Clinical Endoscopy

Original Article

Efficacy of multi-hole self‑expandable metallic stents versus partially covered self‑expandable metallic stents in patients with malignant distal biliary obstruction caused by unresectable pancreatic cancer: a retrospective comparative cohort study in Japan: Shohei Asada, Koh Kitagawa, Fumimasa Tomooka, Jun-ichi Hanatani, Yuki Motokawa, Yui Osaki, Tomihiro Iwata, Kosuke Kaji, Akira Mitoro, Hitoshi Yoshiji; Clin Endosc 2025;58(5):744-756. Published online August 26, 2025; DOI: https://doi.org/10.5946/ce.2024.340

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Background
/Aims: This study aimed to compare the stent patency between the novel multi-hole self-expandable metallic stent (MH-SEMS) and conventional partially covered SEMS (PC-SEMS) for malignant distal biliary obstruction (MDBO) in patients with pancreatic carcinoma.
Methods
This retrospective study compared stent patency between patients with MH-SEMS (n=43) and those with PC-SEMS (n=94). Secondary outcomes were overall survival (OS), incidence of recurrent biliary obstruction (RBO), causes of RBO, and adverse events (AEs).
Results
The median time to RBO did not differ significantly between the MH-SEMS and PC-SEMS groups (318 vs. 460 days, p=0.17). Furthermore, the two groups did not differ significantly in terms of OS and incidence rate of AEs, including RBO and cholecystitis. RBO caused by tumor ingrowth was slightly more common in the MH-SEMS group (p=0.089). The MH-SEMS group had a slightly lower 12-month non-obstruction rate than the PC-SEMS group (33.9% vs. 60.9%). In the MH-SEMS group, stent removal was successful in all seven patients in whom it was attempted.
Conclusions
The clinical outcomes of MH-SEMS and PC-SEMS were similar in patients with MDBO caused by pancreatic carcinoma were similar.

Citations

Citations to this article as recorded by

Multi-Hole Self-Expandable Metallic Stent for Malignant Distal Biliary Obstruction: A Literature Review
Koh Kitagawa, Shohei Asada, Jun-ichi Hanatani, Yuki Motokawa, Yui Osaki, Tomihiro Iwata, Akira Mitoro, Hitoshi Yoshiji
Journal of Clinical Medicine.2026; 15(4): 1410. CrossRef
Efficacy of fully covered self-expanding metal stents removal versus stent-in-stent techniques in recurrent malignant distal biliary obstruction
See Young Lee, Sung Ill Jang, Eui Joo Kim, Dong Ki Lee, Seoyeon Cho, Yeseul Seong, Jung Hyun Jo, Chan Min Jung, In Rae Cho, Woo Hyun Paik, Ji Kon Ryu, Hyun Seok Lee, Sang Hyub Lee, Jae Hee Cho
Scientific Reports.2026;[Epub] CrossRef
Advancements in stent strategies for malignant distal biliary obstruction: defining the clinical role of multi-hole self-expandable metal stents
Sung Yong Han
Clinical Endoscopy.2025; 58(5): 698. CrossRef
Endoscopic biliary drainage with multi-hole self-expandable metallic stent during neoadjuvant chemoradiotherapy in pancreatic cancer
Shohei Asada, Koh Kitagawa, Junichi Hanatani, Yuki Motokawa, Yui Osaki, Tomihiro Iwata, Kosuke Kaji, Akira Mitoro, Minako Nagai, Hitoshi Yoshiji, Masayuki Sho
World Journal of Gastrointestinal Endoscopy.2025;[Epub] CrossRef

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Brief Report

Black esophagus: a life-threatening adverse event associated with endoscopic retrograde cholangiopancreatography: Koh Kitagawa, Hiroyuki Masuda, Akira Mitoro, Fumimasa Tomooka, Shohei Asada, Norihisa Nishimura, Kosuke Kaji, Hitoshi Yoshiji; Clin Endosc 2024;57(2):270-273. Published online May 23, 2023; DOI: https://doi.org/10.5946/ce.2023.047

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Citations

Citations to this article as recorded by

Acute oesophageal necrosis: single centre experience
Şehmus Ölmez, Duran Deha Çetin, Mustafa Harı, Abdullah İlhan, Bünyamin Sarıtaş
BMC Gastroenterology.2026;[Epub] CrossRef
The two-hit hypothesis in acute esophageal necrosis: black esophagus in severe atherosclerosis and untreated gastroesophageal reflux disease: a case report
Sushrut Ingawale, Pujitha Vallivedu, Anchit Chauhan, Jack Jacob, Asim Haider, Prabin Sharma
Journal of Medical Case Reports.2026;[Epub] CrossRef
A Case of Black Esophagus in a Patient Presenting With Dyspnea
Jaehong Jeong, June Hwa Bae, Hyeong Ho Jo, Joong Goo Kwon, Eun Young Kim
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2025; 25(3): 284. CrossRef
Relato de caso: Esôfago negro
Victor Vasconcellos Pardo, Lara Fernandes Polzatto, Vivian Motta Guimarães
Research, Society and Development.2025; 14(9): e5214949535. CrossRef

6,223 View
259 Download
1 Web of Science
4 Crossref

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