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Original Article
- Evaluation of cryoablation using a prototype cryoablation needle in swine liver
- Hyunjoon Son, Jonghyun Lee, Sung Yong Han, Tae In Kim, Dong Uk Kim, Daejin Kim, Gun-Ho Kim
- Clin Endosc 2024;57(5):675-682. Published online July 29, 2024
- DOI: https://doi.org/10.5946/ce.2024.024
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Graphical Abstract
Abstract
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ePub - Background
/Aims: Pancreatic cancer poses significant challenges due to its tendency for late-stage diagnosis and high mortality rates. Cryoablation, a technique used to treat various types of cancer, has shown potential in enhancing the prognosis of pancreatic cancer when combined with other therapies. However, its implementation is often limited by the need for lengthy procedures and specialized equipment. This study aims to develop a cryoablation needle optimized for endoscopic ultrasonography to simplify its application in treating pancreatic cancer.
Methods
The study involved conducting cryoablation experiments on swine liver tissue. It utilized cryo-needles to evaluate the extent of cell death across various temperatures and durations of cryoablation.
Results
The cryoablation system, which employed liquid carbon dioxide, achieved rapid cooling, reaching temperatures below –60 °C within 30 seconds and maintained the cryoablation process for 200 seconds. These conditions resulted in necrosis of the liver tissue. Notable cellular changes were observed up to 15 mm away from the cryoablation needle.
Conclusions
This experimental study successfully demonstrated the efficacy of using a cryo-needle for cryoablation in swine liver tissue. Further trials involving pancreatic tissue are expected to verify its effectiveness, underscoring the importance of continued research to establish its role as a complementary therapy in pancreatic cancer treatment.
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- 111 Download
Case Report
- Acute Liver Failure Secondary to Hepatic Infiltration of Malignant Melanoma
- Yujin Lee, Jaekwang Lee, Hyunsoo Kim, Changkeun Park, Jaekwon Jung, Daejin Kim, Yun Jin Chung, Hanjun Ryu
- Clin Endosc 2022;55(2):287-291. Published online April 1, 2021
- DOI: https://doi.org/10.5946/ce.2020.272
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Abstract
PDFPubReaderePub
- Acute liver failure due to malignant melanoma is uncommon. We presents a case of acute liver failure secondary to hepatic infiltration of a malignant melanoma. An 86-year-old man was admitted with elevated liver enzymes and an increased lactate dehydrogenase level. His condition progressed to acute liver failure, but the etiology of liver failure was unclear. Esophagogastroduodenoscopy was performed to evaluate dyspepsia, which showed signs indicative of malignant melanoma. Based on the endoscopy findings and elevated liver enzyme levels, liver biopsy was performed to confirm the presence of malignant melanoma. Hepatic infiltration of malignant melanoma was observed histologically. However, massive and diffuse liver metastasis is very rare and difficult to identify on imaging studies. If the etiology of liver failure is unclear, diffuse metastatic melanoma infiltration should be considered as differential diagnosis. Early liver biopsy can help to clarify the diagnosis.
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Citations
Citations to this article as recorded by
- HEPATOPATHY SECONDARY TO INFILTRATION BY MALIGNANT MELANOMA: DIAGNOSTIC VALUE OF LIVER BIOPSY
Alejandro García Martínez, Álvaro Morales Prado, Jorge Martínez-Echevarría Gil-Delgado, Daniel Mateos Millán
Revista Española de Enfermedades Digestivas.2024;[Epub] CrossRef - Metastatic melanoma: an unexpected cause of acute liver failure
Robert S. O’Neill, Phillip Leaver, Connor Ryan, Sharron Liang, Santosh Sanagapalli, Rasha Cosman
Clinical Journal of Gastroenterology.2024;[Epub] CrossRef - Tumor lysis syndrome with hepatic failure- A rare presentation of undiagnosed metastatic melanoma
Nicholas Cochran-Caggiano, Brandon Zaffuto, Ryan Dean
JEM Reports.2023; 2(1): 100009. CrossRef - Acute liver failure secondary to malignant infiltration: A single center experience
Rocío González Grande, Ana Bravo Aranda, Inmaculada Santaella Leiva, Susana López Ortega, Miguel Jiménez Pérez
Seminars in Oncology.2023; 50(3-5): 71. CrossRef
- HEPATOPATHY SECONDARY TO INFILTRATION BY MALIGNANT MELANOMA: DIAGNOSTIC VALUE OF LIVER BIOPSY
- 4,617 View
- 153 Download
- 3 Web of Science
- 4 Crossref
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