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Satoru Nonaka 4 Articles
Complications of endoscopic resection in the upper gastrointestinal tract
Takeshi Uozumi, Seiichiro Abe, Mai Ego Makiguchi, Satoru Nonaka, Haruhisa Suzuki, Shigetaka Yoshinaga, Yutaka Saito
Clin Endosc 2023;56(4):409-422.   Published online June 21, 2023
AbstractAbstract PDFPubReaderePub
Endoscopic resection (ER) is widely utilized as a minimally invasive treatment for upper gastrointestinal tumors; however, complications could occur during and after the procedure. Post-ER mucosal defect leads to delayed perforation and bleeding; therefore, endoscopic closure methods (endoscopic hand-suturing, the endoloop and endoclip closure method, and over-the-scope clip method) and tissue shielding methods (polyglycolic acid sheets and fibrin glue) are developed to prevent these complications. During duodenal ER, complete closure of the mucosal defect significantly reduces delayed bleeding and should be performed. An extensive mucosal defect that comprises three-quarters of the circumference in the esophagus, gastric antrum, or cardia is a significant risk factor for post-ER stricture. Steroid therapy is considered the first-line option for the prevention of esophageal stricture, but its efficacy for gastric stricture remains unclear. Methods for the prevention and management of ER-related complications in the esophagus, stomach, and duodenum differ according to the organ; therefore, endoscopists should be familiar with ways of preventing and managing organ-specific complications.


Citations to this article as recorded by  
  • International Digestive Endoscopy Network consensus on the management of antithrombotic agents in patients undergoing gastrointestinal endoscopy
    Seung Joo Kang, Chung Hyun Tae, Chang Seok Bang, Cheol Min Shin, Young-Hoon Jeong, Miyoung Choi, Joo Ha Hwang, Yutaka Saito, Philip Wai Yan Chiu, Rungsun Rerknimitr, Christopher Khor, Vu Van Khien, Kee Don Choi, Ki-Nam Shim, Geun Am Song, Oh Young Lee
    Clinical Endoscopy.2024; 57(2): 141.     CrossRef
  • Risk factors for intraoperative and delayed perforation related with gastric endoscopic submucosal dissection
    Takuya Mimura, Yoshinobu Yamamoto, Haruhisa Suzuki, Kohei Takizawa, Toshiaki Hirasawa, Yoji Takeuchi, Kenji Ishido, Shu Hoteya, Tomonori Yano, Shinji Tanaka, Norihiko Kudara, Masahiro Nakagawa, Yumi Mashimo, Masahiro Ishigooka, Kazutoshi Fukase, Taichi Sh
    Journal of Gastroenterology and Hepatology.2024;[Epub]     CrossRef
  • Endoscopic submucosal dissection for early gastric cancer: It is time to consider the quality of its outcomes
    Gwang Ha Kim
    World Journal of Gastroenterology.2023; 29(43): 5800.     CrossRef
  • 3,260 View
  • 165 Download
  • 3 Web of Science
  • 3 Crossref
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Preclinical Efficacy and Clinical Feasibility of a Novel Aerosol-Exposure Protection Mask for Esophagogastroduodenoscopy
Mai Ego Makiguchi, Seiichiro Abe, Yutaka Okagawa, Satoru Nonaka, Haruhisa Suzuki, Shigetaka Yoshinaga, Ichiro Oda, Okamoto Ryuta, Yutaka Saito
Clin Endosc 2022;55(2):226-233.   Published online December 15, 2021
AbstractAbstract PDFSupplementary MaterialPubReaderePub
/Aims: This study aimed to assess the efficacy of a novel aerosol-exposure protection (AP) mask in preventing coronavirus disease in healthcare professionals during upper gastrointestinal endoscopy and to evaluate its clinical feasibility.
In Study 1, three healthy volunteers volitionally coughed with and without the AP mask in a cleanroom. Microparticles were visualized and counted with a specific measurement system and compared with and without the AP mask. In Study 2, 30 patients underwent endoscopic resection with the AP mask covering the face, and the SpO2 was measured throughout the procedure.
In Study 1, the median number of microparticles in volunteers 1, 2, and 3 with and without the AP mask was 8.5 and 110.0, 7.0 and 51.5, and 8.0 and 95.0, respectively (p<0.01). Using the AP mask, microparticles were reduced by approximately 92%. The median distances of microparticle scattering without the AP mask were 60, 0, and 68 in volunteers 1, 2, and 3, respectively. In Study 2, the mean SpO2 was 96.3%, and desaturation occurred in three patients.
The AP mask could provide protection from aerosol exposure and can be safely used for endoscopy in clinical practice.


Citations to this article as recorded by  
  • Aerosol and Droplet Dispersion Control during Bronchoscopy Using a Newly Developed Oxygen Mask
    Yuki Nagamatsu, Masatoshi Kakihana, Yujin Kudo, Wakako Hamanaka, Yohei Kawaguchi, Yuki Yamada, Chiaki Kanno, Sachio Maehara, Masaru Hagiwara, Tatsuo Ohira, Norihiko Ikeda
    Respiratory Endoscopy.2024; 2(1): 25.     CrossRef
  • A Novel Aerosol-Exposure Protection Mask for Patients During Upper Endoscopy
    Soo-Jeong Cho
    Clinical Endoscopy.2022; 55(2): 208.     CrossRef
  • 3,930 View
  • 249 Download
  • 1 Web of Science
  • 2 Crossref
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Reduced Intravenous Fluorescein Dose for Upper and Lower Gastrointestinal Tract Probe-Based Confocal Laser Endomicroscopy
Kazuya Inoki, Seiichiro Abe, Yusaku Tanaka, Koji Yamamoto, Daisuke Hihara, Ryoji Ichijima, Yukihiro Nakatani, HsinYu Chen, Hiroyuki Takamaru, Masau Sekiguchi, Masayoshi Yamada, Taku Sakamoto, Satoru Nonaka, Haruhisa Suzuki, Shigetaka Yoshinaga, Ichiro Oda, Takahisa Matsuda, Yutaka Saito
Clin Endosc 2021;54(3):363-370.   Published online September 8, 2020
AbstractAbstract PDFPubReaderePub
/Aims: Probe-based confocal laser endomicroscopy (pCLE) requires the administration of intravenous (IV) fluorescein. This study aimed to determine the optimal dose of IV fluorescein for both upper and lower gastrointestinal (GI) tract pCLE.
Patients 20 to 79 years old with gastric high-grade dysplasia (HGD) or colorectal neoplasms (CRNs) were enrolled in the study. The dose de-escalation method was employed with five levels. The primary endpoint of the study was the determination of the optimal dose of IV fluorescein for pCLE of the GI tract. The reduced dose was determined based on off-line reviews by three endoscopists. An insufficient dose of fluorescein was defined as the dose of fluorescein with which the pCLE images were not deemed to be visible. If all three endoscopists determined that the tissue structure was visible, the doses were de-escalated.
A total of 12 patients with gastric HGD and 12 patients with CRNs were enrolled in the study. Doses were de-escalated to 0.5 mg/kg of fluorescein for both non-neoplastic duodenal and colorectal mucosa. All gastric HGD or CRNs were visible with pCLE with IV fluorescein at 0.5 mg/kg.
In the present study, pCLE with IV fluorescein 0.5 mg/kg was adequate to visualize the magnified structure of both the upper and lower GI tract.


Citations to this article as recorded by  
  • Precision endoscopy in colorectal polyps' characterization and planning of endoscopic therapy
    Francesco Vito Mandarino, Silvio Danese, Toshio Uraoka, Adolfo Parra‐Blanco, Yasuharu Maeda, Yutaka Saito, Shin‐Ei Kudo, Michael J. Bourke, Marietta Iacucci
    Digestive Endoscopy.2024;[Epub]     CrossRef
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  • 105 Download
  • 1 Web of Science
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Metachronous Gastric Cancer Following Curative Endoscopic Resection of Early Gastric Cancer
Seiichiro Abe, Ichiro Oda, Takeyoshi Minagawa, Masau Sekiguchi, Satoru Nonaka, Haruhisa Suzuki, Shigetaka Yoshinaga, Amit Bhatt, Yutaka Saito
Clin Endosc 2018;51(3):253-259.   Published online September 18, 2017
AbstractAbstract PDFPubReaderePub
This review article summarizes knowledge about metachronous gastric cancer (MGC) occurring after curative endoscopic resection (ER) of early gastric cancer (EGC), treatment outcomes of patients who developed MGC, and efficacy of Helicobacter pylori eradication to prevent MGC. The incidence of MGC following curative ER increases over time and is higher than in patients undergoing gastrectomy. Increasing age and multifocal EGC are independent risk factors for developing MGC. An MGC following curative ER is usually a small (<20 mm) and differentiated intramucosal cancer. Most MGC lesions are found at an early stage on semiannual or annual surveillance endoscopy and are successfully treated by further ER, with excellent long-term outcomes. Eradication of H. pylori may reduce the risk of MGC following ER of EGC, but further prospective studies with long-term outcomes are required. Surveillance endoscopy following gastric ER should be continued indefinitely, due to the risk of MGC even after successful H. pylori eradication. Risk stratification and tailored endoscopic surveillance schedules need to be developed.


Citations to this article as recorded by  
  • Impact of endoscopy intervals on metachronous gastric cancer after endoscopic submucosal dissection: Comparison between 1 year and half‐a‐year
    Yuichiro Ozeki, Kingo Hirasawa, Atsushi Sawada, Ryosuke Ikeda, Masafumi Nishio, Takehide Fukuchi, Ryosuke Kobayashi, Chiko Sato, Shin Maeda
    Digestive Endoscopy.2024; 36(3): 332.     CrossRef
  • High risk of multiple gastric cancers in Japanese individuals with Lynch syndrome
    Nobuhiko Kanaya, Thijs A. van Schaik, Hideki Aoki, Yumiko Sato, Fumitaka Taniguchi, Kunitoshi Shigeyasu, Kokichi Sugano, Kiwamu Akagi, Hideyuki Ishida, Kohji Tanakaya
    Annals of Gastroenterological Surgery.2024;[Epub]     CrossRef
  • Risk assessment of metachronous gastric cancer development using OLGA and OLGIM systems after endoscopic submucosal dissection for early gastric cancer: a long-term follow-up study
    Yun Suk Na, Sang Gyun Kim, Soo-Jeong Cho
    Gastric Cancer.2023; 26(2): 298.     CrossRef
  • Metachronous lesions after gastric endoscopic submucosal dissection: first assessment of the FAMISH prediction score
    Andreia Rei, Raquel Ortigão, Mariana Pais, Luís P. Afonso, Pedro Pimentel-Nunes, Mário Dinis-Ribeiro, Diogo Libânio
    Endoscopy.2023; 55(10): 909.     CrossRef
  • Variation in the rate of detection of minute and small early gastric cancers at diagnostic endoscopy may reflect the performance of individual endoscopists
    Daisuke Murakami, Masayuki Yamato, Yuji Amano, Takayoshi Nishino, Makoto Arai
    BMJ Open Gastroenterology.2023; 10(1): e001143.     CrossRef
  • Decision to perform additional surgery after non-curative endoscopic submucosal dissection for gastric cancer based on the risk of lymph node metastasis: a long-term follow-up study
    Seunghan Lee, Sang Gyun Kim, Soo-Jeong Cho
    Surgical Endoscopy.2023; 37(10): 7738.     CrossRef
  • Helicobacter pylori Eradication Can Reverse Rho GTPase Expression in Gastric Carcinogenesis
    Jue Lie Kim, Sang Gyun Kim, Enerelt Natsagdorj, Hyunsoo Chung, Soo-Jeong Cho
    Gut and Liver.2023; 17(5): 741.     CrossRef
  • Risk assessment of metachronous gastric cancer after endoscopic submucosal dissection based on endoscopic intestinal metaplasia
    Chino Iizuka, Soichiro Sue, Sho Onodera, Aya Ikeda, Ryosuke Ikeda, Yoshihiro Goda, Kuniyasu Irie, Hiroaki Kaneko, Shin Maeda
    JGH Open.2023; 7(11): 783.     CrossRef
  • Second gastric cancer after curative endoscopic resection of differentiated-type early gastric cancer: post-hoc analysis of a single-arm confirmatory trial
    Masao Yoshida, Kohei Takizawa, Noriaki Hasuike, Hiroyuki Ono, Narikazu Boku, Tomohiro Kadota, Junki Mizusawa, Ichiro Oda, Naohiro Yoshida, Yusuke Horiuchi, Kingo Hirasawa, Yoshinori Morita, Yoshinobu Yamamoto, Manabu Muto, Masao Yoshida, Kohei Takizawa, H
    Gastrointestinal Endoscopy.2022; 95(4): 650.     CrossRef
  • Therapeutic approach to non-curative resection after endoscopic treatment in early gastric cancer
    Eun Jeong Gong, Chang Seok Bang
    Journal of the Korean Medical Association.2022; 65(5): 284.     CrossRef
  • Assessment of Outcomes From 1-Year Surveillance After Detection of Early Gastric Cancer Among Patients at High Risk in Japan
    Yoshinobu Yamamoto, Naohiro Yoshida, Tomonori Yano, Takahiro Horimatsu, Noriya Uedo, Noboru Kawata, Hiromitsu Kanzaki, Shinichiro Hori, Kenshi Yao, Seiichiro Abe, Chikatoshi Katada, Chizu Yokoi, Ken Ohata, Hisashi Doyama, Kenichi Yoshimura, Hideki Ishikaw
    JAMA Network Open.2022; 5(8): e2227667.     CrossRef
  • Management of patients with multiple primary сancer in the practice of a modern oncologist. Case report and literature review
    D. A. Khlanta, G. P. Gens
    Siberian journal of oncology.2022; 21(4): 147.     CrossRef
  • Assigning a different endoscopist for each annual follow-up may contribute to improved gastric cancer detection rates
    Shuhei Unno, Kimihiro Igarashi, Hiroaki Saito, Dai Hirasawa, Toru Okuzono, Yukari Tanaka, Masato Nakahori, Tomoki Matsuda
    Endoscopy International Open.2022; 10(10): E1333.     CrossRef
  • Statistical proof of Helicobacter pylori eradication in preventing metachronous gastric cancer after endoscopic resection in an East Asian population
    Mohsen Karbalaei, Masoud Keikha
    World Journal of Gastrointestinal Surgery.2022; 14(8): 867.     CrossRef
  • Follow-up after endoscopic resection for early gastric cancer in 3 French referral centers
    Bernadette de Rauglaudre, Mathieu Pioche, Fabrice Caillol, Jean-Philippe Ratone, Anna Pellat, Romain Coriat, Jerôme Rivory, Thomas Lambin, Laetitia Dahan, Marc Giovanini, Maximilien Barret
    iGIE.2022; 1(1): 49.     CrossRef
  • Documento de posicionamiento de la AEG, la SEED y la SEAP sobre cribado de cáncer gástrico en poblaciones con baja incidencia
    Joaquín Cubiella, Ángeles Pérez Aisa, Miriam Cuatrecasas, Pilar Díez Redondo, Gloria Fernández Esparrach, José Carlos Marín-Gabriel, Leticia Moreira, Henar Núñez, M. Luisa Pardo López, Enrique Rodríguez de Santiago, Pedro Rosón, José Miguel Sanz Anquela,
    Gastroenterología y Hepatología.2021; 44(1): 67.     CrossRef
  • Incidence of metachronous cancer after endoscopic submucosal dissection: a comparison between undifferentiated-type and differentiated-type early gastric cancer
    Mitsuaki Ishioka, Toshiyuki Yoshio, Yuji Miyamoto, Ken Namikawa, Yoshitaka Tokai, Shoichi Yoshimizu, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiaki Hirasawa, Tomohiro Tsuchida, Junko Fujisaki
    Gastrointestinal Endoscopy.2021; 93(3): 557.     CrossRef
  • Gastric cancer screening in low incidence populations: Position statement of AEG, SEED and SEAP
    Joaquin Cubiella, Ángeles Pérez Aisa, Miriam Cuatrecasas, Pilar Díez Redondo, Gloria Fernández Esparrach, José Carlos Marín-Gabriel, Leticia Moreira, Henar Núñez, M. Luisa Pardo López, Enrique Rodríguez de Santiago, Pedro Rosón, José Miguel Sanz Anquela,
    Gastroenterología y Hepatología (English Edition).2021; 44(1): 67.     CrossRef
  • Molecular risk markers related to local tumor recurrence at histological margin-free endoscopically resected early gastric cancers: A pilot study
    Ho Suk Kang, Mi Jung Kwon, Premi Haynes, Yan Liang, Yuqi Ren, Hyun Lim, Jae Seung Soh, Nan Young Kim, Hye Kyung Lee
    Pathology - Research and Practice.2021; 222: 153434.     CrossRef
  • Characteristics of metachronous gastric neoplasms after curative endoscopic submucosal dissection for early gastric neoplasms
    Shan-Shan Xu, Ning-Li Chai, Xiao-Wei Tang, En-Qiang Linghu, Sha-Sha Wang, Bao Li
    Chinese Medical Journal.2021; 134(21): 2603.     CrossRef
  • Consenso mexicano sobre detección y tratamiento del cáncer gástrico incipiente
    M.E. Icaza-Chávez, M.A. Tanimoto, F.M. Huerta-Iga, J.M. Remes-Troche, R. Carmona-Sánchez, A. Ángeles-Ángeles, F.J. Bosques-Padilla, J.M. Blancas-Valencia, G. Grajales-Figueroa, O.V. Hernández-Mondragón, A.I. Hernández-Guerrero, M.A. Herrera-Servín, F.D. H
    Revista de Gastroenterología de México.2020; 85(1): 69.     CrossRef
  • The Mexican consensus on the detection and treatment of early gastric cancer
    M.E. Icaza-Chávez, M.A. Tanimoto, F.M. Huerta-Iga, J.M. Remes-Troche, R. Carmona-Sánchez, A. Ángeles-Ángeles, F.J. Bosques-Padilla, J.M. Blancas-Valencia, G. Grajales-Figueroa, O.V. Hernández-Mondragón, A.I. Hernández-Guerrero, M.Á. Herrera-Servín, F.D. H
    Revista de Gastroenterología de México (English Edition).2020; 85(1): 69.     CrossRef
  • Long‐term follow up of serum pepsinogens in patients with gastric cancer or dysplasia after Helicobacter pylori eradication
    Gitark Noh, Nayoung Kim, Yonghoon Choi, Hye Seung Lee, Young Jae Hwang, Hee Jin Kim, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee
    Journal of Gastroenterology and Hepatology.2020; 35(9): 1540.     CrossRef
  • Metachronous Gastric Cancer: Another Hurdle for Successful Endoscopic Treatment for Early Gastric Cancer?
    Moon Won Lee, Gwang Ha Kim
    Gut and Liver.2020; 14(2): 145.     CrossRef
  • Clinical Outcomes of Metachronous Gastric Cancer after Endoscopic Resection for Early Gastric Cancer
    Jue Lie Kim, Sang Gyun Kim, Jung Kim, Jae Yong Park, Hyo-Joon Yang, Hyun Ju Kim, Hyunsoo Chung
    Gut and Liver.2020; 14(2): 190.     CrossRef
  • Chemoprevention of gastric cancer development after Helicobacter pylori eradication therapy in an East Asian population: Meta-analysis
    Mitsushige Sugimoto, Masaki Murata, Yoshio Yamaoka
    World Journal of Gastroenterology.2020; 26(15): 1820.     CrossRef
    Tommaso Zurleni, Michele Altomare, Giovanni Serio, Filippo Catalano
    International Journal of Surgery Case Reports.2020;[Epub]     CrossRef
  • Impact of the timing of Helicobacter pylori eradication on the risk of development of metachronous lesions after treatment of early gastric cancer: a population-based cohort study
    Hyun Ju Kim, Yun Jin Kim, Seung In Seo, Woon Geon Shin, Chan Hyuk Park
    Gastrointestinal Endoscopy.2020; 92(3): 613.     CrossRef
  • Gastric cancer prevention strategies: A global perspective
    Leonardo Henry Eusebi, Andrea Telese, Giovanni Marasco, Franco Bazzoli, Rocco Maurizio Zagari
    Journal of Gastroenterology and Hepatology.2020; 35(9): 1495.     CrossRef
  • Metachronous Gastric Cancer Occurring after Endoscopic Resection of Early Gastric Cancer
    Gwang Ha Kim
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2020; 20(4): 295.     CrossRef
  • Somatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer
    Kazuhiro Sakuta, Yu Sasaki, Yasuhiko Abe, Hidenori Sato, Masakuni Shoji, Takao Yaoita, Makoto Yagi, Naoko Mizumoto, Yusuke Onozato, Takashi Kon, Ayumi Koseki, Sonoko Sato, Ryoko Murakami, Yuki Miyano, Yoshiyuki Ueno
    Scientific Reports.2020;[Epub]     CrossRef
  • Clinicopathologic Characteristics of Patients with Gastric Superficial Neoplasia and Risk Factors for Multiple Lesions after Endoscopic Submucosal Dissection in a Western Country
    Gisela Brito-Gonçalves, Diogo Libânio, Pedro Marcos, Inês Pita, Rui Castro, Inês Sá, Mário Dinis-Ribeiro, Pedro Pimentel-Nunes
    GE - Portuguese Journal of Gastroenterology.2020; 27(2): 76.     CrossRef
  • Helicobacter pylori status and risks of metachronous recurrence after endoscopic resection of early gastric cancer: a systematic review and meta-analysis
    Shiyu Xiao, Sizhu Li, Liya Zhou, Wenjun Jiang, Jinzhe Liu
    Journal of Gastroenterology.2019; 54(3): 226.     CrossRef
  • Helicobacter pylori Eradication for Metachronous Gastric Cancer: An Unsuitable Methodology Impeding Broader Clinical Usage
    Alexios-Fotios A. Mentis, Efthimios Dardiotis
    Frontiers in Oncology.2019;[Epub]     CrossRef
  • Common Locations of Gastric Cancer: Review of Research from the Endoscopic Submucosal Dissection Era
    Su Jin Kim, Cheol Woong Choi
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • UEG Week 2019 Poster Presentations

    United European Gastroenterology Journal.2019; 7(S8): 189.     CrossRef
  • Helicobacter pylori Infection following Endoscopic Resection of Early Gastric Cancer
    Lan Li, Chaohui Yu
    BioMed Research International.2019; 2019: 1.     CrossRef
  • Prophylaxis and early diagnosis of stomach cancer
    I. G. Bakulin, S. S. Pirogov, N. V. Bakulina, E. A. Stadnik, N. N. Golubev
    Dokazatel'naya gastroenterologiya.2018; 7(2): 44.     CrossRef
  • Linked Color Imaging and Blue Laser Imaging for Upper Gastrointestinal Screening
    Hiroyuki Osawa, Yoshimasa Miura, Takahito Takezawa, Yuji Ino, Tsevelnorov Khurelbaatar, Yuichi Sagara, Alan Kawarai Lefor, Hironori Yamamoto
    Clinical Endoscopy.2018; 51(6): 513.     CrossRef
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  • 283 Download
  • 35 Web of Science
  • 39 Crossref
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