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Systematic Review and Meta-analysis
- The impact of linked color imaging on adenoma detection rate in colonoscopy: a systematic review and meta-analysis
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Bruna Haueisen Figueiredo Zwetkoff
, Luiz Ronaldo Alberti, Fábio Gontijo Rodrigues, Nelson Carvas Junior, José Celso Ardengh, Otavio Micelli Neto, Fernando Rodrigues Guzman, Marcelo Morganti Ferreira Dias, Guilherme Camarotti de Oliveira Canejo, Carlos Eduardo Oliveira dos Santos - Clin Endosc 2025;58(2):225-239. Published online October 24, 2024
- DOI: https://doi.org/10.5946/ce.2024.072
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Graphical Abstract
Abstract
PDF - Background
/Aims: Colorectal cancer prevention relies on surveillance colonoscopy, with the adenoma detection rate as a key factor in examination quality. Linked color imaging (LCI) enhances lesion contrast and improves the examination performance. This systematic review and meta-analysis aimed to evaluate the effect of LCI on adenoma detection rate in adults who underwent colonoscopy.
Methods
We searched the Medline, PubMed, BIREME, LILACS, and Scientific Electronic Library Online databases for randomized controlled trials comparing the use of LCI versus white light imaging (WLI), published up to March 2023. The outcomes included lesion characteristics, number of adenomas per patient, and the additional polyp detection rate.
Results
Sixteen studies were included in the analysis, which showed that LCI was more accurate than WLI in detecting adenomas, with an increased number of adenomas detected per patient. Although LCI performed well in terms of lesion size, morphology, and location, the subgroup analyses did not reveal any statistically significant differences between LCI and WLI. The addition of LCI did not result in significant improvements in the detection of serrated lesions, and there were no differences in the withdrawal time between groups.
Conclusions
LCI has been shown to be effective in detecting colonic lesions, improving the number of adenomas detected per patient and improving polyp detection rate without negatively affecting other quality criteria in colonoscopy. -
Citations
Citations to this article as recorded by
- Virtual chromoendoscopy with linked color imaging versus dye-chromoendoscopy in the surveillance of patients with long-standing colonic inflammatory bowel disease
Roberto Gabbiadini, Gianluca Franchellucci, Francesco Minini, Arianna Dal Buono, Giuseppe Privitera, Marco Spadaccini, Giulia Migliorisi, Lorenzo Petronio, Valeria Farinola, Antonio Di Martino, Cristina Bezzio, Cesare Hassan, Alessandro Repici, Alessandro
Journal of Crohn's and Colitis.2026;[Epub] CrossRef - Efficacy of image-enhanced endoscopy for colorectal polyp detection
Reo Kobayashi, Naohisa Yoshida, Ken Inoue
Clinical Endoscopy.2026; 59(4): 485. CrossRef - Linked color imaging improves polyp miss rates in total colonoscopy in a multicenter randomized back to back trial
Ryo Shimoda, Daisuke Yamaguchi, Kazutoshi Hashiguchi, Kazuhiro Mizukami, Akira Aso, Takashi Akutagawa, Koichi Miyahara, Tetsuro Honda, Keiichi Hashiguchi, Tetsuya Ohira, Kensuke Fukuda, Masayuki Kabayama, Hideaki Miyamoto, Ryosuke Gushima, Yorinobu Sumida
Scientific Reports.2025;[Epub] CrossRef - Comparison of adenoma detection rate using the novel 5-LED vs xenon-light endoscopic system: Propensity score matching analysis
Tatsuhiro Ito, Satoshi Osawa, Takanori Yamada, Keisuke Inagaki, Tomohiro Takebe, Satoru Takahashi, Shunya Onoue, Kiichi Sugiura, Natsuki Ishida, Tomoharu Matsuura, Mihoko Yamade, Moriya Iwaizumi, Yasushi Hamaya, Ken Sugimoto
Endoscopy International Open.2025;[Epub] CrossRef
- Virtual chromoendoscopy with linked color imaging versus dye-chromoendoscopy in the surveillance of patients with long-standing colonic inflammatory bowel disease
- 6,011 View
- 323 Download
- 4 Web of Science
- 4 Crossref
Review
- Advanced endoscopic imaging for detection of Barrett’s esophagus
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Netanel Zilberstein
, Michelle Godbee, Neal A. Mehta, Irving Waxman - Clin Endosc 2024;57(1):1-10. Published online January 5, 2024
- DOI: https://doi.org/10.5946/ce.2023.031
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Abstract
PDF
- Barrett’s esophagus (BE) is the precursor to esophageal adenocarcinoma (EAC), and is caused by chronic gastroesophageal reflux. BE can progress over time from metaplasia to dysplasia, and eventually to EAC. EAC is associated with a poor prognosis, often due to advanced disease at the time of diagnosis. However, if BE is diagnosed early, pharmacologic and endoscopic treatments can prevent progression to EAC. The current standard of care for BE surveillance utilizes the Seattle protocol. Unfortunately, a sizable proportion of early EAC and BE-related high-grade dysplasia (HGD) are missed due to poor adherence to the Seattle protocol and sampling errors. New modalities using artificial intelligence (AI) have been proposed to improve the detection of early EAC and BE-related HGD. This review will focus on AI technology and its application to various endoscopic modalities such as high-definition white light endoscopy, narrow-band imaging, and volumetric laser endomicroscopy.
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Citations
Citations to this article as recorded by- Revising the Model for Accurate Cost-Effectiveness of Barrett’s Esophagus Surveillance
Shenglong Li
Gastroenterology.2026; 170(4): 860. CrossRef - Update on the management of Barrett’s neoplasia
Sharmila Subramaniam, Elisabetta Mastrorocco, Mohan Ramchandani, Pradeep Bhandari
Frontline Gastroenterology.2026; 17(e1): e23. CrossRef - Gender disparities and woman-specific trends in Barrett’s esophagus in the United States: An 11-year nationwide population-based study
Karina Fatakhova, Faisal Inayat, Hassam Ali, Pratik Patel, Attiq Ur Rehman, Arslan Afzal, Muhammad Sarfraz, Shiza Sarfraz, Gul Nawaz, Ahtshamullah Chaudhry, Rubaid Dhillon, Arthur Dilibe, Benjamin Glazebnik, Lindsey Jones, Emily Glazer
World Journal of Methodology.2025;[Epub] CrossRef - Image-enhanced endoscopy in upper gastrointestinal disease: focusing on texture and color enhancement imaging and red dichromatic imaging
Jae Yong Park
Clinical Endoscopy.2025; 58(2): 163. CrossRef - Future of image enhanced endoscopy of esophageal adenocarcinoma
Kerem Parlar, Mert Cakir, Ozlem Ozer, Prateek Sharma
Clinical Endoscopy.2025; 58(4): 503. CrossRef - Advances in diagnostic techniques for eosinophilic esophagitis: a systematic review of emerging noninvasive methods
Abdulrhman Khaled Al Abdulqader
European Journal of Medical Research.2025;[Epub] CrossRef - Advancements in Barrett's esophagus detection: The role of artificial intelligence and its implications
Sara Massironi
World Journal of Gastroenterology.2024; 30(11): 1494. CrossRef - Advanced Esophageal Endoscopy
Kyoungwon Jung, Rebecca M. Haug, Andrew Y. Wang
Gastroenterology Clinics of North America.2024; 53(4): 603. CrossRef
- Revising the Model for Accurate Cost-Effectiveness of Barrett’s Esophagus Surveillance
- 15,806 View
- 399 Download
- 7 Web of Science
- 8 Crossref
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