Endoscopic submucosal dissection is a technically challenging but highly effective technique for the treatment of well selected early neoplasms in the digestive tract. Although it is frequently performed in East Asian countries, the Western world has not adopted this technique yet, probably due in part to the difficulty to learn it. Ex vivo and in vivo animal models are invaluable tools to overcome at least the beginning of the learning curve, although the initial step is the acquisition of basic knowledge about early diagnosis of neoplasias, and observing real procedures in expert centers. The practical issues, advantages, and disadvantages of the ex vivo and in vivo models are discussed.

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• Novel quantitative assessment indicators for efficiency and precision of endoscopic submucosal dissection in animal training models by analyzing an electrical surgical unit
  Teppei Masunaga, Motohiko Kato, Motoki Sasaki, Kentaro Iwata, Kurato Miyazaki, Yoko Kubosawa, Mari Mizutani, Yusaku Takatori, Noriko Matsuura, Atsushi Nakayama, Kaoru Takabayashi, Naohisa Yahagi
  Digestive Endoscopy.2024; 36(1): 19.     CrossRef
• Intraoperative bleeding model for swine gastric endoscopic submucosal dissection via heparinization
  Teppei Masunaga, Motoki Sasaki, Moe Sato, Daisuke Minezaki, Kohei Morioka, Anna Tojo, Hinako Sakurai, Kentaro Iwata, Kurato Miyazaki, Yoko Kubosawa, Mari Mizutani, Teppei Akimoto, Yusaku Takatori, Shintaro Kawasaki, Noriko Matsuura, Atsushi Nakayama, Tomo
  Endoscopy International Open.2024; 12(11): E1360.     CrossRef
• Simulator-based training method in gastrointestinal endoscopy training and currently available simulators
  Yuri Kim, Jeong Hoon Lee, Gin Hyug Lee, Ga Hee Kim, Gunn Huh, Seung Wook Hong, Hwoon-Yong Jung
  Clinical Endoscopy.2023; 56(1): 1.     CrossRef
• Usefulness of a new polyvinyl alcohol hydrogel (PVA-H)-based simulator for endoscopic submucosal dissection training: a pilot study
  Dong Seok Lee, Gin Hyug Lee, Sang Gyun Kim, Kook Lae Lee, Ji Won Kim, Ji Bong Jeong, Yong Jin Jung, Hyoun Woo Kang
  Clinical Endoscopy.2023; 56(5): 604.     CrossRef
• A survey of physician training and credentialing in endoscopic submucosal dissection in the United States
  Sohi Mistry, Omar Alaber, Apoorva Krishna Chandar, Lady Katherine Mejia Perez, John Dumot, Amit Bhatt, Amitabh Chak
  Surgical Endoscopy.2022; 36(5): 2794.     CrossRef
• The colonoscopic vacuum model–simulating biomechanical restrictions to provide a realistic colonoscopy training environment
  Jana Steger, Christina Kwade, Maximilian Berlet, Roman Krumpholz, Stefanie Ficht, Dirk Wilhelm, Petra Mela
  International Journal of Computer Assisted Radiology and Surgery.2022; 18(1): 105.     CrossRef
• An innovative next-generation endoscopic submucosal injection material with a 2-step injection system (with video)
  Ryohei Hirose, Takaaki Nakaya, Yuji Naito, Takuma Yoshida, Risa Bandou, Tomo Daidoji, Ken Inoue, Osamu Dohi, Naohisa Yoshida, Yoshito Itoh
  Gastrointestinal Endoscopy.2021; 93(2): 503.     CrossRef
• Differences between two sodium hyaluronate-based submucosal injection materials currently used in Japan based on viscosity analysis
  Ryohei Hirose, Takuma Yoshida, Yuji Naito, Naoto Watanabe, Hikaru Hashimoto, Satoshi Sugino, Risa Bandou, Tomo Daidoji, Ken Inoue, Osamu Dohi, Naohisa Yoshida, Takaaki Nakaya, Yoshito Itoh
  Scientific Reports.2021;[Epub]     CrossRef
• Performance comparison between next-generation and shear-thinning hydrogel-based submucosal injection materials
  Ryohei Hirose, Takaaki Nakaya, Yuji Naito, Naohisa Yoshida, Yoshito Itoh
  Gastrointestinal Endoscopy.2021; 93(3): 777.     CrossRef
• Comparison of sodium alginate-based and sodium hyaluronate-based submucosal injection materials based on rheological analysis
  Ryohei Hirose, Naoto Watanabe, Yuji Naito, Hikaru Hashimoto, Satoshi Sugino, Takuma Yoshida, Risa Bandou, Tomo Daidoji, Ken Inoue, Osamu Dohi, Naohisa Yoshida, Takaaki Nakaya, Yoshito Itoh
  Journal of the Mechanical Behavior of Biomedical Materials.2021; 124: 104816.     CrossRef
• Enhancement of the safety and efficacy of colorectal endoscopic submucosal dissection using a CO2 laser
  Takuma Noguchi, Hisanao Hazama, Takahiro Nishimura, Yoshinori Morita, Kunio Awazu
  Lasers in Medical Science.2020; 35(2): 421.     CrossRef
• Current state of education and training for endoscopic submucosal dissection: Translating strategy and success to the USA
  Thomas R. McCarty, Hiroyuki Aihara
  Digestive Endoscopy.2020; 32(6): 851.     CrossRef
• How to master endoscopic submucosal dissection in the USA
  Andrey Iskrenov Kotzev, Dennis Yang, Peter V. Draganov
  Digestive Endoscopy.2019; 31(1): 94.     CrossRef
• Development of Sodium Polyacrylate-Based High-Performance Submucosal Injection Material with Pseudoplastic Fluid Characteristics
  Ryohei Hirose, Naohisa Yoshida, Yuji Naito, Takuma Yoshida, Risa Bandou, Tomo Daidoji, Ken Inoue, Osamu Dohi, Hideyuki Konishi, Takaaki Nakaya, Yoshito Itoh
  ACS Biomaterials Science & Engineering.2019; 5(12): 6794.     CrossRef
• A local structured training program with live pigs allows performing ESD along the gastrointestinal tract with results close to those of Japanese experts
  Jérémie Jacques, Romain Legros, Aurélie Charissoux, Laura Mesturoux, Claude-Yves Couquet, Paul Carrier, Tessa Tabouret, Virginie Valgueblasse, Marilyne Debette-Gratien, Anne Le-Sidaner, Veronique Loustaud-Ratti, Denis Sautereau
  Digestive and Liver Disease.2016; 48(12): 1457.     CrossRef
• Endoscopic submucosal dissection
  John T. Maple, Barham K. Abu Dayyeh, Shailendra S. Chauhan, Joo Ha Hwang, Sri Komanduri, Michael Manfredi, Vani Konda, Faris M. Murad, Uzma D. Siddiqui, Subhas Banerjee
  Gastrointestinal Endoscopy.2015; 81(6): 1311.     CrossRef
• New isolated bovine colon model dedicated to colonic ESD hands-on training: development and first evaluation
  Mathieu Pioche, Jérôme Rivory, Guillermo Aguero-Garcete, Olivier Guillaud, Marc O’Brien, Cyril Lafon, Nicolas Reversat, Toshio Uraoka, Naohisa Yahagi, Thierry Ponchon
  Surgical Endoscopy.2015; 29(11): 3209.     CrossRef
• The Ideal Experimental Training Session for Minimally Invasive Endoluminal Techniques
  Sakai P
  Gastroenterology & Hepatology: Open Access.2015;[Epub]     CrossRef
• ESD Around the World: United States
  Norio Fukami
  Gastrointestinal Endoscopy Clinics of North America.2014; 24(2): 313.     CrossRef
• Colorectal ESD
  Yutaka Saito, Taku Sakamoto, Takeshi Nakajima, Takahisa Matsuda
  Gastrointestinal Endoscopy Clinics of North America.2014; 24(2): 245.     CrossRef
• Endoscopic submucosal dissection training with ex vivo human gastric remnants
  David V. Pham, Anand Shah, Frank J. Borao, Steven Gorcey
  Surgical Endoscopy.2014; 28(1): 222.     CrossRef
• Training Methods and Models for Colonoscopic Insertion, Endoscopic Mucosal Resection, and Endoscopic Submucosal Dissection
  Naohisa Yoshida, Nilesh Fernandopulle, Yutaka Inada, Yuji Naito, Yoshito Itoh
  Digestive Diseases and Sciences.2014; 59(9): 2081.     CrossRef
• Gastric ESD
  Takuji Gotoda, Khek-Yu Ho, Roy Soetikno, Tonya Kaltenbach, Peter Draganov
  Gastrointestinal Endoscopy Clinics of North America.2014; 24(2): 213.     CrossRef
• ESD training: A challenging path to excellence
  Alberto Herreros de Tejada
  World Journal of Gastrointestinal Endoscopy.2014; 6(4): 112.     CrossRef