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Peter Nau 1 Article
Experience with Peroral Endoscopic Myotomy for Achalasia and Spastic Esophageal Motility Disorders at a Tertiary U.S. Center
Maen Masadeh, Peter Nau, Subhash Chandra, Jagpal Klair, John Keech, Kalpaj Parekh, Rami El Abiad, Henning Gerke
Clin Endosc 2020;53(3):321-327.   Published online November 20, 2019
DOI: https://doi.org/10.5946/ce.2019.110
AbstractAbstract PDFPubReaderePub
Background
/Aims: Peroral endoscopic myotomy (POEM) is a novel procedure for the treatment of achalasia and spastic esophageal disorders. Experience with POEM is limited, but its reported outcomes are excellent. It is deemed safe even for patients with prior interventions.
Methods
This retrospective review included patients who underwent POEM at a tertiary US center. POEM was performed in a multidisciplinary approach by advanced endoscopists and foregut surgeons. Clinical success was defined as a post-POEM Eckardt score ≤3.
Results
A total of 125 patients were included. Median follow-up period was 18 months (interquartile range, 10–22 months). Clinical success was achieved in 92% of patients and persisted at 12 months in 88% of patients. Mucosal barrier failure (MBF) occurred in 7 patients, 2 of whom required surgical intervention. MBF was more common in patients with prior laparoscopic Heller myotomy (19% vs. 3%, p=0.015). MBF requiring surgical intervention occurred early in the learning curve.
Conclusions
POEM is safe and effective in the treatment of achalasia and spastic esophageal disorders even after failed prior interventions.

Citations

Citations to this article as recorded by  
  • Comparing clinical outcomes of peroral endoscopic myotomy for achalasia between Eastern and Western countries: a systematic review and meta-analysis
    Han Zhang, Xinxin Pu, Shu Huang, Huifang Xia, Kang Zou, Xinyi Zeng, Jiao Jiang, Wensen Ren, Yan Peng, Muhan Lü, Xiaowei Tang
    Diseases of the Esophagus.2024;[Epub]     CrossRef
  • Surgical and per-oral endoscopic myotomy (POEM) for the treatment of primary esophageal motility disorders: A systematic analysis of current trends in Germany between 2011 and 2019
    Jennis Kandler, Tobias Essing, David Schöler, Georg Flügen, Wolfram T. Knoefel, Christoph Roderburg, Tom Luedde, Sven H. Loosen, Dong Keon Yon
    PLOS ONE.2024; 19(1): e0297265.     CrossRef
  • Learning curve for esophageal peroral endoscopic myotomy: a systematic review and meta-analysis
    Srinivas R. Puli, Mihir S. Wagh, David Forcione, Harishankar Gopakumar
    Endoscopy.2023; 55(04): 355.     CrossRef
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    Current Opinion in Gastroenterology.2021; 37(4): 397.     CrossRef
  • Long-term Outcomes of Per-oral Endoscopic Myotomy in Spastic Esophageal Motility Disorders
    Zaheer Nabi, Radhika Chavan, Mohan Ramchandani, Jahangeer Basha, Nitin Jagtap, Arun Karyampudi, Santosh Darisetty, Manu Tandan, Rajesh Goud, Guduru Venkat Rao, Duvvur Nageshwar Reddy
    Journal of Clinical Gastroenterology.2021; 55(7): 594.     CrossRef
  • Outcomes of peroral endoscopic myotomy in patients with achalasia and prior bariatric surgery: A multicenter experience
    S Bomman, J S Klair, M Ashat, R El Abiad, H Gerke, J Keech, K Parekh, P Nau, Y Hanada, L M Wong Kee Song, R Kozarek, S Irani, D Low, A Ross, R Krishnamoorthi
    Diseases of the Esophagus.2021;[Epub]     CrossRef
  • Spastic Motility Disorders: Diagnosis and Management in the Era of the Chicago Classification
    Mario Costantini, Renato Salvador, Andrea Costantini
    Foregut: The Journal of the American Foregut Society.2021; 1(3): 254.     CrossRef
  • Non-achalasia esophageal motility disorders: Role of per-oral endoscopic myotomy
    Zaheer Nabi, Duvuur Nageshwar Reddy
    International Journal of Gastrointestinal Intervention.2020; 9(2): 67.     CrossRef
  • Peroral Endoscopic Myotomy, a Well-Established, Efficacious, and Safe Treatment Option for Achalasia: Is the History of Previous Treatment a Hurdle or Not?
    Young Hoon Youn
    Clinical Endoscopy.2020; 53(3): 247.     CrossRef
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