KSGE
Search
- Page Path
- HOME > Search
Systematic Review and Meta-Analysis
- Hybrid argon plasma coagulation in Barrett’s esophagus: a systematic review and meta-analysis
- Sagar N. Shah, Nabil El Hage Chehade, Amirali Tavangar, Alyssa Choi, Marc Monachese, Kenneth J. Chang, Jason B. Samarasena
- Clin Endosc 2023;56(1):38-49. Published online January 30, 2023
- DOI: https://doi.org/10.5946/ce.2022.179
-
Abstract
PDF
Supplementary Material
PubReader
ePub - Background
/Aims: Patients with Barrett’s esophagus are at increased risk of developing esophageal adenocarcinoma. Endoscopic therapies aim to eradicate dysplastic and metaplastic tissues. Hybrid argon plasma coagulation (hybrid-APC) utilizes submucosal fluid injection to create a protective cushion prior to ablation that shields the submucosa from injury. We performed a pooled meta-analysis to evaluate the safety and efficacy of hybrid-APC.
Methods
We conducted a systematic search of major electronic databases in April 2022. Studies that included patients with dysplastic and non-dysplastic Barrett’s esophagus undergoing treatment with hybrid-APC were eligible for inclusion. Outcome measures included complete remission of intestinal metaplasia (CR-IM), stricture formation, serious adverse events, and number of sessions necessary to achieve CR-IM.
Results
Overall pooled CR-IM rate for patients undergoing hybrid-APC was 90.8% (95% confidence interval [CI], 0.872–0.939; I2=0%). Pooled stricture rate was 2.0% (95% CI, 0.005–0.042; I2=0%). Overall serious adverse event rate was 2.7% (95% CI, 0.007–0.055; I2=0%).
Conclusions
Results of the current meta-analysis suggest that hybrid-APC is associated with high rates of CR-IM and a favorable safety profile. Interpretation of these results is limited by the inclusion of retrospective cohort and case series data. Randomized controlled trials that standardize treatment and outcome evaluation protocols are necessary to understand how this treatment option is comparable to the current standards of care. -
Citations
Citations to this article as recorded by
- High Quality Barrett’s Esophagus Examination and Endoscopic Eradication Therapy
Shirin Dey, Kevin Shah, Srinadh Komanduri
Gastrointestinal Endoscopy Clinics of North America.2025; 35(3): 523. CrossRef - Safety and feasibility of argon plasma coagulation for gastric low-grade dysplasia: a systematic review and meta-analysis
Jun-young Seo, Sun Jae Moon, Ah Young Lee, Ji Yong Ahn
Surgical Endoscopy.2025; 39(8): 5127. CrossRef - Potential applications of artificial intelligence for optimizing the treatment of patients with esophageal metaplasia and hiatal hernias
O.S. Tyvonchuk, I.V. Babii, A. Sargsyan, O.O. Hulenko
EMERGENCY MEDICINE.2025; 21(6): 621. CrossRef - Role of Endoscopy in the Diagnosis and Management of Esophageal Cancer
Jennifer Ma, Sharon Pan, Rachel Mortan, Faisal Shaukat Ali, Nirav Thosani, Vaibhav Wadhwa
Journal of Clinical Medicine.2025; 14(22): 8169. CrossRef - Application of electrosurgery in gastrointestinal endoscopy
Hongrui Wang, Jiuzhou Zhao, Yu Zhou
Progress in Medical Devices.2024;[Epub] CrossRef - Hybrid Argon Plasma Coagulation for Barrett’s Esophagus and for Colonic Mucosal Resection—A Systematic Review and Meta-Analysis
Maria Manuela Estevinho, Rolando Pinho, João Carlos Silva, João Correia, Pedro Mesquita, Teresa Freitas
Biomedicines.2023; 11(4): 1139. CrossRef - Hybrid-APC treatment for gastric vascular ectasia of
atypical location after failed radiofrequency ablation
José Manuel Palma García, Raúl Honrubia López, Cristina Fernández de Castro, Carmen Comas Redondo
Revista Española de Enfermedades Digestivas.2023;[Epub] CrossRef - Thermal ablative therapies in the gastrointestinal tract
Hendrik Manner
Current Opinion in Gastroenterology.2023; 39(5): 370. CrossRef - Endoscopic Management of Dysplastic Barrett’s Oesophagus and Early Oesophageal Adenocarcinoma
Leonardo Henry Eusebi, Andrea Telese, Chiara Castellana, Rengin Melis Engin, Benjamin Norton, Apostolis Papaefthymiou, Rocco Maurizio Zagari, Rehan Haidry
Cancers.2023; 15(19): 4776. CrossRef - Critical Decision Making: Technical Aspects of Esophageal Ablation
Felice Schnoll-Sussman
Foregut: The Journal of the American Foregut Society.2023; 3(3): 314. CrossRef
- High Quality Barrett’s Esophagus Examination and Endoscopic Eradication Therapy
- 7,858 View
- 208 Download
- 8 Web of Science
- 10 Crossref
First
Prev
