Clinical Endoscopy

Original Articles

Efficacy and safety of endoscopic ultrasound-guided hepaticogastrostomy for biliary drainage in hypervascular hepatocellular carcinoma: a retrospective study from Japan: Kenneth Tachi, Kazuo Hara, Nozomi Okuno, Shin Haba, Takamichi Kuwahara, Toshitaka Fukui, Ahmed Mohammed Sadek, Hossam El-Din Shaaban Mahmoud Ibrahim, Minako Urata, Takashi Kondo, Yoshitaro Yamamoto; Clin Endosc 2025;58(3):448-456. Published online November 11, 2024; DOI: https://doi.org/10.5946/ce.2024.079

Graphical Abstract Abstract PDF: Background
/Aims: Biliary obstruction drainage in patients with hepatocellular carcinoma (HCC) is associated with symptom palliation, improved access to chemotherapy, and improved survival. Stent placement and exchange via endoscopic retrograde cholangiopancreatography biliary drainage risk traversing the HCC, a hypervascular tumor and causing bleeding. Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) potentially prevents procedure-related bleeding. Therefore, we evaluated the efficacy and safety of EUS-HGS as an alternative treatment for biliary obstruction in patients with HCC.
Methods
This was a retrospective study of all EUS-HGS procedures performed in patients with HCC at the Aichi Cancer Center Hospital, Japan, from February 2017 to August 2023.
Results
A total of 14 EUS-HGS procedures (42.9% primary) were attempted in 10 HCC patients (mean age 71.5 years, 80.0% male). Clinical and technical success rates were 92.9% and 90.9%, respectively. The observed procedure details in the 13 successful procedures included B3 puncture (53.8%), 22-G needle (53.8%), fully covered self-expandable metal stent (100%), and mean procedure time (32.7 minutes). There was no bleeding. Mild complications occurred in 27.3%. All patients resumed oral intake within 24 hours.
Conclusions
EUS-HGS is a technically feasible and clinically effective initial or salvage drainage option for the treatment of biliary obstruction in patients with HCC.

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Safety and efficacy of trans-afferent loop endoscopic ultrasound-guided pancreaticojejunostomy for post pancreaticoduodenectomy anastomotic stricture using the forward-viewing echoendoscope: a retrospective study from Japan: Ahmed Sadek, Kazuo Hara, Nozomi Okuno, Shin Haba, Takamichi Kuwahara, Toshitaka Fukui, Minako Urata, Takashi Kondo, Yoshitaro Yamamoto, Kenneth Tachi; Clin Endosc 2025;58(2):311-319. Published online August 26, 2024; DOI: https://doi.org/10.5946/ce.2024.089

Graphical Abstract Abstract PDF Supplementary Material

Background
/Aims: Endoscopic ultrasound (EUS)-guided pancreatic duct drainage is a well-established procedure for managing pancreaticojejunostomy anastomotic strictures (PJAS) post-Whipple surgery. In this study, we examined the effectiveness and safety of EUS-guided pancreaticojejunostomy (EUS-PJS).
Methods
This retrospective, single-arm study was performed at Aichi Cancer Center Hospital on 10 patients who underwent EUS-guided pancreaticojejunostomy through the afferent jejunal loop using a forward-viewing echoendoscope when endoscopic retrograde pancreatography failed. Our primary endpoint was technical success rate, defined as successful stent insertion. The secondary endpoints were early and late adverse events.
Results
A total of 10 patients underwent EUS-PJS between February 2019 and October 2023. The technical success rate was 100%. The median procedure time was 23.5 minutes. No remarkable early or late adverse events related to the procedure, except for fever, occurred in two patients. The median follow-up duration was 9.5 months, and the median number of stent exchanges was two. A stent-free state was achieved in three patients.
Conclusions
EUS-PJS for PJAS management after pancreaticoduodenectomy appears to be an effective and safe procedure with the potential advantages of fewer reinterventions and the creation of a permanent drainage fistula.

Citations

Citations to this article as recorded by

Endoscopic ultrasound-guided recanalization of pancreaticojejunostomy anastomotic stricture using a forward-viewing echoendoscope
Shota Iwata, Takuji Iwashita, Takuya Koizumi, Yosuke Ohashi, Akinori Maruta, Shinya Uemura, Masahito Shimizu
Endoscopy.2026; 58(S 01): E274. CrossRef
Transanastomotic Forward-Viewing EUS-Guided Pancreatic Duct Drainage via Afferent Loop for Pancreaticojejunostomy Anastomotic Stricture After Pancreaticoduodenectomy
Tadahisa Inoue, Rena Kitano, Tomoya Kitada, Kazumasa Sakamoto, Satoshi Kimoto, Jun Arai, Kiyoaki Ito
Digestive Diseases and Sciences.2025; 70(1): 413. CrossRef
Management of Pancreaticojejunostomy Strictures: A New Perspective with Forward-Viewing EUS
Radhika Chavan
Digestive Diseases and Sciences.2025; 70(5): 1740. CrossRef
Transforming endoscopic approaches to post-pancreaticoduodenectomy anastomotic strictures: beyond the surface
Yu-Ting Kuo
Clinical Endoscopy.2025; 58(2): 259. CrossRef
Forward-viewing echoendoscope-guided pancreaticojejunostomy for post-pancreaticoduodenectomy stricture
Toru Kaneko, Mitsuhiro Kida, Takahiro Kurosu, Yutaro Saito, Shiori Koyama, Tomohiro Betto, Chika Kusano
Endoscopy.2025; 57(S 01): E384. CrossRef
Long-Term Outcomes of EUS-Guided Pancreatic Duct Drainage for the Management of Benign Pancreaticojejunostomy Anastomotic Stricture—A Retrospective Cohort Study
Indria Melianti, Kazuo Hara, Takamichi Kuwahara, Shin Haba, Nozomi Okuno, Shimpei Matsumoto, Hiroki Koda, Keigo Oshiro, Tomoki Ogata
Journal of Clinical Medicine.2025; 14(23): 8439. CrossRef

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6 Crossref

Safety and efficacy of endoscopic ultrasound-guided pancreatic duct drainage using a drill dilator: a retrospective study in Japan: Ahmed Sadek, Kazuo Hara, Nozomi Okuno, Shin Haba, Takamichi Kuwahara, Toshitaka Fukui, Minako Urata, Takashi Kondo, Yoshitaro Yamamoto, Kenneth Tachi; Clin Endosc 2024;57(5):666-674. Published online June 5, 2024; DOI: https://doi.org/10.5946/ce.2023.272

Graphical Abstract Abstract PDF Supplementary Material

Background
/Aims: Dilation of the tract before stent deployment is a challenging step in endoscopic ultrasound-guided pancreatic duct drainage (EUS-PDD). In this study, we examined the effectiveness and safety of a novel spiral dilator, Tornus ES (Asahi Intec), for EUS-PDD.
Methods
This was a retrospective, single-arm, observational study at Aichi Cancer Center Hospital. The punctured tract was dilated using a Tornus ES dilator in all EUS-PDD cases. Our primary endpoint was the technical success rate of initial tract dilation. Technical success was defined as successful fistula dilation using a Tornus ES followed by successful stent insertion. Secondary endpoints were procedure times and early adverse events.
Results
A total of 12 patients were included between December 2021 and March 2023. EUS-PDD was performed in 11 patients for post-pancreaticoduodenectomy anastomotic strictures and one patient with pancreatitis with duodenal perforation. The technical success rates of stent insertion and fistula dilation using a Tornus ES dilator was 100%. The median procedure time was 24 minutes. No remarkable adverse events related to the procedure were observed, apart from fever, which occurred in 2 patients.
Conclusions
Tract dilation in EUS-PDD using a Tornus ES is effective and safe.

Citations

Citations to this article as recorded by

Use of a screw dilator for pancreaticobiliary disease
Christina S. Gainey, Albert Manudhane, Todd H. Baron
Gastrointestinal Endoscopy.2026; 104(3): 467. CrossRef
Endoscopic ultrasound–guided pancreaticogastrostomy with subsequent pancreatoscopy-guided lithotripsy as a first-line approach for pancreatic head duct stones (with videos)
Tadahisa Inoue, Rena Kitano, Tomoya Kitada, Shun Futagami, Masato Yano, Kazumasa Sakamoto, Satoshi Kimoto, Jun Arai, Masanao Nakamura, Kiyoaki Ito
Gastrointestinal Endoscopy.2026;[Epub] CrossRef
Turning the screw on resistant tracts: lessons from cardiology for pancreaticobiliary endoscopy
Puneet Chhabra
Gastrointestinal Endoscopy.2026; 104(3): 471. CrossRef
Feasibility of endoscopic ultrasound‐guided hepaticogastrostomy using a novel long balloon catheter
Yuichi Takano, Naoki Tamai, Masataka Yamawaki, Jun Noda, Tetsushi Azami, Fumitaka Niiya, Naotaka Maruoka, Tatsuya Yamagami, Masatsugu Nagahama
DEN Open.2025;[Epub] CrossRef
Endoscopic ultrasound-guided pancreatic duct drainage: Progress and future outlook
Si-Yao Wang, Si-Qiao Zhao, Shu-Peng Wang, Yue Zhang, Si-Yu Sun, Sheng Wang
World Journal of Gastrointestinal Surgery.2025;[Epub] CrossRef
Removal of the intrahepatically migrated and impacted plastic stent over malignant stricture using drill dilator
Daiki Yamashige, Susumu Hijioka, Yoshikuni Nagashio, Shota Harai, Mark Chatto, Yutaka Saito, Takuji Okusaka
Endoscopy.2025; 57(S 01): E734. CrossRef
Fluoroscopy Time Required for Each Step of Interventional Endoscopic Ultrasonography
Masafumi Watanabe, Kosuke Okuwaki, Mitsuhiro Kida, Hiroshi Imaizumi, Kai Adachi, Akihiro Tamaki, Taro Hanaoka, Daisuke Ogawa, Chika Kusano
Journal of Digestive Endoscopy.2025; 16(03): 136. CrossRef
Balloon-assisted ERCP for bile duct stones in surgically altered anatomy: current techniques, devices, and evolving strategies
Haruka Toyonaga, Makoto Masaki, Arata Oka, Hidetoshi Nakata, Shoji Takayama, Tatsuya Nakagawa, Takuya Takayama, Masahiro Orino, Hironao Matsumoto, Takeshi Yamashina, Masaaki Shimatani
Therapeutic Advances in Gastroenterology.2025;[Epub] CrossRef
Long-Term Outcomes of EUS-Guided Pancreatic Duct Drainage for the Management of Benign Pancreaticojejunostomy Anastomotic Stricture—A Retrospective Cohort Study
Indria Melianti, Kazuo Hara, Takamichi Kuwahara, Shin Haba, Nozomi Okuno, Shimpei Matsumoto, Hiroki Koda, Keigo Oshiro, Tomoki Ogata
Journal of Clinical Medicine.2025; 14(23): 8439. CrossRef
A novel spiral dilator for pancreatic duct drainage: catching two birds with one stone
Han Taek Jeong, Jimin Han
Clinical Endoscopy.2024; 57(5): 608. CrossRef
Technical outcomes between a drill dilator and ultra-tapered mechanical dilator during EUS-guided pancreaticogastrostomy: Comparative study
Takeshi Ogura, Saori Ueno, Atsushi Okuda, Nobu Nishioka, Jun Sakamoto, Jun Matsuno, Yuki Uba, Mitsuki Tomita, Nobuhiro Hattori, Junichi Nakamura, Kimi Bessho, Hiroki Nishikawa
Endoscopy International Open.2024;[Epub] CrossRef

8,965 View
375 Download
10 Web of Science
11 Crossref

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