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Sun-Kyung Na 1 Article
Comparison between the Effectiveness of Oral Phloroglucin and Cimetropium Bromide as Premedication for Diagnostic Esophagogastroduodenoscopy: An Open-Label, Randomized, Comparative Study
Hye-Won Yun, Ki-Nam Shim, Sun-Kyung Na, Jae-In Ryu, Min-Jin Lee, Eun-Mi Song, Seong-Eun Kim, Hye-Kyoung Jung, Sung-Ae Jung
Clin Endosc 2015;48(1):48-51.   Published online January 31, 2015
AbstractAbstract PDFPubReaderePub

Suppression of gastrointestinal (GI) peristalsis during GI endoscopy commonly requires antispasmodic agents such as hyoscine butylbromide, atropine, glucagon, and cimetropium bromide. This study examined the efficacy of oral phloroglucin for the suppression of peristalsis, its impact on patient compliance, and any associated complications, and compared it with intravenous or intramuscular cimetropium bromide administration.


This was a randomized, investigator-blind, prospective comparative study. A total of 172 patients were randomized into two groups according to the following medications administered prior to upper endoscopy: oral phloroglucin (group A, n=86), and cimetropium bromide (group B, n=86). The numbers and the degrees of peristalsis events at the antrum and second duodenal portion were assessed for 30 seconds.


A significantly higher number of gastric peristalsis events was observed in group A (0.49 vs. 0.08, p<0.001), but the difference was not clinically significant. No significant difference between both groups was found in the occurrence of duodenal peristalsis events (1.79 vs. 1.63, p=0.569). The incidence of dry mouth was significantly higher with cimetropium bromide than with phloroglucin (50% vs. 15.1%, p<0.001).


Oral phloroglucin can be used as an antispasmodic agent during upper endoscopy, and shows antispasmodic efficacy and adverse effects similar to those of cimetropium bromide.


Citations to this article as recorded by  
  • Effectiveness of oral phloroglucinol as a premedication for unsedated esophagogastroduodenoscopy: A prospective, double-blinded, placebo-controlled, randomized trial
    HyeIn Jung, Hyun Jung Kim, Eun Sung Choi, Ju Yup Lee, Kyung Sik Park, Kwang Bum Cho, Yoo Jin Lee, Lise Lotte Gluud
    PLOS ONE.2021; 16(8): e0255016.     CrossRef
  • Cimetropium bromide does not improve polyp and adenoma detection during colonoscope withdrawal
    Peel Jung, Su B. Park, Hyung W. Kim, Dae H. Kang, Cheol W. Choi, Su J. Kim, Hyeong S. Nam, Dae G. Ryu, Joung B. Hong, Dong J. Kim
    Medicine.2018; 97(25): e11253.     CrossRef
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