Clinical Endoscopy

Systematic Review and Meta-Analysis

Hybrid argon plasma coagulation in Barrett’s esophagus: a systematic review and meta-analysis: Sagar N. Shah, Nabil El Hage Chehade, Amirali Tavangar, Alyssa Choi, Marc Monachese, Kenneth J. Chang, Jason B. Samarasena; Clin Endosc 2023;56(1):38-49. Published online January 30, 2023; DOI: https://doi.org/10.5946/ce.2022.179

Abstract PDF Supplementary Material PubReader ePub

Background
/Aims: Patients with Barrett’s esophagus are at increased risk of developing esophageal adenocarcinoma. Endoscopic therapies aim to eradicate dysplastic and metaplastic tissues. Hybrid argon plasma coagulation (hybrid-APC) utilizes submucosal fluid injection to create a protective cushion prior to ablation that shields the submucosa from injury. We performed a pooled meta-analysis to evaluate the safety and efficacy of hybrid-APC.
Methods
We conducted a systematic search of major electronic databases in April 2022. Studies that included patients with dysplastic and non-dysplastic Barrett’s esophagus undergoing treatment with hybrid-APC were eligible for inclusion. Outcome measures included complete remission of intestinal metaplasia (CR-IM), stricture formation, serious adverse events, and number of sessions necessary to achieve CR-IM.
Results
Overall pooled CR-IM rate for patients undergoing hybrid-APC was 90.8% (95% confidence interval [CI], 0.872–0.939; I2=0%). Pooled stricture rate was 2.0% (95% CI, 0.005–0.042; I2=0%). Overall serious adverse event rate was 2.7% (95% CI, 0.007–0.055; I2=0%).
Conclusions
Results of the current meta-analysis suggest that hybrid-APC is associated with high rates of CR-IM and a favorable safety profile. Interpretation of these results is limited by the inclusion of retrospective cohort and case series data. Randomized controlled trials that standardize treatment and outcome evaluation protocols are necessary to understand how this treatment option is comparable to the current standards of care.

Citations

Citations to this article as recorded by

High Quality Barrett’s Esophagus Examination and Endoscopic Eradication Therapy
Shirin Dey, Kevin Shah, Srinadh Komanduri
Gastrointestinal Endoscopy Clinics of North America.2025; 35(3): 523. CrossRef
Safety and feasibility of argon plasma coagulation for gastric low-grade dysplasia: a systematic review and meta-analysis
Jun-young Seo, Sun Jae Moon, Ah Young Lee, Ji Yong Ahn
Surgical Endoscopy.2025; 39(8): 5127. CrossRef
Potential applications of artificial intelligence for optimizing the treatment of patients with esophageal metaplasia and hiatal hernias
O.S. Tyvonchuk, I.V. Babii, A. Sargsyan, O.O. Hulenko
EMERGENCY MEDICINE.2025; 21(6): 621. CrossRef
Role of Endoscopy in the Diagnosis and Management of Esophageal Cancer
Jennifer Ma, Sharon Pan, Rachel Mortan, Faisal Shaukat Ali, Nirav Thosani, Vaibhav Wadhwa
Journal of Clinical Medicine.2025; 14(22): 8169. CrossRef
Application of electrosurgery in gastrointestinal endoscopy
Hongrui Wang, Jiuzhou Zhao, Yu Zhou
Progress in Medical Devices.2024;[Epub] CrossRef
Hybrid Argon Plasma Coagulation for Barrett’s Esophagus and for Colonic Mucosal Resection—A Systematic Review and Meta-Analysis
Maria Manuela Estevinho, Rolando Pinho, João Carlos Silva, João Correia, Pedro Mesquita, Teresa Freitas
Biomedicines.2023; 11(4): 1139. CrossRef
Hybrid-APC treatment for gastric vascular ectasia of atypical location after failed radiofrequency ablation
José Manuel Palma García, Raúl Honrubia López, Cristina Fernández de Castro, Carmen Comas Redondo
Revista Española de Enfermedades Digestivas.2023;[Epub] CrossRef
Thermal ablative therapies in the gastrointestinal tract
Hendrik Manner
Current Opinion in Gastroenterology.2023; 39(5): 370. CrossRef
Endoscopic Management of Dysplastic Barrett’s Oesophagus and Early Oesophageal Adenocarcinoma
Leonardo Henry Eusebi, Andrea Telese, Chiara Castellana, Rengin Melis Engin, Benjamin Norton, Apostolis Papaefthymiou, Rocco Maurizio Zagari, Rehan Haidry
Cancers.2023; 15(19): 4776. CrossRef
Critical Decision Making: Technical Aspects of Esophageal Ablation
Felice Schnoll-Sussman
Foregut: The Journal of the American Foregut Society.2023; 3(3): 314. CrossRef

7,858 View
208 Download
8 Web of Science
10 Crossref

Focused Review Series: Expanding the Indication with Safety Issue of Endoscopic Ultrasound

Endoscopic Ultrasound-Guided Portal Pressure Measurement and Interventions: Jason B. Samarasena, Kenneth J. Chang; Clin Endosc 2018;51(3):222-228. Published online May 31, 2018; DOI: https://doi.org/10.5946/ce.2018.079

Abstract PDF PubReader ePub

A growing number of studies have explored endoscopic ultrasound (EUS)-guided vascular catheterization. Potential clinical applications of EUS-guided portal venous access include angiography, measurement of the portosystemic pressure gradient, EUS-guided transhepatic intrahepatic portosystemic shunt creation and portal vein sampling for the evaluation in gastrointestinal cancer. The following article reviews the different devices and techniques employed in these applications.

Citations

Citations to this article as recorded by

Endoscopic Ultrasound: Liver Biopsy and Portal Pressure Measurement
Cristina Chiodi, Endashaw Omer
Current Hepatology Reports.2025;[Epub] CrossRef
Advances in portal pressure measurement: Endoscopic techniques, challenges, and implications for liver transplantation
Neeraj Singla, Venishetty Shantan, Anushka Saraswat, Aniruddha Pratap Singh
World Journal of Hepatology.2025;[Epub] CrossRef
Endo-hepatology: Why should we do endoscopic ultrasound-guided interventions to the liver that we could do through the skin?
Claudio Calvanese, Pietro Fusaroli
World Journal of Gastroenterology.2024; 30(40): 4333. CrossRef
Head-to-head comparison of endoscopic ultrasound and transjugular portal pressure measurements
I. Dragomir, C. Pojoga, C. Hagiu, V. Rednic, R. I. Orzan, P. Fischer, O. Nicoara-Farcau, H. Stefanescu, B. Procopet, A. Seicean
Endoscopy.2024; 56(S 02): S67. CrossRef
Performance of Endoscopic Ultrasound-Guided Versus Percutaneous Liver Biopsy in Diagnosing Stage 3–4 Fibrosis
Alyssa Y. Choi, Xiaodong Li, Wenchang Guo, Vishal S. Chandan, Jason Samarasena, John G. Lee, Kenneth J. Chang, Ke-Qin Hu
Digestive Diseases and Sciences.2023; 68(9): 3774. CrossRef
I Do It My Way: Alternative Approaches in Multidisciplinary Management of GI Diseases
Sagarika Satyavada, Sidhartha Tavri
Digestive Disease Interventions.2023; 07(04): 225. CrossRef
Liver Biopsy and Pressure Hemodynamics: GI Perspective
Varun Kesar, Vivek Kesar, Klaus Monkemuller, Paul Yeaton
Digestive Disease Interventions.2023; 07(04): 280. CrossRef
Methods for assessing portal hypertension
S.M. Chooklin, S.S. Chuklin
EMERGENCY MEDICINE.2023; 19(6): 393. CrossRef
Radiology-guided percutaneous approach is superior to EUS for performing liver biopsies
Kaveh Hajifathalian, Kenneth J Chang, Reem Z Sharaiha
Gut.2022; 71(4): 845. CrossRef
Endoscopic Ultrasound Evaluation of Portal Pressure
Enrico O. Souto
Clinics in Liver Disease.2022; 26(1): e1. CrossRef
The role of endoscopic ultrasound for portal hypertension in liver cirrhosis
Cosmas Rinaldi Adithya Lesmana, Maria Satya Paramitha, Rino A. Gani, Laurentius A. Lesmana
Journal of Medical Ultrasonics.2022; 49(3): 359. CrossRef
Endoscopic Ultrasound-Guided Porto-systemic Pressure Gradient Measurement Correlates with Histological Hepatic Fibrosis
Alyssa Y. Choi, Kenneth J. Chang, Jason B. Samarasena, John G. Lee, Xiaodong Li, Wenchang Guo, Vishal S. Chandan, Ke-Qin Hu
Digestive Diseases and Sciences.2022; 67(12): 5685. CrossRef
Advances in Management of Pancreatitis Related Portal Hypertension
Ujas Patel, Thammasak Mingbunjerdsuk, Ahmed M. Gabr, Meir Mizrahi, Fady Salama, Moamen Gabr
Digestive Disease Interventions.2022; 06(02): 108. CrossRef
Endohepatology – current status
Jerome C. Edelson, Natalie E. Mitchell, Don C. Rockey
Current Opinion in Gastroenterology.2022; 38(3): 216. CrossRef
The use of endoscopic ultrasound in the diagnosis and management of portal hypertension
Wim Laleman, Emma Vanderschueren, Schalk Van der Merwe, Kenneth J. Chang
Best Practice & Research Clinical Gastroenterology.2022; 60-61: 101811. CrossRef
EUS-Guided Portal Venous Sampling of Circulating Tumor Cells
Christopher G. Chapman, Irving Waxman
Current Gastroenterology Reports.2019;[Epub] CrossRef

11,579 View
199 Download
14 Web of Science
16 Crossref

Focused Review Series: EUS-Guided Therapeutic Interventions

Endoscopic Ultrasound-Guided Direct Intervention for Solid Pancreatic Tumors: Jimin Han, Kenneth J. Chang; Clin Endosc 2017;50(2):126-137. Published online March 30, 2017; DOI: https://doi.org/10.5946/ce.2017.034

Abstract PDF PubReader ePub

Development and use of linear-array echoendoscope and endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) have made endoscopic ultrasound (EUS) more of an interventional procedure than a purely diagnostic procedure. This is a literature review of previously published clinical studies on EUS-guided direct intervention for solid pancreatic tumors, including EUS-guided fine needle injection (EUS-FNI) of antitumor agents, EUS-guided fiducial marker placement, EUS-guided brachytherapy and EUS-guided tumor ablation.

Citations

Citations to this article as recorded by

Emergent Role of Intra-Tumor Radioactive Implantation in Pancreatic Cancer
Pathipat Durongpongkasem, Amanda H. Lim, Nam Q. Nguyen
Cancers.2026; 18(2): 302. CrossRef
Impact of Different Modalities of Radiotherapy in Locally Advanced Pancreatic Cancer: A Review and Meta‐Analysis
Amanda H. Lim, Olga Sukocheva, Jana Bednarz, Dylan Bartholomeusz, Christopher K. Rayner, Edmund Tse, Nam Q. Nguyen
Journal of Gastroenterology and Hepatology.2025; 40(10): 2413. CrossRef
Endo-hepatology: Bridging the gap between lumen and liver
Walaa Abdelhamed, Mohamed El-Kassas
World Journal of Gastroenterology.2025;[Epub] CrossRef
Endoscopic Ultrasound-Guided Antitumor Therapy
Yousuke Nakai
Gastrointestinal Endoscopy Clinics of North America.2024; 34(1): 79. CrossRef
Advances in Endoscopic Ultrasound in Pancreatic Cancer Screening, Diagnosis, and Palliative Care
Wenyu Zhang, Jingzheng Chen, Wei Zhang, Min Xu
Biomedicines.2024; 13(1): 76. CrossRef
Direct image-guided retroperitoneal approach and treatment of the pancreas by using natural orifice transluminal endoscopic surgery after EUS sugar-assisted radiofrequency ablation (with video)
Leonardo Sosa-Valencia, Giulia Pecorella, Gerlinde Averous, Julieta Montanelli, Fanélie Wanert, Lee Swanström
Gastrointestinal Endoscopy.2022; 95(3): 573. CrossRef
Endoscopic Management of Pancreatobiliary Malignancies
Dong Wook Lee, Eun Young Kim
Digestive Diseases and Sciences.2022; 67(5): 1635. CrossRef
Estimation of porcine pancreas optical properties in the 600–1100 nm wavelength range for light-based therapies
Pranav Lanka, Leonardo Bianchi, Andrea Farina, Martina De Landro, Antonio Pifferi, Paola Saccomandi
Scientific Reports.2022;[Epub] CrossRef
Gold Nanoparticles-Mediated Photothermal Therapy of Pancreas Using GATE: A New Simulation Platform
Somayeh Asadi, Leonardo Bianchi, Martina De Landro, Paola Saccomandi
Cancers.2022; 14(22): 5686. CrossRef
Endoscopic Ultrasound–Guided Fiducial Placement for Stereotactic Body Radiation Therapy in Pancreatic Malignancy
Seong-Hun Kim, Eun Ji Shin
Clinical Endoscopy.2021; 54(3): 314. CrossRef
Diagnostic and Interventional Role of Endoscopic Ultrasonography for the Management of Pancreatic Neuroendocrine Neoplasms
Giuseppinella Melita, Socrate Pallio, Andrea Tortora, Stefano Francesco Crinò, Antonio Macrì, Gianlorenzo Dionigi
Journal of Clinical Medicine.2021; 10(12): 2638. CrossRef
Advanced Endoscopic Techniques for the Diagnosis of Pancreatic Cancer and Management of Biliary and GastricOutlet Obstruction
Yousuke Nakai, Zachary Smith, Kenneth J. Chang, Kulwinder S. Dua
Surgical Oncology Clinics of North America.2021; 30(4): 639. CrossRef
New Isotopes for the Treatment of Pancreatic Cancer in Collaboration With CERN: A Mini Review
Claudia Burkhardt, Léo Bühler, David Viertl, Thierry Stora
Frontiers in Medicine.2021;[Epub] CrossRef
PID Controlling Approach Based on FBG Array Measurements for Laser Ablation of Pancreatic Tissues
Sanzhar Korganbayev, Annalisa Orrico, Leonardo Bianchi, Davide Paloschi, Alexey Wolf, Alexander Dostovalov, Paola Saccomandi
IEEE Transactions on Instrumentation and Measurement.2021; 70: 1. CrossRef
Endoscopic retrograde cholangiopancreatography guided interventions in the management of pancreatic cancer
Muhammad Nadeem Yousaf, Hamid Ehsan, Ahsan Wahab, Ahmad Muneeb, Fizah S Chaudhary, Richard Williams, Christopher J Haas
World Journal of Gastrointestinal Endoscopy.2020; 12(10): 323. CrossRef
Necrosis volume and Choi criteria predict the response to endoscopic ultrasonography-guided HybridTherm ablation of locally advanced pancreatic cancer
Sabrina Gloria Giulia Testoni, Gabriele Capurso, Maria Chiara Petrone, Maurizio Barbera, Walter Linzenbold, Markus Enderle, Simone Gusmini, Roberto Nicoletti, Emanuel Della Torre, Alberto Mariani, Gemma Rossi, Livia Archibugi, Francesco De Cobelli, Michel
Endoscopy International Open.2020; 08(10): E1511. CrossRef
EUS-guided fine-needle injection for pancreatic cancer: back to the future
Yousuke Nakai, Kenneth J. Chang
Gastrointestinal Endoscopy.2020; 92(5): 1053. CrossRef
EUS-guided irreversible electroporation using endoscopic needle-electrode in porcine pancreas
Jae Min Lee, Hyuk Soon Choi, Hoon Jai Chun, Eun Sun Kim, Bora Keum, Yeon Seok Seo, Yoon Tae Jeen, Hong Sik Lee, Soon Ho Um, Chang Duck Kim, Hong Bae Kim
Surgical Endoscopy.2019; 33(2): 658. CrossRef
Management of Gastrointestinal Neuroendocrine Tumors
Rongzhi Wang, Rui Zheng-Pywell, H Alexander Chen, James A Bibb, Herbert Chen, J Bart Rose
Clinical Medicine Insights: Endocrinology and Diabetes.2019;[Epub] CrossRef
Current Status of Endoscopic Ultrasound Techniques for Pancreatic Neoplasms
Yousuke Nakai, Naminatsu Takahara, Suguru Mizuno, Hirofumi Kogure, Kazuhiko Koike
Clinical Endoscopy.2019; 52(6): 527. CrossRef
Future Perspectives on Endoscopic Ultrasonography-Guided Therapy for Pancreatic Neoplasm
Woo Hyun Paik, Sang Hyub Lee, Sunguk Jang
Clinical Endoscopy.2018; 51(3): 229. CrossRef
Diagnosis of Pancreatic Neuroendocrine Tumors
Dong Wook Lee, Michelle Kang Kim, Ho Gak Kim
Clinical Endoscopy.2017; 50(6): 537. CrossRef

11,994 View
228 Download
24 Web of Science
22 Crossref

First
Prev
Page of 1
Next
Last

Search