Clinical Endoscopy

Original Articles

Histological Architecture of Gastric Epithelial Neoplasias That Showed Absent Microsurface Patterns, Visualized by Magnifying Endoscopy with Narrow-Band Imaging: Kenta Chuman, Kenshi Yao, Takao Kanemitsu, Takashi Nagahama, Masaki Miyaoka, Haruhiko Takahashi, Kentaro Imamura, Rino Hasegawa, Toshiharu Ueki, Hiroshi Tanabe, Seiji Haraoka, Akinori Iwashita; Clin Endosc 2021;54(2):222-228. Published online November 24, 2020; DOI: https://doi.org/10.5946/ce.2020.090

Background
/Aims: The objective of this study was to elucidate the histological structure of the absent microsurface patterns (MSPs) that were visualized by magnifying endoscopy with narrow-band imaging (M-NBI).
Methods
The study included consecutive gastric epithelial neoplasias for which M-NBI findings and histological findings could be compared on a one-to-one basis. The lesions were classified as absent MSPs and present MSPs based on the findings obtained using M-NBI. Of the histopathological findings for each lesion that corresponded to M-NBI findings, crypt opening densities, crypt lengths, crypt opening diameters, intercrypt distances, and crypt angles were measured and compared.
Results
Thirty-six lesions were included in the analysis; of these, 17 lesions exhibited absent MSP and 19 lesions exhibited present MSP. Comparing the histological measurements for absent MSPs vs. present MSPs, median crypt opening density was 0.9 crypt openings/mm vs. 4.8 crypt openings/mm (p<0.001), respectively. The median crypt length, median crypt opening diameter, median intercrypt distance, and median crypt angle were 80.0 μm vs. 160 μm (p<0.001), 40.0 μm vs. 44.2 μm (p=0.09), 572.5 μm vs. 166.7 μm (p<0.001), and 21.6 degrees vs. 15.5 degrees (p<0.001), respectively.
Conclusions
Histological findings showed that lesions exhibiting absent MSPs had lower crypt opening density, shorter crypt length, greater intercrypt distance, and larger crypt angle.

Citations

Citations to this article as recorded by

The staining results of early gastric cancer by indigo carmine chromoendoscopy associated with histological structure: a retrospective study
Xiaosa Jiang, Lingzhi Qin, Yujie Hao, Qian Yang, Yueqin Zheng, Baicang Zou, Lei Dong, Na Liu, Jinhai Wang, Bin Qin
BMC Cancer.2024;[Epub] CrossRef
Magnifying Endoscopy with Narrow-Band Imaging for Duodenal Neuroendocrine Tumors
Gwang Ha Kim, Kiyoun Yi, Dong Chan Joo, Moon Won Lee, Hye Kyung Jeon, Bong Eun Lee
Journal of Clinical Medicine.2023; 12(9): 3106. CrossRef

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Magnified Endoscopic Findings of Multiple White Flat Lesions: A New Subtype of Gastric Hyperplastic Polyps in the Stomach: Rino Hasegawa, Kenshi Yao, Shoutomi Ihara, Masaki Miyaoka, Takao Kanemitsu, Kenta Chuman, Go Ikezono, Akikazu Hirano, Toshiharu Ueki, Hiroshi Tanabe, Atsuko Ota, Seiji Haraoka, Akinori Iwashita; Clin Endosc 2018;51(6):558-562. Published online November 21, 2018; DOI: https://doi.org/10.5946/ce.2018.104

Abstract PDF PubReader ePub

Background
/Aims: While the occurrence of multiple whitish flat elevated lesions (MWFL) was first reported in 2007, no studies on MWFL have been published to date. The present retrospective observational study aimed to clarify the endoscopic findings and clinicopathological features of MWFL.
Methods
Subjects were consecutive patients who underwent upper gastrointestinal endoscopy as part of routine screening between April 2014 and March 2015. The conventional white-light, non-magnifying and magnifying narrow-band images were reviewed. Clinical features were compared between patients with and without MWFL.
Results
The conventional endoscopic findings of MWFL include multiple whitish, flat, and slightly elevated lesions of various sizes, mainly located in the gastric body and fundus. Narrow-band imaging enhanced the contrast of MWFL and background mucosa, and magnifying narrow-band imaging depicted a uniformly long, narrow, and elliptical marginal crypt epithelium with an unclear microvascular pattern. Histopathological findings revealed hyperplastic changes of the foveolar epithelium, and parietal cell protrusions and oxyntic gland dilatations were observed in the fundic glands, without any intestinal metaplasia. The rate of acid-reducing drug use was significantly higher in patients with MWFL than in those without (100% [13/13] vs. 53.7% [88/164], p<0.001).
Conclusions
The present study indicated a relationship between the presence and endoscopic features of MWFL and history of acidreducing drug use.

Citations

Citations to this article as recorded by

Endoscopic findings and outcomes of gastric mucosal changes relating to potassium‐competitive acid blocker and proton pump inhibitor therapy
Satoshi Shinozaki, Hiroyuki Osawa, Yoshimasa Miura, Hiroaki Nomoto, Hirotsugu Sakamoto, Yoshikazu Hayashi, Tomonori Yano, Edward J. Despott, Hironori Yamamoto
DEN Open.2025;[Epub] CrossRef
Association between occurrence of multiple white and flat elevated gastric lesions and oral proton pump inhibitor intake
Rino Hasegawa, Kenshi Yao, Takao Kanemitsu, Hisatomi Arima, Takayuki Hirase, Yuuya Hiratsuka, Kazuhiro Takeda, Kentaro Imamura, Kensei Ohtsu, Yoichiro Ono, Masaki Miyaoka, Takashi Hisabe, Toshiharu Ueki, Hiroshi Tanabe, Atsuko Ohta, Satoshi Nimura
Clinical Endoscopy.2024; 57(1): 65. CrossRef
Randomised clinical trial: 3-year interim analysis results of the VISION trial to evaluate the long-term safety of vonoprazan as maintenance treatment in patients with erosive oesophagitis
Ken Haruma, Yoshikazu Kinoshita, Takashi Yao, Ryoji Kushima, Junichi Akiyama, Nobuo Aoyama, Tatsuhiro Kanoo, Kouji Miyata, Naomi Kusumoto, Naomi Uemura
BMC Gastroenterology.2023;[Epub] CrossRef
Helicobacter pylori Eradication-Related Development of Multiple White and Flat Elevated Lesions in the Stomach
Akira Hokama, Mayumi Shiroma, Mami Tomiyama, Yuko Tasato, Maki Setake
Chonnam Medical Journal.2023; 59(3): 203. CrossRef
Differential diagnosis of superficial duodenal epithelial tumor and non-neoplastic lesion in duodenum by magnified endoscopic examination with image-enhanced endoscopy
Atsushi Nakayama, Motohiko Kato, Teppei Masunaga, Yoko Kubosawa, Yukie Hayashi, Mari Mizutani, Yoshiyuki Kiguchi, Motoki Sasaki, Yusaku Takatori, Noriko Matsuura, Makoto Mutaguchi, Kaoru Takabayashi, Naohisa Yahagi
Journal of Gastroenterology.2022; 57(3): 164. CrossRef
Gastric Corpus Hypertrophy with a Bleeding Hyperplastic Polyp in a Helicobacter pylori-naive Subject after Long-term Proton Pump Inhibitor Use
Jong Hyeon Jeong, Sun-Young Lee, Hye Seung Han
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2022; 22(1): 63. CrossRef
The effect of proton pump inhibitors and vonoprazan on the development of ‘gastric mucosal redness’
Satoshi Shinozaki, Hiroyuki Osawa, Yoshimasa Miura, Yoshikazu Hayashi, Hirotsugu Sakamoto, Tomonori Yano, Alan Lefor, Hironori Yamamoto
Biomedical Reports.2022;[Epub] CrossRef
Changes in gastric morphology during long-term use of vonoprazan compared to proton pump inhibitors
S Shinozaki, H Osawa, Y Hayashi, H Sakamoto, Y Miura, AK Lefor, H Yamamoto
Singapore Medical Journal.2022; 63(5): 283. CrossRef
Image-enhanced endoscopy for real-time differentiation between hyperplastic and fundic gland polyps in the stomach
Amit Kumar Dutta, Noriya Uedo, Deepu David, Jagan Chandramohan, Abhishek Jain, Itish Patnayak, Piyush Gupta, Bharath K. Ayapati, Kaushik Chatterjee, Rajeeb Jaleel, Reuben T. Kurien, Sudipta D. Chowdhury, Ebby G. Simon, Anjilivelil J. Joseph, Anna B. Pulim
Indian Journal of Gastroenterology.2022; 41(6): 599. CrossRef
Characteristics of non-neoplastic epithelium that appears within gastric cancer with and without Helicobacter pylori eradication: A retrospective study
Hiroto Noda, Mitsuru Kaise, Ryuichi Wada, Eriko Koizumi, Kumiko Kirita, Kazutoshi Higuchi, Jun Omori, Teppei Akimoto, Osamu Goto, Hiroshi Kawachi, Katsuhiko Iwakiri, Sanjiv Mahadeva
PLOS ONE.2021; 16(3): e0248333. CrossRef
Proton Pump Inhibitor-Related Gastric Mucosal Changes
Gwang Ha Kim
Gut and Liver.2021; 15(5): 646. CrossRef
Gastric Hyperplastic Polyps: A Benign Entity? Analysis of Recurrence and Neoplastic Transformation in a Cohort Study
Mafalda João, Miguel Areia, Susana Alves, Luís Elvas, Filipe Taveira, Daniel Brito, Sandra Saraiva, Ana Teresa Cadime
GE - Portuguese Journal of Gastroenterology.2021; 28(5): 328. CrossRef
British Society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma
Matthew Banks, David Graham, Marnix Jansen, Takuji Gotoda, Sergio Coda, Massimiliano di Pietro, Noriya Uedo, Pradeep Bhandari, D Mark Pritchard, Ernst J Kuipers, Manuel Rodriguez-Justo, Marco R Novelli, Krish Ragunath, Neil Shepherd, Mario Dinis-Ribeiro
Gut.2019; 68(9): 1545. CrossRef
Multiple White Flat Lesions of the Corpus: Subtype of Hyperplastic Polyps vs. Intestinal Metaplasia
Su Jin Kim, Cheol Woong Choi
Clinical Endoscopy.2018; 51(6): 503. CrossRef

6,467 View
224 Download
12 Web of Science
14 Crossref

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