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Evaluation of cryoablation using a prototype cryoablation needle in swine liver
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Hyunjoon Son, Jonghyun Lee, Sung Yong Han, Tae In Kim, Dong Uk Kim, Daejin Kim, Gun-Ho Kim
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Clin Endosc 2024;57(5):675-682. Published online July 29, 2024
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DOI: https://doi.org/10.5946/ce.2024.024
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 Graphical Abstract
 Abstract
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 - Background
/Aims: Pancreatic cancer poses significant challenges due to its tendency for late-stage diagnosis and high mortality rates. Cryoablation, a technique used to treat various types of cancer, has shown potential in enhancing the prognosis of pancreatic cancer when combined with other therapies. However, its implementation is often limited by the need for lengthy procedures and specialized equipment. This study aims to develop a cryoablation needle optimized for endoscopic ultrasonography to simplify its application in treating pancreatic cancer.
Methods
The study involved conducting cryoablation experiments on swine liver tissue. It utilized cryo-needles to evaluate the extent of cell death across various temperatures and durations of cryoablation.
Results
The cryoablation system, which employed liquid carbon dioxide, achieved rapid cooling, reaching temperatures below –60 °C within 30 seconds and maintained the cryoablation process for 200 seconds. These conditions resulted in necrosis of the liver tissue. Notable cellular changes were observed up to 15 mm away from the cryoablation needle.
Conclusions
This experimental study successfully demonstrated the efficacy of using a cryo-needle for cryoablation in swine liver tissue. Further trials involving pancreatic tissue are expected to verify its effectiveness, underscoring the importance of continued research to establish its role as a complementary therapy in pancreatic cancer treatment.
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Quality indicators of endoscopic ultrasound in the pancreatobiliary system: a brief review of current guidelines
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Sung Yong Han, Hyung Ku Chon, Seong-Hun Kim, Sang Hyub Lee, The Research Group for Endoscopic Ultrasound in Korean Society of Gastrointestinal Endoscopy
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Clin Endosc 2024;57(2):158-163. Published online June 9, 2023
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DOI: https://doi.org/10.5946/ce.2023.064
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Abstract
PDFPubReaderePub
- Since its development, the use of endoscopic ultrasonography (EUS) in the pancreas and the biliary tract has become increasingly important. The accuracy of EUS varies depending on the experience of the endoscopist. Hence, quality control measures using appropriate indicators are required to reduce these variations. American Society for Gastrointestinal Endoscopy and European Society of Gastrointestinal Endoscopy have announced the EUS quality indicators. Here, we reviewed the quality indicators of the EUS procedure in the current published guidelines.
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Citations
Citations to this article as recorded by  - A remnant cystic duct presenting as a duodenal subepithelial tumor
Gwang Ha Kim, Dong Chan Joo
Clinical Endoscopy.2024; 57(2): 268. CrossRef
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Convex versus Radial Echoendoscopes - Comparison of Capability for Evaluating the Pancreatobiliary Junction
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Sung Yong Han, Dong Uk Kim
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Clin Endosc 2018;51(3):211-212. Published online May 16, 2018
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DOI: https://doi.org/10.5946/ce.2018.065
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PDFPubReaderePub
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Citations
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Sheng Wang, Jintao Guo, Xiang Liu, Nan Ge, Guoxin Wang, Jinlong Hu, Kai Zhang, Siyu Sun
Endoscopic Ultrasound.2021; 10(6): 431. CrossRef
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Bile Duct Patency Maintained after Intraductal Radiofrequency Ablation in a Case of Hepatocellular Cholangiocarcinoma with Bile Duct Invasion
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Sung Yong Han, Geun Am Song, Dong Uk Kim, Dong Hoon Baek, Moon Won Lee, Gwang Ha Kim
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Clin Endosc 2018;51(2):201-205. Published online August 31, 2017
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DOI: https://doi.org/10.5946/ce.2017.097
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Abstract
PDFPubReaderePub
- Combined hepatocellular-cholangiocarcinoma (HCC-CC) with bile duct invasion (BDI) is rare. In unresectable cases, biliary stent placement and photodynamic therapy (PDT) are used for resolving obstructive jaundice. However, stent occlusion remains problematic, and PDT is expensive and time-consuming. Intraductal radiofrequency ablation (RFA) is an emerging procedure for palliation in these patients. It has potential benefits including less expense, lower rates of severe complication, longer maintenance of ductal patency, and easier technique compared with PDT or stenting alone. We report a 67-year-old man who underwent repeated intraductal RFA for HCC-CC and HCC with BDI (HCC-BDI), for whom bile duct patency was maintained without additional biliary procedures.
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Citations
Citations to this article as recorded by - Clinical and cost effectiveness of endoscopic bipolar radiofrequency ablation for the treatment of malignant biliary obstruction: a systematic review
Fiona Beyer, Stephen Rice, Giovany Orozco-Leal, Madeleine Still, Hannah O’Keefe, Nicole O’Connor, Akvile Stoniute, Dawn Craig, Stephen Pereira, Louise Carr, John Leeds
Health Technology Assessment.2023; : 1. CrossRef - Improving biliary stent patency for malignant obstructive jaundice using endobiliary radiofrequency ablation: experience in 150 patients
Ya-Lin Kong, Hong-Yi Zhang, Cheng-Li Liu, Xiao-Jun He, Gang Zhao, Cheng Wang, Ling-Hong Kong, Jing Zhao
Surgical Endoscopy.2022; 36(3): 1789. CrossRef
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