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2 "Kang Nyeong Lee"
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Original Article
Risk Factors and Clinical Outcomes of Non-Curative Resection in Patients with Early Gastric Cancer Treated with Endoscopic Submucosal Dissection: A Retrospective Multicenter Study in Korea
Si Hyung Lee, Min Cheol Kim, Seong Woo Jeon, Kang Nyeong Lee, Jong Jae Park, Su Jin Hong, Korean Society of Gastrointestinal Endoscopy Endoscopic Submucosal Dissection Research Group
Clin Endosc 2020;53(2):196-205.   Published online October 25, 2019
DOI: https://doi.org/10.5946/ce.2019.123
AbstractAbstract PDFPubReaderePub
Background
/Aims: The purpose of this study was to investigate the risk factors and long-term clinical outcomes of non-curative resection (NCR) in a large-scale patient population.
Methods
We retrospectively analyzed the clinical data of 3,094 patients who underwent endoscopic submucosal dissection (ESD) of early gastric cancer from March 2005 to March 2018 at 13 institutions in Korea. We analyzed the risk factors for NCR and the survival between patients with curative resection and those with NCR with no additional treatment.
Results
The NCR rate was 21.4% (661/3,094). In multivariate regression analysis, the risk factors affecting NCR with ESD were old age, undifferentiated tumor, tumor location in the upper body, tumor size ≥2 cm, and presence of an ulcer. In Cox proportional hazard regression analysis, tumor size ≥2 cm, submucosal invasion, positive horizontal margin, and lymphovascular invasion were risk factors for local recurrence. In Kaplan-Meier analysis, there was no statistically significant difference in the overall survival between the two groups (log-rank p=0.788). However, disease-specific survival was significantly lower in the NCR group (log-rank p=0.038).
Conclusions
Clinicians should be aware of the risk factors for NCR and local recurrence after ESD for early gastric cancer, and should consider providing additional treatment after NCR.

Citations

Citations to this article as recorded by  
  • Management Strategy of Non-curative ESD in Gastric Cancer: Curative Criteria, and the Critical Building Block for Determining Beyond It
    Hyuk Lee
    Journal of Gastric Cancer.2025; 25(1): 210.     CrossRef
  • Enhancing Lymph Node Metastasis Risk Prediction in Early Gastric Cancer Through the Integration of Endoscopic Images and Real-World Data in a Multimodal AI Model
    Donghoon Kang, Han Jo Jeon, Jie-Hyun Kim, Sang-Il Oh, Ye Seul Seong, Jae Young Jang, Jung-Wook Kim, Joon Sung Kim, Seung-Joo Nam, Chang Seok Bang, Hyuk Soon Choi
    Cancers.2025; 17(5): 869.     CrossRef
  • Risk factors for pathological upgrading and noncurative resection in patients with gastric mucosal lesions after endoscopic submucosal dissection
    Pingjiang Wang, Xu Zhao, Ruicai Wang, Dong Xu, Haiping Yang
    BMC Gastroenterology.2024;[Epub]     CrossRef
  • Endoscopic and clinicopathological features of early gastric papillary adenocarcinoma
    Zhenxiang Zuo, Xing Qi, Xiujie Cui, Bin Yu, Huimin Zhang, Honglei Wu
    Frontiers in Oncology.2024;[Epub]     CrossRef
  • Comprehensive analysis of risk factors associated with submucosal invasion in patients with early-stage gastric cancer
    Bin-Bin Yan, Li-Na Cheng, Hui Yang, Xiu-Ling Li, Xiu-Qi Wang
    World Journal of Gastroenterology.2024; 30(47): 5007.     CrossRef
  • Pathology Reporting of Gastric Endoscopic Resections: Recommendations From the International Collaboration on Cancer Reporting
    Chanjuan Shi, Fleur Webster, Iris D. Nagtegaal, Michael J. Bourke, Seung-mo Hong, M. Priyanthi Kumarasinghe, Alfred K. Lam, Gregory Lauwers, Maria O’Donovan, Rachel S. van der Post, Tetsuo Ushiku, Michael Vieth, Christina Selinger
    Gastroenterology.2023; 164(7): 1039.     CrossRef
  • Nomogram for pre-procedural prediction of non-curative endoscopic resection in patients with early gastric cancer
    So Young Han, Hong Jin Yoon, Jie-Hyun Kim, Hye Sun Lee, Jaeyoung Chun, Young Hoon Youn, Hyojin Park
    Surgical Endoscopy.2023; 37(6): 4594.     CrossRef
  • Endoscopic submucosal dissection for early gastric cancer: It is time to consider the quality of its outcomes
    Gwang Ha Kim
    World Journal of Gastroenterology.2023; 29(43): 5800.     CrossRef
  • Cancer Patient Perception Survey to Develop Korean Medicine Clinical Practice Guidelines for Gastric Cancer
    Dong Hyeon Kim, Jong Hee Kim, Ji Hye Park, Hwa Seung Yoo, Hyeong Joon Jeon, So Jung Park
    Journal of Physiology & Pathology in Korean Medicine.2023; 37(4): 81.     CrossRef
  • Endoscopic treatment for early gastric cancer
    Ji Yong Ahn
    Journal of the Korean Medical Association.2022; 65(5): 276.     CrossRef
  • Therapeutic approach to non-curative resection after endoscopic treatment in early gastric cancer
    Eun Jeong Gong, Chang Seok Bang
    Journal of the Korean Medical Association.2022; 65(5): 284.     CrossRef
  • Endoscopic diagnosis of early gastric cancer
    Dong Chan Joo, Gwang Ha Kim
    Journal of the Korean Medical Association.2022; 65(5): 267.     CrossRef
  • Long‑term outcome of the endoscopic submucosal dissection of early gastric cancer: A comparison between patients with and without liver cirrhosis
    Seung Kim, Moon Joo, Ah-Young Yoo, Seong Kim, Won Kim, Beom Lee, Jong Park, Hoon Chun, Sang Lee
    Oncology Letters.2022;[Epub]     CrossRef
  • Clinico-pathologic determinants of non-e-curative outcome following en-bloc endoscopic submucosal dissection in patients with early gastric neoplasia
    Kidane Siele Embaye, Chao Zhang, Matiwos Araya Ghebrehiwet, Zhihao Wang, Fengdi Zhang, Liwei Liu, Shenghui Qin, Lingzhi Qin, Jun Wang, Xi Wang
    BMC Cancer.2021;[Epub]     CrossRef
  • Factors associated with overall survival in early gastric cancer patients who underwent additional surgery after endoscopic submucosal dissection
    Zhi Zheng, Fan-Di Bu, Hao Chen, Jie Yin, Rui Xu, Jun Cai, Jun Zhang, Hong-Wei Yao, Zhong-Tao Zhang
    World Journal of Clinical Cases.2021; 9(10): 2192.     CrossRef
  • Establishing Machine Learning Models to Predict Curative Resection in Early Gastric Cancer with Undifferentiated Histology: Development and Usability Study
    Chang Seok Bang, Ji Yong Ahn, Jie-Hyun Kim, Young-Il Kim, Il Ju Choi, Woon Geon Shin
    Journal of Medical Internet Research.2021; 23(4): e25053.     CrossRef
  • Population Attributable Fraction of Helicobacter pylori Infection–Related Gastric Cancer in Korea: A Meta-Analysis
    Yoon Park, Moran Ki
    Cancer Research and Treatment.2021; 53(3): 744.     CrossRef
  • Very low rate of residual neoplasia after non-curative endoscopic submucosal dissection: a western single-center experience
    João Santos-Antunes, Margarida Marques, Fátima Carneiro, Guilherme Macedo
    European Journal of Gastroenterology & Hepatology.2021; 33(9): 1161.     CrossRef
  • Editors' Choice of Noteworthy Clinical Endoscopy Publications in the First Decade
    Gwang Ha Kim, Kwang An Kwon, Do Hyun Park, Jimin Han
    Clinical Endoscopy.2021; 54(5): 633.     CrossRef
  • Non-Curative Resection: Should Clinicians Consider Providing Additional Surgery for All Patients?
    Waku Hatta, Takuji Gotoda, Atsushi Masamune
    Clinical Endoscopy.2020; 53(2): 109.     CrossRef
  • Protocol for expanded indications of endoscopic submucosal dissection for early gastric cancer in China: a multicenter, ambispective, observational, open-cohort study
    Zhi Zheng, Jie Yin, Ziyu Li, Yingjiang Ye, Bo Wei, Xin Wang, Yantao Tian, Mengyi Li, Qian Zhang, Na Zeng, Rui Xu, Guangyong Chen, Jie Zhang, Peng Li, Jun Cai, Hongwei Yao, Jun Zhang, Zhongtao Zhang, Shutian Zhang
    BMC Cancer.2020;[Epub]     CrossRef
  • Predictive Factors and Long-Term Outcomes of Early Gastric Carcinomas in Patients with Non-Curative Resection by Endoscopic Submucosal Dissection


    Ping Xu, Yun Wang, Yini Dang, Qin Huang, Jianhua Wang, Weifeng Zhang, Yifeng Zhang, Guoxin Zhang
    Cancer Management and Research.2020; Volume 12: 8037.     CrossRef
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  • 21 Web of Science
  • 22 Crossref
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Case Report
Endoscopic Treatment of a Symptomatic Ileal Lipoma with Recurrent Ileocolic Intussusceptions by Using Cap-Assisted Colonoscopy
Eun Sung Lee, Kang Nyeong Lee, Kyung Soo Choi, Hang Lak Lee, Dae Won Jun, Oh Young Lee, Byung Chul Yoon, Ho Soon Choi
Clin Endosc 2013;46(4):414-417.   Published online July 31, 2013
DOI: https://doi.org/10.5946/ce.2013.46.4.414
AbstractAbstract PDFPubReaderePub

A 73-year-old woman presented with intermittent abdominal pain and weight loss of 15 kg for 2 years. Colonoscopy revealed an erythematous polypoid tumor with a long and wide stalk in the cecum, but with air inflation, it abruptly went away through the ileocecal valve (ICV). An abdominal computed tomography showed a well-demarcated pedunculated subepithelial mass of 2.6×2.7 cm size with fat attenuation in the terminal ileum. It was an intussusceptum of the ileal lipoma through the ICV. This ileal lipoma was causing her symptoms because repeated ileocolic intussusceptions resulted in intermittent intestinal obstructions. In order to avoid surgical sequelae of ileal resection, snare polypectomy using cap-assisted colonoscopy technique was performed within the ileum without complications. The histopathology report confirmed it as a subepithelial lipoma. After endoscopic resection of the ileal lipoma, the patient has been free of symptoms and was restored to the original weight.

Citations

Citations to this article as recorded by  
  • Extraction of terminal ileal lipomas to cecum can facilitate endoscopic resection: A case series with video
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    DEN Open.2025;[Epub]     CrossRef
  • A Rare Case of Multiple Ileal Lipoma in A Young Male
    Ramprashanth MP
    Journal of Surgery Research and Practice.2024; : 1.     CrossRef
  • Terminal Ileum Lipoma Causing Ileocolic Intussusception: A Case Report and Literature Review
    Siddhant Dogra, Jason Wei, Benjamin Wadowski, Virginia Devi-Chou, Leandra Krowsoski, Rajiv R Shah
    Cureus.2023;[Epub]     CrossRef
  • Successful endoscopic management of adult ileocecal intussusception secondary to a large ileal lipoma
    Akira Teramoto, Seiji Hamada, Takahiro Utsumi, Daizen Hirata, Yasushi Sano
    VideoGIE.2021; 6(4): 187.     CrossRef
  • Life‐threatening gastrointestinal bleeding from a giant ileal lipoma
    Amy Donovan, Sandun Abeyasundara, Hajir Nabi
    ANZ Journal of Surgery.2020;[Epub]     CrossRef
  • Intususcepción íleo-cólica de lipoma ileal como causa de hemorragia digestiva baja
    Eduardo Valdivielso Cortázar, María López Álvarez, Alberto Guerrero Montañes, Loreto Yañez González-Dopeso, Jesus Ángel Yañez López, Pedro Antonio Alonso Aguirre
    Gastroenterología y Hepatología.2017; 40(7): 457.     CrossRef
  • Ileocolic intussusception of ileal lipoma as a cause of lower gastrointestinal bleeding
    Eduardo Valdivielso Cortázar, María López Álvarez, Alberto Guerrero Montañes, Loreto Yañez González-Dopeso, Jesus Ángel Yañez López, Pedro Antonio Alonso Aguirre
    Gastroenterología y Hepatología (English Edition).2017; 40(7): 457.     CrossRef
  • Unroofing Technique as an Option for the Endoscopic Treatment of Giant Gastrointestinal Lipomas
    Marcela Kopáčová, Stanislav Rejchrt, Jan Bureš
    Acta Medica (Hradec Kralove, Czech Republic).2015; 58(4): 115.     CrossRef
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  • 66 Download
  • 8 Crossref
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