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Therapeutic Outcomes of Endoscopic Resection of Early Gastric Cancer with Undifferentiated-Type Histology: A Korean ESD Registry Database Analysis
Chang Seok Bang, Jae Myung Park, Gwang Ho Baik, Jong Jae Park, Moon Kyung Joo, Jae Young Jang, Seong Woo Jeon, Suck Chei Choi, Jae Kyu Sung, Kwang Bum Cho
Clin Endosc 2017;50(6):569-577.   Published online July 25, 2017
DOI: https://doi.org/10.5946/ce.2017.017
AbstractAbstract PDFPubReaderePub
Background
/Aims: To assess the therapeutic outcomes of endoscopic resection (ER) of early gastric cancer (EGC) with undifferentiated-type histology.
Methods
Cases of ER of EGC with undifferentiated-type histology in the Korean endoscopic submucosal dissection (ESD) registry database were identified and reviewed. The immediate outcomes, including en bloc resection, complete resection, and curative resection rates, and long-term outcomes, including recurrence and survival rates, were extracted and analyzed.
Results
From 2006 to 2015, 275 EGCs with undifferentiated-type histology from 275 patients were identified. The immediate outcomes were as follows: en bloc resection rate: 92.4%; complete resection rate: 80%; and curative resection rate: 36.4%. Compared to patients with lesions that were beyond the expanded indication, those with expanded indication lesions showed better therapeutic outcomes. There was no difference in immediate outcomes between patients with poorly differentiated adenocarcinoma (PDC) and signet ring cell carcinoma (SRC). However, compared to ER of SRC, ER of PDC had a stronger association with submucosal invasion (41.9% vs. 23.6%, p=0.003). With regard to long-term outcomes, there was no difference between lesions with curative and non-curative resections in the recurrence and mortality rates. These rates also did not differ between PDC and SRC (median follow up: 3.96 years).
Conclusions
ER confined to expanded indication lesions can be considered for treatment of EGC with undifferentiated-type histology.

Citations

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    Chang Seok Bang, Gwang Ho Baik
    Clinical Endoscopy.2019; 52(1): 30.     CrossRef
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    Jie-Hyun Kim
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    Jie-Hyun Kim
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Feedback Survey of the Effect, Burden, and Cost of the National Endoscopic Quality Assessment Program during the Past 5 Years in Korea
Yu Kyung Cho, Jeong Seop Moon, Dong Su Han, Yong Chan Lee, Yeol Kim, Bo Young Park, Il-Kwun Chung, Jin-Oh Kim, Jong Pil Im, Jae Myung Cha, Hyun Gun Kim, Sang Kil Lee, Hang Lak Lee, Jae Young Jang, Eun Sun Kim, Yunho Jung, Chang Mo Moon, Ethics and Quality Control Committee of Korean Society of Gastrointestinal Endoscopy
Clin Endosc 2016;49(6):542-547.   Published online March 2, 2016
DOI: https://doi.org/10.5946/ce.2015.113
AbstractAbstract PDFPubReaderePub
Background
/Aims: In Korea, the nationwide gastric cancer screening program recommends biennial screening for individuals aged 40 years or older by way of either an upper gastrointestinal series or endoscopy. The national endoscopic quality assessment (QA) program began recommending endoscopy in medical institutions in 2009. We aimed to assess the effect, burden, and cost of the QA program from the viewpoint of medical institutions.
Methods
We surveyed the staff of institutional endoscopic units via e-mail.
Results
Staff members from 67 institutions replied. Most doctors were endoscopic specialists. They responded as to whether the QA program raised awareness for endoscopic quality (93%) or improved endoscopic practice (40%). The percentages of responders who reported improvements in the diagnosis of gastric cancer, the qualifications of endoscopists, the quality of facilities and equipment, endoscopic procedure, and endoscopic reprocessing were 69%, 60%, 66%, 82%, and 75%, respectively. Regarding reprocessing, many staff members reported that they had bought new automated endoscopic preprocessors (3%), used more disinfectants (34%), washed endoscopes longer (28%), reduced the number of endoscopies performed to adhere to reprocessing guidelines (9%), and created their own quality education programs (59%). Many responders said they felt that QA was associated with some degree of burden (48%), especially financial burden caused by purchasing new equipment. Reasonable quality standards (45%) and incentives (38%) were considered important to the success of the QA program.
Conclusions
Endoscopic quality has improved after 5 years of the mandatory endoscopic QA program.

Citations

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  • Monthly endoscopy surveillance culture facilitates detection of breaches in the scope reprocessing procedure: 5‐year experience in an endoscopy center
    Shu‐Hui Chen, Theophile Liu, Huei‐Wen Lai, Hui‐Lan Chang, Hsu‐Heng Yen
    Advances in Digestive Medicine.2022; 9(2): 103.     CrossRef
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    American Journal of Infection Control.2021; 49(8): 1031.     CrossRef
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    Hee Seok Moon, Eun Kwang Choi, Ji Hyun Seo, Jeong Seop Moon, Ho June Song, Kyoung Oh Kim, Jong Jin Hyun, Sung Kwan Shin, Beom Jae Lee, Sang Heon Lee
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    Dong-Hoon Yang
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  • 125 Download
  • 5 Web of Science
  • 7 Crossref
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Survey of Endoscope Reprocessing in Korea
Jeong Bae Park, Jae Nam Yang, Yun Jeong Lim, Ja Seol Koo, Jae Young Jang, Sang Hoon Park, Su Jin Hong, Sang-Woo Kim, Hoon Jai Chun, Disinfection Management Committee of the Korean Society of Gastrointestinal Endoscopy
Clin Endosc 2015;48(1):39-47.   Published online January 31, 2015
DOI: https://doi.org/10.5946/ce.2015.48.1.39
AbstractAbstract PDFPubReaderePub
Background/Aims

There is a growing emphasis on quality management in endoscope reprocessing. Previous surveys conducted in 2002 and 2004 were not practitioner-oriented. Therefore, this survey is significant for being the first to target actual participants in endoscope reprocessing in Korea.

Methods

This survey comprised 33 self-filled questions, and was personally delivered to nurses and nursing auxiliaries in the endoscopy departments of eight hospitals belonging to the society. The anonymous responses were collected after 1 week either by post or in person by committee members.

Results

The survey included 100 participants. In the questionnaire addressing compliance rates with the reprocessing guideline, the majority (98.9%) had a high compliance rate compared to 27% of respondents in 2002 and 50% in 2004. The lowest rate of compliance with a reprocessing procedure was reported for transporting the contaminated endoscope in a sealed container. Automated endoscope reprocessors were available in all hospitals. Regarding reprocessing time, more than half of the subjects replied that reprocessing took more than 15 minutes (63.2%).

Conclusions

The quality management of endoscope reprocessing has improved as since the previous survey. A national survey expanded to include primary clinics is required to determine the true current status of endoscope reprocessing.

Citations

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    Advances in Digestive Medicine.2022; 9(2): 103.     CrossRef
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    Hye Young Shin, Da Hun Jang, Jae Kwan Jun
    American Journal of Infection Control.2021; 49(8): 1031.     CrossRef
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    Hee Seok Moon, Eun Kwang Choi, Ji Hyun Seo, Jeong Seop Moon, Ho June Song, Kyoung Oh Kim, Jong Jin Hyun, Sung Kwan Shin, Beom Jae Lee, Sang Heon Lee
    Clinical Endoscopy.2017; 50(4): 345.     CrossRef
  • Feedback Survey of the Effect, Burden, and Cost of the National Endoscopic Quality Assessment Program during the Past 5 Years in Korea
    Yu Kyung Cho, Jeong Seop Moon, Dong Su Han, Yong Chan Lee, Yeol Kim, Bo Young Park, Il-Kwun Chung, Jin-Oh Kim, Jong Pil Im, Jae Myung Cha, Hyun Gun Kim, Sang Kil Lee, Hang Lak Lee, Jae Young Jang, Eun Sun Kim, Yunho Jung, Chang Mo Moon
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    Young-Seok Cho
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  • 8,487 View
  • 93 Download
  • 9 Web of Science
  • 9 Crossref
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Reviews
Lymph Node Metastases in Esophageal Carcinoma: An Endoscopist's View
Jin Woong Cho, Suck Chei Choi, Jae Young Jang, Sung Kwan Shin, Kee Don Choi, Jun Haeng Lee, Sang Gyun Kim, Jae Kyu Sung, Seong Woo Jeon, Il Ju Choi, Gwang Ha Kim, Sam Ryong Jee, Wan Sik Lee, Hwoon-Yong Jung, Korean ESD Study Group
Clin Endosc 2014;47(6):523-529.   Published online November 30, 2014
DOI: https://doi.org/10.5946/ce.2014.47.6.523
AbstractAbstract PDFPubReaderePub

One of the most important prognostic factors in esophageal carcinoma is lymph node metastasis, and in particular, the number of affected lymph nodes, which influences long-term outcomes. The esophageal lymphatic system is connected longitudinally and transversally; thus, the pattern of lymph node metastases is very complex. Early esophageal cancer frequently exhibits skipped metastasis, and minimal surgery using sentinel node navigation cannot be performed. In Korea, most esophageal cancer cases are squamous cell carcinoma (SCC), although the incidence of adenocarcinoma has started to increase recently. Most previous reports have failed to differentiate between SCC and adenocarcinoma, despite the fact that the Union for International Cancer Control (7th edition) and American Joint Committee on Cancer staging systems both consider these separately because they differ in cause, biology, lymph node metastasis, and outcome. Endoscopic tumor resection is an effective and safe treatment for lesions with no associated lymph node metastasis. Esophageal mucosal cancer confined to the lamina propria is an absolute indication for endoscopic resection, and a lesion that has invaded the muscularis mucosae can be cured by local resection if invasion to the lymphatic system has not occurred.

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Close layer
Stricture Occurring after Endoscopic Submucosal Dissection for Esophageal and Gastric Tumors
Gwang Ha Kim, Sam Ryong Jee, Jae Young Jang, Sung Kwan Shin, Kee Don Choi, Jun Haeng Lee, Sang Gyun Kim, Jae Kyu Sung, Suck Chei Choi, Seong Woo Jeon, Byung Ik Jang, Kyu Chan Huh, Dong Kyung Chang, Sung-Ae Jung, Bora Keum, Jin Woong Cho, Il Ju Choi, Hwoon-Yong Jung, Korean ESD Study Group
Clin Endosc 2014;47(6):516-522.   Published online November 30, 2014
DOI: https://doi.org/10.5946/ce.2014.47.6.516
AbstractAbstract PDFPubReaderePub

Endoscopic submucosal dissection (ESD) is a widely accepted treatment for early gastric and esophageal cancer. Compared to endoscopic mucosal resection, ESD has the advantage of enabling en bloc removal of tumors regardless of their size. However, ESD can result in a large artificial ulcer, which may lead to a considerable deformity. Circumferential mucosal defects of more than three-fourths the esophageal circumference, long longitudinal mucosal defects (>30 mm), and lesions in the upper esophagus are significant risk factors for the development of post-ESD strictures of the esophagus. In the stomach, a circumferential mucosal defects more than three-fourths in extent and longitudinal mucosal defects >5 cm are risk factors of post-ESD stricture. If scheduled early, regular endoscopic balloon dilation is effective in controlling and preventing post-ESD stricture. Moreover, intralesional steroid injections or oral steroids can achieve remission of dysphagia or reduce the need for repeated endoscopic balloon dilation. However, further study is needed to improve the prevention of stricture formation.

Citations

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  • A novel twin-grasper assisted mucosal inverted closure technique for closing large artificial gastric mucosal defects
    Qinbo Cai, Huanjie Chen, Haobin Hou, Wenqing Dong, Lele Zhang, Minxuan Shen, Shaoxiong Yi, Rongman Xie, Xun Hou, Wentong Lan, Yulong He, Dongjie Yang
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    Fatih Aslan, Serhat Özer, Orhun Çığ Taşkın
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    Enrique Pérez-Cuadrado Robles, Tom G. Moreels , Hubert Piessevaux , Ralph Yeung, Tarik Aouattah , Pierre H. Deprez
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    Mike T. Wei, Shai Friedland
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Case Reports
A Case of Endoscopic Full-Thickness Resection in a Patient with Gastric High-Grade Dysplasia Unsuitable for Endoscopic Submucosal Dissection
Jung Min Chae, Jae Young Jang, Seonghun Hong, Jung Wook Kim, Young Woon Chang
Clin Endosc 2014;47(4):353-357.   Published online July 28, 2014
DOI: https://doi.org/10.5946/ce.2014.47.4.353
AbstractAbstract PDFPubReaderePub

Gastric high-grade dysplasia is an important premalignant lesion in gastric epithelial cells and has a high possibility of transforming to adenocarcinoma. Therefore, biopsy-proven high-grade dysplasia should be treated with en bloc resection methods such as endoscopic mucosal resection or endoscopic submucosal dissection (ESD). We report the case of a 63-year-old male patient, diagnosed with gastric high-grade dysplasia at the angle and lesser curvature side of the lower body. The patient was initially treated with ESD, although histopathology subsequently showed horizontal margin involvement. Since the lesion was diffusely edematous and margins were uncertain because of the previous ESD treatment, we chose to treat the patient with laparoscopy-assisted endoscopic full-thickness resection (EFTR). EFTR is a recently developed procedure, which uses both endoscopic and laparoscopic techniques to resect the full-thickness of the tissue. The final pathologic report revealed high-grade dysplasia and a focal intramucosal carcinoma of 0.8×0.7 cm. We conclude that EFTR can be an effective alternative treatment in gastric high-grade dysplasia unsuitable for ESD.

Citations

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  • Endoscopic diagnosis and treatment of gastric dysplasia and early cancer: Current evidence and what the future may hold
    Edward Young, Hamish Philpott, Rajvinder Singh
    World Journal of Gastroenterology.2021; 27(31): 5126.     CrossRef
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    Jeffrey Fiorenza, Pavlos Kaimakliotis
    Techniques in Gastrointestinal Endoscopy.2015; 17(3): 108.     CrossRef
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  • 2 Web of Science
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A Case of Early Gastric Cancer with Solitary Metastasis to the Pleura
Eun Jung Hwang, Jae Young Jang, Yun Wha Kim, Seok Ho Dong, Hyo Jong Kim, Byung-Ho Kim, Young Woon Chang
Clin Endosc 2013;46(6):666-670.   Published online November 19, 2013
DOI: https://doi.org/10.5946/ce.2013.46.6.666
AbstractAbstract PDFPubReaderePub

The incidence of early gastric cancer (EGC) has increased to >50% in Korea owing to a higher detection rate caused by rapid advances in diagnostic instrumentation. EGC with distant metastasis has been rarely reported. Here, we report the case of a 76-year-old woman in whom general EGC was initially diagnosed by endoscopy and endoscopic ultrasonography. She subsequently underwent endoscopic submucosal dissection (ESD). Histological examination of the ESD specimen revealed that neoplastic cells were located predominantly in the submucosal layer and submucosal lymphatic channels. Metastatic cancer cells were also found in the pleural effusion. After conducting all analyses, including immunohistochemical staining, we concluded that the patient had primary EGC with pleural metastasis.

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  • 4 Crossref
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Review
A Review of Current Disinfectants for Gastrointestinal Endoscopic Reprocessing
Sanghoon Park, Jae Young Jang, Ja Seol Koo, Jeong Bae Park, Yun Jeong Lim, Su Jin Hong, Sang-Woo Kim, Hoon Jai Chun, Disinfection Management Committee, The Korean Society of Gastrointestinal Endoscopy
Clin Endosc 2013;46(4):337-341.   Published online July 31, 2013
DOI: https://doi.org/10.5946/ce.2013.46.4.337
AbstractAbstract PDFPubReaderePub

Gastrointestinal endoscopy is gaining popularity for diagnostic and therapeutic purposes. However, concerns over endoscope-related nosocomial infections are increasing, together with interest by the general public in safe and efficient endoscopy. For this reason, reprocessing the gastrointestinal endoscope is an important step for effective performance of endoscopy. Disinfectants are essential to the endoscope reprocessing procedure. Before selecting an appropriate disinfectant, their characteristics, limitations and means of use must be fully understood. Herein, we review the characteristics of several currently available disinfectants, including their uses, potency, advantages, and disadvantages. Most disinfectants can be used to reprocess gastrointestinal endoscopes if the manufacturer's guidelines are followed. The selection and use of a suitable disinfectant depends on the individual circumstances of each endoscopy suite.

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Case Report
A Case of Esophageal Squamous Cell Carcinoma with Pancreatic Metastasis
Choulki Park, Jae Young Jang, Youn Hwa Kim, Eun Jung Hwang, Ki Yong Na, Kyung-Yup Kim, Jae Hyun Park, Young Woon Chang
Clin Endosc 2013;46(2):197-200.   Published online March 31, 2013
DOI: https://doi.org/10.5946/ce.2013.46.2.197
AbstractAbstract PDFPubReaderePub

Solitary pancreatic metastasis of esophageal cancer is extremely rare. We report the case of a 58-year-old male admitted with esophageal cancer. Additional asymptomatic solitary hepatic and pancreatic masses were observed in the staging work-up for esophageal cancer. The hepatic mass was confirmed as a primary hepatocellular carcinoma with an ultrasound-guided needle biopsy. An esophagectomy with a distal pancreatectomy and radiofrequency ablation for hepatocellular carcinoma were performed. Histologically, the pancreatic mass was confirmed to be a metastasis from the esophageal cancer. The patient has been followed up with chemotherapy.

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Original Article
Endoscopic Ultrasound Elastography for the Pancreas in Korea: A Preliminary Single Center Study
Tae Hee Lee, Young Deok Cho, Sang-Woo Cha, Joo Young Cho, Jae Young Jang, Soung Won Jeong, Hyun Jong Choi, Jong Ho Moon
Clin Endosc 2013;46(2):172-177.   Published online March 31, 2013
DOI: https://doi.org/10.5946/ce.2013.46.2.172
AbstractAbstract PDFPubReaderePub
Background/Aims

Endoscopic ultrasound elastography (EUS-EG) has been widely used for the evaluation of pancreatic cancer in the Western world. To date, there is very little experience with EUS-EG in Korea. We described the results of comparison between normal pancreas and pancreatic cancer in Korea.

Methods

The present study was performed at a tertiary hospital on 35 subjects comprising 20 with normal pancreas (control group) and 15 with pancreatic cancer (disease group). We compared the EUS-EG performance of the two groups.

Results

The pancreas in the control group showed a mean elasticity value of 0.53% (95% confidence interval [CI], 0.45 to 0.61). The elasticity value was higher than that previously reported from Western country (0.47%; 95% CI, 0.38 to 0.57). In the disease group, the mean elasticity value of pancreatic lesions was 0.02% (95% CI, 0.01 to 0.02). The mean elasticity value of the disease group was significantly lower than that of the control group (p<0.0001).

Conclusions

EUS-EG could be a highly sensitive diagnostic modality for pancreatic cancer in Korea with little EUS-EG experience. We also provided the reference range of elasticity value of normal pancreas, which might be valuable in the interpretation of pancreatic elasticity data for Korean adults.

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Focused Review Series: Globalization and Universalization of ESD
The Usefulness of Magnifying Endoscopy and Narrow-Band Imaging in Measuring the Depth of Invasion before Endoscopic Submucosal Dissection
Jae Young Jang
Clin Endosc 2012;45(4):379-385.   Published online November 30, 2012
DOI: https://doi.org/10.5946/ce.2012.45.4.379
AbstractAbstract PDFPubReaderePub

With the widespread application of endoscopic submucosal dissection for the treatment of gastrointestinal neoplasms, accurate determination of the invasion depth prior to intervention has become an indispensable part of treatment planning. Narrow-band imaging (NBI) is a novel endoscopic technique that may enhance the accuracy of diagnosis. Magnifying endoscopy with NBI has been shown to be effective for determining invasion depth for intrapapillary capillary loop classification of esophageal cancer and microvascular pattern of stomach cancer. Such precise pre-treatment staging of early neoplastic lesions in the gastrointestinal tract warrants timely initiation of disease-tailored treatment and, ultimately, better quality of life and improved patient survival.

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Review
Recent Advances in Image-enhanced Endoscopy
Won Young Cho, Jae Young Jang, Don Haeng Lee, The Endoscopic Technology and Investigation Study Group
Clin Endosc 2011;44(2):65-75.   Published online December 31, 2011
DOI: https://doi.org/10.5946/ce.2011.44.2.65
AbstractAbstract PDFPubReaderePub

The desire to better recognized such malignancies, which may be difficult to distinguish from inflammation or trauma, has accelerated the development of endoscopy with new optical technologies. Narrow-band imaging is a novel endoscopic technique that may enhance the accuracy of diagnosis using narrow-bandwidth filters in a red-green-blue sequential illumination system. Autofluorescence imaging is based on the detection of natural tissue fluorescence emitted by endogenous molecules. I-scan technology using a digital filter that modifies normal images through software functions, is the newly developed image-enhanced endoscopic technology from PENTAX. Flexible spectral imaging color enhancement enhances the visualization of mucosal structure and microcirculation by the selection of spectral transmittance with a dedicated wavelength. Confocal laser endomicroscopy images were collected with an argon beam with a scanning depth of 0 (epithelium) to 250 µm (lamina propria) and analyzed using the reflected light.

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