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Case Report
Giant Brunner’s Gland Hamartoma of the Duodenal Bulb Presenting with Upper Gastrointestinal Bleeding and Obstruction
Ju Hyoung Lee, Kyeong Min Jo, Tae Oh Kim, Jong Ha Park, Seung Hyun Park, Jae Won Jung, So Chong Hur, Sung Yeun Yang
Clin Endosc 2016;49(6):570-574.   Published online October 13, 2016
AbstractAbstract PDFPubReaderePub
Brunner’s gland hamartomas are small benign lesions that are most commonly found in the bulb of the duodenum. They are very uncommon, and most are found incidentally during upper gastrointestinal series or esophagogastroduodenoscopy. The lesions tend to be asymptomatic, but patients may present with symptoms of duodenal obstruction or hemorrhage secondary to ulceration. Histologically, a Brunner's gland hamartoma consists of the components of Brunner's gland cells, as well as glandular, adipose and muscle cells. In this study, we report the case of a 30-year-old man who presented with upper gastrointestinal bleeding and obstructive symptoms due to a giant Brunner's gland hamartoma in the duodenal bulb. The hamartoma was successfully removed by endoscopic resection. No significant complications were observed. Microscopically, the lesion was found to be entirely composed of variable Brunner's glands and adipocytes.


Citations to this article as recorded by  
  • Brunner’s gland hamartomas: Not always benign
    Manar Shmais, Ahmad Mousawi, Fadi Mourad, Ala I. Sharara
    Arab Journal of Gastroenterology.2024; 25(1): 70.     CrossRef
  • The Characteristics and Treatment Outcomes of 71 Duodenal Brunner’s Gland Adenomas with Endoscopic Submucosal Dissection
    Ying Xiang, Jinyan Liu, Nan ya Wang, Dehua Tang, Lei Wang, Ping xiao Zou, Guifang Xu, Qin Huang
    Digestive Diseases.2023; 41(6): 852.     CrossRef
  • Giant brunner gland hamartoma: An unusual cause of upper gastrointestinal bleed
    Bershic Valantine, ManjunathB Venkatapur, Sultan Nawahirsha, SBabu Kumar
    Gastroenterology, Hepatology and Endoscopy Practice.2023; 3(3): 90.     CrossRef
  • A giant Brunner’s gland hamartoma being treated as a pedunculated polyp: a case report
    Lizhi Yi, Zhengyu Cheng, Huarong Qiu, Jianjun Yang, Tao Wang, Ke Liu
    BMC Gastroenterology.2019;[Epub]     CrossRef
  • 8,807 View
  • 152 Download
  • 4 Web of Science
  • 4 Crossref
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Tracheal Involvement in Crohn Disease: the First Case in Korea
Seunghyun Park, Jongha Park, Hyun-Kuk Kim, Ji Yeon Kim, So Chong Hur, Ju Hyoung Lee, Jae Won Jung, Juwon Lee
Clin Endosc 2016;49(3):310-310.   Published online May 24, 2016
Corrects: Clin Endosc 2016;49(2):202
  • 5,038 View
  • 49 Download
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Case Report
Tracheal Involvement in Crohn Disease: the First Case in Korea
Seunghyun Park, Jongha Park, Hyun-Kuk Kim, Ji Yeon Kim, So Chong Hur, Ju Hyung Lee, Jae Won Jung, Juwon Lee
Clin Endosc 2016;49(2):202-206.   Published online February 16, 2016
Correction in: Clin Endosc 2016;49(3):310
AbstractAbstract PDFPubReaderePub
Respiratory involvement in Crohn disease (CD) is rare condition with only about a dozen reported cases. We report the first case of CD with tracheal involvement in Korea. An 18-year-old woman with CD was hospitalized because of coughing, dyspnea, and fever sustained for 3 weeks. Because she had stridor in her neck, we performed computed tomography of the neck, which showed circumferential wall thickening of the larynx and hypopharynx. Bronchoscopy revealed mucosal irregularity, ulceration, and exudates debris in the proximal trachea, and bronchial biopsy revealed chronic inflammation with granulation tissue. Based on these findings, we suspected CD with tracheal involvement and began administering intravenous methylprednisolone at 1 mg/kg per day, after which her symptoms and bronchoscopic findings improved.


Citations to this article as recorded by  
  • Tracheobronchitis and laryngitis associated with Crohn's disease
    Shogo Nakai, Moeko Morikawa, Toshiya Hiramatsu, Yurina Murakami, Koji Nishimoto, Sayomi Matsushima, Masanori Harada, Tomohiro Uto, Jun Sato, Shiro Imokawa, Takafumi Suda
    Respiratory Medicine Case Reports.2023; 46: 101918.     CrossRef
  • Tracheobronchial Crohn’s Disease: Case Report and Systematic Review of the Literature
    Rao G Raghava, Vishal Sharma, Srikant Kashinath Malegaonkar, Sahajal Dhooria, Inderpaul Singh Sehgal, Kuruswamy Thurai Prasad, Amanjit Bal, Ritesh Agarwal, Valliappan Muthu
    Inflammatory Bowel Diseases.2022; 28(3): e33.     CrossRef
  • Granulomatous tracheo‐bronchitis from Crohn's disease
    Amr J. Alwakeel, Stéphane Beaudoin
    Respirology Case Reports.2022;[Epub]     CrossRef
  • Nonasthmatic eosinophilic bronchitis in an ulcerative colitis patient – a putative adverse reaction to mesalazine: A case report and review of literature
    Andrei Tudor Cernomaz, Gabriela Bordeianu, Cristina Terinte, Cristina Maria Gavrilescu
    World Journal of Clinical Cases.2020; 8(18): 4162.     CrossRef
  • Obstrucción de la vía aérea central por enfermedad inflamatoria intestinal y rescate terapéutico con membrana de oxigenación extracorpórea
    M. Ramírez-Romero, B. Hernández-Alonso, C. García-Polo, A.J. Abraldes-Bechiarelli, A. Garrino-Fernández, A. Gordillo-Brenes
    Medicina Intensiva.2018; 42(5): 317.     CrossRef
  • Central airway obstruction due to inflammatory bowel disease and rescue with extracorporeal membrane oxygenation
    M. Ramírez-Romero, B. Hernández-Alonso, C. García-Polo, A.J. Abraldes-Bechiarelli, A. Garrino-Fernández, A. Gordillo-Brenes
    Medicina Intensiva (English Edition).2018; 42(5): 317.     CrossRef
    TA A Fedorina, GV V Nedugov
    Science and Innovations in Medicine.2018; 3(3): 57.     CrossRef
  • Managing Head and Neck Malignancy Arising in a Field of Crohn Disease Inflammation: Report of a Case
    Christina Yver, Darshana Jhala, Amanda Muir, Devraj Basu
    Ear, Nose & Throat Journal.2017; 96(10-11): E1.     CrossRef
  • 8,668 View
  • 83 Download
  • 9 Web of Science
  • 8 Crossref
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