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Most-read are based on citations from 2023 ~ 2025.

Reviews
Alteration in gut microbiota after colonoscopy: proposed mechanisms and the role of probiotic interventions
Hyeong Ho Jo, Moon Young Lee, Se Eun Ha, Dong Han Yeom, Yong Sung Kim
Clin Endosc 2025;58(1):25-39.   Published online September 2, 2024
DOI: https://doi.org/10.5946/ce.2024.147
AbstractAbstract PDFPubReaderePub
Colonoscopy, a widely used procedure for diagnosing and treating colonic diseases, induces transient gastrointestinal symptoms and alterations in the gut microbiota. This review comprehensively examines the evidence on alterations in the gut microbiota following colonoscopy and their possible mechanisms. Factors such as rapid colonic evacuation, increased osmolality, and mucus thinning caused by bowel preparation and exposure to oxygen during the procedure contribute to these alterations. Typically, the alterations revert to the baseline within a short time. However, their long-term implications remain unclear, necessitating further investigation. Split-dose bowel preparation and CO2 insufflation during the procedure result in fewer alterations in the gut microbiota. Probiotic administration immediately after colonoscopy shows promise in reducing alterations and gastrointestinal symptoms. However, the widespread use of probiotics remains controversial due to the transient nature of both the symptoms and gut microbial alterations following a colonoscopy. Probiotics may offer greater benefits to individuals with preexisting gastrointestinal symptoms. Thus, probiotic administration may be a viable option for selected patients.

Citations

Citations to this article as recorded by  
  • Response to Ge and Chen
    Akira Higashimori, Natsumi Maeda, Yasuhiro Fujiwara
    American Journal of Gastroenterology.2025;[Epub]     CrossRef
  • Is It Advisable to Use Probiotics Routinely After a Colonoscopy? A Rapid Comprehensive Review of the Evidence
    Matteo Piciucchi, Alice Rossi, Alissa Satriano, Raffaele Manta
    Medical Sciences.2025; 13(2): 76.     CrossRef
  • Modulation of Gut Microbiota and Antibiotic Resistance Genes by Heat-Killed Enterococcus faecalis EF-2001 in High-Fat Diet-Induced Obesity Mice: A Shotgun Metagenomics Study
    Ranjith Kumar Manoharan, Kwon-Il Han, Hyun-Dong Shin, Yura Lee, Sunhwa Baek, Eunjung Moon, Youn Bum Park, Junhui Cho, Sathiyaraj Srinivasan
    Bioengineering.2025; 12(7): 741.     CrossRef
  • Efficacy of Fecal Microbial Transplantation for Improving Symptoms of Irritable Bowel Syndrome - A Pilot Study for Voluntary Participants in Korea
    Jung Won Lee, Nayoung Kim
    The Korean Journal of Gastroenterology.2024; 84(4): 168.     CrossRef
  • 27,922 View
  • 840 Download
  • 2 Web of Science
  • 4 Crossref
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Colon stenting as a bridge to surgery in obstructive colorectal cancer management
Dong Hyun Kim, Han Hee Lee
Clin Endosc 2024;57(4):424-433.   Published online March 8, 2024
DOI: https://doi.org/10.5946/ce.2023.138
AbstractAbstract PDFPubReaderePub
Colonic stent placement is a commonly used bridging strategy for surgery in patients with obstructive colorectal cancer. The procedure involves the placement of a self-expandable metallic stent (SEMS) across the obstructive lesion to restore intestinal patency and alleviate the symptoms of obstruction. By allowing patients to receive surgery in a planned and staged manner with time for preoperative optimization and bowel preparation, stent placement may reduce the need for emergency surgery, which is associated with higher complication rates and poorer outcomes. This review focuses on the role of colon stenting as a bridge to surgery in the management of obstructive colorectal cancer. SEMS as a bridge to surgery for left-sided colon cancer has been demonstrated to be particularly useful; however, further research is needed for its application in cases of right-sided colon cancer. Colon stent placement also has limitations and potential complications including stent migration, re-obstruction, and perforation. However, the timing of curative surgery after SEMS placement remains inconclusive. Considering the literature to date, performing surgery at an interval of approximately 2 weeks is considered appropriate. Therefore, colonic stent placement may be an effective strategy as a bridge to surgery in patients with obstructive colorectal cancer.

Citations

Citations to this article as recorded by  
  • Chitosan Approaches in Colon Cancer Therapy: Understanding its Macromolecular Interactions and Structure-Property Relationships
    Sankha Bhattacharya, Dilpreet Singh
    Journal of Macromolecular Science, Part B.2025; : 1.     CrossRef
  • A rare case of massive colonic distention secondary to undiagnosed colon adenocarcinoma
    Chloe Lahoud, Toni Habib, Michel Al Achkar, Tyler Grantham, Nissar Ahmed
    Medical Reports.2025; 12: 100207.     CrossRef
  • Optimal Timing of Surgery After Insertion of Self‐Expandable Metallic Stent to Obstructive Colorectal Neoplasm as a Bridge to Surgery
    Dong Hyun Kim, Hyun Lim, Jung‐Wook Kim, Yunho Jung, Hyun‐Soo Kim, Ki‐Hyun Kim, Jin Won Kim, Young‐Eun Joo, Bo‐In Lee, Han Hee Lee
    Journal of Gastroenterology and Hepatology.2025; 40(7): 1809.     CrossRef
  • Development of colonic stent simulator using three-dimensional printing technique: a simulator development study in Korea
    Hyundam Gu, Suyoung Lee, Sol Kim, Hye-Lim Jang, Da-Woon Choi, Kyu Seok Kim, Yu Ri Shin, Dae Young Cheung, Bo-In Lee, Jin Il Kim, Han Hee Lee
    Clinical Endoscopy.2024; 57(6): 790.     CrossRef
  • Self-Expandable Metal Stents for Obstructing Colon Cancer and Extracolonic Cancer: A Review of Latest Evidence
    Pedro Marílio Cardoso, Eduardo Rodrigues-Pinto
    Cancers.2024; 17(1): 87.     CrossRef
  • 14,625 View
  • 767 Download
  • 5 Web of Science
  • 5 Crossref
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International Digestive Endoscopy Network consensus on the management of antithrombotic agents in patients undergoing gastrointestinal endoscopy
Seung Joo Kang, Chung Hyun Tae, Chang Seok Bang, Cheol Min Shin, Young-Hoon Jeong, Miyoung Choi, Joo Ha Hwang, Yutaka Saito, Philip Wai Yan Chiu, Rungsun Rerknimitr, Christopher Khor, Vu Van Khien, Kee Don Choi, Ki-Nam Shim, Geun Am Song, Oh Young Lee, The Korean Society of Gastrointestinal Endoscopy Task Force on Clinical Practice Guidelines
Clin Endosc 2024;57(2):141-157.   Published online March 14, 2024
DOI: https://doi.org/10.5946/ce.2024.002
AbstractAbstract PDFPubReaderePub
Antithrombotic agents, including antiplatelet agents and anticoagulants, are widely used in Korea because of the increasing incidence of cardiocerebrovascular disease and the aging population. The management of patients using antithrombotic agents during endoscopic procedures is an important clinical challenge. The clinical practice guidelines for this issue, developed by the Korean Society of Gastrointestinal Endoscopy, were published in 2020. However, new evidence on the use of dual antiplatelet therapy and direct anticoagulant management has emerged, and revised guidelines have been issued in the United States and Europe. Accordingly, the previous guidelines were revised. Cardiologists were part of the group that developed the guideline, and the recommendations went through a consensus-reaching process among international experts. This guideline presents 14 recommendations made based on the Grading of Recommendations, Assessment, Development, and Evaluation methodology and was reviewed by multidisciplinary experts. These guidelines provide useful information that can assist endoscopists in the management of patients receiving antithrombotic agents who require diagnostic and elective therapeutic endoscopy. It will be revised as necessary to cover changes in technology, evidence, or other aspects of clinical practice.

Citations

Citations to this article as recorded by  
  • EUS-guided gallbladder drainage for patients with antithrombotic therapy: Intervention or medication?
    Liqi Sun, Jiang Liu
    Gastrointestinal Endoscopy.2025; 101(1): 226.     CrossRef
  • Do all antithrombotic agents have a similar impact on small bowel bleeding?
    Chung Hyun Tae, Ki-Nam Shim
    Clinical Endoscopy.2025; 58(1): 80.     CrossRef
  • Response
    Tae-Geun Gweon, Hyun Gun Kim
    Gastrointestinal Endoscopy.2025; 101(4): 925.     CrossRef
  • Medical disputes involving lower gastrointestinal endoscopies: cases from the Korean Medical Dispute Mediation and Arbitration Agency
    Eun Hye Oh, Jeong Eun Shin, Jun Yong Bae, Yoon Suk Lee, Yehyun Park, Yong Hwan Kwon, Chang Nyol Paik, Jun Kyu Lee, Tae Hee Lee
    The Korean Journal of Internal Medicine.2025; 40(3): 404.     CrossRef
  • Contemporary approaches in the peri-endoscopic management of antithrombotic agents: current paradigms, challenges, and prognostications
    Jiaxuan Zuo, Wei Jiang, Lumei Wang, Kaiqi Yang, Peng Li, Shutian Zhang, Rui Cheng
    Therapeutic Advances in Gastroenterology.2025;[Epub]     CrossRef
  • Prediction of immediate bleeding after cold snare polypectomy: A prospective observational study
    Shin Ju Oh, Yunho Jung, Young Hwangbo, Young Sin Cho, Il Kwun Chung, Chang Kyun Lee
    Medicine.2024; 103(36): e39597.     CrossRef
  • 13,219 View
  • 597 Download
  • 6 Web of Science
  • 6 Crossref
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Role of endoscopy in eosinophilic esophagitis
Eun-Jin Yang, Kee Wook Jung
Clin Endosc 2025;58(1):1-9.   Published online July 5, 2024
DOI: https://doi.org/10.5946/ce.2024.023
AbstractAbstract PDFPubReaderePub
Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease involving inflammation of the esophagus. Endoscopy is essential in the diagnosis and treatment of EoE and shows typical findings, including esophageal edema, rings, exudates, furrows, and stenosis. However, studies involving pediatric and adult patients with EoE suggest that even a normally appearing esophagus can be diagnosed as EoE by endoscopic biopsy. Therefore, in patients with suspected EoE, biopsy samples should be obtained from the esophagus regardless of endoscopic appearance. Moreover, follow-up endoscopies with biopsy after therapy initiation are usually recommended to assess response. Although previous reports of endoscopic ultrasonography findings in patients with EoE have shown diffuse thickening of the esophageal wall, including lamina propria, submucosa, and muscularis propria, its role in EoE remains uncertain and requires further investigation. Endoscopic dilation or bougienage is a safe and effective procedure that can be used in combination with medical and/or dietary elimination therapy in patients with esophageal stricture for the management of dysphagia and to prevent its recurrence.

Citations

Citations to this article as recorded by  
  • The Dynamic Evolution of Eosinophilic Esophagitis
    Amir Farah, Tarek Assaf, Jawad Hindy, Wisam Abboud, Mostafa Mahamid, Edoardo Vincenzo Savarino, Amir Mari
    Diagnostics.2025; 15(3): 240.     CrossRef
  • Endoscopic Management of Eosinophilic Esophagitis: A Narrative Review on Diagnosis and Treatment
    Andrea Pasta, Francesco Calabrese, Manuele Furnari, Edoardo Vincenzo Savarino, Pierfrancesco Visaggi, Giorgia Bodini, Elena Formisano, Patrizia Zentilin, Edoardo Giovanni Giannini, Elisa Marabotto
    Journal of Clinical Medicine.2025; 14(11): 3756.     CrossRef
  • Eosinophilic Esophagitis: Emerging Insights Into Diagnosis and Management
    Hyun Ho Choi
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2025; 25(2): 117.     CrossRef
  • When Manometry and Functional Lumen Imaging Probe Disagree: The Current Limitations of the Chicago Classification Version 4.0 and Probable Extended Indications of Functional Lumen Imaging Probe
    Kee Wook Jung, John E Pandolfino
    Journal of Neurogastroenterology and Motility.2025; 31(3): 304.     CrossRef
  • 11,780 View
  • 577 Download
  • 2 Web of Science
  • 4 Crossref
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Clinical practice guidelines for percutaneous endoscopic gastrostomy
Chung Hyun Tae, Ju Yup Lee, Moon Kyung Joo, Chan Hyuk Park, Eun Jeong Gong, Cheol Min Shin, Hyun Lim, Hyuk Soon Choi, Miyoung Choi, Sang Hoon Kim, Chul-Hyun Lim, Jeong-Sik Byeon, Ki-Nam Shim, Geun Am Song, Moon Sung Lee, Jong-Jae Park, Oh Young Lee, Korean Society of Gastrointestinal Endoscopy Task Force on Clinical Practice Guidelines
Clin Endosc 2023;56(4):391-408.   Published online June 23, 2023
DOI: https://doi.org/10.5946/ce.2023.062
AbstractAbstract PDFSupplementary MaterialPubReaderePub
With an aging population, the number of patients with difficulty in swallowing due to medical conditions is gradually increasing. In such cases, enteral nutrition is administered through a temporary nasogastric tube. However, the long-term use of a nasogastric tube leads to various complications and a decreased quality of life. Percutaneous endoscopic gastrostomy (PEG) is the percutaneous placement of a tube into the stomach that is aided endoscopically and may be an alternative to a nasogastric tube when enteral nutritional is required for four weeks or more. This paper is the first Korean clinical guideline for PEG developed jointly by the Korean College of Helicobacter and Upper Gastrointestinal Research and led by the Korean Society of Gastrointestinal Endoscopy. These guidelines aimed to provide physicians, including endoscopists, with the indications, use of prophylactic antibiotics, timing of enteric nutrition, tube placement methods, complications, replacement, and tube removal for PEG based on the currently available clinical evidence.

Citations

Citations to this article as recorded by  
  • A Case of Perforated Peritonitis Caused by the Migration of a Single‐Puncture Gastric Wall Fixation Device Following Percutaneous Endoscopic Gastrostomy
    Yuu Kodama, Yuji Mizokami, Hidemitsu Nishizawa, Gen Maeda, Gen Kimura, Yuzo Toyama, Shingo Asahara, Ryuji Nagahama, Hideki Sunagawa
    DEN Open.2026;[Epub]     CrossRef
  • A systematic review and quality appraisal of guidelines and recommendations for home enteral tube feeding in adults
    Andriana Korai, Isabella Thomson, Sharon Carey, Margaret Allman-Farinelli
    European Journal of Clinical Nutrition.2025; 79(2): 104.     CrossRef
  • One-Year Mortality After Percutaneous Endoscopic Gastrostomy: The Prognostic Role of Nutritional Biomarkers and Care Settings
    Nermin Mutlu Bilgiç, Güldan Kahveci, Ekmel Burak Özşenel, Sema Basat
    Nutrients.2025; 17(5): 904.     CrossRef
  • Malnutrition and perioperative nutritional rehabilitation in major operations
    Konstantinos Lasithiotakis, Alexandros Andreou, Hammam Migdadi, Evangelos I. Kritsotakis
    European Surgery.2025;[Epub]     CrossRef
  • Endoscopic gastrostomy as a method of enteral nutrition providing
    E. A. Drobyazgin, Yu. V. Chikinev, A. V. Korobeynikov, A. S. Polyakevich, I. V. Peshkova, S. G. Stofin
    Filin’s Clinical endoscopy.2025; 67(1): 54.     CrossRef
  • Clinical Advances in Percutaneous Endoscopic Gastrostomy: A 2023 Clinical Practice Guideline-Based Review
    Ji Yong Ahn
    The Korean Journal of Medicine.2025; 100(2): 54.     CrossRef
  • Timing of Gastrostomy Relative to Tracheostomy After Complete Cervical Spinal Cord Injury: Impact on Hospitalization Outcomes and Complication Rates
    Ahmad Essa, Armaan K. Malhotra, Husain Shakil, Avery B. Nathens, Eva Y. Yuan, Yingshi He, Francois Mathieu, Michael C. Sklar, Jefferson R. Wilson, Christopher D. Witiw, Jetan H. Badhiwala
    Neurosurgery.2025;[Epub]     CrossRef
  • Outcomes of early compared with delayed initiation of feeding after placement of percutaneous endoscopic gastrostomy tube: A systematic review and meta‐analysis
    Mudathir Ibrahim, Ceilidh McKenney, Camilla Sophia Rossi, Susan Khader Ibrahim, Ahmed Alnajar, Gianmarco Cancelli, Matthew McKenney, Michelle Demetres, Zi Yuan, Jeffrey Nicastro, Joel Horovitz
    Journal of Parenteral and Enteral Nutrition.2025;[Epub]     CrossRef
  • Predictors of failure of percutaneous endoscopic gastrostomy tube placement: a retrospective study in a tertiary care center in the USA
    Ryan Xin, Cassandra Sanossian, Melissa Fazzari, Brandon Mui, Marouf Hossain, Jennifer Katz
    Clinical Endoscopy.2025; 58(3): 418.     CrossRef
  • Gastric outlet and duodenal bulb obstruction: A rare complication due to migrated gastrostomy tube
    Merve Eren Durmuş, Serkan Öcal, Ayhan Hilmi Çekin, Gökhan Köker
    Geriatric Nursing.2025; 65: 103426.     CrossRef
  • Mortalidad y futilidad en pacientes a quienes se les realizó gastrostomía entre 2020 a 2023
    Oscar Mauricio Ardila Suárez, Erick Ricardo Licona Vera, Sebastián Fernando Niño Ramírez
    Revista colombiana de Gastroenterología.2025; 40(2): 160.     CrossRef
  • A Multicenter Survey of Percutaneous Endoscopic Gastrostomy in 2019 at Korean Medical Institutions
    Jun Woo Park, Tae Gyun Kim, Kwang Bum Cho, Jeong Seok Kim, Jin Woong Cho, Jung Won Jeon, Sun Gyo Lim, Chan Gyoo Kim, Hong Jun Park, Tae Jun Kim, Eun Sun Kim, Su Jin Jeong, Yong Hwan Kwon
    Gut and Liver.2024; 18(1): 77.     CrossRef
  • Fast-track discharge following percutaneous endoscopic gastrostomy removal in head and neck cancer patients after remission: a feasibility and safety study
    Daniel Conceição, Luís Correia Gomes, Fátima Francisco, Ivone Frade, Joana Gramacho, Sandra Faias, Isabel Claro
    Journal of Gastrointestinal Surgery.2024; 28(6): 943.     CrossRef
  • When to feed after percutaneous endoscopic gastrostomy: A systematic review and meta‐analysis of randomized controlled trials
    Matthew L. Bechtold, Zahid Ijaz Tarar, Muhammad N. Yousaf, Ghady Moafa, Abdul M. Majzoub, Xheni Deda, Michelle L. Matteson‐Kome, Srinivas R. Puli
    Nutrition in Clinical Practice.2024; 39(5): 1191.     CrossRef
  • The Effect of Oral Diet Training in Indwelling Nasogastric Tube Patients with Prolonged Dysphagia
    Byung-chan Choi, Sook Joung Lee, Eunseok Choi, Sangjee Lee, Jungsoo Lee
    Nutrients.2024; 16(15): 2424.     CrossRef
  • The Impact of Palliative Decompressive Gastrostomy Tube Placement on Patients and Their Caregivers: A Mixed Methods Analysis
    Jeffrey L. Roberson, Julia A. Gasior, Sara P. Ginzberg, Emna Bakillah, Jesse Passman, Lauren Shreve, Catherine E. Sharoky, Gregory Nadolski, Katherine R. Courtright, Elinore J. Kaufman
    Annals of Surgical Oncology.2024; 31(10): 6931.     CrossRef
  • 10,784 View
  • 677 Download
  • 13 Web of Science
  • 16 Crossref
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Role of endoscopy in patients with achalasia
So Young Han, Young Hoon Youn
Clin Endosc 2023;56(5):537-545.   Published online June 2, 2023
DOI: https://doi.org/10.5946/ce.2023.001
AbstractAbstract PDFPubReaderePub
Achalasia is an esophageal motility disorder characterized by impaired lower esophageal sphincter relaxation and peristalsis of the esophageal body. With the increasing prevalence of achalasia, interest in the role of endoscopy in its diagnosis, treatment, and monitoring is also growing. The major diagnostic modalities for achalasia include high-resolution manometry, esophagogastroduodenoscopy, and barium esophagography. Endoscopic assessment is important for early diagnosis to rule out diseases that mimic achalasia symptoms, such as pseudo-achalasia, esophageal cancer, esophageal webs, and eosinophilic esophagitis. The major endoscopic characteristics suggestive of achalasia include a widened esophageal lumen and food residue in the esophagus. Once diagnosed, achalasia can be treated either endoscopically or surgically. The preference for endoscopic treatment is increasing owing to its minimal invasiveness. Botulinum toxins, pneumatic balloon dilation, and peroral endoscopic myotomy (POEM) are important endoscopic treatments. Previous studies have demonstrated excellent treatment outcomes for POEM, with >95% improvement in dysphagia, making POEM the mainstay treatment option for achalasia. Several studies have reported an increased risk of esophageal cancer in patients with achalasia. However, routine endoscopic surveillance remains controversial owing to the lack of sufficient data. Further studies on surveillance methods and duration are warranted to establish concordant guidelines for the endoscopic surveillance of achalasia.

Citations

Citations to this article as recorded by  
  • O papel da endoscopia no diagnóstico e tratamento de Acalasia
    Rebeca Silva Moreira da Fraga, José Joaquim de Almeida Figueiredo, Thaisa de Moraes Ribeiro Espírito Santo, Esteban Sadovsky
    Revista Brasileira de Pesquisa em Saúde/Brazilian Journal of Health Research.2025; 26(supl_3): 107.     CrossRef
  • Effect of sex on the outcomes of peroral endoscopic myotomy for the treatment of achalasia
    Chen-Yi Zhao, Ning Xu, Hao Dong, Ning-Li Chai, En-Qiang Linghu
    World Journal of Gastroenterology.2025;[Epub]     CrossRef
  • Postoperative Pain Management Strategies Following Peroral Endoscopic Myotomy (POEM): A Review
    Jun Lu, Wentao Ji, Chao Sang, Zhi Wang, Lulong Bo
    Journal of Pain Research.2025; Volume 18: 2761.     CrossRef
  • Peroral endoscopic myotomy for achalasia combined with esophageal varices
    Ah Young Lee, Joo Young Cho
    Clinical Endoscopy.2025; 58(3): 490.     CrossRef
  • The role of cap-assisted endoscopy and its future implications
    Sol Kim, Bo-In Lee
    Clinical Endoscopy.2024; 57(3): 293.     CrossRef
  • Never judge a book by its cover: the role of timed barium esophagography in patients with complete symptom relief after peroral endoscopic myotomy
    Tae Hee Lee
    Clinical Endoscopy.2024; 57(5): 604.     CrossRef
  • Advanced Esophageal Endoscopy
    Kyoungwon Jung, Rebecca M. Haug, Andrew Y. Wang
    Gastroenterology Clinics of North America.2024; 53(4): 603.     CrossRef
  • Case of Concomitant Endoscopic Treatment of Achalasia with Superficial Esophageal Cancer
    Myung-Hun Lee, Kyoungwon Jung, Jae Hyun Kim, Sung Eun Kim, Won Moon, Moo In Park, Seun Ja Park
    The Korean Journal of Gastroenterology.2023; 82(5): 248.     CrossRef
  • 9,302 View
  • 479 Download
  • 7 Web of Science
  • 8 Crossref
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Original Article
White spots around colorectal tumors are cancer-related findings and may aid endoscopic diagnosis: a prospective study in Japan
Kai Korekawa, Yusuke Shimoyama, Fumiyoshi Fujishima, Hiroshi Nagai, Takeo Naito, Rintaro Moroi, Hisashi Shiga, Yoichi Kakuta, Yoshitaka Kinouchi, Atsushi Masamune
Clin Endosc 2024;57(5):637-646.   Published online June 21, 2024
DOI: https://doi.org/10.5946/ce.2024.027
Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReaderePub
Background
/Aims: During endoscopy, white spots (WS) are sometimes observed around benign or malignant colorectal tumors; however, few reports have investigated WS, and their significance remains unknown. Therefore, we investigated the significance of WS from clinical and pathological viewpoints and evaluated its usefulness in endoscopic diagnosis.
Methods
Clinical data of patients with lesions diagnosed as epithelial tumors from January 1, 2019, to December 31, 2020, were analyzed (n=3,869). We also performed a clinicopathological analysis of adenomas or carcinomas treated with endoscopic resection (n=759). Subsequently, detailed pathological observations of the WS were performed.
Results
The positivity rates for WS were 9.3% (3,869 lesions including advanced cancer and non-adenoma/carcinoma) and 25% (759 lesions limited to adenoma and early carcinoma). Analysis of 759 lesions showed that the WS-positive lesion group had a higher proportion of cancer cases and larger tumor diameters than the WS-negative group. Multiple logistic analysis revealed the following three statistically significant risk factors for carcinogenesis: positive WS, flat lesions, and tumor diameter ≥5 mm. Pathological analysis revealed that WS were macrophages that phagocytosed fat and mucus and were white primarily because of fat.
Conclusions
WS are cancer-related findings and can become a new criterion for endoscopic resection in the future.
  • 9,263 View
  • 353 Download
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Reviews
Role of endoscopy in gastroesophageal reflux disease
Daniel Martin Simadibrata, Elvira Lesmana, Ronnie Fass
Clin Endosc 2023;56(6):681-692.   Published online October 12, 2023
DOI: https://doi.org/10.5946/ce.2023.182
AbstractAbstract PDFPubReaderePub
In general, gastroesophageal reflux disease (GERD) is diagnosed clinically based on typical symptoms and/or response to proton pump inhibitor treatment. Upper gastrointestinal endoscopy is reserved for patients presenting with alarm symptoms, such as dysphagia, odynophagia, significant weight loss, gastrointestinal bleeding, or anorexia; those who meet the criteria for Barrett’s esophagus screening; those who report a lack or partial response to proton pump inhibitor treatment; and those with prior endoscopic or surgical anti-reflux interventions. Newer endoscopic techniques are primarily used to increase diagnostic yield and provide an alternative to medical or surgical treatment for GERD. The available endoscopic modalities for the diagnosis of GERD include conventional endoscopy with white-light imaging, high-resolution and high-magnification endoscopy, chromoendoscopy, image-enhanced endoscopy (narrow-band imaging, I- SCAN, flexible spectral imaging color enhancement, blue laser imaging, and linked color imaging), and confocal laser endomicroscopy. Endoscopic techniques for treating GERD include esophageal radiofrequency energy delivery/Stretta procedure, transoral incisionless fundoplication, and endoscopic full-thickness plication. Other novel techniques include anti-reflux mucosectomy, peroral endoscopic cardiac constriction, endoscopic submucosal dissection, and endoscopic band ligation. Currently, many of the new endoscopic techniques are not widely available, and their use is limited to centers of excellence.

Citations

Citations to this article as recorded by  
  • Exploring esophagogastric junction morphology and contractile integral: implications for refractory gastroesophageal reflux disease pathophysiology
    Sihui Lin, Zhilong Chen, Wei Jiang, Yucheng Zhu
    Scandinavian Journal of Gastroenterology.2025; 60(2): 130.     CrossRef
  • Patients Presenting With Reflux Symptoms - Whom to Test and Whom to Treat?
    Noy Lapidot Alon, Tomas Navarro Rodriguez, Ronnie Fass
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2025; 25(1): 7.     CrossRef
  • 'Unmasking Endoscopic Patterns in PPI-Refractory GERD: Insights into Findings and Risk Factors'
    A Samad
    Endoscopy.2025; 57(S 02): S335.     CrossRef
  • Potassium-competitive Acid Blockers for Treatment of Extraesophageal Symptoms and Signs
    Gwang Ha Kim, Ronnie Fass
    Journal of Neurogastroenterology and Motility.2025; 31(2): 170.     CrossRef
  • ESÔFAGO DE BARRETT: UMA REVISÃO BIBLIOGRÁFICA
    Marcelo Vinícius Pereira Silva, Elaine Timm, Allan Martins De Oliveira, Elizeu Augusto De Freitas Junior , Marlison Caldas Gonçalves Pereira
    Brazilian Medical Students.2025;[Epub]     CrossRef
  • Better diagnostic accuracy for GERD observed with the new MNBI cutoff: an observational study in Vietnam
    Hang Dao Viet, Hue Luu Thi Minh, Long Hoang Bao, Phuong Do Nhat, Long Dao Van
    BMC Gastroenterology.2025;[Epub]     CrossRef
  • Long-term efficacy of endoscopic radiofrequency Stretta therapy for patients with refractory gastroesophageal reflux disease
    Sung Eun Kim
    Clinical Endoscopy.2024; 57(1): 48.     CrossRef
  • Correlation of Endoscopic and Histopathological Diagnoses in Upper Gastrointestinal Tract Lesions: A Cross-Sectional Study
    Sudhasmita Rauta, Pratima Baisakh, Aswini K Sahoo, Dhiren K Panda, Manas R Baisakh, Sushree s Dash
    Cureus.2024;[Epub]     CrossRef
  • The role of ghrelin and leptin in the formation of morphological changes esophagus of patients with gastro-esophageal reflux disease against type 2 diabetes
    Olha Bondar-Keleberda
    EUREKA: Health Sciences.2023; (4): 24.     CrossRef
  • 8,610 View
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  • 7 Web of Science
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Potassium-competitive acid blocker-associated gastric mucosal lesions
Kimitoshi Kubo, Noriko Kimura, Mototsugu Kato
Clin Endosc 2024;57(4):417-423.   Published online February 29, 2024
DOI: https://doi.org/10.5946/ce.2023.279
AbstractAbstract PDFPubReaderePub
Since the introduction of vonoprazan, a potassium-competitive acid blocker (P-CAB), it has been demonstrated to reversibly inhibit gastric acid secretion by engaging in potassium-competitive ionic binding to H+/K+-ATPase. In contrast, proton pump inhibitors (PPIs) achieve H+/K+-ATPase inhibition through covalent binding to cysteine residues of the proton pump. Reported cases have indicated an emerging trend of P-CAB-related gastropathies, similar to those associated with PPIs, as well as unique gastropathies specific to P-CAB use, such as the identification of web-like mucus. Pathologically, parietal cell profusions, which show a positively correlated with hypergastrinemia, have a higher incidence in P-CAB users compared to PPI users. Thus, this review aims to summarize the endoscopic and pathological findings reported to date concerning P-CAB-related gastric mucosal lesions. Additionally, it seeks to discuss the differences between the PPIs and P-CABs in terms of the formation and frequency of associated gastropathies. This review highlights the evident differences in the mechanism of action and potency of acid inhibition between P-CABs and PPIs, notably contributing to differences in the formation and frequency of associated gastropathies. It emphasizes the necessity to distinguish between P-CAB-related and PPI-related gastropathies in the clinical setting.

Citations

Citations to this article as recorded by  
  • Profound gastric mucosal changes and severe rebound acid hypersecretion after long‐term Vonoprazan use: A case report
    Hiroko Suda, Sachi Eto, Koichi Sakurai
    DEN Open.2025;[Epub]     CrossRef
  • Bloqueadores ácidos competitivos de potasio (PCABs): estado del arte
    José Augusto Urrego, William Otero, Hugo Cedrón, Hernando Marulanda, Alejandro Piscoya, Juan Sebastián Frías-Ordoñez, Lina Otero
    Revista de Gastroenterología del Perú.2025; 45(1): 38.     CrossRef
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    Eun Jeong Gong, Chang Seok Bang
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    Masaya Iwamuro, Yoshiyasu Kono, Takehiro Tanaka, Seiji Kawano, Nobumasa Ikeda
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    Satoshi Shinozaki, Hirotsugu Sakamoto, Hiroyuki Osawa, Tomonori Yano, Hironori Yamamoto
    Biomedical Reports.2024;[Epub]     CrossRef
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  • 596 Download
  • 3 Web of Science
  • 5 Crossref
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Case Report
Successful removal of remnant cystic duct stump stone using single-operator cholangioscopy-guided electrohydraulic lithotripsy: two case reports
Sung Hyeok Ryou, Hong Ja Kim
Clin Endosc 2023;56(3):375-380.   Published online January 5, 2023
DOI: https://doi.org/10.5946/ce.2021.273
AbstractAbstract PDFPubReaderePub
Cholecystectomy is the best method for treating gallstone diseases. However, 10%–30% of patients who undergo a cholecystectomy continue to complain of upper abdominal pain, dyspepsia, or jaundice—this is referred to as postcholecystectomy syndrome. Cystic duct stump stones are a troublesome cause of postcholecystectomy syndrome. Conventionally, surgery is mainly performed to remove cystic duct stump stones. However, repeated surgery can cause complications, such as postoperative bleeding, biliary injury, and wound infection. As an alternative method of surgery, endoscopic retrograde cholangiopancreatography is sometimes used to remove cystic duct stump stones, although the success rate is not high due to technical difficulties. Recently, peroral cholangioscopy, which can directly observe the bile duct, has been suggested as an alternative method. We report two cases in which a cystic duct stump stone was successfully removed via a single-operator cholangioscopy, after failure with an endoscopic retrograde cholangiopancreatography.

Citations

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    Changjin Nam, Jun Suh Lee, Ji Su Kim, Tae Yoon Lee, Young Chul Yoon
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    Amit Kumar, Harindra Kumar Goje, Nimesh Kumar Tarway, Vivek Hande
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  • Laparoscopic management of remnant gall bladder with stones: Lessons from a tertiary care centre's experience
    Gilbert Samuel Jebakumar, Jeevanandham Muthiah, Loganathan Jayapal, R. Santhosh Kumar, Siddhesh Tasgaonkar, K.S. Santhosh Anand, J.K.A. Jameel, Sudeepta Kumar Swain, K.J. Raghunath, Prasanna Kumar Reddy, Tirupporur Govindaswamy Balachandar
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    Gwang Ha Kim, Dong Chan Joo
    Clinical Endoscopy.2024; 57(2): 268.     CrossRef
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  • 248 Download
  • 5 Web of Science
  • 5 Crossref
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Reviews
Endoscopic retrograde cholangiopancreatography-related complications: risk stratification, prevention, and management
Clement Chun Ho Wu, Samuel Jun Ming Lim, Christopher Jen Lock Khor
Clin Endosc 2023;56(4):433-445.   Published online July 17, 2023
DOI: https://doi.org/10.5946/ce.2023.013
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Endoscopic retrograde cholangiopancreatography (ERCP) plays a crucial role in the management of pancreaticobiliary disorders. Although the ERCP technique has been refined over the past five decades, it remains one of the endoscopic procedures with the highest rate of complications. Risk factors for ERCP-related complications are broadly classified into patient-, procedure-, and operator-related risk factors. Although non-modifiable, patient-related risk factors allow for the closer monitoring and instatement of preventive measures. Post-ERCP pancreatitis is the most common complication of ERCP. Risk reduction strategies include intravenous hydration, rectal nonsteroidal anti-inflammatory drugs, and pancreatic stent placement in selected patients. Perforation is associated with significant morbidity and mortality, and prompt recognition and treatment of ERCP-related perforations are key to ensuring good clinical outcomes. Endoscopy plays an expanding role in the treatment of perforations. Specific management strategies depend on the location of the perforation and the patient’s clinical status. The risk of post-ERCP bleeding can be attenuated by preprocedural optimization and adoption of intra-procedural techniques. Endoscopic measures are the mainstay of management for post-ERCP bleeding. Escalation to angioembolization or surgery may be required for refractory bleeding. Post-ERCP cholangitis can be reduced with antibiotic prophylaxis in high risk patients. Bile culture-directed therapy plays an important role in antimicrobial treatment.

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  • Comparison of the incidence of post-endoscopic retrograde cholangiopancreatography pancreatitis in patients with and without diabetes: a meta-analysis
    Fang Jia, Fujing Lv, Shutian Zhang
    Surgical Endoscopy.2025; 39(2): 807.     CrossRef
  • Small common bile duct - the risk factor for post-ercp pancreatitis in patients with choledocholithiasis
    Ivan Mamontov, Tamara Tamm, Kostiantyn Kramarenko, Dmytro Ryabushchenko, Dmytro Sytnik, Samer Dghaili
    Wiadomości Lekarskie.2025; 77(12): 2388.     CrossRef
  • Multidisciplinary Therapeutic Approaches to Pancreatic Cancer According to the Resectability Status
    Aurelio Mauro, Carlotta Faverio, Leonardo Brizzi, Stefano Mazza, Davide Scalvini, Daniele Alfieri, Alessandro Cappellini, Fabio Chicco, Carlo Ciccioli, Claudia Delogu, Marco Bardone, Anna Gallotti, Anna Pagani, Francesca Torello Viera, Andrea Anderloni
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  • Effect of periampullary diverticulum morphology on ERCP cannulation and clinical results
    Yavuz Cagir, Muhammed Bahaddin Durak, Cem Simsek, Ilhami Yuksel
    Scandinavian Journal of Gastroenterology.2025; 60(4): 292.     CrossRef
  • Delayed bleeding after endoscopic sphincterotomy in patients receiving anticoagulants
    Mitsushige Sugimoto, Masaki Murata, Kento Shionoya, Takayoshi Tsuchiya, Takao Itoi
    Digestive Endoscopy.2025; 37(7): 733.     CrossRef
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    Alexandre Gomes
    Cureus.2025;[Epub]     CrossRef
  • Development of a Checklist for Evaluating Pancreatobiliary Endoscopy Training Facilities and Educational Programs
    Hyung Ku Chon, Sung-Jo Bang, Eaum Seok Lee, Tae Ju Jeon, Chang Hwan Park
    The Korean Journal of Pancreas and Biliary Tract.2025; 30(2): 93.     CrossRef
  • Burden and cost of post–endoscopic retrograde cholangiopancreatography pancreatitis among commercially insured people undergoing endoscopic retrograde cholangiopancreatography
    Anna Tavakkoli, Kandice A. Kapinos, B. Joseph Elmunzer, Richard S. Kwon, David M. Troendle, Song Zhang, Amit G. Singal
    Gastrointestinal Endoscopy.2025;[Epub]     CrossRef
  • Preprocedural score system for post-ERCP pancreatitis risk stratification in patients with billiary obstruction
    I.М. Mamontov, D.D. Riabushchenko, Т.І. Tamm, K.О. Kramarenko, S. Dghaili, V.V. Nepomniashchyi
    Український радіологічний та онкологічний журнал.2025; 33(1): 9.     CrossRef
  • Prevalence and Characteristics of Post-endoscopic Retrograde Cholangiopancreatography (ERCP) Complications in Patients With Biliopancreatic Disorders: A Retrospective Study
    Jose Luis Vallejo Romero, Yazmin Cardenas Ramos, Floricel Olimpia Villegas Amador, Sandra Allison Barrueta Orive, Erick Mauricio Aldana Carbajal, Maria Guadalupe Ramirez Lugo, Karen Andrea Martinez Martinez, Diana Laura Montiel Covarrubias, Luis Eduardo N
    Cureus.2025;[Epub]     CrossRef
  • Prevention of post-ERCP complications
    Lotfi Triki, Andrea Tringali, Marianna Arvanitakis, Tommaso Schepis
    Best Practice & Research Clinical Gastroenterology.2024; 69: 101906.     CrossRef
  • International Digestive Endoscopy Network consensus on the management of antithrombotic agents in patients undergoing gastrointestinal endoscopy
    Seung Joo Kang, Chung Hyun Tae, Chang Seok Bang, Cheol Min Shin, Young-Hoon Jeong, Miyoung Choi, Joo Ha Hwang, Yutaka Saito, Philip Wai Yan Chiu, Rungsun Rerknimitr, Christopher Khor, Vu Van Khien, Kee Don Choi, Ki-Nam Shim, Geun Am Song, Oh Young Lee
    Clinical Endoscopy.2024; 57(2): 141.     CrossRef
  • Double-guidewire technique for selective biliary cannulation does not increase the rate of post-endoscopic retrograde cholangiopancreatography pancreatitis in patients with naïve papilla
    Han Taek Jeong, June Hwa Bae, Ho Gak Kim, Jimin Han
    Clinical Endoscopy.2024; 57(2): 226.     CrossRef
  • Computed tomography-based prediction of pancreatitis following biliary metal stent placement with the convolutional neural network
    Tsuyoshi Hamada, Koichiro Yasaka, Yousuke Nakai, Rintaro Fukuda, Ryunosuke Hakuta, Kazunaga Ishigaki, Sachiko Kanai, Kensaku Noguchi, Hiroki Oyama, Tomotaka Saito, Tatsuya Sato, Tatsunori Suzuki, Naminatsu Takahara, Hiroyuki Isayama, Osamu Abe, Mitsuhiro
    Endoscopy International Open.2024; 12(06): E772.     CrossRef
  • IDEN Consensus on Management of Antithrombotic Agents in Patients Undergoing Gastrointestinal Endoscopy
    Seung Joo Kang, Chung Hyun Tae, Chang Seok Bang, Cheol Min Shin, Young-Hoon Jeong, Miyoung Choi, Joo Ha Hwang, Yutaka Saito, Philip Wai Yan Chiu, Rungsun Rerknimitr, Christopher Khor, Vu Van Khien, Kee Don Choi, Ki-Nam Shim, Geun Am Song, Oh Young Lee
    The Korean Journal of Gastroenterology.2024; 83(6): 217.     CrossRef
  • International Digestive Endoscopy Network Consensus on the Management of Antithrombotic Agents in Patients Undergoing Gastrointestinal Endoscopy
    Seung Joo Kang, Chung Hyun Tae, Chang Seok Bang, Cheol Min Shin, Young-Hoon Jeong, Miyoung Choi, Joo Ha Hwang, Yutaka Saito, Philip Wai Yan Chiu, Rungsun Rerknimitr, Christopher Khor, Vu Van Khien, Kee Don Choi, Ki-Nam Shim, Geun Am Song, Oh Young Lee
    Gut and Liver.2024; 18(5): 764.     CrossRef
  • Risk factors for acute pancreatitis after endoscopic retrograde cholangiopancreatography: a retrospective single-center study
    I.М. Mamontov, D.D. Rjabushhenko, Т.І. Tamm, К.О. Kramarenko, V.V. Nepomniashchyi, A.T. Ustinov
    Український радіологічний та онкологічний журнал.2024; 32(3): 287.     CrossRef
  • Could assessment of genetic susceptibility be an effective solution to prevent pancreatitis from occurring after endoscopic retrograde cholangiopancreatography?
    Jae Min Lee
    The Korean Journal of Internal Medicine.2023; 38(6): 783.     CrossRef
  • 8,210 View
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Painless colonoscopy: fact or fiction?
Pieter Sinonquel, Alexander Jans, Raf Bisschops
Clin Endosc 2024;57(5):581-587.   Published online June 27, 2024
DOI: https://doi.org/10.5946/ce.2024.001
AbstractAbstract PDFPubReaderePub
Although colonoscopy is a routinely performed procedure, it is not devoid of challenges, such as the potential for perforation and considerable patient discomfort, leading to patients postponing the procedure with several healthcare risks. This review delves into preprocedural and procedural solutions, and emerging technologies aimed at addressing the drawbacks of colonoscopies. Insufflation and sedation techniques, together with various other methods, have been explored to increase patient satisfaction, and thereby, the quality of endoscopy. Recent advances in this field include the prevention of loop formation, encompassing the use of variable-stiffness endoscopes, computer-guided scopes, magnetic endoscopic imaging, robotics, and capsule endoscopy. An autonomous endoscope that relies on self-propulsion to completely avoid looping is a potentially groundbreaking technology for the next generation of endoscopes. Nevertheless, critical techniques need to be refined to ensure the development of effective and efficient endoscopes.

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  • Polyp Matching in Colon Capsule Endoscopy: Pioneering CCE-Colonoscopy Integration Towards an AI-Driven Future
    Ian Io Lei, Ramesh Arasaradnam, Anastasios Koulaouzidis
    Journal of Clinical Medicine.2024; 13(23): 7034.     CrossRef
  • 7,472 View
  • 490 Download
  • 1 Web of Science
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Advanced endoscopic imaging for detection of Barrett’s esophagus
Netanel Zilberstein, Michelle Godbee, Neal A. Mehta, Irving Waxman
Clin Endosc 2024;57(1):1-10.   Published online January 5, 2024
DOI: https://doi.org/10.5946/ce.2023.031
AbstractAbstract PDFPubReaderePub
Barrett’s esophagus (BE) is the precursor to esophageal adenocarcinoma (EAC), and is caused by chronic gastroesophageal reflux. BE can progress over time from metaplasia to dysplasia, and eventually to EAC. EAC is associated with a poor prognosis, often due to advanced disease at the time of diagnosis. However, if BE is diagnosed early, pharmacologic and endoscopic treatments can prevent progression to EAC. The current standard of care for BE surveillance utilizes the Seattle protocol. Unfortunately, a sizable proportion of early EAC and BE-related high-grade dysplasia (HGD) are missed due to poor adherence to the Seattle protocol and sampling errors. New modalities using artificial intelligence (AI) have been proposed to improve the detection of early EAC and BE-related HGD. This review will focus on AI technology and its application to various endoscopic modalities such as high-definition white light endoscopy, narrow-band imaging, and volumetric laser endomicroscopy.

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  • Gender disparities and woman-specific trends in Barrett’s esophagus in the United States: An 11-year nationwide population-based study
    Karina Fatakhova, Faisal Inayat, Hassam Ali, Pratik Patel, Attiq Ur Rehman, Arslan Afzal, Muhammad Sarfraz, Shiza Sarfraz, Gul Nawaz, Ahtshamullah Chaudhry, Rubaid Dhillon, Arthur Dilibe, Benjamin Glazebnik, Lindsey Jones, Emily Glazer
    World Journal of Methodology.2025;[Epub]     CrossRef
  • Image-enhanced endoscopy in upper gastrointestinal disease: focusing on texture and color enhancement imaging and red dichromatic imaging
    Jae Yong Park
    Clinical Endoscopy.2025; 58(2): 163.     CrossRef
  • Advancements in Barrett's esophagus detection: The role of artificial intelligence and its implications
    Sara Massironi
    World Journal of Gastroenterology.2024; 30(11): 1494.     CrossRef
  • Advanced Esophageal Endoscopy
    Kyoungwon Jung, Rebecca M. Haug, Andrew Y. Wang
    Gastroenterology Clinics of North America.2024; 53(4): 603.     CrossRef
  • 7,466 View
  • 329 Download
  • 4 Web of Science
  • 4 Crossref
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Endoscopic management of postoperative bleeding
Sung Hyeok Ryou, Ki Bae Bang
Clin Endosc 2023;56(6):706-715.   Published online November 2, 2023
DOI: https://doi.org/10.5946/ce.2023.028
AbstractAbstract PDFPubReaderePub
Postoperative gastrointestinal bleeding is a rare but serious complication that can lead to prolonged hospitalization and significant morbidity and mortality. It can be managed by reoperation, endoscopy, or radiological intervention. Although reoperation carries risks, particularly in critically ill postoperative patients, minimally invasive interventions, such as endoscopy or radiological intervention, confer advantages. Endoscopy allows localization of the bleeding focus and hemostatic management at the same time. Although there have been concerns regarding the potential risk of creating an anastomotic disruption or perforation during early postoperative endoscopy, endoscopic management has become more popular over time. However, there is currently no consensus on the best endoscopic management for postoperative gastrointestinal bleeding because most practices are based on retrospective case series. Furthermore, there is a wide range of individual complexities in anatomical and clinical settings after surgery. This review focused on the safety and effectiveness of endoscopic management in various surgical settings.

Citations

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  • Letter to the editor on “early postoperative endoscopy for predicting anastomotic leakage after minimally invasive esophagectomy: A large-volume retrospective study”
    Judith Sánchez-Zavaleta, Doyler Cubas-García
    Surgery.2025; 180: 108890.     CrossRef
  • Evaluating the efficacy of a novel hemostatic powder compared with traditional treatments in nonvariceal upper GI bleeding: a multicenter, randomized, noninferiority study
    Da Hyun Jung, Jun Chul Park, Joon Sung Kim, Moon Won Lee, Hyuk Lee, Gwang Ha Kim
    Gastrointestinal Endoscopy.2025; 101(4): 792.     CrossRef
  • Gastrointestinale Endoskopie im postoperativen Komplikationsmanagement
    Marcus Kantowski, Gabriel Alexander Salg
    Allgemein- und Viszeralchirurgie up2date.2025; 19(01): 53.     CrossRef
  • The impact of ERAS-based nursing interventions on postoperative complication management and prognosis in early gastrointestinal tumor endoscopic resection: a prospective randomized controlled study
    Yun Shen, Yu Xi, Li Gu Xian Ru, Huayu Liu
    Langenbeck's Archives of Surgery.2025;[Epub]     CrossRef
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  • 3 Web of Science
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Drainage for fluid collections post pancreatic surgery and acute pancreatitis: similar but different?
Yousuke Nakai, Saburo Matsubara, Tsuyoshi Mukai, Tsuyoshi Hamada, Takashi Sasaki, Hirotoshi Ishiwatari, Susumu Hijioka, Hideyuki Shiomi, Mamoru Takenaka, Takuji Iwashita, Atsuhiro Masuda, Tomotaka Saito, Hiroyuki Isayama, Ichiro Yasuda, for the WONDERFUL study group in Japan
Clin Endosc 2024;57(6):735-746.   Published online May 17, 2024
DOI: https://doi.org/10.5946/ce.2023.254
AbstractAbstract PDFPubReaderePub
Postoperative pancreatic fistulas (POPFs) are common adverse events that occur after pancreatic surgery. Endoscopic ultrasonography (EUS)-guided drainage (EUS-D) is a first-line treatment, similar to that for pancreatic fluid collection (PFCs) after acute pancreatitis. However, some POPFs do not develop fluid collections depending on the presence or location of the surgical drain, whereas others develop fluid collections, such as postoperative fluid collections (POPFCs). Although POPFCs are similar to PFCs, the strategy and modality for POPF management need to be modified according to the presence of fluid collections, surgical drains, and surgical type. As discussed for PFCs, the indications, timing, and selection of interventions or stents for EUS-D have not been fully elucidated for POPFs. In this review, we discuss the management of POPFs and POPFCs in comparison with PFCs due to acute pancreatitis and summarize the topics that should be addressed in future studies.

Citations

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  • Management of Postoperative Pancreatic Fluid Collection and Role of Endoscopy: A Case Series and Review of the Literature
    Chiara Coluccio, Ilaria Tarantino, Maria Chiara Petrone, Edoardo Forti, Stefano Francesco Crinò, Alessandro Fugazza, Roberto Di Mitri, Cecilia Binda, Davide Trama, Arnaldo Amato, Alessandro Redaelli, Germana De Nucci, Fabia Attili, Mario Luciano Brancacci
    Diagnostics.2025; 15(10): 1258.     CrossRef
  • Percutaneous mini–invasive interventions in the treatment of peripancreatic fluid accumulation after pancreatic resection
    M. V. Kostylev, V. P. Shkarban, V. I. Trachuk, V. O. Shatalo
    The Ukrainian Journal of Clinical Surgery.2025; 92(3): 20.     CrossRef
  • Acute Necrotizing Pancreatitis—Advances and Challenges in Management for Optimal Clinical Outcomes
    Ioana Dumitrascu, Narcis Octavian Zarnescu, Eugenia Claudia Zarnescu, Mihai Radu Pahomeanu, Alexandru Constantinescu, Dana Galieta Minca, Radu Virgil Costea
    Medicina.2025; 61(7): 1186.     CrossRef
  • 7,255 View
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  • 1 Web of Science
  • 3 Crossref
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As how artificial intelligence is revolutionizing endoscopy
Jean-Francois Rey
Clin Endosc 2024;57(3):302-308.   Published online March 8, 2024
DOI: https://doi.org/10.5946/ce.2023.230
AbstractAbstract PDFPubReaderePub
With incessant advances in information technology and its implications in all domains of our lives, artificial intelligence (AI) has emerged as a requirement for improved machine performance. This brings forth the query of how this can benefit endoscopists and improve both diagnostic and therapeutic endoscopy in each part of the gastrointestinal tract. Additionally, it also raises the question of the recent benefits and clinical usefulness of this new technology in daily endoscopic practice. There are two main categories of AI systems: computer-assisted detection (CADe) for lesion detection and computer-assisted diagnosis (CADx) for optical biopsy and lesion characterization. Quality assurance is the next step in the complete monitoring of high-quality colonoscopies. In all cases, computer-aided endoscopy is used, as the overall results rely on the physician. Video capsule endoscopy is a unique example in which a computer operates a device, stores multiple images, and performs an accurate diagnosis. While there are many expectations, we need to standardize and assess various software packages. It is important for healthcare providers to support this new development and make its use an obligation in daily clinical practice. In summary, AI represents a breakthrough in digestive endoscopy. Screening for gastric and colonic cancer detection should be improved, particularly outside expert centers. Prospective and multicenter trials are mandatory before introducing new software into clinical practice.

Citations

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  • Effectiveness of a novel artificial intelligence-assisted colonoscopy system for adenoma detection: a prospective, propensity score-matched, non-randomized controlled study in Korea
    Jung-Bin Park, Jung Ho Bae
    Clinical Endoscopy.2025; 58(1): 112.     CrossRef
  • Usefulness of an artificial intelligence-based colonoscopy report generation support system
    Tatsushi Naito, Takuto Nosaka, Tomoko Tanaka, Yu Akazawa, Kazuto Takahashi, Masahiro Ohtani, Yasunari Nakamoto
    Clinical Endoscopy.2025; 58(2): 327.     CrossRef
  • Deep Learning-Based Real-Time Organ Localization and Transit Time Estimation in Wireless Capsule Endoscopy
    Seung-Joo Nam, Gwiseong Moon, Jung-Hwan Park, Yoon Kim, Yun Jeong Lim, Hyun-Soo Choi
    Biomedicines.2024; 12(8): 1704.     CrossRef
  • Understanding the discrepancy in the effectiveness of artificial intelligence-assisted colonoscopy: from randomized controlled trials to clinical reality
    Jung Ho Bae
    Clinical Endoscopy.2024; 57(6): 765.     CrossRef
  • Edge Artificial Intelligence Device in Real-Time Endoscopy for Classification of Gastric Neoplasms: Development and Validation Study
    Eun Jeong Gong, Chang Seok Bang, Jae Jun Lee
    Biomimetics.2024; 9(12): 783.     CrossRef
  • 7,250 View
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  • 6 Web of Science
  • 5 Crossref
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Case Report
Polyposis of gastrointestinal tract after COVID-19 mRNA vaccination: a report of two cases
Jun Ho Kim, Eun Hye Oh, Dong Soo Han
Clin Endosc 2024;57(3):402-406.   Published online April 12, 2024
DOI: https://doi.org/10.5946/ce.2023.268
AbstractAbstract PDFPubReaderePub
Cronkhite-Canada syndrome is a rare gastrointestinal polyposis syndrome with distinctive clinical features and endoscopic findings. Diagnosis can be challenging without suspicion, and the disease carries high mortality due to complications such as infection, gastrointestinal bleeding, and malignancies. This paper presents two cases of Cronkhite-Canada syndrome occurring after coronavirus disease 2019 (COVID-19) mRNA vaccination. Both cases exhibited typical clinical findings, including hypogeusia, onychodystrophy, alopecia, and weight loss. Typical polyposis in the gastrointestinal tract was confirmed through endoscopies. As symptomatic treatment did not improve the symptoms, corticosteroids were administered, and symptoms and laboratory test results improved immediately. The patients improved upon corticosteroids tapering. These cases illustrate typical presentations of Cronkhite-Canada syndrome and the course of the disease following corticosteroid treatment. Additionally, they suggest the possibility that Cronkhite-Canada syndrome may be triggered by COVID-19 mRNA vaccination.

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  • Elasomeran/tozinameran

    Reactions Weekly.2024; 2015(1): 165.     CrossRef
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  • 134 Download
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Original Article
Endoscopic resection of gastric gastrointestinal stromal tumor using clip-and-cut endoscopic full-thickness resection: a single-center, retrospective cohort in Korea
Yuri Kim, Ji Yong Ahn, Hwoon-Yong Jung, Seokin Kang, Ho June Song, Kee Don Choi, Do Hoon Kim, Jeong Hoon Lee, Hee Kyong Na, Young Soo Park
Clin Endosc 2024;57(3):350-363.   Published online February 15, 2024
DOI: https://doi.org/10.5946/ce.2023.144
Graphical AbstractGraphical Abstract AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background
/Aims: To overcome the technical limitations of classic endoscopic resection for gastric gastrointestinal stromal tumors (GISTs), various methods have been developed. In this study, we examined the role and feasibility of clip-and-cut procedures (clip-and-cut endoscopic full-thickness resection [cc-EFTR]) for gastric GISTs.
Methods
Medical records of 83 patients diagnosed with GISTs after endoscopic resection between 2005 and 2021 were retrospectively reviewed. Moreover, clinical characteristics and outcomes were analyzed.
Results
Endoscopic submucosal dissection (ESD) and cc-EFTR were performed in 51 and 32 patients, respectively. The GISTs were detected in the upper third of the stomach for ESD (52.9%) and cc-EFTR (90.6%). Within the cc-EFTR group, a majority of GISTs were located in the deep muscularis propria or serosal layer, accounting for 96.9%, as opposed to those in the ESD group (45.1%). The R0 resection rates were 51.0% and 84.4% in the ESD and cc-EFTR groups, respectively. Seven (8.4%) patients required surgical treatment (six patients underwent ESD and one underwent cc-EFTR,) due to residual tumor (n=5) and post-procedure adverse events (n=2). Patients undergoing R0 or R1 resection did not experience recurrence during a median 14-month follow-up period, except for one patient in the ESD group.
Conclusions
cc-EFTR displayed a high R0 resection rate; therefore, it is a safe and effective therapeutic option for small gastric GISTs.

Citations

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  • Advancements in Endoscopic Treatment for Gastric Subepithelial Tumors
    Osamu Goto, Kazutoshi Higuchi, Eriko Koizumi, Katsuhiko Iwakiri
    Gut and Liver.2025; 19(2): 151.     CrossRef
  • Endoscopic resection penetrating the muscularis propria for gastric gastrointestinal stromal tumors: advances and challenges
    Jin Woong Cho
    Clinical Endoscopy.2024; 57(3): 329.     CrossRef
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  • 186 Download
  • 2 Web of Science
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Review
A practical approach for small bowel bleeding
Sung Eun Kim, Hyun Jin Kim, Myeongseok Koh, Min Cheol Kim, Joon Sung Kim, Ji Hyung Nam, Young Kwan Cho, A Reum Choe, The Research Group for Capsule Endoscopy and Enteroscopy of the Korean Society of Gastrointestinal Endoscopy
Clin Endosc 2023;56(3):283-289.   Published online May 11, 2023
DOI: https://doi.org/10.5946/ce.2022.302
AbstractAbstract PDFPubReaderePub
Gastrointestinal (GI) bleeding is one of the most common conditions among patients visiting emergency departments in Korea. GI bleeding is divided into upper and lower GI bleeding, according to the bleeding site. GI bleeding is also divided into overt and occult GI bleeding based on bleeding characteristics. In addition, obscure GI bleeding refers to recurrent or persistent GI bleeding from a source that cannot be identified after esophagogastroduodenoscopy or colonoscopy. The small intestine is the largest part of the alimentary tract. It extends from the pylorus to the cecum. The small intestine is difficult to access owing to its long length. Moreover, it is not fixed to the abdominal cavity. When hemorrhage occurs in the small intestine, the source cannot be found in many cases because of the characteristics of the small intestine. In practice, small-intestinal bleeding accounts for most of the obscure GI bleeding. Therefore, in this review, we introduce and describe systemic approaches and examination methods, including video capsule endoscopy and balloon enteroscopy, that can be performed in patients with suspected small bowel bleeding in clinical practice.

Citations

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  • Effect of Different Types of Antithrombotic Agents on Clinical Outcomes in Patients With Small Bowel Bleeding Who Underwent Balloon‐Assisted Enteroscopy: A KASID Multicenter Study
    Jihye Park, Jin Su Kim, Joo Hye Song, Kwangwoo Nam, Seong‐Eun Kim, Eui Sun Jeong, Jae Hyun Kim, Seong Ran Jeon
    Journal of Gastroenterology and Hepatology.2025; 40(2): 456.     CrossRef
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    Chung Hyun Tae, Ki-Nam Shim
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    Won Shik Kim, Beom Jae Lee, Moon Kyung Joo, Seung Han Kim, Jong-Jae Park
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    Sohaib Asif, Yajun Ying, Tingting Qian, Jun Yao, Jinjie Qu, Vicky Yang Wang, Rongbiao Ying, Dong Xu, Mohamadreza (Mohammad) Khosravi
    International Journal of Intelligent Systems.2025;[Epub]     CrossRef
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    Carla Azevedo Zaibak, Sara Monteiro Barbosa, Nathalia Machado De Lima, Jordane Lula Cruz, Angela Maria Pereira Costa, Maria Eduarda da Silva Borges, Mariana Vasconcellos De Oliveira, Danyelly Rodrigues Machado
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    Hajin Lee, Younghee Choe, Jung Heo, Gwkang Hui Park, Su Young Lee, Young Wook Cho, Hyo Suk Kim
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    Seunghyun Hong, Gwang Ha Kim
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    Nikos Viazis, Dimitris Christodoulou, Vasilis Papastergiou, Konstantinos Mousourakis, Dimitra Kozompoli, Giannis Stasinos, Konstantina Dimopoulou, Periklis Apostolopoulos, Fotios Fousekis, Christos Liatsos, Nikolaos Kyriakos, Theodoros Argyropoulos, Georg
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    Jung Min Bae
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    Thanaboon Chaemsupaphan, Tanawat Geeratragool, Napat Angkathunyakul, Arissa Phothisirisakulwong, Monthira Maneerattanaporn
    Clinical Endoscopy.2024; 57(4): 552.     CrossRef
  • 6,583 View
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Original Article
Endoscopic ultrasound-guided coiling and glue is safe and superior to endoscopic glue injection in gastric varices with severe liver disease: a retrospective case control study
Kapil D. Jamwal, Rajesh K. Padhan, Atul Sharma, Manoj K. Sharma
Clin Endosc 2023;56(1):65-74.   Published online January 3, 2023
DOI: https://doi.org/10.5946/ce.2021.119
Graphical AbstractGraphical Abstract AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background
/Aims: Gastric varices (GV) are present in 25% of cirrhotic patients with high rates of rebleeding and mortality. Data on endoscopic ultrasound (EUS)-guided treatment in severe liver disease (model for end stage liver disease sodium [MELD-Na] >18 and Child-Turcotte-Pugh [CTP] C with GV) are scarce. Thus, we performed a retrospective comparison of endoscopic glue injection with EUS-guided therapy in cirrhotic patients with large GV.
Methods
A retrospective study was performed in the tertiary hospitals of India. A total of 80 patients were recruited. The inclusion criteria were gastroesophageal varices type 2, isolated gastric varices type 1, bleeding within 6 weeks, size of GV >10 mm, and a MELD-Na >18. Treatment outcomes and complications of endoscopic glue injection and EUS-guided GV therapy were compared.
Results
In this study, the patients’ age, sex, liver disease severity (CTP, MELD-Na) and clinical parameters were comparable. The median number of procedures, injected glue volume, complications, and GV obturation were better in the EUS group, respectively. On subgroup analysis of the EUS method (e.g., direct gastric fundus vs. paragastric collateral [PGC] coil placement), PGC coil placement showed decreased coil requirement, less injected glue volume, decreased luminal coil extrusion, and increased successful GV obturation.
Conclusions
EUS-guided treatment is more efficient and safer, and requires a smaller number of treatment sessions, as compared to endoscopic treatment in severe liver disease patients with large GV. Furthermore, PGC coil placement increases the complete obliteration of GV.

Citations

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    P. Krishna Bharadwaj, Santhosh E. Kumar, Sudipta Dhar Chowdhury, Ebby George Simon, Shyamkumar Nidugala Keshava, A. J. Joseph, Reuben Thomas Kurien, Uday George Zachariah, Ashish Goel
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    Shivam Khare, Anil Arora, Jijo Varghese, Vikas Singla, Asif Rahman, Ashish Kumar, Piyush Ranjan, Mandhir Kumar, Praveen Sharma, Naresh Bansal, Shrihari Anikhindi, Munish Sachdeva, Asheish Khandelwal, Mayank Gupta, Suprabhat Giri
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Review
Simulator-based training method in gastrointestinal endoscopy training and currently available simulators
Yuri Kim, Jeong Hoon Lee, Gin Hyug Lee, Ga Hee Kim, Gunn Huh, Seung Wook Hong, Hwoon-Yong Jung
Clin Endosc 2023;56(1):1-13.   Published online January 6, 2023
DOI: https://doi.org/10.5946/ce.2022.191
AbstractAbstract PDFPubReaderePub
The apprenticeship-based training method (ABTM) is highly effective for gastrointestinal (GI) endoscopic training. However, the conventional ABTM has significant issues. Although many supplementary training methods (TMs) have been developed and utilized, they cannot entirely replace the ABTM, which remains the major TM strategy. Currently, new TM construction is crucial and necessary due to financial constraints, difficulty of obtaining sufficient training time due to patient safety-related regulations, and catastrophic damage caused by disasters such as the coronavirus disease 2019 pandemic. The simulator-based TM (SBTM) is widely accepted as an alternative to the ABTM, owing to the SBTM’s advantages. Since the 1960s, many GI endoscopy training simulators have been developed and numerous studies have been published on their effectiveness. While previous studies have focused on the simulator’s validity, this review focused on the accessibility of simulators that were introduced by the end of 2021. Although the current SBTM is effective in GI endoscopic education, extensive improvements are needed to replace the ABTM. Incorporating simulator-incorporated TMs into an improved ABTM is an attempt to overcome the incompleteness of the current SBTM. Until a new simulator is developed to replace the ABTM, it is desirable to operate a simulator-integrated and well-coordinated TM that is suitable for each country and institution.

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Close layer
Original Article
Endoscopic ultrasound-guided gastrojejunostomy with a direct technique without previous intestinal filling using a tubular fully covered self-expandable metallic stent
Hakan Şentürk, İbrahim Hakkı Köker, Koray Koçhan, Sercan Kiremitçi, Gülseren Seven, Ali Tüzün İnce
Clin Endosc 2024;57(2):209-216.   Published online July 3, 2023
DOI: https://doi.org/10.5946/ce.2023.022
Graphical AbstractGraphical Abstract AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background
/Aims: Endoscopic ultrasonography-guided gastrojejunostomy is a minimally invasive method for the management of gastric outlet obstruction. Conventionally, a lumen-apposing metal stent (LAMS) is used to create an anastomosis. However, LAMS is expensive and not widely available. In this report, we described a tubular fully covered self-expandable metallic stent (T-FCSEMS) for this purpose.
Methods
Twenty-one patients (15 men [71.4%]; median age, 66 years; range, 40–87 years) were included in this study. A total of 19 malignant (12 pancreatic, 6 gastric, and 1 metastatic rectal cancer) and 2 benign cases were observed. The proximal jejunum was punctured with a 19 G needle. The stomach and jejunum walls were dilated with a 6 F cystotome, and a 20×80 mm polytetrafluoroethylene T-FCSEMS (Hilzo) was deployed. Oral feeding was initiated after 12 to 18 hours and solid foods after 48 hours.
Results
The median procedure time was 33 minutes (range, 23–55 minutes). After two weeks, 19 patients tolerated oral feeding. In patients with malignancy, the median survival time was 118 days (range, 41–194 days). No serious complications or deaths occurred. All patients with malignancy tolerated oral food intake until they expired.
Conclusions
T-FCSEMS is safe and effective. This stent should be considered as an alternative to LAMS for gastric outlet obstruction.

Citations

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  • Tubular fully covered self-expandable metallic stents for endoscopic ultrasound-guided gastrojejunostomy: moving forward or taking a step back?
    Rami G. El Abiad, Mouen A. Khashab
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    Sun Gyo Lim, Chan Gyoo Kim
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  • 217 Download
  • 2 Web of Science
  • 3 Crossref
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Review
Application of artificial intelligence for diagnosis of early gastric cancer based on magnifying endoscopy with narrow-band imaging
Yusuke Horiuchi, Toshiaki Hirasawa, Junko Fujisaki
Clin Endosc 2024;57(1):11-17.   Published online January 5, 2024
DOI: https://doi.org/10.5946/ce.2023.173
AbstractAbstract PDFPubReaderePub
Although magnifying endoscopy with narrow-band imaging is the standard diagnostic test for gastric cancer, diagnosing gastric cancer using this technology requires considerable skill. Artificial intelligence has superior image recognition, and its usefulness in endoscopic image diagnosis has been reported in many cases. The diagnostic performance (accuracy, sensitivity, and specificity) of artificial intelligence using magnifying endoscopy with narrow band still images and videos for gastric cancer was higher than that of expert endoscopists, suggesting the usefulness of artificial intelligence in diagnosing gastric cancer. Histological diagnosis of gastric cancer using artificial intelligence is also promising. However, previous studies on the use of artificial intelligence to diagnose gastric cancer were small-scale; thus, large-scale studies are necessary to examine whether a high diagnostic performance can be achieved. In addition, the diagnosis of gastric cancer using artificial intelligence has not yet become widespread in clinical practice, and further research is necessary. Therefore, in the future, artificial intelligence must be further developed as an instrument, and its diagnostic performance is expected to improve with the accumulation of numerous cases nationwide.

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  • Combination of artificial intelligence endoscopic diagnosis and Kimura‐Takemoto classification determined by endoscopic experts may effectively evaluate the stratification of gastric atrophy in post‐eradication status
    Kumiko Kirita, Seiji Futagami, Ken Nakamura, Shuhei Agawa, Nobue Ueki, Kazutoshi Higuchi, Mayu Habiro, Rie Kawawa, Yusuke Kato, Tomohiro Tada, Katsuhiko Iwakiri
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    Negin Letafatkar, Amr Ali Mohamed Abdelgawwad El-Sehrawy, KDV Prasad, Ahmad Alkhayyat, Ehsan Amini-Salehi, Maryam Hasanpour, Masoomeh Namdar Taleshani, Mohammad Hashemi, Hadi Alotaibi, Pegah Rashidian, Mohammad-Hossein Keivanlou, Soheil Hassanipour
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    Gwang Ha Kim
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Close layer
Original Article
Evaluation of the mechanical properties of current biliary self-expandable metallic stents: axial and radial force, and axial force zero border
Wataru Yamagata, Toshio Fujisawa, Takashi Sasaki, Rei Ishibashi, Tomotaka Saito, Shuntaro Yoshida, Shizuka No, Kouta Inoue, Yousuke Nakai, Naoki Sasahira, Hiroyuki Isayama
Clin Endosc 2023;56(5):633-649.   Published online April 10, 2023
DOI: https://doi.org/10.5946/ce.2022.201
Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReaderePub
Background
/Aims: Mechanical properties (MPs) and axial and radial force (AF and RF) may influence the efficacy and complications of self-expandable metallic stent (SEMS) placement. We measured the MPs of various SEMSs and examined their influence on the SEMS clinical ability.
Methods
We evaluated the MPs of 29 types of 10-mm SEMSs. RF was measured using a conventional measurement device. AF was measured using the conventional and new methods, and the correlation between the methods was evaluated.
Results
A high correlation in AFs was observed, as measured by the new and conventional manual methods. AF and RF scatterplots divided the SEMSs into three subgroups according to structure: hook-and-cross-type (low AF and RF), cross-type (high AF and low RF), and laser-cut-type (intermediate AF and high RF). The hook-and-cross-type had the largest axial force zero border (>20°), followed by the laser-cut and cross types.
Conclusions
MPs were related to stent structure. Hook-and-cross-type SEMSs had a low AF and high axial force zero border and were considered safest because they caused minimal stress on the biliary wall. However, the increase in RF must be overcome.

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Close layer
Review
Complications of endoscopic resection in the upper gastrointestinal tract
Takeshi Uozumi, Seiichiro Abe, Mai Ego Makiguchi, Satoru Nonaka, Haruhisa Suzuki, Shigetaka Yoshinaga, Yutaka Saito
Clin Endosc 2023;56(4):409-422.   Published online June 21, 2023
DOI: https://doi.org/10.5946/ce.2023.024
AbstractAbstract PDFPubReaderePub
Endoscopic resection (ER) is widely utilized as a minimally invasive treatment for upper gastrointestinal tumors; however, complications could occur during and after the procedure. Post-ER mucosal defect leads to delayed perforation and bleeding; therefore, endoscopic closure methods (endoscopic hand-suturing, the endoloop and endoclip closure method, and over-the-scope clip method) and tissue shielding methods (polyglycolic acid sheets and fibrin glue) are developed to prevent these complications. During duodenal ER, complete closure of the mucosal defect significantly reduces delayed bleeding and should be performed. An extensive mucosal defect that comprises three-quarters of the circumference in the esophagus, gastric antrum, or cardia is a significant risk factor for post-ER stricture. Steroid therapy is considered the first-line option for the prevention of esophageal stricture, but its efficacy for gastric stricture remains unclear. Methods for the prevention and management of ER-related complications in the esophagus, stomach, and duodenum differ according to the organ; therefore, endoscopists should be familiar with ways of preventing and managing organ-specific complications.

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    Fady Daniel
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    Hye Kyung Jeon, Gwang Ha Kim
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    A.A. Paratovskaya, M.Yu. Agapov, N.A. Belinskaya, T.F. Savostyanov, E.E. Topuzov
    Russian Journal of Evidence-Based Gastroenterology.2025; 14(1): 104.     CrossRef
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    Adam Mylonakis, Maria Dimitrakoudi, Diamantina Vasilatou, Dimitrios Tsapralis, Georgios Vasiliadis, Nikolaos Koliakos, Panagiotis Sakarellos, Emmanouil I. Kapetanakis, Dimitrios Schizas
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  • International Digestive Endoscopy Network consensus on the management of antithrombotic agents in patients undergoing gastrointestinal endoscopy
    Seung Joo Kang, Chung Hyun Tae, Chang Seok Bang, Cheol Min Shin, Young-Hoon Jeong, Miyoung Choi, Joo Ha Hwang, Yutaka Saito, Philip Wai Yan Chiu, Rungsun Rerknimitr, Christopher Khor, Vu Van Khien, Kee Don Choi, Ki-Nam Shim, Geun Am Song, Oh Young Lee
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    Seung Joo Kang, Chung Hyun Tae, Chang Seok Bang, Cheol Min Shin, Young-Hoon Jeong, Miyoung Choi, Joo Ha Hwang, Yutaka Saito, Philip Wai Yan Chiu, Rungsun Rerknimitr, Christopher Khor, Vu Van Khien, Kee Don Choi, Ki-Nam Shim, Geun Am Song, Oh Young Lee
    The Korean Journal of Gastroenterology.2024; 83(6): 217.     CrossRef
  • International Digestive Endoscopy Network Consensus on the Management of Antithrombotic Agents in Patients Undergoing Gastrointestinal Endoscopy
    Seung Joo Kang, Chung Hyun Tae, Chang Seok Bang, Cheol Min Shin, Young-Hoon Jeong, Miyoung Choi, Joo Ha Hwang, Yutaka Saito, Philip Wai Yan Chiu, Rungsun Rerknimitr, Christopher Khor, Vu Van Khien, Kee Don Choi, Ki-Nam Shim, Geun Am Song, Oh Young Lee
    Gut and Liver.2024; 18(5): 764.     CrossRef
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    Gwang Ha Kim
    World Journal of Gastroenterology.2023; 29(43): 5800.     CrossRef
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Case Report
Colorectal carcinoma and chronic inflammatory demyelinating polyneuropathy: is there a possible paraneoplastic association?
Adnan Malik, Faisal Inayat, Muhammad Hassan Naeem Goraya, Gul Nawaz, Ahmad Mehran, Atif Aziz, Saad Saleem
Clin Endosc 2023;56(2):245-251.   Published online July 28, 2021
DOI: https://doi.org/10.5946/ce.2021.076
AbstractAbstract PDFPubReaderePub
A plethora of paraneoplastic syndromes have been reported as remote effects of colorectal carcinoma (CRC). However, there is a dearth of data pertaining to the association of this cancer with demyelinating neuropathies. Herein, we describe the case of a young woman diagnosed with chronic inflammatory demyelinating polyneuropathy (CIDP). Treatment with intravenous immunoglobulins and prednisone did not improve her condition, and her neurological symptoms worsened. Subsequently, she was readmitted with exertional dyspnea, lightheadedness, malaise, and black stools. Colonoscopy revealed a necrotic mass in the ascending colon, which directly invaded the second part of the duodenum. Pathologic results confirmed the diagnosis of locally advanced CRC. Upon surgical resection of the cancer, her CIDP showed dramatic resolution without any additional therapy. Patients with CRC may develop CIDP as a type of paraneoplastic syndrome. Clinicians should remain cognizant of this potential association, as it is of paramount importance for the necessary holistic clinical management.

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  • Cutaneous Paraneoplastic Syndromes in Colorectal Cancer Patients
    Vlad Alexandru Ionescu, Gina Gheorghe, Teodor Florin Georgescu, Vlad Buica, Mihai-Stefan Catanescu, Iris-Andreea Cercel, Beatrice Budeanu, Mihail Budan, Ancuta Nastac, Ninel Iacobus Antonie, Daniel O. Costache, Raluca Simona Costache, Nicolae Bacalbasa, L
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    Yiyi Luo, Gang Peng, Jiahua Liang, Xuwei Song, Jiayu Tang
    Brain, Behavior, & Immunity - Health.2025; 45: 100985.     CrossRef
  • Polineuropatía crónica inflamatoria desmielinizante: caso clínico
    Maira Alexandra Quisnia Amaguaya, Prissila Banesa Calderón Guaraca, Rodrigo Jose Mendoza Rivas
    Anatomía Digital.2024; 7(3.3): 52.     CrossRef
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Original Article
Costs involved in compliance with new endoscope reprocessing guidelines
David Hoffman, Christina Cool
Clin Endosc 2024;57(4):534-541.   Published online January 26, 2024
DOI: https://doi.org/10.5946/ce.2023.164
Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReaderePub
Background
/Aims: In March 2022, the Association for the Advancement of Medical Instrumentation (AAMI) released the American National Standards Institute (ANSI)/AAMI ST91:2021, their latest update on comprehensive, flexible, and semirigid endoscope reprocessing. These updated standards recommend the sterilization of high-risk endoscopes when possible and provide new recommendations for the precleaning, leak testing, manual cleaning, visual inspection, automated reprocessing, drying, storage, and transport of endoscopes.
Methods
ANSI/AAMI ST91:2021 was compared with ANSI/AAMI ST91:2015 for major reprocessing differences that result in either time and/or cost increases. Time estimates were captured by explicit recommendation inclusion or taken from the literature. All the costs were estimated using publicly available resources.
Results
The updated standards represent a potential 24.3-minute and 52.35 to 67.57 United States dollars increase per procedure in terms of reprocessing time and spending, respectively, not including capital investments. Capital costs per procedure were highly dependent on the procedure volume of the facility.
Conclusions
The new AAMI standards recommend several major changes, such as sterilization, for facilities to reprocess and manage endoscopes between uses. As more facilities increase their reprocessing methods to reflect the updated standards, they do so at a cost and introduce several delays. As the reprocessing landscape evolves, facilities should consider their true costs and alternative solutions, such as single-use endoscopes.

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  • Streamlining Endoscopy Cleaning: The Impact of a New Detergent on Time and Water Use
    Joshua Hicks, Mutsa Mutowo
    Journal of Market Access & Health Policy.2025; 13(2): 23.     CrossRef
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    Christina Cool, Ian Haislip, Christian Escobar, Jacqueline Mojica
    Journal of Comparative Effectiveness Research.2025;[Epub]     CrossRef
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Reviews
Role of contrast-enhanced harmonic endoscopic ultrasonography (EUS) and EUS elastography in pancreatic lesions
Yasunobu Yamashita, Masayuki Kitano
Clin Endosc 2024;57(2):164-174.   Published online January 17, 2024
DOI: https://doi.org/10.5946/ce.2023.074
AbstractAbstract PDFPubReaderePub
Pancreatic cancers have a poor prognosis, and their incident rates have risen. Endoscopic ultrasonography (EUS) is an efficient and reliable diagnostic modality for pancreatic lesions, providing high spatial resolution. However, while EUS helps to detect minor pancreatic lesions, nearly all solid pancreatic lesions are hypoechoic, which creates difficulty in making differential diagnoses of pancreatic lesions. When diagnosing pancreatic lesions, the performance of image-enhanced EUS techniques is essential, such as EUS elastography or contrast-enhanced harmonic EUS (CH-EUS). CH-EUS diagnosis is based on assessing the vascularity of lesions, whereas tissue elasticity is measured via EUS elastography. Elastography is either strain or shear-wave, depending on the different mechanical properties being evaluated. The usefulness of enhanced EUS techniques is demonstrated in this review for the differential diagnosis of pancreatic lesions, including solid and cystic lesions, and pancreatic cancer staging.

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    Pancreatology.2025; 25(3): 289.     CrossRef
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    Hiroyuki Kojima, Takao Itoi, Atsushi Sofuni, Takayoshi Tsuchiya, Reina Tanaka, Ryosuke Tonozuka, Shuntaro Mukai, Kenjiro Yamamoto, Yukitoshi Matsunami, Hirohito Minami
    Journal of Hepato-Biliary-Pancreatic Sciences.2025;[Epub]     CrossRef
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    Peter Slodička, Vít Navrátil, Vincent Dansou Zoundjiekpon, Lumír Kunovský
    Medicína pro praxi.2025; 22(2): 111.     CrossRef
  • Endoscopic Contrast-Enhanced Ultrasound and Fine-Needle Aspiration or Biopsy for the Diagnosis of Pancreatic Solid Lesions: A Systematic Review and Meta-Analysis
    Giorgio Esposto, Giuseppe Massimiani, Linda Galasso, Paolo Santini, Raffaele Borriello, Irene Mignini, Maria Elena Ainora, Alberto Nicoletti, Lorenzo Zileri Dal Verme, Antonio Gasbarrini, Sergio Alfieri, Giuseppe Quero, Maria Assunta Zocco
    Cancers.2024; 16(9): 1658.     CrossRef
  • Endoscopic Ultrasound and Gastric Sub-Epithelial Lesions: Ultrasonographic Features, Tissue Acquisition Strategies, and Therapeutic Management
    Marzia Varanese, Marco Spadaccini, Antonio Facciorusso, Gianluca Franchellucci, Matteo Colombo, Marta Andreozzi, Daryl Ramai, Davide Massimi, Roberto De Sire, Ludovico Alfarone, Antonio Capogreco, Roberta Maselli, Cesare Hassan, Alessandro Fugazza, Alessa
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  • Endoscopic Ultrasound-Guided Pancreatic Tissue Sampling: Lesion Assessment, Needles, and Techniques
    Jahnvi Dhar, Jayanta Samanta, Zaheer Nabi, Manik Aggarwal, Maria Cristina Conti Bellocchi, Antonio Facciorusso, Luca Frulloni, Stefano Francesco Crinò
    Medicina.2024; 60(12): 2021.     CrossRef
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Detecting colorectal lesions with image-enhanced endoscopy: an updated review from clinical trials
Mizuki Nagai, Sho Suzuki, Yohei Minato, Fumiaki Ishibashi, Kentaro Mochida, Ken Ohata, Tetsuo Morishita
Clin Endosc 2023;56(5):553-562.   Published online July 26, 2023
DOI: https://doi.org/10.5946/ce.2023.055
AbstractAbstract PDFPubReaderePub
Colonoscopy plays an important role in reducing the incidence and mortality of colorectal cancer by detecting adenomas and other precancerous lesions. Image-enhanced endoscopy (IEE) increases lesion visibility by enhancing the microstructure, blood vessels, and mucosal surface color, resulting in the detection of colorectal lesions. In recent years, various IEE techniques have been used in clinical practice, each with its unique characteristics. Numerous studies have reported the effectiveness of IEE in the detection of colorectal lesions. IEEs can be divided into two broad categories according to the nature of the image: images constructed using narrowband wavelength light, such as narrowband imaging and blue laser imaging/blue light imaging, or color images based on white light, such as linked color imaging, texture and color enhancement imaging, and i-scan. Conversely, artificial intelligence (AI) systems, such as computer-aided diagnosis systems, have recently been developed to assist endoscopists in detecting colorectal lesions during colonoscopy. To better understand the features of each IEE, this review presents the effectiveness of each type of IEE and their combination with AI for colorectal lesion detection by referencing the latest research data.

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  • Advanced Endoscopic Imaging for Detection of Dysplasia in Inflammatory Bowel Disease
    Laura Alexandra Lucaciu, Edward John Despott
    Gastrointestinal Endoscopy Clinics of North America.2025; 35(1): 141.     CrossRef
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    Fumiaki Ishibashi, Sho Suzuki
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    Jeongseok Kim, Tae-Geun Gweon, Min Seob Kwak, Su Young Kim, Seong Jung Kim, Hyun Gun Kim, Sung Noh Hong, Eun Sun Kim, Chang Mo Moon, Dae Seong Myung, Dong-Hoon Baek, Shin Ju Oh, Hyun Jung Lee, Ji Young Lee, Yunho Jung, Jaeyoung Chun, Dong-Hoon Yang, Eun R
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    One-Zoong Kim
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  • Advantages of new generation colonoscopes on adenoma detection: A propensity-score matching study
    Toshihiro Nishizawa, Osamu Toyoshima, Shuntaro Yoshida, Yoshiyuki Takahashi, Hideki Nakagawa, Hiroya Mizutani, Yosuke Kataoka, Takamitsu Kanazawa, Hirotoshi Ebinuma, Keisuke Hata
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    Yunho Jung
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    Kyueng-Whan Min, One-Zoong Kim
    Journal of Digestive Cancer Research.2024; 12(2): 90.     CrossRef
  • Texture and color enhancement imaging versus white light imaging for the detection of colorectal adenomas: Systematic review and meta-analysis
    Stefan Mitev, Humza Saeed, Ch Faizan Rasheed, Abdullah, Stefan Murvakov, Vassil Sirakov, Stefan Tchernodrinski, Zoya Spassova
    Endoscopy International Open.2024;[Epub]     CrossRef
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    Yong Soo Kwon, Su Young Kim
    Journal of the Korean Medical Association.2023; 66(11): 652.     CrossRef
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    Donghwan Kim, Eunsun Kim
    Journal of the Korean Medical Association.2023; 66(11): 658.     CrossRef
  • 5,643 View
  • 284 Download
  • 10 Web of Science
  • 11 Crossref
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Original Article
Double-guidewire technique for selective biliary cannulation does not increase the rate of post-endoscopic retrograde cholangiopancreatography pancreatitis in patients with naïve papilla
Han Taek Jeong, June Hwa Bae, Ho Gak Kim, Jimin Han
Clin Endosc 2024;57(2):226-236.   Published online January 26, 2024
DOI: https://doi.org/10.5946/ce.2023.128
Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReaderePub
Background
/Aims: This study aimed to compare the safety of the double-guidewire technique (DGT) with that of the conventional single-guidewire technique (SGT) in real-world situations.
Methods
A total of 240 patients with naïve papilla who underwent endoscopic retrograde cholangiopancreatography (ERCP) at Daegu Catholic University Medical Center between January 2021 and December 2021 were included. The primary outcome was the rate of post-ERCP pancreatitis (PEP) in the SGT and DGT groups.
Results
A total of 163 patients (67.9%) belonged to the SGT group, and 77 (32.1%) belonged to the DGT group. The rates of successful biliary cannulation were 95.7% and 83.1% in the SGT and DGT groups, respectively (p=0.002). In the study group, PEP occurred in 14 patients (5.8%). The PEP rates were not significantly different between the SGT and DGT groups (4.3% vs. 9.1%, p=0.150). In the multivariate analysis, the age of <50 years (odds ratio [OR], 9.305; 95% confidence interval [CI], 1.367–63.358; p=0.023) and hyperlipidemia (OR, 7.384; 95% CI, 1.103–49.424; p=0.039) were significant risk factors for PEP in the DGT group.
Conclusions
DGT did not increase the PEP rate in patients with naïve papilla. In addition, the age of <50 years and hyperlipidemia were significant risk factors for PEP in the DGT group.
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