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Peter Nau 1 Article
Experience with Peroral Endoscopic Myotomy for Achalasia and Spastic Esophageal Motility Disorders at a Tertiary U.S. Center
Maen Masadeh, Peter Nau, Subhash Chandra, Jagpal Klair, John Keech, Kalpaj Parekh, Rami El Abiad, Henning Gerke
Clin Endosc 2020;53(3):321-327.   Published online November 20, 2019
AbstractAbstract PDFPubReaderePub
/Aims: Peroral endoscopic myotomy (POEM) is a novel procedure for the treatment of achalasia and spastic esophageal disorders. Experience with POEM is limited, but its reported outcomes are excellent. It is deemed safe even for patients with prior interventions.
This retrospective review included patients who underwent POEM at a tertiary US center. POEM was performed in a multidisciplinary approach by advanced endoscopists and foregut surgeons. Clinical success was defined as a post-POEM Eckardt score ≤3.
A total of 125 patients were included. Median follow-up period was 18 months (interquartile range, 10–22 months). Clinical success was achieved in 92% of patients and persisted at 12 months in 88% of patients. Mucosal barrier failure (MBF) occurred in 7 patients, 2 of whom required surgical intervention. MBF was more common in patients with prior laparoscopic Heller myotomy (19% vs. 3%, p=0.015). MBF requiring surgical intervention occurred early in the learning curve.
POEM is safe and effective in the treatment of achalasia and spastic esophageal disorders even after failed prior interventions.


Citations to this article as recorded by  
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    Diseases of the Esophagus.2024;[Epub]     CrossRef
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  • Outcomes of peroral endoscopic myotomy in patients with achalasia and prior bariatric surgery: A multicenter experience
    S Bomman, J S Klair, M Ashat, R El Abiad, H Gerke, J Keech, K Parekh, P Nau, Y Hanada, L M Wong Kee Song, R Kozarek, S Irani, D Low, A Ross, R Krishnamoorthi
    Diseases of the Esophagus.2021;[Epub]     CrossRef
  • Spastic Motility Disorders: Diagnosis and Management in the Era of the Chicago Classification
    Mario Costantini, Renato Salvador, Andrea Costantini
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  • Non-achalasia esophageal motility disorders: Role of per-oral endoscopic myotomy
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    International Journal of Gastrointestinal Intervention.2020; 9(2): 67.     CrossRef
  • Peroral Endoscopic Myotomy, a Well-Established, Efficacious, and Safe Treatment Option for Achalasia: Is the History of Previous Treatment a Hurdle or Not?
    Young Hoon Youn
    Clinical Endoscopy.2020; 53(3): 247.     CrossRef
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