Clinical Endoscopy

Case Report

Tranexamic Acid-Induced Acute Renal Cortical Necrosis in Post-Endoscopic Papillectomy Bleeding: Doo Hyun Ko, Tae Hyung Kim, Jong Wook Kim, Ja Joong Gu, Baek Hyun Yoon, Ji Hong Oh, Seung Goun Hong; Clin Endosc 2017;50(6):609-613. Published online August 9, 2017; DOI: https://doi.org/10.5946/ce.2017.021

Acute renal failure can be the result of acute renal cortical necrosis (RCN), which commonly occurs from complications occurring during pregnancy. RCN is rarely caused by medications, although tranexamic acid, which is used in patients with acute bleeding for its antifibrinolytic effects, reportedly causes acute RCN in rare cases. An 82-year-old woman experienced gastrointestinal bleeding after endoscopic papillectomy of an ampullary adenoma. The bleeding was controlled with tranexamic acid administration; however, 4 days later, her urine volume decreased and she developed pulmonary edema and dyspnea. Serum creatinine levels increased from 0.8 to 3.9 mg/dL and dialysis was performed. Abdominal pelvic computed tomography with contrast enhancement revealed bilateral RCN with no renal cortex enhancement. Renal dysfunction and oliguria persisted and hemodialysis was continued. Clinicians must be aware that acute RCN can occur after tranexamic acid administration to control bleeding.

Citations

Citations to this article as recorded by

The Effects of Tranexamic Acid on Renal Outcomes in Patients Undergoing Cardiovascular Surgery: A Systematic Review and Meta-Analysis Compliant With Preferred Reporting Items for Systematic Reviews and Meta-Analyses
Bo Zhang, Li-xian He, Yun-tai Yao
Journal of Cardiothoracic and Vascular Anesthesia.2026; 40(3): 844. CrossRef
Efficacy and Safety of Tranexamic Acid in Solid Cancer Surgeries: A Systematic Review and Meta-analysis of Randomized Controlled Trials with GRADE Assessment
Asmaa Soliman, Ahmed Adel Abdel Azim, Abdullrahman Elgarawany, Ahmed S.A Osman, Ahmed Rezk, Sally Muhamed Seliem, Elsayed S. Moubarak, Suliman Hassan Abdalaziz, Israa Ahmed Qutob
Annals of Surgical Oncology.2026;[Epub] CrossRef
Tranexamic acid-induced acute bilateral renal cortical necrosis in a young trauma patient: a case report and literature review
Jérémy Berri, Moglie Le Quintrec Donnette, Ingrid Millet, Leila Chenine, Jean-Emmanuel Serre, Manal Mazloum
BMC Nephrology.2025;[Epub] CrossRef
The safety of tranexamic acid administration in total knee arthroplasty: a population‐based study from Taiwan
L.‐I. Hsu, H.‐W. Hsu, J.‐W. Chen, S.‐T. Wei, S.‐M. Hou
Anaesthesia.2023; 78(3): 303. CrossRef
Tranexamic acid in total knee arthroplasty
C. R. Bailey
Anaesthesia.2023; 78(3): 275. CrossRef
Intraoperative use of tranexamic acid to reduce blood loss during cytoreductive surgery for advanced ovarian cancer: A randomized controlled clinical trial
Xijun Yang, Mao Chai, Lingfang Xia, Zhiyong He, Xiaohua Wu, Jun Zhang
Acta Obstetricia et Gynecologica Scandinavica.2023; 102(7): 950. CrossRef
Safe and Effective Blood Preservation Through Acute Normovolemic Hemodilution and Low-Dose Tranexamic Acid in Open Partial Hepatectomy
Jian Yang, Jing Zhang, Jiayan Luo, Jie Ouyang, Qicai Qu, Qitao Wang, Yongyu Si
Journal of Pain Research.2023; Volume 16: 3905. CrossRef
Systematic review of hematuria and acute renal failure with tranexamic acid
Stephanie G. Lee, John Fralick, Christopher J. D. Wallis, Monica Boctor, Michelle Sholzberg, Michael Fralick
European Journal of Haematology.2022; 108(6): 510. CrossRef
Safety of Tranexamic Acid in Hip and Knee Arthroplasty in High-risk Patients
Jashvant Poeran, Jimmy J. Chan, Nicole Zubizarreta, Madhu Mazumdar, Leesa M. Galatz, Calin S. Moucha
Anesthesiology.2021; 135(1): 57. CrossRef
N-methylamphetamine (“Crystal Meth”)−Associated Acute Renal Cortical Necrosis
Anu Gupta, Michael Kuperman, Silvi Shah
Kidney International Reports.2018; 3(6): 1473. CrossRef

9,811 View
199 Download
11 Web of Science
10 Crossref

First
Prev
Page of 1
Next
Last

Search