Clinical Endoscopy

Two-Stage Peroral Endoscopic Myotomy for Sigmoid-Type Achalasia: Hak Su Kim, Hee Kyung Kim, Weon Jin Ko; Clin Endosc 2020;53(2):232-235. Published online July 16, 2019; DOI: https://doi.org/10.5946/ce.2019.067

Abstract PDF Supplementary Material PubReader ePub: Peroral endoscopic myotomy (POEM) has been recently considered as the first treatment option for achalasia. The standard POEM procedures are often successful in most patients, but sometimes technical challenges are encountered. We report a new technique that is divided between two tunneling sites in the esophagus for sigmoid-type achalasia. A 40-year-old male patient with dysphagia for 10 years was diagnosed with a sigmoid-shaped esophagus at our hospital. We devised a two-stage myotomy technique to treat sigmoidtype achalasia. The myotomy was first performed in the upper part of the greater flexion area and then in the lower part of the flexion. We termed this method “two-stage POEM”, which was successfully performed without any complications. This new POEM method can also be used to improve symptoms in patients with achalasia who have a structural deformity that may result in a high change of treatment failure.

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Effectiveness of Autologous Platelet-Rich Plasma for the Healing of Ulcers after Endoscopic Submucosal Dissection: Eunju Jeong, In kyung Yoo, Ozlem Ozer Cakir, Hee Kyung Kim, Won Hee Kim, Sung Pyo Hong, Joo Young Cho; Clin Endosc 2019;52(5):472-478. Published online May 17, 2019; DOI: https://doi.org/10.5946/ce.2018.152

Background
/Aims: Platelet-rich plasma (PRP) has been used for wound healing in various medical fields. The aim of this study was to evaluate the clinical efficacy and safety of local PRP injections after endoscopic submucosal dissection (ESD).
Methods
Patients were non-randomly divided into the following two groups: (1) control group in which patients were administered only an intravenous proton pump inhibitor (PPI), and (2) a study group in which patients were administered an intravenous PPI and a topical PRP injection. We assessed the reduction in the ulcer area and stage of the ulcer after the procedure (24 hours, 48 hours, and 28 days after endoscopic surgery).
Results
We enrolled 7 study and 7 control patients. In the study group, the rate of ulcer reduction was 59% compared to 52% in the control group (p=0.372), 28 days after ESD. There were 5 patients in the S stage and 2 patients in the H stage in the study group compared to no patient in the S stage and 7 patients in the H stage in the control group (p=0.05), 28 days after ESD. There were no serious complications in either group.
Conclusions
The local injection of PRP is a safe and effective procedure for ulcer healing after ESD.

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Clinical efficacy of blood derivatives on wound healing: A systematic review and network meta‐analysis
Yanhong Wu, Guang Peng, Yuzhi Wang, Jianwu Chen, Bin Zhang, Jianbing Tang, Biao Cheng
International Wound Journal.2024;[Epub] CrossRef
Endoscopic Shielding With Platelet-rich Plasma After Resection Of Large Colorectal Lesions
Vicente Lorenzo-Zúñiga, Vicente Moreno de Vega, Ramón Bartolí
Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2021; 31(3): 376. CrossRef
The Additive Effect of Platelet-Rich Plasma in the Treatment of Actively Bleeding Peptic Ulcer
Waseem M. Seleem, Amr Shaaban Hanafy
Clinical Endoscopy.2021; 54(6): 864. CrossRef
Endless Challenges in Overcoming Complications Associated with Endoscopic Submucosal Dissection
Satoshi Ono, Shun Ito, Kenji Ogata
Clinical Endoscopy.2019; 52(5): 395. CrossRef

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Endoscopic Submucosal Dissection Followed by Concurrent Chemoradiotherapy in Patients with Early Esophageal Cancer with a High Risk of Lymph Node Metastasis: Hee Kyung Kim, Weon Jin Ko, Chang-Il Kwon, Ga Won Song, In Kyun Yoo, Ji Hyun Song, Hak Su Kim, Joo Young Cho; Clin Endosc 2019;52(5):502-505. Published online May 14, 2019; DOI: https://doi.org/10.5946/ce.2018.176

Abstract PDF PubReader ePub

Endoscopic submucosal dissection is recommended as an alternative therapy for early esophageal cancer. However, achieving curative resection in this procedure remains controversial since precise prediction of lymph node metastasis can be difficult. Here, we present the preliminary results of endoscopic submucosal dissection followed by concurrent chemoradiotherapy for early esophageal cancer with a high risk of lymph node metastasis. From May 2006 to January 2014, six patients underwent concurrent chemoradiotherapy after endoscopic submucosal dissection with a median follow-up period of 63 months. No complications were encountered during concurrent chemoradiotherapy. Although local recurrence did not occur in all patients, two patients were diagnosed with metachronous cancer. Overall, the survival rate was 100%. Thus, endoscopic submucosal dissection followed by concurrent chemoradiotherapy may be a feasible treatment for early esophageal cancer in patients with a high risk of lymph node metastasis. Future prospective large-scale studies are warranted to confirm our results.

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Unveiling Therapeutic Targets for Esophageal Cancer: A Comprehensive Review
Rakesh Acharya, Ananya Mahapatra, Henu Kumar Verma, L. V. K. S. Bhaskar
Current Oncology.2023; 30(11): 9542. CrossRef
Editorial “Discrepancy Between the Clinical and Final Pathological Findings of Lymph Node Metastasis in Superficial Esophageal Cancer”
Rian M. Hasson, Joseph D. Phillips
Annals of Surgical Oncology.2019; 26(9): 2662. CrossRef

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The Early Onset of Disease May Be a Risk Factor for Decreased Bone Mineral Density in Patients with Inflammatory Bowel Disease: Hwa Jong Kim, Su Jin Hong, Young Woo Jeon, Jae Pil Han, Seung Hyo Han, Jee Heon Kang, Jae Woong Tae, Hee Sook Lim, Hee Kyung Kim, Bong Min Ko, Moon Sung Lee; Clin Endosc 2013;46(1):71-76. Published online January 31, 2013; DOI: https://doi.org/10.5946/ce.2013.46.1.71

Abstract PDF PubReader ePub

Background/Aims

The pathogenesis of bone loss in patients with inflammatory bowel disease (IBD) is complex, multifactorial, and only partly understood. We aimed to examine the extent and risk factors of bone mass reduction and to analyze the impact of early onset of a disease before attaining peak bone mass in IBD patients.

Methods

We compared the risk factors for osteoporosis and BMD at the lumbar spine and the hip bone in IBD patients.

Results

A total of 44 patients with IBD were enrolled. Twenty-one and 23 patients were diagnosed as IBD before and after the age of 30 and designated as group A and group B, respectively. Group A had significant bone mass reduction at the lumbar spine than group B (BMD, 1.01±0.10 vs. 1.14±0.17, p<0.01; T-score, -1.22±0.84 vs. -0.08±1.39, p<0.01; Z-score, -1.11±0.81 vs. -0.03±1.32, p<0.01, respectively). Multivariate analysis showed that patients diagnosed as IBD before the age of 30 had possible risk factor of bone mass reduction (hazard ratio, 3.96; p=0.06).

Conclusions

Bone mass reduction was more severe in patients who were diagnosed with IBD before the age of 30 than in those diagnosed after the age of 30.

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Small and Large Intestine (II): Inflammatory Bowel Disease, Short Bowel Syndrome, and Malignant Tumors of the Digestive Tract
Yolanda Ber, Santiago García-Lopez, Carla J. Gargallo-Puyuelo, Fernando Gomollón
Nutrients.2021; 13(7): 2325. CrossRef
Infliximab for very early‐onset inflammatory bowel disease: A tertiary center experience in Japan
Ichiro Takeuchi, Yoichiro Kaburaki, Katsuhiro Arai, Hirotaka Shimizu, Yuri Hirano, Satoru Nagata, Toshiaki Shimizu
Journal of Gastroenterology and Hepatology.2020; 35(4): 593. CrossRef
Advances in nutritional therapy in inflammatory bowel diseases: Review
Andrzej Wędrychowicz
World Journal of Gastroenterology.2016; 22(3): 1045. CrossRef
Nutritional aspect of pediatric inflammatory bowel disease: its clinical importance
Seung Kim, Hong Koh
Korean Journal of Pediatrics.2015; 58(10): 363. CrossRef
Biomarkers of Cartilage and Surrounding Joint Tissue
Anne S Siebuhr, Yi He, Natasja S Gudmann, Aurelie Gram, Cecilie F Kjelgaard-Petersen, Per Qvist, Morten A Karsdal, Anne C Bay-Jensen
Biomarkers in Medicine.2014; 8(5): 713. CrossRef
Crohn's disease and growth deficiency in children and adolescents
Marco Gasparetto
World Journal of Gastroenterology.2014; 20(37): 13219. CrossRef
Can Early Onset of Disease Be One of the Risk Factors for Low Bone Mineral Density in Patients with Inflammatory Bowel Disease?
Kwang An Kwon, Yang Suh Ku
Clinical Endoscopy.2013; 46(1): 5. CrossRef

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A Hypereosinophilic Syndrome Presenting as Eosinophilic Colitis: Young Woo Jeon, Su Jin Hong, Hwa Jong Kim, Jae Pil Han, Hee Kyung Kim, Bong Min Ko, Sung Kyu Park, Moon Sung Lee; Clin Endosc 2012;45(4):444-447. Published online November 30, 2012; DOI: https://doi.org/10.5946/ce.2012.45.4.444

Abstract PDF PubReader ePub

Hypereosinophilic syndrome (HES) has three defining features: marked hypereosinophilia for at least 6 months, no confirmed etiology for the eosinophilia, and eosinophilia-related symptoms or organ dysfunction. However, a shorter period of hypereosinophilia with symptoms requiring eosinophil-lowering therapy is also acceptable. We report a case of HES presenting as eosinophilic colitis. Although hypereosinophilia was present for 3 months, this patient needed to be treated with eosionphil-lowering therapy for severe hematochezia. After systemic corticosteroid therapy, symptoms caused by organ involvement were dramatically improved.

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Hyper-eosinophilic syndrome: An uncommon cause of chronic abdominal pain in an elderly male
Dibya L Praharaj, Bipadabhanjan Mallick, Preetam Nath, Sarat C Panigrahi, Anil C Anand, Rajkumar Sharma
Tropical Doctor.2021; 51(4): 640. CrossRef
Platelet-derived growth factor receptor-alpha-positive myeloid neoplasm presenting as eosinophilic gastrointestinal disease
Gregory M. Constantine, JeanAnne Ware, Thomas Brown, Lauren Thumm, Natasha Kamal, Sheila Kumar, David Kleiner, Irina Maric, Amy D. Klion
The Journal of Allergy and Clinical Immunology: In Practice.2020; 8(6): 2089. CrossRef
Gastrointestinal Manifestations of Hypereosinophilic Syndromes and Mast Cell Disorders: a Comprehensive Review
Vivian C. Nanagas, Anna Kovalszki
Clinical Reviews in Allergy & Immunology.2019; 57(2): 194. CrossRef
Hypereosinophilic Syndrome Presenting as Intussusception in Adults
Nuri Chon, WooJung Kim, Sang Young Park, Kwang Hyun Kim
Korean Journal of Medicine.2014; 87(5): 585. CrossRef
Syndrome hyperéosinophilique de type myéloprolifératif révélé par une ascite : à propos d’un cas
M. Boudabbous, H. Mnif, H. Bellaj, K. Yaïch, L. Chtourou, L. Mnif, A. Amouri, N. Tahri
Journal Africain d'Hépato-Gastroentérologie.2014; 8(2): 89. CrossRef
Recurrent cutaneous necrotizing eosinophilic vasculitis: a case report and review of the literature
Wenfei Li, Wang Cao, Haiyan Song, Yanxia Ciu, Xianmei Lu, Furen Zhang
Diagnostic Pathology.2013;[Epub] CrossRef

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Correlation of Narrow Band Imaging with Magnifying Colonoscopy and Histology in Colorectal Tumors: Hee Yong Yoo, Moon Sung Lee, Bong Min Ko, Hee Kyung Kim, Hyung Su Ahn, Seung Hyo Han, Jun Yong Bae, Seul Ki Min, Jong Chan Lee, Chang Beom Ryu; Clin Endosc 2011;44(1):44-50. Published online September 30, 2011; DOI: https://doi.org/10.5946/ce.2011.44.1.44

Abstract PDF PubReader ePub

Background/Aims

Narrow band imaging (NBI) is a new technique that uses optical filters for imaging of mucosal morphology. The aim of this study was to correlate findings of NBI with magnifying colonoscopy and histology for prediction of neoplastic colorectal lesion.

Methods

Between September 2005 and December 2007, 107 colon polyps from 68 patients were detected by conventional colonoscopy and subsequently evaluated by NBI with magnifying colonoscopy and analyzed for a pit pattern and a capillary pattern. More analysis was done regarding thickness and irregularity of capillary features.

Results

Pit pattern with NBI magnification to discriminate between neoplastic and non-neoplastic lesions had a sensitivity of 88.9% and a specificity of 87.5%; capillary pattern yielded test performance characteristics of 91.9% and 87.5%. In respect of capillary thickness, invisible capillaries were found significantly more often in hyperplastic lesions. All thick capillaries were found in neoplastic polyps, and found significantly more often in carcinomas with submucosal massive invasion (sm-m) (p<0.01). In respect of capillary irregularity, invisible capillaries were found significantly more often in hyperplasic lesions, and severely irregular capillaries were found significantly more often in sm-m lesions (p<0.01).

Conclusions

Observation of capillary thickness and irregularity by NBI magnification is useful for correlating histological grade with carcinoma, especially with depth of submucosal invasion.

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Multidisciplinary Treatment Strategy for Early Colon Cancer: A Review-An English Version
Gyung Mo Son, Su Bum Park, Tae Un Kim, Byung-Soo Park, In Young Lee, Joo-Young Na, Dong Hoon Shin, Sang Bo Oh, Sung Hwan Cho, Hyun Sung Kim, Hyung Wook Kim
Journal of the Anus, Rectum and Colon.2022; 6(4): 203. CrossRef
Clinical practice guideline for endoscopic resection of early gastrointestinal cancer
Chan Hyuk Park, Dong-Hoon Yang, Jong Wook Kim, Jie-Hyun Kim, Ji Hyun Kim, Yang Won Min, Si Hyung Lee, Jung Ho Bae, Hyunsoo Chung, Kee Don Choi, Jun Chul Park, Hyuk Lee, Min-Seob Kwak, Bun Kim, Hyun Jung Lee, Hye Seung Lee, Miyoung Choi, Dong-Ah Park, Jong
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Chan Hyuk Park, Dong-Hoon Yang, Jong Wook Kim, Jie-Hyun Kim, Ji Hyun Kim, Yang Won Min, Si Hyung Lee, Jung Ho Bae, Hyunsoo Chung, Kee Don Choi, Jun Chul Park, Hyuk Lee, Min-Seob Kwak, Bun Kim, Hyun Jung Lee, Hye Seung Lee, Miyoung Choi, Dong-Ah Park, Jong
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Chan Hyuk Park, Dong-Hoon Yang, Jong Wook Kim, Jie-Hyun Kim, Ji Hyun Kim, Yang Won Min, Si Hyung Lee, Jung Ho Bae, Hyunsoo Chung, Kee Don Choi, Jun Chul Park, Hyuk Lee, Min-Seob Kwak, Bun Kim, Hyun Jung Lee, Hye Seung Lee, Miyoung Choi, Dong-Ah Park, Jong
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2020; 20(2): 117. CrossRef
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Chan Hyuk Park, Dong-Hoon Yang, Jong Wook Kim, Jie-Hyun Kim, Ji Hyun Kim, Yang Won Min, Si Hyung Lee, Jung Ho Bae, Hyunsoo Chung, Kee Don Choi, Jun Chul Park, Hyuk Lee, Min-Seob Kwak, Bun Kim, Hyun Jung Lee, Hye Seung Lee, Miyoung Choi, Dong-Ah Park, Jong
The Korean Journal of Gastroenterology.2020; 75(5): 264. CrossRef
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Sam E. Mason, Liam Poynter, Zoltan Takats, Ara Darzi, James M. Kinross
American Journal of Gastroenterology.2019; 114(8): 1219. CrossRef
Effectiveness of systematic training in the application of narrow‐band imaging international colorectal endoscopic (NICE) classification for optical diagnosis of colorectal polyps: Experience from a single center in China
Yinhe Sikong, Xiangchun Lin, Kuiliang Liu, Jing Wu, Wu Lin, Nan Wei, Guojun Jiang, Weiping Tai, Hui Su, Hong Liu, Mingming Meng
Digestive Endoscopy.2016; 28(5): 583. CrossRef
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Ling Yin Zhu, Lin Ren, Zhizheng Ge, Xiao Bo Li
European Journal of Gastroenterology & Hepatology.2014; 26(12): 1428. CrossRef
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Linda K Wanders, James E East, Sanne E Uitentuis, Mariska M G Leeflang, Evelien Dekker
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Cesare Hassan, Alessandro Repici, Angelo Zullo, Vijay Kanakadandi, Prateek Sharma
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