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Original Articles
- Bile acid sequestrants in poor healing after endoscopic therapy of Barrett’s esophagus
- Lukas Welsch, Andrea May, Tobias Blasberg, Jens Wetzka, Elisa Müller, Myriam Heilani, Mireen Friedrich-Rust, Mate Knabe
- Clin Endosc 2023;56(2):194-202. Published online March 9, 2023
- DOI: https://doi.org/10.5946/ce.2022.121
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Graphical Abstract
Abstract
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ePub - Background
/Aims: Endoscopic therapy for neoplastic Barrett’s esophagus (BE) has become the standard of care over the past two decades. In clinical practice, we regularly encounter patients who fail to achieve complete squamous epithelialization of the esophagus. Although the therapeutic strategies in the individual stages of BE, dysplasia, and esophageal adenocarcinoma are well studied and largely standardized, the problem of inadequate healing after endoscopic therapy is only marginally considered. This study aimed to shed light on the variables influencing inadequate wound healing after endoscopic therapy and the effect of bile acid sequestrants (BAS) on healing.
Methods
Retrospective analysis of endoscopically treated neoplastic BE in a single referral center.
Results
In 12.1% out of 627 patients, insufficient healing was present 8 to 12 weeks after previous endoscopic therapy. The average follow-up duration was 38.8±18.4 months. Complete healing was achieved in 13 patients already after intensifying proton pump inhibitor therapy. Out of 48 patients under BAS, 29 patients (60.4%) showed complete healing. An additional eight patients (16.7%) improved, but only partial healing was achieved. Eleven (22.9%) patients showed no response to BAS augmented therapy.
Conclusions
In cases of insufficient healing even under exhaustion of proton pump inhibitors, treatment with BAS can be an option as an ultimate healing attempt. -
Citations
Citations to this article as recorded by
- 2,820 View
- 163 Download
- 1 Web of Science
- 2 Crossref
- Epidemiology of early esophageal adenocarcinoma
- Thuy-Van P. Hang, Zachary Spiritos, Anthony M. Gamboa, Zhengjia Chen, Seth Force, Vaishali Patel, Saurabh Chawla, Steven Keilin, Nabil F. Saba, Bassel El-Rayes, Qiang Cai, Field F. Willingham
- Clin Endosc 2022;55(3):372-380. Published online February 11, 2022
- DOI: https://doi.org/10.5946/ce.2021.152
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Abstract
PDFPubReaderePub
- Background
/Aims: Endoscopic resection has become the preferred treatment approach for select early esophageal adenocarcinoma (EAC); however, the epidemiology of early stage disease has not been well defined.
Methods
Surveillance Epidemiology and End Results (SEER) data were analyzed to determine age-adjusted incidence rates among major epithelial carcinomas, including EAC, from 1973 to 2017. The percent change in incidence over time was compared according to tumor subtype. Early T-stage, node-negative EAC without metastasis was examined from 2004 to 2017 when precise T-stage data were available.
Results
The percent change in annual incidence from 1973 to 2017 was 767% for EAC. Joinpoint analysis showed that the average annual percent change in EAC from 1973 to 2017 was 5.11% (95% confidence interval, 4.66%–5.56%). The annual percent change appeared to plateau between 2004 and 2017; however, early EAC decreased from 2010 to 2017, with an annual percent change of -5.78%.
Conclusions
There has been a 7-fold increase in the incidence of EAC, which was significantly greater than that of the other major epithelial malignancies examined. More recently, the incidence of early EAC has been decreasing. Approximately one in five patients has node negative, potentially resectable early stage disease. -
Citations
Citations to this article as recorded by- Histology Shift in Esophageal Cancer Between Biopsies and Resections After Neoadjuvant Therapy: A Pilot Study
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International Journal of Surgical Pathology.2024; 32(5): 920. CrossRef - Concise Commentary: It’s All Downhill from Here—How Diagnostic and Therapeutic Advances May Decrease the Incidence Rates of Gastroesophageal Junction and Esophageal Adenocarcinoma
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Mohammad Sadra Gholami Chahkand, Fatemeh Esmaeilpour Moallem, Fatemeh Ghasemi-Kebria, Reza Malekzadeh, Gholamreza Roshandel, Mohammad Taher
Middle East Journal of Digestive Diseases.2024; 16(1): 28. CrossRef - Epidemiologie der Adenokarzinome des Ösophagus und des ösophagogastralen Übergangs
Sabine Luttmann, Andrea Eberle, Joachim Hübner
Die Onkologie.2023; 29(6): 470. CrossRef - Evaluation of Esophageal Dysphagia in Elderly Patients
Khanh Hoang Nicholas Le, Eric E. Low, Rena Yadlapati
Current Gastroenterology Reports.2023; 25(7): 146. CrossRef - Molecular Biology and Clinical Management of Esophageal Adenocarcinoma
Shulin Li, Sanne Johanna Maria Hoefnagel, Kausilia Krishnawatie Krishnadath
Cancers.2023; 15(22): 5410. CrossRef - Progress in Clinical Management of Esophago-Jejunal Anastomotic Fistula with Total Gastrectomy for Adenocarcinoma of the Esophagogastric Junction
天伟 赖
Advances in Clinical Medicine.2023; 13(11): 17210. CrossRef - Cranberry Proanthocyanidins Mitigate Reflux-Induced Transporter Dysregulation in an Esophageal Adenocarcinoma Model
Yun Zhang, Katherine M. Weh, Bridget A. Tripp, Jennifer L. Clarke, Connor L. Howard, Shruthi Sunilkumar, Amy B. Howell, Laura A. Kresty
Pharmaceuticals.2023; 16(12): 1697. CrossRef - Lessons learned in clinical epidemiology of esophageal adenocarcinoma
Hye Kyung Jung
Clinical Endoscopy.2022; 55(3): 365. CrossRef
- Histology Shift in Esophageal Cancer Between Biopsies and Resections After Neoadjuvant Therapy: A Pilot Study
- 5,044 View
- 270 Download
- 6 Web of Science
- 9 Crossref
Focused Review Series: Updates on Capsule Endoscopy from Esophagus to Colon
- Current and Future Use of Esophageal Capsule Endoscopy
- Junseok Park, Young Kwan Cho, Ji Hyun Kim
- Clin Endosc 2018;51(4):317-322. Published online July 31, 2018
- DOI: https://doi.org/10.5946/ce.2018.101
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Abstract
PDFPubReaderePub
- Capsule endoscopy can be a diagnostic option for patients with esophageal diseases who cannot tolerate esophagogastroduodenoscopy.Functional modifications of the capsule allow for thorough examination of the esophagus. Esophageal capsule endoscopy has so farfailed to show sufficient performance to justify the replacement of traditional endoscopy for the diagnosis of esophageal diseasesbecause the esophagus has a short transit time and common pathologies appear near the esophagogastric junction. However,technological improvements are being introduced to overcome the limitations of capsule endoscopy, which is expected to become agood alternative to conventional endoscopy.
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Citations
Citations to this article as recorded by- Barrett’s Esophagus: Who and How Do We Screen?
Bibek Saha, Anjul Verma, Prasad G. Iyer
Current Treatment Options in Gastroenterology.2024; 22(2): 23. CrossRef - Detachable string magnetically controlled capsule endoscopy for the noninvasive diagnosis of esophageal diseases: A prospective, blind clinical study
Yan-Ling Yang, Huang-Wen Qin, Zhao-Yu Chen, Hui-Ning Fan, Yi Yu, Wei Da, Jin-Shui Zhu, Jing Zhang
World Journal of Gastroenterology.2024; 30(9): 1121. CrossRef - Cascade-EC Network: Recognition of Gastrointestinal Multiple Lesions Based on EfficientNet and CA_stm_Retinanet
Xudong Guo, Lei Xu, Shengnan Li, Meidong Xu, Yuan Chu, Qinfen Jiang
Journal of Imaging Informatics in Medicine.2024;[Epub] CrossRef - Endoscopic Advances in the Diagnosis and Management of Gastroesophageal Reflux Disease
Priyadarshini Loganathan, Mahesh Gajendran, Abhilash Perisetti, Hemant Goyal, Rupinder Mann, Randy Wright, Shreyas Saligram, Nirav Thosani, Chandraprakash Umapathy
Medicina.2024; 60(7): 1120. CrossRef - The evolving role of small-bowel capsule endoscopy
Silvia Pecere, Michele Francesco Chiappetta, Livio Enrico Del Vecchio, Edward Despott, Xavier Dray, Anastasios Koulaouzidis, Lorenzo Fuccio, Alberto Murino, Emanuele Rondonotti, Manon Spaander, Cristiano Spada
Best Practice & Research Clinical Gastroenterology.2023; 64-65: 101857. CrossRef - The Future of Minimally Invasive Capsule Panendoscopy: Robotic Precision, Wireless Imaging and AI-Driven Insights
Miguel Mascarenhas, Miguel Martins, João Afonso, Tiago Ribeiro, Pedro Cardoso, Francisco Mendes, Patrícia Andrade, Helder Cardoso, João Ferreira, Guilherme Macedo
Cancers.2023; 15(24): 5861. CrossRef - Design and implementation of a highly integrated dual hemisphere capsule robot
Yongshun Zhang, Xu Liu, Guanxi Liu, Xuan Ji, Huiyuan Yang, Zhenhu Liu
Biomedical Microdevices.2022;[Epub] CrossRef - Capsule endoscopy - a non-invasive modality to investigate the GI tract: out with the old and in with the new?
Priya Oka, Mark McAlindon, Reena Sidhu
Expert Review of Gastroenterology & Hepatology.2022; 16(7): 591. CrossRef - Proton pump inhibitor in the prevention of upper gastrointestinal mucosal injury associated with dual antiplatelet therapy after coronary artery bypass grafting (DACAB-GI-2): study protocol for a randomized controlled trial
Yunpeng Zhu, Xiaojin Wang, Yi Yang, Lei Liu, Qiang Zhao, Lifen Yu
Trials.2022;[Epub] CrossRef - Expanding beyond endoscopy: A review of non-invasive modalities in Barrett’s esophagus screening and surveillance
Dariush Shahsavari, Praneeth Kudaravalli, John Erikson L Yap, Kenneth J Vega
World Journal of Gastroenterology.2022; 28(32): 4516. CrossRef - Dynamic tracking effect of a magnetic navigated dual hemisphere capsule robot
Yongshun Zhang, Xu Liu, Zhenhu Liu, Zihao Zhao, Hai Dong, Dianlong Wang
Robotica.2022; 40(12): 4586. CrossRef - Artificial intelligence and deep learning for small bowel capsule endoscopy
Roberto Trasolini, Michael F. Byrne
Digestive Endoscopy.2021; 33(2): 290. CrossRef - Esophageal Cancer: An Updated Review
Michael DiSiena, Alexander Perelman, John Birk, Houman Rezaizadeh
Southern Medical Journal.2021; 114(3): 161. CrossRef - Detachable string magnetically controlled capsule endoscopy for complete observation of the upper gastrointestinal tract
Hui Xiu, Yanyan Lu, Xishuang Liu, Fuguo Liu, Lingyu Zhang, Chengye Zhao, Xueguo Sun
European Journal of Gastroenterology & Hepatology.2021; 33(4): 508. CrossRef - Novel Clinical Applications and Technical Developments in Video Capsule Endoscopy
Shahrad Hakimian, Mark Hanscom, David R. Cave
Gastrointestinal Endoscopy Clinics of North America.2021; 31(2): 399. CrossRef - Next-generation ingestible devices: sensing, locomotion and navigation
Fahad N Alsunaydih, Mehmet R Yuce
Physiological Measurement.2021; 42(4): 04TR01. CrossRef - An intelligent compression system for wireless capsule endoscopy images
Dallel Bouyaya, Said Benierbah, Mohammed Khamadja
Biomedical Signal Processing and Control.2021; 70: 102929. CrossRef - Examination of Entire Gastrointestinal Tract: A Perspective of Mouth to Anus (M2A) Capsule Endoscopy
Ji Hyung Nam, Kwang Hoon Lee, Yun Jeong Lim
Diagnostics.2021; 11(8): 1367. CrossRef - Lavage, Simethicone, and Prokinetics—What to Swallow with a Video Capsule
Martin Keuchel, Niehls Kurniawan, Marc Bota, Peter Baltes
Diagnostics.2021; 11(9): 1711. CrossRef - Innovations in Screening Tools for Barrett’s Esophagus and Esophageal Adenocarcinoma
Matthew G. Bell, Prasad G. Iyer
Current Gastroenterology Reports.2021;[Epub] CrossRef - Applicability of colon capsule endoscopy as pan-endoscopy: From bowel preparation, transit, and rating times to completion rate and patient acceptance
Fanny E.R. Vuik, Sarah Moen, Stella A.V. Nieuwenburg, Eline H. Schreuders, Ernst J. Kuipers, Manon C.W. Spaander
Endoscopy International Open.2021; 09(12): E1852. CrossRef - Development and Application of Magnetically Controlled Capsule Endoscopy in Detecting Gastric Lesions
Yaoping Zhang, Yanning Zhang, Xiaojun Huang, Amosy M'Koma
Gastroenterology Research and Practice.2021; 2021: 1. CrossRef - Development and validation of a risk prediction model to diagnose Barrett's oesophagus (MARK-BE): a case-control machine learning approach
Avi Rosenfeld, David G Graham, Sarah Jevons, Jose Ariza, Daryl Hagan, Ash Wilson, Samuel J Lovat, Sarmed S Sami, Omer F Ahmad, Marco Novelli, Manuel Rodriguez Justo, Alison Winstanley, Eliyahu M Heifetz, Mordehy Ben-Zecharia, Uria Noiman, Rebecca C Fitzge
The Lancet Digital Health.2020; 2(1): e37. CrossRef - Better view by detachable string magnetically controlled capsule endoscopy for esophageal observation: a retrospective comparative study
J Song, T Bai, L Zhang, X-L Xiang, X-P Xie, X-H Hou
Diseases of the Esophagus.2020;[Epub] CrossRef - Recent advances in understanding and preventing oesophageal cancer
James Franklin, Janusz Jankowski
F1000Research.2020; 9: 276. CrossRef - USB capsule endoscope for retrograde imaging of the esophagus
Ivan Martincek, Peter Banovcin, Matej Goraus, Martin Duricek
Journal of Biomedical Optics.2020;[Epub] CrossRef - Follow-up on: optimizing lesion detection in small bowel capsule endoscopy and beyond: from present problems to future solutions
Michael Vasilakakis, Anastasios Koulaouzidis, Diana E Yung, John N Plevris, Ervin Toth, Dimitris K Iakovidis
Expert Review of Gastroenterology & Hepatology.2019; 13(2): 129. CrossRef - Gastrointestinal diagnosis using non-white light imaging capsule endoscopy
Gerard Cummins, Benjamin F. Cox, Gastone Ciuti, Thineskrishna Anbarasan, Marc P. Y. Desmulliez, Sandy Cochran, Robert Steele, John N. Plevris, Anastasios Koulaouzidis
Nature Reviews Gastroenterology & Hepatology.2019; 16(7): 429. CrossRef - Reflux esophagitis, functional and non-functional
Serhat Bor
Best Practice & Research Clinical Gastroenterology.2019; 40-41: 101649. CrossRef
- Barrett’s Esophagus: Who and How Do We Screen?
- 6,397 View
- 135 Download
- 30 Web of Science
- 29 Crossref
Review
- Quality Indicators in Barrett’s Esophagus: Time to Change the Status Quo
- Samuel Han, Sachin Wani
- Clin Endosc 2018;51(4):344-351. Published online July 31, 2018
- DOI: https://doi.org/10.5946/ce.2018.099
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Abstract
PDFPubReaderePub
- The push for high quality care in all fields of medicine highlights the importance of establishing and adhering to quality indicators.In response, several gastrointestinal societies have established quality indicators specific to Barrett’s esophagus, which serve to createthresholds for performance while standardizing practice and guiding value-based care. Recent studies, however, have consistentlydemonstrated the lack of adherence to these quality indicators, particularly in surveillance (appropriate utilization of endoscopy andobtaining biopsies using the Seattle protocol) and endoscopic eradication therapy practices. These findings suggest that innovativeinterventions are needed to address these shortcomings in order to deliver high quality care to patients with Barrett’s esophagus.
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Citations
Citations to this article as recorded by- Measuring and improving quality in esophageal care and swallowing disorders
Alexander T Reddy, Joshua P Lee, David A Leiman
Diseases of the Esophagus.2024;[Epub] CrossRef - Impact of Residing in Below Median Household Income Districts on Outcomes in Patients with Advanced Barrett’s Esophagus
Suqing Li, Yusuke Fujiyoshi, Sechiv Jugnundan, Gary May, Norman Marcon, Jeffrey Mosko, Christopher Teshima
Journal of the Canadian Association of Gastroenterology.2023; 6(4): 137. CrossRef - Clinical variation in surveillance and management of Barrett’s esophagus: A cross-sectional study of gastroenterologists and gastrointestinal surgeons
Jamielyn DC Cruz, David Paculdo, Divya Ganesan, Meredith Baker, Rebecca J Critchley-Thorne, Nicholas J Shaheen, Sachin Wani, John W Peabody
Medicine.2022; 101(51): e32187. CrossRef - Risk Factors for Self-Expandable Metal Stent Complications in the Treatment of Esophageal Cancer: A Scoping Review
Connor K. Wilson, Sara R. Frankowski, Susan C. Steelman, Issam Makhoul
SN Comprehensive Clinical Medicine.2020; 2(8): 1163. CrossRef
- Measuring and improving quality in esophageal care and swallowing disorders
- 6,010 View
- 102 Download
- 3 Web of Science
- 4 Crossref
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