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Seungkoo Lee 1 Article
Ménétrier’s Disease as a Gastrointestinal Manifestation of Active Cytomegalovirus Infection in a 22-Month-Old Boy: A Case Report with a Review of the Literature of Korean Pediatric Cases
Jeana Hong, Seungkoo Lee, Yoonjung Shon
Clin Endosc 2018;51(1):89-94.   Published online June 13, 2017
AbstractAbstract PDFPubReaderePub
Ménétrier’s disease (MD), which is characterized by hypertrophic gastric folds and foveolar cell hyperplasia, is the most common gastrointestinal (GI) cause of protein-losing enteropathy (PLE). The clinical course of MD in childhood differs from that in adults and has often been reported to be associated with cytomegalovirus (CMV) infection. We present a case of a previously healthy 22-month-old boy presenting with PLE, who was initially suspected to have an eosinophilic GI disorder (EGID). However, he was eventually confirmed, by detection of CMV DNA using polymerase chain reaction (PCR) with gastric tissue, to have MD associated with an active CMV infection. We suggest that endoscopic and pathological evaluation is necessary for the differential diagnosis of MD. In addition, CMV DNA detection using PCR analysis of biopsy tissue is recommended to confirm the etiologic agent of MD regardless of the patient’s age or immune status.


Citations to this article as recorded by  
  • Clinical Manifestation of Cytomegalovirus-Associated Protein-Losing Enteropathy in Children
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    Nutrients.2023; 15(13): 2844.     CrossRef
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    European Journal of Pediatrics.2021; 180(3): 679.     CrossRef
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    Pediatric Gastroenterology, Hepatology & Nutrition.2021; 24(1): 109.     CrossRef
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    Hou-Hong Wang, Can-Can Zhao, Xiao-Lei Wang, Ze-Nong Cheng, Zong-Yu Xie
    World Journal of Clinical Cases.2021; 9(23): 6943.     CrossRef
  • Ménétrier’s disease in a patient with refractory ulcerative colitis: a clinical challenge and review of the literature
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    BMJ Case Reports.2021; 14(10): e246137.     CrossRef
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