Xanthoma is an uncommon nonneoplastic lesion resulting from the accumulation of histiocytes. It predominantly shows cutaneous manifestations associated with dyslipidemia. However, xanthoma of the esophagus is extremely rare. To the best of our knowledge, only 14 cases have been reported thus far. The clinical significance of this lesion has not been established. However, this lesion should be distinguished grossly from ectopic sebaceous glands and small subepithelial tumors such as carcinoid and granular cell tumor. Moreover, signet ring cell carcinoma, which contains round cells with abundant cytoplasm and has similar histologic features to xanthoma, should be distinguished microscopically.

Citations

Citations to this article as recorded by  

• Multiple heterotopic sebaceous glands in the oesophagus: A case report and literature review
  Yuan Fang, Zhi Wang, Yong Qiang Yang, Bei Wen Song, Wen Bin Gou
  Tropical Doctor.2024; 54(1): 49.     CrossRef
• Esophageal xanthoma with nearby coexistent squamous cell carcinoma observed using magnifying endoscopy with narrow-band imaging
  Tomohiko Mannami, Tsukasa Sakaki, Takehiro Tanaka, Yasushi Fukumoto, Toshiyuki Wakatsuki, Shinichi Furutachi, Shin’ichi Shimizu, Tsuyoshi Umekawa, Mayu Mitsumune, Hanako Nagahara, Genyo Ikeda, Nobukiyo Fujiwara
  Clinical Journal of Gastroenterology.2022; 15(2): 325.     CrossRef
• Diffuse xanthoma in early esophageal cancer: A case report
  Xiao-Yun Yang, Kuang-I Fu, Yan-Ping Chen, Zhen-Wei Chen, Jing Ding
  World Journal of Clinical Cases.2021; 9(19): 5259.     CrossRef
• Case Report of a Proposed, Novel, Endoscopic “Whitehead Pimple” Sign of Ectopic Esophageal Sebaceous Glands Based on Their Mimicking the Dermatologic and Histopathologic Characteristics of Cutaneous Whitehead Pimples/Closed Comedones
  Amy Le, Mitual Amin, Mitchell S. Cappell
  Digestive Diseases and Sciences.2019; 64(7): 2049.     CrossRef
• A Yellowish Granular Lesion in the Esophagus
  Seong Keun Lee, Chul Hong Park, Min Hee Jung
  The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2018; 18(1): 74.     CrossRef
• Magnifying Endoscopy for Esophageal Ectopic Sebaceous Glands
  Mu Song Jeon, Gwang Ha Kim, Dong Young Jeong, Byeong Kyu Park, Moon Won Lee, So-Jeong Lee, Do Youn Park
  Clinical Endoscopy.2018; 51(5): 495.     CrossRef
• Nodular Esophageal Xanthoma: A Case Report and Review of the Literature
  Ahmed Dirweesh, Muhammad Khan, Sumera Bukhari, Cheryl Rimmer, Robert Shmuts
  Case Reports in Gastrointestinal Medicine.2017; 2017: 1.     CrossRef

Colonic lipomas, which often occur in elderly women, usually have small size and occur mainly in the cecum and ascending colon. Most colonic lipomas are asymptomatic and identified incidentally at the time of endoscopy or surgery. However, they may cause symptoms such as bleeding, obstruction or intussusception as their size increases. Intermittent episodes of intussusception are uncommon but may be caused by large pedunculated lipoma. In a 68-year-old woman suffering intermittent abdominal pain, 5.5×4.5×3.8-cm huge mass was found by colonoscopy at proximal ascending colon, which was intussuscepted to proximal transverse colon on abdominal computed tomography. Segmental right colonic resection was conducted. We report a case of symptomatic giant pedunculated colonic lipoma causing intussusception requiring surgical intervention, with a successful recovery after surgery.

Citations

Citations to this article as recorded by  

• Large colonic lipoma with a laterally spreading tumor treated by endoscopic submucosal dissection: A case report
  Jun Yong Bae, Hun Kyu Kim, Yee Jin Kim, Se Woong Kim, Youngeun Lee, Chang Beom Ryu, Moon Sung Lee
  World Journal of Clinical Cases.2023; 11(26): 6194.     CrossRef
• Concomitant ileocecal intussusception due to cecal lipoma and paraduodenal hernia
  Thomas A. O'Hara, Maeghan L. Ciampa, Constance L. Joel, Kay E. Bush, Robyn M. Hatley
  Journal of Pediatric Surgery Case Reports.2022; 78: 102186.     CrossRef
• Colon lipoma causing intussusception in adults: literature review
  Antonio LO CASTO, Marta FARINELLA, Crispino R. TOSTO, Emanuela FARINELLA, Alessandro MASSARA, Vito RODOLICO
  Journal of Radiological Review.2022;[Epub]     CrossRef
• Kolon kanserini taklit eden kolon lipomu: Olgu sunumu
  İlke Evrim SEÇİNTİ, Betül ŞİMŞEK, Salih ŞİMŞEK, Süleyman UYSAL, Ozan ÖZTÜRK
  Mustafa Kemal Üniversitesi Tıp Dergisi.2022; 13(46): 230.     CrossRef
• Large lipoma of the ascending colon: a case report and review of literature
  Aya N Farfour, Noor A AbuOmar, Fahad I Alsohaibani
  Journal of Surgical Case Reports.2020;[Epub]     CrossRef
• Curative endoscopic treatment of intussusception due to a giant colonic lipoma using a wedged balloon and ligation with detachable snares
  Masahiro Okada, Hirotsugu Sakamoto, Yoshikazu Hayashi, Tomonori Yano, Satoshi Shinozaki, Keijiro Sunada, Alan Kawarai Lefor, Hironori Yamamoto
  Clinical Journal of Gastroenterology.2019; 12(4): 320.     CrossRef
• Lipome géant colique : à propos d’un cas à l’origine d’une invagination iléo-colique
  A. S. Ouedraogo, K. S. Somda, M. Zida, A. Lamien-Sanou, W. N. Ramde, W. P. L. Guiguimde, V. Konsegre, F. A. H. A. Ido, O. M. Lompo-Goumbri
  Journal Africain du Cancer / African Journal of Cancer.2015; 7(3): 140.     CrossRef
• A 4-cm lipoma of the transverse colon causing colonic intussusception: A case report and literature review
  XIAO-CONG ZHOU, KE-QIONG HU, YI JIANG
  Oncology Letters.2014; 8(3): 1090.     CrossRef