Imaging mass spectrometry (IMS) is currently receiving large attention from the mass spectrometric community, although its use is not yet well known in the clinic. As matrix-assisted laser desorption/ionization time-of-flight (MALDI)-IMS can show the biomolecular changes in cells as well as tissues, it can be an ideal tool for biomedical diagnostics as well as the molecular diagnosis of clinical specimens, especially aimed at the prompt detection of premalignant lesions much earlier before overt mass formation, or for obtaining histologic clues from endoscopic biopsy. Besides its use for pathologic diagnosis, MALDI-IMS is also a powerful tool for the detection and localization of drugs, proteins, and lipids in tissue. Measurement of parameters that define and control the implications, challenges, and opportunities associated with the application of IMS to biomedical tissue studies might be feasible through a deep understanding of mass spectrometry. In this focused review series, new insights into the molecular processes relevant to IMS as well as other field applications are introduced.

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  • Oncoproteomics: Trials and tribulations
    Li Zhou, Qifu Li, Jiandong Wang, Canhua Huang, Edouard C. Nice
    PROTEOMICS – Clinical Applications.2016; 10(4): 516.     CrossRef
  • Identifying Diffuse Axonal Injury by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight
    Guanheng Ren, Donghua Zou, Ping Huang, Zhengdong Li, Yu Shao, Kaifei Deng, Yijiu Chen, Ningguo Liu
    American Journal of Forensic Medicine & Pathology.2016; 37(4): 279.     CrossRef
  • Surface-Assisted Laser Desorption/Ionization of Trinitrotoluene on Porous Silicon under Ambient Conditions
    Yury Kuzishchin, Igor Martynov, Dmitriy Dovzhenko, Gennadii Kotkovskii, Alexander Chistyakov
    The Journal of Physical Chemistry C.2015; 119(11): 6382.     CrossRef
  • Imaging Mass Spectrometry in Papillary Thyroid Carcinoma for the Identification and Validation of Biomarker Proteins
    Kyueng-Whan Min, Joo-Young Bang, Kwang Pyo Kim, Wan-Seop Kim, Sang Hwa Lee, Selina Rahman Shanta, Jeong Hwa Lee, Ji Hye Hong, So Dug Lim, Young-Bum Yoo, Chan-Hyun Na
    Journal of Korean Medical Science.2014; 29(7): 934.     CrossRef
  • Recent Advances in Molecular Imaging of Premalignant Gastrointestinal Lesions and Future Application for Early Detection of Barrett Esophagus
    Kwang Hyun Ko, Na Young Han, Chang Il Kwon, Hoo Keun Lee, Jong Min Park, Eun Hee Kim, Ki Baik Hahm
    Clinical Endoscopy.2014; 47(1): 7.     CrossRef
  • Molecular Imaging for Theranostics in Gastroenterology: One Stone to Kill Two Birds
    Kwang Hyun Ko, Chang-Il Kown, Jong Min Park, Hoo Geun Lee, Na Young Han, Ki Baik Hahm
    Clinical Endoscopy.2014; 47(5): 383.     CrossRef
  • Predictive proteomic biomarkers for inflammatory bowel disease-associated cancer: Where are we now in the era of the next generation proteomics?
    Jong-Min Park
    World Journal of Gastroenterology.2014; 20(37): 13466.     CrossRef
  • 8,419 View
  • 65 Download
  • 7 Crossref
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