Skip Navigation
Skip to contents

Clin Endosc : Clinical Endoscopy

Search
Advanced Search
OPEN ACCESS
mobile search button mobile menu button

Search

Page Path
HOME > Search
91 "Endoscopic mucosal resection"
Filter
Filter
Article category
Keywords
More +
Publication year
More +
Authors
More +
Funded articles
Review
Undifferentiated-type early gastric cancer: from margin demarcation to complete resection
Satoru Mizutani, Seiichiro Abe, Yutaka Saito
Received February 17, 2026  Accepted May 8, 2026  Published online August 10, 2026  
DOI: https://doi.org/10.5946/ce.2026.062    [Epub ahead of print]
AbstractAbstract PDF
Gastric cancer remains a major global health burden, particularly in Asia, where widespread implementation of endoscopic screening has increased the detection of early gastric cancer (EGC). With advances in endoscopic techniques, endoscopic resection (ER), especially endoscopic submucosal dissection, has become the standard treatment for EGC with a negligible risk of lymph node metastasis (LNM). Undifferentiated-type EGC (UD-EGC) is associated with a higher risk of LNM than differentiated-type EGC. However, favorable long-term outcomes can be achieved with curative resection. Despite this, accurate endoscopic detection, characterization, and delineation of UD-EGC remain a challenge because of their subtle morphology and unique growth pattern. Image-enhanced endoscopy, particularly magnifying endoscopy with narrow-band imaging, plays an important role in diagnosis and assessment of the lateral extent of the lesion. In Japan, accumulating evidence, including prospective multicenter trials, has led to the classification of intramucosal UD-EGC ≤2 cm without ulceration, as an absolute indication for ER in the latest clinical guidelines. Short and long-term outcomes after curative ER for UD-EGC are comparable to those after surgical resection. This review summarizes the current literature on the diagnosis and endoscopic management of UD-EGC, providing a comparative overview of differences in endoscopic treatment recommendations among international guidelines.
  • 424 View
  • 29 Download
Close layer
Original Articles
Treatment procedures for intractable gastroesophageal reflux disease after peroral endoscopic myotomy for achalasia: a retrospective study in South Korea
Ah Young Lee, Seong Hwan Kim, Joo Young Cho
Clin Endosc 2026;59(4):612-621.   Published online July 29, 2026
DOI: https://doi.org/10.5946/ce.2025.253
Graphical AbstractGraphical Abstract AbstractAbstract PDF
Background
/Aims: No study has compared the safety and efficacy of anti-reflux mucosal ablation (ARMA), anti-reflux mucosectomy (ARMS), and Stretta radiofrequency (SRF) for intractable gastroesophageal reflux disease (GERD) after peroral endoscopic myotomy (POEM).
Methods
Twenty-two patients with post-POEM GERD underwent either ARMA (n=12), ARMS (n=6), or SRF (n=4). GERD questionnaire (GERDQ) score, endoscopic Los Angeles classification, flap valve grade based on Hill’s type EndoFLIP distensibility index (DI), and rate of proton pump inhibitor withdrawal were analyzed and compared. The factors associated with the occurrence of post-POEM intractable GERD were also evaluated.
Results
The ARMS group demonstrated a significant improvement in GERDQ scores after 6 months of follow-up (p=0.04). No significant differences were observed in the endoscopic Los Angeles grade (p=0.68), flap valve grade (p=0.38), or EndoFLIP DI (p=0.15). Type III achalasia and posterior myotomy orientation during POEM were identified as risk factors for reintervention. Postprocedural adverse events (bleeding and stricture) occurred in the ARMA and ARMS groups.
Conclusions
Among the three procedures, ARMS produced the most notable improvement in symptoms, whereas endoscopic esophagitis and EndoFLIP DI did not show a similar improvement.
  • 381 View
  • 13 Download
  • 1 Web of Science
Close layer
Depth of noninjecting resection using bipolar soft coagulation mode for 6 to 9 mm colorectal polyps: a retrospective study in Japan
Yoshifumi Watanabe, Mitsuo Tokuhara, Hidetoshi Nakata, Hiroko Nakahira, Ikuko Torii, Yasumasa Sumitomo
Clin Endosc 2026;59(1):115-123.   Published online December 18, 2025
DOI: https://doi.org/10.5946/ce.2025.100
Graphical AbstractGraphical Abstract AbstractAbstract PDF
Background
/Aims: Endoscopic resection of colorectal polyps reduces mortality from colorectal cancer. We report here a novel resection method, known as noninjecting resection using bipolar soft coagulation mode (NIRBS), and assess its feasibility. This study aimed to compare the resection depth achieved with NIRBS to those achieved with cold snare polypectomy (CSP) and conventional endoscopic mucosal resection (CEMR).
Methods
Patients with 6 to 9 mm colorectal polyps underwent endoscopic resection at Hoshigaoka Medical Center between October 2023 and January 2024. We analyzed the thickness of resected submucosal tissue following the use of NIRBS, CSP, and CEMR.
Results
We identified 95 polyps, including adenomas and serrated lesions. The proportions of specimens containing submucosal tissue were 21.4%, 100.0%, and 97.9% in CSP, CEMR, and NIRBS, respectively. The median submucosal tissue thickness for CEMR and NIRBS was 1,167 and 1,125 µm, respectively, which was significantly greater than 0 µm for CSP. For NIRBS, the median thickness was 1,140 and 1,017 µm for the expert and non-expert endoscopists, respectively.
Conclusions
The depth of submucosal resection with NIRBS exceeded 1,000 μm regardless of endoscopist experience. NIRBS can be a useful resection method for patients with colorectal polyps, including those with non-submucosally invasive carcinomas.
  • 1,615 View
  • 81 Download
Close layer
The comparative study of Stretta radiofrequency and anti-reflux mucosectomy in the management of intractable gastroesophageal reflux disease: a single-center retrospective study from Korea
Ah Young Lee, Ji Woo Choi, Jeong Haeng Heo, Jun Young Chung, Seong Hwan Kim, Joo Young Cho
Clin Endosc 2025;58(3):409-417.   Published online May 7, 2025
DOI: https://doi.org/10.5946/ce.2024.163
Graphical AbstractGraphical Abstract AbstractAbstract PDF
Background
/Aims: Chronic gastroesophageal reflux disease (GERD) requires symptom relief and treatment of associated conditions. In this study, we aimed to compare anti-reflux mucosectomy (ARMS) and Stretta radiofrequency (SRF) for treating patients with chronic GERD who are unresponsive to proton pump inhibitors (PPIs) and to identify the indications for each procedure.
Methods
Data of patients who underwent ARMS or SRF between March 2021 and April 2023 were analyzed. Changes in GERD questionnaire (GERDQ) scores, endoscopic Los Angeles (LA) grade, flap valve grade (FVG) based on Hill’s type, EndoFLIP distensibility index (DI), endoscopic Barrett’s epithelium (BE) resolution rate, and PPI withdrawal rate were compared between the two groups.
Results
Improvements in the GERDQ scores and PPI withdrawal rates were similar between the groups. The ARMS group showed significantly better changes in endoscopic LA grade, FVG, and EndoFLIP DI than the SRF group. The complications were more prevalent in the ARMS group than in the SRF group.
Conclusions
The change in endoscopic LA grade before and after the procedure was significantly higher in the ARMS group than in the SRF group. Significant improvements in endoscopic FVG, BE resolution, and EndoFLIP DI were observed only with the ARMS group.

Citations

Citations to this article as recorded by  
  • Anti-reflux mucosal ablation: A good method for proton pump inhibitor dependent gastroesophageal reflux disease
    Jing-yu Zhu, Yi-heng Yao, Ming Qi, Liang Liu
    Indian Journal of Gastroenterology.2026; 45(4): 788.     CrossRef
  • Bridging the Therapeutic Gap: Clinical Efficacy of Endoscopic Radiofrequency Stretta Therapy for Gastroesophageal Reflux Disease in Korea
    Yang Won Min
    Journal of Neurogastroenterology and Motility.2026; 32(2): 148.     CrossRef
  • Restoring the barrier: endoscopic antireflux mucosal interventions for intractable post-peroral endoscopic myotomy reflux
    Do Hoon Kim
    Clinical Endoscopy.2026; 59(4): 590.     CrossRef
  • Redefining endoscopic management of refractory gastroesophageal reflux disease: the role of Stretta radiofrequency therapy and antireflux mucosectomy
    Yuto Shimamura
    Clinical Endoscopy.2025; 58(3): 398.     CrossRef
  • Comment on ‘The comparative study of Stretta radiofrequency and anti-reflux mucosectomy in the management of intractable gastroesophageal reflux disease: a single-center retrospective study from Korea’
    Yiheng Yao, Guolei Shi, Liang Liu
    Clinical Endoscopy.2025; 58(5): 782.     CrossRef
  • Comments on ‘The comparative study of Stretta radiofrequency and anti-reflux mucosectomy in the management of intractable gastroesophageal reflux disease: a single-center retrospective study from Korea’
    Gwang Ha Kim
    Clinical Endoscopy.2025; 58(6): 948.     CrossRef
  • 4,717 View
  • 144 Download
  • 6 Web of Science
  • 6 Crossref
Close layer
Utility of underwater endoscopic mucosal resection combined with a protruding anchor by saline injection for superficial non-ampullary duodenal tumors: a retrospective study in Japan
Yoshie Nomoto, Satoshi Shinozaki, Yoshimasa Miura, Hiroyuki Osawa, Yuji Ino, Tomonori Yano, Nikolaos Lazaridis, Hironori Yamamoto
Clin Endosc 2025;58(4):561-568.   Published online March 12, 2025
DOI: https://doi.org/10.5946/ce.2024.181
Graphical AbstractGraphical Abstract AbstractAbstract PDF
Background
/Aims: Underwater endoscopic mucosal resection (UEMR) is the standard resection method for superficial non-ampullary duodenal tumors (SNADETs). We developed a novel UEMR technique that creates an anchor by protruding the distal fold with a saline injection (UEMR-A). The aim of this study was to clarify the usefulness of UEMR-A compared to conventional UEMR (UEMR-C).
Methods
This retrospective observational study included patients who underwent UEMR for SNADETs.
Results
A total of 141 patients were included and divided into UEMR-A (n=54) and UEMR-C (n=87) groups. Lesion resection was performed significantly more frequently by an expert endoscopist in the UEMR-C group compared to the UEMR-A group (p<0.001). The procedure time for UEMR-A was significantly shorter than that for UEMR-C (p=0.018), despite the additional time required for submucosal injection. The R0 resection rate was significantly higher in the UEMR-A group than in the UEMR-C group (p=0.004). The horizontal margins were significantly clearer in the UEMR-A group than in the UEMR-C group (p=0.018). Multivariate analysis revealed that the use of UEMR-A was the only significant positive factor for R0 resection.
Conclusions
The UEMR-A technique for SNADETs appears to improve R0 resection rates and reduce procedure times compared to the UEMR-C technique.

Citations

Citations to this article as recorded by  
  • Advancement of endoscopic treatment in GI tract
    Yoshimasa Miura
    Journal of Nihon University Medical Association.2025; 84(3): 119.     CrossRef
  • Evaluation of a modified underwater endoscopic mucosal resection technique for duodenal neoplasms: clinical implications and future directions
    Ji Yong Ahn
    Clinical Endoscopy.2025; 58(4): 544.     CrossRef
  • Reply to the comments on ‘Utility of underwater endoscopic mucosal resection combined with a protruding anchor by saline injection for superficial non-ampullary duodenal tumors: a retrospective study in Japan'
    Hironori Yamamoto, Yoshie Nomoto, Satoshi Shinozaki, Yoshimasa Miura, Hiroyuki Osawa
    Clinical Endoscopy.2025; 58(6): 953.     CrossRef
  • A reformative underwater endoscopic mucosal resection technique for superficial non-ampullary duodenal tumors
    Yiheng Yao, Guolei Shi, Xingjie Shen, Liang Liu
    Clinical Endoscopy.2025; 58(6): 951.     CrossRef
  • 5,381 View
  • 283 Download
  • 3 Web of Science
  • 4 Crossref
Close layer
Systematic Review and Meta-analysis
Cold snare polypectomy versus cold endoscopic mucosal resection for small colorectal polyps: a meta-analysis of randomized controlled trials
Vishali Moond, Priyadarshini Loganathan, Sheza Malik, Dushyant Singh Dahiya, Babu P. Mohan, Daryl Ramai, Michele McGinnis, Deepak Madhu, Mohammad Bilal, Aasma Shaukat, Saurabh Chandan
Clin Endosc 2024;57(6):747-758.   Published online August 23, 2024
DOI: https://doi.org/10.5946/ce.2024.081
Graphical AbstractGraphical Abstract AbstractAbstract PDFSupplementary Material
Background
/Aims: Cold snare polypectomy (CSP) is routinely performed for small colorectal polyps (≤10 mm). However, challenges include insufficient resection depth and immediate bleeding, hindering precise pathological evaluation. We aimed to compare the outcomes of cold endoscopic mucosal resection (CEMR) with that of CSP for colorectal polyps ≤10 mm, using data from randomized controlled trials (RCTs).
Methods
Multiple databases were searched in December 2023 for RCTs reporting outcomes of CSP versus CEMR for colorectal polyps ≤10 mm in size. Our primary outcomes were rates of complete and en-bloc resections, while our secondary outcomes were total resection time (seconds) and adverse events, including immediate bleeding, delayed bleeding, and perforation.
Results
The complete resection rates did not significantly differ (CSP, 91.8% vs. CEMR 94.6%), nor did the rates of en-bloc resection (CSP, 98.9% vs. CEMR, 98.3%) or incomplete resection (CSP, 6.7% vs. CEMR, 4.8%). Adverse event rates were similarly insignificant in variance. However, CEMR had a notably longer mean resection time (133.51 vs. 91.30 seconds).
Conclusions
Our meta-analysis of seven RCTs showed that while both CSP and CEMR are equally safe and effective for resecting small (≤10 mm) colorectal polyps, the latter is associated with a longer resection time.

Citations

Citations to this article as recorded by  
  • Recent advancement in size measurement during endoscopy
    Hye Kyung Jeon, Gwang Ha Kim
    Clinical Endoscopy.2026; 59(1): 1.     CrossRef
  • Does the size of the cold snare affect the outcome of cold snare polypectomy in the colon? A KASID prospective multicenter study
    Seongwoo Choi, Jaeyoung Chun, Geunhyuk Choi, Yoojin Lee, Taegeun Gweon, Yunho Jung
    Intestinal Research.2026; 24(1): 76.     CrossRef
  • Iatrogenic colon perforation: endoscopic management or surgery
    Seung Bum Lee
    Clinical Endoscopy.2026; 59(1): 33.     CrossRef
  • Efficacy and safety ranking of endoscopic resection techniques for colorectal polyps: a systematic review and network meta-analysis
    Shirui Li, Yue Lei, Yunfan Deng, Sheng Dai, Dehai Xiong, Qi Fan, Xiuyang Li
    Therapeutic Advances in Gastroenterology.2026;[Epub]     CrossRef
  • Histopathologic outcomes comparison between cold snare polypectomy and cold snare EMR for colorectal polyps: a full-thickness serial sectioning analysis
    Ran Chen, Shiya Hong, Jie Gao, Zhi Ni, Peichun Peng, Shuling Lai, Xiaoqing Huang, Yueping Zheng, Qingyong Zhang, Tingting Lin, Bo Hu, Rongchun Zhang
    Gastroenterology Report.2026;[Epub]     CrossRef
  • Effective Polypectomy Practice
    Malique Delbrune, Thomas Enke, Mohammad Bilal
    Gastrointestinal Endoscopy Clinics of North America.2026;[Epub]     CrossRef
  • 13,560 View
  • 388 Download
  • 5 Web of Science
  • 6 Crossref
Close layer
Case Report
A rare case of esophageal mucoepidermoid carcinoma successfully treated via endoscopic submucosal dissection
So Eun Jeun, Kyung Bin Kim, Bong Eun Lee, Gwang Ha Kim, Moon Won Lee, Dong Chan Joo
Clin Endosc 2024;57(5):683-687.   Published online June 18, 2024
DOI: https://doi.org/10.5946/ce.2024.051
AbstractAbstract PDF
Esophageal mucoepidermoid carcinoma (EMEC) is a special subtype of esophageal malignancy, accounting for less than 1% of all cases of primary esophageal carcinoma. Pathologically, it consists of a mixture of adenocarcinoma and squamous cell carcinoma with mucin-secreting cells. Special staining for mucicarmine helps to diagnose EMEC. We present a rare case of EMEC successfully treated via endoscopic submucosal dissection (ESD). A 63-year-old man was referred to our tertiary hospital. On esophagogastroduodenoscopy, a 6-mm-sized subtle reddish depressed lesion was identified in the mid-esophagus. Diagnostic ESD was performed with a high suspicion of carcinoma. Histopathologic findings were consistent with EMEC which was confined to the lamina propria without lymphatic invasion. We plan to do a careful follow-up without administering adjuvant chemotherapy or radiotherapy. Due to the small volume of the lesion, establishing a diagnosis was difficult through forceps biopsy alone. However, by using ESD, we could confirm and successfully treat a rare case of early-stage EMEC.

Citations

Citations to this article as recorded by  
  • Esophageal Squamous Cell Carcinoma with Ductal Differentiation
    Qianqian Li, Yabin Shi, Xu Han, Jialu Zhou, Lin Kang, Huanfen Zhao
    International Journal of Surgical Pathology.2026;[Epub]     CrossRef
  • Insights from literature of esophageal mucoepidermoid carcinoma in a female: A rare case report
    Saltuk Bugra Yolburun, Ozlem Ceren Gunizi, Gulsum Ozlem Elpek
    World Journal of Clinical Cases.2025;[Epub]     CrossRef
  • 8,127 View
  • 238 Download
  • 1 Web of Science
  • 2 Crossref
Close layer
Review
The role of cap-assisted endoscopy and its future implications
Sol Kim, Bo-In Lee
Clin Endosc 2024;57(3):293-301.   Published online February 7, 2024
DOI: https://doi.org/10.5946/ce.2023.051
AbstractAbstract PDF
Cap-assisted endoscopy refers to a procedure in which a short tube made of a polymer (mostly transparent) is attached to the distal tip of the endoscope to enhance its diagnostic and therapeutic capabilities. It is reported to be particularly useful in: (1) minimizing blind spots during screening colonoscopy, (2) providing a constant distance from a lesion for clear visualization during magnifying endoscopy, (3) accurately assessing the size of various gastrointestinal lesions, (4) preventing mucosal injury during foreign body removal, (5) securing adequate workspace in the submucosal space during endoscopic submucosal dissection or third space endoscopy, (6) providing an optimal approach angle to a target, and (7) suctioning mucosal and submucosal tissue with negative pressure for resection or approximation. Here, we review various applications of attachable caps in diagnostic and therapeutic endoscopy and their future implications.

Citations

Citations to this article as recorded by  
  • Endoscopic approaches to reduce the incidence of interval colon cancer
    Saurabh Chandan
    Gastrointestinal Endoscopy.2026; 103(1): 26.     CrossRef
  • The Optimal Timing and Effectiveness of a Transparent Cap in the Endoscopic Removal of Bony Foreign Bodies From the Esophagus
    Sheng-Chun Lin, Ting-Han Wang, Er-Hsiang Yang, Chien-Ming Chiang, Wei-Lun Chang, Chiao-Hsiung Chuang, Chiung-Yu Chen, Xi-Zhang Lin, Hsueh-Chien Chiang
    Clinical and Translational Gastroenterology.2026; 17(1): e00955.     CrossRef
  • Endoscopic transparent cap assisted hemostasis: A multicenter retrospective cohort study
    Ömer Küçükdemirci, Talat Ayyildiz, Berk Bas, Hasan Eruzun, Nisa Efe, Ahmet Bektas
    World Journal of Gastroenterology.2026;[Epub]     CrossRef
  • The use of botulinum toxin in the treatment of upper esophageal sphincter spasm: a diagnostic protocol and case series
    Barbara Jamróz, Mateusz Szurek, Dorota Wasko-Czopnik
    Polski Przegląd Otorynolaryngologiczny.2026; 15(2): 9.     CrossRef
  • Endoscopic Treatment of Upper Gastrointestinal Bleeding
    Yu Jin Kim, Heung Up Kim
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2026; 26(2): 131.     CrossRef
  • Transparent cap scope tamponade: an inexpensive, efficient, and underappreciated maneuver for bleeding visualization and hemostasis
    Brandon Rodgers, Swapnil Patel, Matthew T. Moyer
    VideoGIE.2025; 10(6): 333.     CrossRef
  • Efficacy and safety of cap-assisted colonoscopy in endoscopic retrograde cholangiopancreatography for patients after Billroth II gastrectomy
    Chun-Xiao Hu, Sheng-Yue Zhou, Xiao-Hua Ye
    World Chinese Journal of Digestology.2025; 33(9): 707.     CrossRef
  • Terminal ileum in screening colonoscopy: routine practice or risk-stratified approach?
    Seong-Jung Kim
    Clinical Endoscopy.2025; 58(5): 696.     CrossRef
  • Gastroscope-assisted oral cavity and nasopharynx examination
    Aman Yadav, Benjamin McKillen, Cheng Yu Chen, Robert Hackett, Lukas Witting, Alexander Huelsen
    VideoGIE.2025; 10(12): 615.     CrossRef
  • A retrospective single-center study of transnasal ileus tube insertion accompanied with cap-assisted endoscopic advancement for malignant adhesive bowel obstruction
    Su-Yu Chen, Rui Huang, Yu Zhang, Zhao-Fei Xie, He Huang, Hong Shi
    Scientific Reports.2024;[Epub]     CrossRef
  • 10,830 View
  • 411 Download
  • 5 Web of Science
  • 10 Crossref
Close layer
Original Article
Significance of rescue hybrid endoscopic submucosal dissection in difficult colorectal cases
Hayato Yamaguchi, Masakatsu Fukuzawa, Takashi Kawai, Takahiro Muramatsu, Taisuke Matsumoto, Kumiko Uchida, Yohei Koyama, Akira Madarame, Takashi Morise, Shin Kono, Sakiko Naito, Naoyoshi Nagata, Mitsushige Sugimoto, Takao Itoi
Clin Endosc 2023;56(6):778-789.   Published online July 26, 2023
DOI: https://doi.org/10.5946/ce.2022.268
Graphical AbstractGraphical Abstract AbstractAbstract PDFSupplementary Material
Background
/Aims: Hybrid endoscopic submucosal dissection (ESD), in which an incision is made around a lesion and snaring is performed after submucosal dissection, has some advantages in colorectal surgery, including shorter procedure time and preventing perforation. However, its value for rescue resection in difficult colorectal ESD cases remains unclear. This study evaluated the utility of rescue hybrid ESD (RH-ESD).
Methods
We divided 364 colorectal ESD procedures into the conventional ESD group (C-ESD, n=260), scheduled hybrid ESD group (SH-ESD, n=69), and RH-ESD group (n=35) and compared their clinical outcomes.
Results
Resection time was significantly shorter in the following order: RH-ESD (149 [90–197] minutes) >C-ESD (90 [60–140] minutes) >SH-ESD (52 [29–80] minutes). The en bloc resection rate increased significantly in the following order: RH-ESD (48.6%), SH-ESD (78.3%), and C-ESD (97.7%). An analysis of factors related to piecemeal resection of RH-ESD revealed that the submucosal dissection rate was significantly lower in the piecemeal resection group (25% [20%–30%]) than in the en bloc resection group (40% [20%–60%]).
Conclusions
RH-ESD was ineffective in terms of curative resection because of the low en bloc resection rate, but was useful for avoiding surgery.

Citations

Citations to this article as recorded by  
  • Management of Large Non-Pedunculated Polyps of the Colon: Practice-Oriented Answers to Clinical Questions
    Cecilia Capelli, Alberto Gattuso, Luigi Tuccillo, Marco Di Marco, Leonardo Frazzoni
    Journal of Clinical Medicine.2026; 15(3): 929.     CrossRef
  • Optimal endoscopic treatment for rectal neuroendocrine tumors, confirmed after forceps biopsy: a Korean Association for the Study of Intestinal Diseases multicenter, randomized noninferiority trial
    Tae-Geun Gweon, Seong-Jung Kim, Dae Seong Myung, Yunho Jung, Jun Lee, Dong-Hoon Yang
    Gastrointestinal Endoscopy.2026; 104(1): 86.     CrossRef
  • Letter to the Editor: Deep margin positivity in small rectal neuroendocrine tumors - pathological insights for post-endoscopic submucosal dissection management
    Ling-Feng Zou, Yan Luo, Cheng-Long Wang
    World Journal of Clinical Oncology.2026;[Epub]     CrossRef
  • Exploring different techniques for endoscopic submucosal dissection of gastrointestinal lesions: a review of the literature
    Giulio Calabrese, Marcello Maida, Darshan Parekh, Yohei Minato, Alessandro Vitello, Alberto Murino, Rui Morais, Emanuele Sinagra, Daryl Ramai, Ken Ohata, Sandro Sferrazza
    Expert Review of Anticancer Therapy.2025; 25(7): 755.     CrossRef
  • Salvage Surgery After Non-Curative Endoscopic Submucosal Dissection for Early Colorectal Cancer: A Comprehensive Review
    Felix Aigner, Christoph Skias, David Duller, Sebastian Wisiak, Karin Strohmeyer, Zoltan Horvath, Nicole Koter
    Journal of Clinical Medicine.2025; 14(17): 6343.     CrossRef
  • Safety and efficacy of hybrid versus conventional endoscopic submucosal dissection for removal of gastrointestinal lesions: A meta-analysis
    Adnan Bhat, Allah Dad, Kinza Bakht, Muhammad Arham, Humza Saeed, Zahra Ali, Faseeh Haider, Saniya Ishtiaq, Anchit Chauhan, Danyal Bakht, Adil Ahmed, Ali Naseem, Imran Ali Reshi, Dennis Yang, Peter Vassilev Draganov
    International Journal of Gastrointestinal Intervention.2025; 14(4): 134.     CrossRef
  • Colorectal endoscopic submucosal dissection defect closure: promising but still evolving
    Yunho Jung
    Clinical Endoscopy.2025; 58(6): 856.     CrossRef
  • Planned Hybrid Endoscopic Submucosal Dissection as Alternative for Colorectal Neoplasms: A Propensity Score-Matched Study
    Yu-xin Zhang, Xun Liu, Fang Gu, Shi-gang Ding
    Digestive Diseases and Sciences.2024; 69(3): 949.     CrossRef
  • Understanding hybrid endoscopic submucosal dissection subtleties
    João Paulo de Souza Pontual, Alexandre Moraes Bestetti, Diogo Turiani Hourneaux de Moura
    Clinical Endoscopy.2023; 56(6): 738.     CrossRef
  • 7,223 View
  • 164 Download
  • 10 Web of Science
  • 9 Crossref
Close layer
Review
Complications of endoscopic resection in the upper gastrointestinal tract
Takeshi Uozumi, Seiichiro Abe, Mai Ego Makiguchi, Satoru Nonaka, Haruhisa Suzuki, Shigetaka Yoshinaga, Yutaka Saito
Clin Endosc 2023;56(4):409-422.   Published online June 21, 2023
DOI: https://doi.org/10.5946/ce.2023.024
AbstractAbstract PDF
Endoscopic resection (ER) is widely utilized as a minimally invasive treatment for upper gastrointestinal tumors; however, complications could occur during and after the procedure. Post-ER mucosal defect leads to delayed perforation and bleeding; therefore, endoscopic closure methods (endoscopic hand-suturing, the endoloop and endoclip closure method, and over-the-scope clip method) and tissue shielding methods (polyglycolic acid sheets and fibrin glue) are developed to prevent these complications. During duodenal ER, complete closure of the mucosal defect significantly reduces delayed bleeding and should be performed. An extensive mucosal defect that comprises three-quarters of the circumference in the esophagus, gastric antrum, or cardia is a significant risk factor for post-ER stricture. Steroid therapy is considered the first-line option for the prevention of esophageal stricture, but its efficacy for gastric stricture remains unclear. Methods for the prevention and management of ER-related complications in the esophagus, stomach, and duodenum differ according to the organ; therefore, endoscopists should be familiar with ways of preventing and managing organ-specific complications.

Citations

Citations to this article as recorded by  
  • Transcutaneous Electrical Acupoint Stimulation Reduces Postoperative Abdominal Pain after Endoscopic Submucosal Dissection: A Single-Center, Prospective, and Randomized Controlled Trial
    Xu-ming Liu, Yu-xuan Qi, Jian-yong Zheng, Si-qi Hao, Wen-wen Hao, Yi Du, Wen-jing Li, Li-xin An
    Chinese Journal of Integrative Medicine.2026; 32(8): 720.     CrossRef
  • Nationwide Survey on Endoscopic Submucosal Dissection for Early Gastric Cancer in Korea: Results From the Korean College of Helicobacter and Upper Gastrointestinal Research (KCHUGR) 2023 Survey
    Jae Yong Park, Jeong Hoon Lee, Tae-Se Kim, Da Hyun Jung, Bong Eun Lee, Yonghoon Choi, Wan-Sik Lee, Young-Il Kim, Sun Hyung Kang, Hyunsoo Chung, Su Jin Kim, Joon Sung Kim, Donghoon Kang, Su Youn Nam, Seung Han Kim, Hyo-Joon Yang, Hyun Lim, Jin Lee, Seon-Yo
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2026; 26(1): 50.     CrossRef
  • Nationwide Survey on Endoscopic Submucosal Dissection for Early Gastric Cancer in Korea: Results From the Korean College of Helicobacter and Upper Gastrointestinal Research (KCHUGR) 2023 Survey
    Jae Yong Park, Jeong Hoon Lee, Tae-Se Kim, Da Hyun Jung, Bong Eun Lee, Yonghoon Choi, Wan-Sik Lee, Young-Il Kim, Sun Hyung Kang, Hyunsoo Chung, Su Jin Kim, Joon Sung Kim, Donghoon Kang, Su Youn Nam, Seung Han Kim, Hyo-Joon Yang, Hyun Lim, Jin Lee, Seon-Yo
    Journal of Gastric Cancer.2026; 26(2): 169.     CrossRef
  • Metformin for preventing esophageal stricture after circumferential endoscopic submucosal dissection in a canine model
    Ling Yang, Binbin Xu, Chunwei Fan, Yuju Huang, Li Yu
    Gastroenterology Report.2026;[Epub]     CrossRef
  • Feasibility of Zeosuture M for gastric endoscopic submucosal dissection defect closure during anticoagulation: a preclinical porcine study from Japan
    Yohei Minato, Tadateru Maehata, Yoshinori Sato, Fumio Itoh, Ken Ohata, Keisuke Tateishi
    Clinical Endoscopy.2026; 59(4): 593.     CrossRef
  • Mitigating risk following upper gastrointestinal Endoscopic Submucosal Dissection: preventing bleeding, perforation and stricture formation
    Giulio Calabrese, Rossella Maresca, Livio Bonacci, Tommaso Rozera, Giuseppe Spinosa, Federico Barbaro, Sandro Sferrazza
    Best Practice & Research Clinical Gastroenterology.2026; : 102126.     CrossRef
  • The Current Landscape of Endoscopic Submucosal Training in the United States
    Mike T. Wei, Shai Friedland, Joo Ha Hwang
    Current Gastroenterology Reports.2025;[Epub]     CrossRef
  • Gastric polyps are not created equal: Know your enemy
    Fady Daniel
    World Journal of Gastroenterology.2025;[Epub]     CrossRef
  • Endoscopic Resection for Superficial Non-Ampullary Duodenal Epithelial Tumors
    Hye Kyung Jeon, Gwang Ha Kim
    Gut and Liver.2025; 19(1): 19.     CrossRef
  • Diagnosis and treatment of three synchronous early squamous cell carcinomas of the esophagus: case report
    A.A. Paratovskaya, M.Yu. Agapov, N.A. Belinskaya, T.F. Savostyanov, E.E. Topuzov
    Russian Journal of Evidence-Based Gastroenterology.2025; 14(1): 104.     CrossRef
  • Primary esophageal lymphoma: An individual participant data meta-analysis
    Adam Mylonakis, Maria Dimitrakoudi, Diamantina Vasilatou, Dimitrios Tsapralis, Georgios Vasiliadis, Nikolaos Koliakos, Panagiotis Sakarellos, Emmanouil I. Kapetanakis, Dimitrios Schizas
    Surgery.2025; 185: 109534.     CrossRef
  • Duodenal mucosal autotransplantation
    Kambiz Kadkhodayan, Shayan Irani, Saurabh Chandan, Sagar Pathak, Maham Hayat, Abdullah Abbasi, Muhammad K. Hasan, Natalie Cosgrove, Deepanshu Jain, Dennis Yang, Charanjeet Singh
    VideoGIE.2025; 10(10): 529.     CrossRef
  • Evaluation of a modified underwater endoscopic mucosal resection technique for duodenal neoplasms: clinical implications and future directions
    Ji Yong Ahn
    Clinical Endoscopy.2025; 58(4): 544.     CrossRef
  • Clinicopathologic Factors Influencing Endoscopic Versus Surgical Approaches in Patients With T1b Gastric Carcinoma With Lymphoid Stroma
    Sun Mi Lee, Ji Young Kim
    Journal of Surgical Oncology.2025; 132(5): 876.     CrossRef
  • Value of endoscopic submucosal dissection in diagnosing gastric mucosa-associated lymphoid tissue lymphoma: A case report
    Shuo-Hui Li, Wei-Wei Niu, Xiao-Xia Huo, Hong Zhang, Li-Min Shi, Ya-Ting Liu, Jia-Jing Xing, Zhi-Xin Feng, Na Wang
    World Journal of Gastroenterology.2025;[Epub]     CrossRef
  • Endoscopic closure for mucosal defects after endoscopic resection of gastrointestinal tumors
    Gwang Ha Kim
    Journal of Innovative Medical Technology.2025; 3(2): 50.     CrossRef
  • International Digestive Endoscopy Network consensus on the management of antithrombotic agents in patients undergoing gastrointestinal endoscopy
    Seung Joo Kang, Chung Hyun Tae, Chang Seok Bang, Cheol Min Shin, Young-Hoon Jeong, Miyoung Choi, Joo Ha Hwang, Yutaka Saito, Philip Wai Yan Chiu, Rungsun Rerknimitr, Christopher Khor, Vu Van Khien, Kee Don Choi, Ki-Nam Shim, Geun Am Song, Oh Young Lee
    Clinical Endoscopy.2024; 57(2): 141.     CrossRef
  • Risk factors for intraoperative and delayed perforation related with gastric endoscopic submucosal dissection
    Takuya Mimura, Yoshinobu Yamamoto, Haruhisa Suzuki, Kohei Takizawa, Toshiaki Hirasawa, Yoji Takeuchi, Kenji Ishido, Shu Hoteya, Tomonori Yano, Shinji Tanaka, Norihiko Kudara, Masahiro Nakagawa, Yumi Mashimo, Masahiro Ishigooka, Kazutoshi Fukase, Taichi Sh
    Journal of Gastroenterology and Hepatology.2024; 39(7): 1358.     CrossRef
  • IDEN Consensus on Management of Antithrombotic Agents in Patients Undergoing Gastrointestinal Endoscopy
    Seung Joo Kang, Chung Hyun Tae, Chang Seok Bang, Cheol Min Shin, Young-Hoon Jeong, Miyoung Choi, Joo Ha Hwang, Yutaka Saito, Philip Wai Yan Chiu, Rungsun Rerknimitr, Christopher Khor, Vu Van Khien, Kee Don Choi, Ki-Nam Shim, Geun Am Song, Oh Young Lee
    The Korean Journal of Gastroenterology.2024; 83(6): 217.     CrossRef
  • International Digestive Endoscopy Network Consensus on the Management of Antithrombotic Agents in Patients Undergoing Gastrointestinal Endoscopy
    Seung Joo Kang, Chung Hyun Tae, Chang Seok Bang, Cheol Min Shin, Young-Hoon Jeong, Miyoung Choi, Joo Ha Hwang, Yutaka Saito, Philip Wai Yan Chiu, Rungsun Rerknimitr, Christopher Khor, Vu Van Khien, Kee Don Choi, Ki-Nam Shim, Geun Am Song, Oh Young Lee
    Gut and Liver.2024; 18(5): 764.     CrossRef
  • Endoscopic submucosal dissection for early gastric cancer: It is time to consider the quality of its outcomes
    Gwang Ha Kim
    World Journal of Gastroenterology.2023; 29(43): 5800.     CrossRef
  • 14,886 View
  • 316 Download
  • 17 Web of Science
  • 21 Crossref
Close layer
Original Article
Evaluation of a new method, “non-injection resection using bipolar soft coagulation mode (NIRBS)”, for colonic adenomatous lesions
Mitsuo Tokuhara, Masaaki Shimatani, Kazunari Tominaga, Hiroko Nakahira, Takuya Ohtsu, Katsuyasu Kouda, Makoto Naganuma
Clin Endosc 2023;56(5):623-632.   Published online May 18, 2023
DOI: https://doi.org/10.5946/ce.2022.200
Graphical AbstractGraphical Abstract AbstractAbstract PDFSupplementary Material
Background
/Aims: Endoscopic resection of all colorectal adenomatous lesions with a low complication rate, simplicity, and negative residuals is challenging. Hence, we developed a new method called “non-injection resection using bipolar soft coagulation mode (NIRBS)” method, adapted for colorectal lesions. In addition, we evaluated the effectiveness of this method.
Methods
We performed NIRBS throughout a 12-month period for all colorectal lesions which snare resection was acceptable without cancerous lesions infiltrating deeper than the submucosal layer.
Results
A total of 746 resected lesions were included in the study, with a 4.5 mm mean size (range, 1–35 mm). The major pathological breakdowns were as follows: 64.3% (480/746) were adenomas, and 5.0% (37/746) were intraepithelial adenocarcinomas (Tis lesions). No residuals were observed in any of the 37 Tis lesions (mean size, 15.3 mm). Adverse events included bleeding (0.4%) but no perforation.
Conclusions
NIRBS allowed the resection of multiple lesions with simplicity because of the non-injection and without perforating due to the minimal burn effect of the bipolar snare set in the soft coagulation mode. Therefore, NIRBS can be used to resect adenomatous lesions easily, including Tis lesions, from small to large lesions without leaving residuals.

Citations

Citations to this article as recorded by  
  • Depth of noninjecting resection using bipolar soft coagulation mode for 6 to 9 mm colorectal polyps: a retrospective study in Japan
    Yoshifumi Watanabe, Mitsuo Tokuhara, Hidetoshi Nakata, Hiroko Nakahira, Ikuko Torii, Yasumasa Sumitomo
    Clinical Endoscopy.2026; 59(1): 115.     CrossRef
  • International Digestive Endoscopy Network consensus on the management of antithrombotic agents in patients undergoing gastrointestinal endoscopy
    Seung Joo Kang, Chung Hyun Tae, Chang Seok Bang, Cheol Min Shin, Young-Hoon Jeong, Miyoung Choi, Joo Ha Hwang, Yutaka Saito, Philip Wai Yan Chiu, Rungsun Rerknimitr, Christopher Khor, Vu Van Khien, Kee Don Choi, Ki-Nam Shim, Geun Am Song, Oh Young Lee
    Clinical Endoscopy.2024; 57(2): 141.     CrossRef
  • IDEN Consensus on Management of Antithrombotic Agents in Patients Undergoing Gastrointestinal Endoscopy
    Seung Joo Kang, Chung Hyun Tae, Chang Seok Bang, Cheol Min Shin, Young-Hoon Jeong, Miyoung Choi, Joo Ha Hwang, Yutaka Saito, Philip Wai Yan Chiu, Rungsun Rerknimitr, Christopher Khor, Vu Van Khien, Kee Don Choi, Ki-Nam Shim, Geun Am Song, Oh Young Lee
    The Korean Journal of Gastroenterology.2024; 83(6): 217.     CrossRef
  • International Digestive Endoscopy Network Consensus on the Management of Antithrombotic Agents in Patients Undergoing Gastrointestinal Endoscopy
    Seung Joo Kang, Chung Hyun Tae, Chang Seok Bang, Cheol Min Shin, Young-Hoon Jeong, Miyoung Choi, Joo Ha Hwang, Yutaka Saito, Philip Wai Yan Chiu, Rungsun Rerknimitr, Christopher Khor, Vu Van Khien, Kee Don Choi, Ki-Nam Shim, Geun Am Song, Oh Young Lee
    Gut and Liver.2024; 18(5): 764.     CrossRef
  • A method of “Noninjecting Resection using Bipolar Soft coagulation mode; NIRBS” for superficial non-ampullary duodenal epithelial tumor: a pilot study
    Mitsuo Tokuhara, Yasushi Sano, Yoshifumi Watanabe, Hidetoshi Nakata, Hiroko Nakahira, Shingo Furukawa, Takuya Ohtsu, Naohiro Nakamura, Takashi Ito, Ikuko Torii, Takeshi Yamashina, Masaaki Shimatani, Makoto Naganuma
    BMC Gastroenterology.2024;[Epub]     CrossRef
  • 7,537 View
  • 128 Download
  • 5 Web of Science
  • 5 Crossref
Close layer
Reviews
Endoscopic treatment for rectal neuroendocrine tumor: which method is better?
Seung Min Hong, Dong Hoon Baek
Clin Endosc 2022;55(4):496-506.   Published online July 11, 2022
DOI: https://doi.org/10.5946/ce.2022.115
AbstractAbstract PDF
Recently, research on rectal neuroendocrine tumors (NETs) has increased during the last few decades. Rectal NETs measuring <10 mm without atypical features and confined to the submucosal layer have only 1% risk of metastasis, and the long-term survival probability of patients without metastasis at the time of diagnosis is approximately 100%. Therefore, the current guidelines suggest endoscopic resection of rectal NETs of <10 mm is regarded as a safe therapeutic option. However, there are currently no clear recommendations for technique selection for endoscopic resection. The choice of treatment modality for rectal NETs should be based on the lesion size, endoscopic characteristics, grade of differentiation, depth of vertical involvement, lymphovascular invasion, and risk of metastasis. Moreover, the complete resection rate, complications, and experience at the center should be considered. Modified endoscopic mucosal resection is the most suitable resection method for rectal NETs of <10 mm, because it is an effective and safe technique that is relatively simple and less time-consuming compared with endoscopic submucosal dissection. Endoscopic submucosal dissection should be considered when the tumor size is >10 mm, suctioning is not possible due to fibrosis in the lesion, or when the snaring for modified endoscopic mucosal resection does not work well.

Citations

Citations to this article as recorded by  
  • Response
    Tomoya Ueda, Shunsuke Yoshii
    Gastrointestinal Endoscopy.2026; 103(2): 392.     CrossRef
  • Is salvage treatment necessary after incomplete resection of rectal neuroendocrine tumors: A systematic review and meta-analysis
    Jae Hyun Kim, Jung Won Lee, Hyun Jung Kim, Seung Min Hong, Seun Ja Park
    World Journal of Gastroenterology.2026;[Epub]     CrossRef
  • Defining endoscopic candidacy for intermediate size rectal neuroendocrine tumors
    Yu-Hang Sheng, Qi-Yang Chen, Xiao-Meng Li, Zhi-Xiang Zhou, Tian-Le Xue
    World Journal of Gastroenterology.2026;[Epub]     CrossRef
  • Optimal endoscopic treatment for rectal neuroendocrine tumors, confirmed after forceps biopsy: a Korean Association for the Study of Intestinal Diseases multicenter, randomized noninferiority trial
    Tae-Geun Gweon, Seong-Jung Kim, Dae Seong Myung, Yunho Jung, Jun Lee, Dong-Hoon Yang
    Gastrointestinal Endoscopy.2026; 104(1): 86.     CrossRef
  • A rare cause of subepithelial tumor in the rectum
    Yong Bo Park, Dong Hoon Baek
    Clinical Endoscopy.2026; 59(2): 320.     CrossRef
  • Recent updates on the endoscopic treatment of rectal neuroendocrine tumor
    Sunghyeok Ryou, Kwangwoo Nam
    Intestinal Research.2026; 24(2): 208.     CrossRef
  • Comparison between ligation-assisted and precutting endoscopic mucosal resection for small rectal neuroendocrine tumors: a CHASID study
    Sunghyeok Ryou, Yunho Jung, Dae Sung Kim, Hee Seok Moon, Hoon Sup Koo, Hyun Deok Shin, Ki Bae Bang, Kyu Chan Huh
    The Korean Journal of Internal Medicine.2026; 41(3): 432.     CrossRef
  • Predicting Remnant Tumor After Incomplete Resection of Rectal Neuroendocrine Tumors: The KASID Multicenter Retrospective Cohort Study
    Hyung‐Hoon Oh, Jae‐Gon Lee, Jung‐Hyun Ji, Seoyoon Choi, Ki‐Young Lim, Hyeong‐Ho Jo, Chang‐Kyo Oh, Shin‐Ju Oh, Dong‐Hyun Kim, Eunmi Song, Jaeyoung Chun, Young‐Eun Joo, Yunho Jung
    Journal of Gastroenterology and Hepatology.2026; 41(8): 2365.     CrossRef
  • NANETS Guidelines for the diagnosis and management of stage I–III rectal neuroendocrine tumors
    Hagen Kennecke, Ebrahim Delpassand, Seth Felder, Ferga Gleeson, Julie Hallet, David Horowitz, Martin Hyrcza, Bryson W Katona, Maria Kiely, Michelle Kim, Nadine Mallak, Vicky Parkins, Madhulika G Varma, Janice Pasieka
    Endocrine-Related Cancer.2026;[Epub]     CrossRef
  • Rectal mantle cell lymphoma endoscopically mimicking ulcerative proctitis: A case report
    Karam Karam, Kim Charro, Dorra Kechaou, Wajed Abarah, Jacquot Rakotobe, Christophe Locher
    World Journal of Clinical Cases.2026;[Epub]     CrossRef
  • Establishment of a swine model of delayed bleeding after endoscopic procedure
    Shohei Uehara, Fumisato Sasaki, Hisashi Sahara, Akihito Tanaka, Makoto Hinokuchi, Hidehito Maeda, Shiho Arima, Shinichi Hashimoto, Shuji Kanmura, Akio Ido
    DEN Open.2025;[Epub]     CrossRef
  • Rare Case of Mantle Cell Lymphoma With Multiple Rectal Lesions
    Lumir Kunovsky, Eliska Tvrdikova, Jozef Michalka, Jan Trna
    United European Gastroenterology Journal.2025; 13(5): 831.     CrossRef
  • Metachronous Liver Metastasis during Long-term Follow-up after Endoscopic Submucosal Dissection of a Small Rectal Neuroendocrine Neoplasm
    Yasuhiko Hamada, Masahiko Tameda, Hayato Nakagawa
    Internal Medicine.2025; 64(15): 2323.     CrossRef
  • Comparison of endoscopic submucosal dissection and modified endoscopic mucosal resection for rectal neuroendocrine tumors
    Yoshiyasu Kitagawa, Takuto Suzuki, Akihiro Miyakawa, Kenichiro Okimoto, Tomoaki Matsumura, Toshiyasu Shiratori, Hideaki Ishigami, Takeshi Mine, Hideyuki Takashiro, Hirofumi Saito, Naoya Kato
    Scientific Reports.2025;[Epub]     CrossRef
  • Endoscopic full-thickness resection: A definitive solution for local complete resection of small rectal neuroendocrine neoplasms
    Xiao-Long Zhang, Yang-Yang Jiang, Ying-Ying Chang, Yu-Li Sun, Ying Zhou, Yao-Hui Wang, Xiao-Tan Dou, Hui-Min Guo, Ting-Sheng Ling
    World Journal of Gastroenterology.2025;[Epub]     CrossRef
  • Band ligation EMR is safe and effective technique for removal of gastric NENs
    M Lucarini, M Costetti, G Sereni, C Manzotti, S Romano
    Endoscopy.2025; 57(S 02): S483.     CrossRef
  • Endoscopic resection of rectal neuroendocrine tumors: zero disease-related deaths during a 10-year follow-up period
    Yasuyo Hayashi, Haruei Ogino, Yosuke Minoda, Yoshimasa Tanaka, Yoshitaka Hata, Masaru Kubokawa, Seiichiro Sakisaka, Kazuhiro Haraguchi, Shin-ichiro Fukuda, Soichi Itaba, Daisuke Yoshimura, Shunsuke Takahashi, Munehiro Tanaka, Hiroaki Kubo, Shinichi Somada
    BMC Gastroenterology.2025;[Epub]     CrossRef
  • Double Band Ligation-Assisted Endoscopic Submucosal Resection for Rectal Neuroendocrine Tumors: Comparison With Conventional Endoscopic Mucosal Resection With Ligation (With Video)
    Yuan Gao, Liansong Ye, Xu Li, Long He, Bin Yu, Wei Liu, Yuwan Cao, Liuxiang Chen, Yi Mou, Ou Chen, Jia Xie, Jiang Du, Qiongying Zhang, Bing Hu
    Clinical and Translational Gastroenterology.2025; 16(5): e00830.     CrossRef
  • Risk factors for residual tumors in histologically incompletely resected rectal neuroendocrine tumors
    Jung-Bin Park, Ga Hee Kim, Minjun Kim, Seung Wook Hong, Sung Wook Hwang, Sang Hyoung Park, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Seok-Byung Lim, Seung-Mo Hong, Dong-Hoon Yang
    Digestive and Liver Disease.2025; 57(7): 1473.     CrossRef
  • A single center retrospective analysis of feasibility of diagnostic endoscopic resection for grade 1 or 2 gastric neuroendocrine tumors
    Jin Ook Jang, Won Jun Jang, Cheol Woong Choi, Eun Jeung Choi, Su Jin Kim, Dae Gon Ryu, Su Bum Park, Jae Hun Chung, Si Hak Lee, Sun Hwi Hwang
    Scientific Reports.2025;[Epub]     CrossRef
  • Submucosal saline injection and mini-probe endoscopic ultrasound to assess endoscopic resectability of colorectal subepithelial tumors
    Jung-Bin Park, Ji Eun Baek, June Hwa Bae, Seung Wook Hong, Sung Wook Hwang, Sang Hyoung Park, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Dong-Hoon Yang
    The Korean Journal of Internal Medicine.2025; 40(4): 592.     CrossRef
  • Long-term outcomes of endoscopic resection of 1-1.5 cm sized grade 1 rectal neuroendocrine tumor: A retrospective study
    Minjee Kim, Yuwon Kim, Ji Eun Kim, Sung Noh Hong, Dong Kyung Chang, Young-Ho Kim, Eun Ran Kim
    World Journal of Gastroenterology.2025;[Epub]     CrossRef
  • Redefining therapeutic thresholds and global guidelines: Toward precision management of intermediate-sized rectal neuroendocrine tumors
    Dan Hu, Jiang Yu, Meng-Xue Wang, Hao-Ling Zhang
    World Journal of Gastroenterology.2025;[Epub]     CrossRef
  • Long-term outcome of grade 1 rectal neuroendocrine tumor ≤1 cm after incomplete endoscopic resection
    Jong Sun Park, Hye Lynn Jeon, Bumhee Park, Jong Hoon Park, Gil Ho Lee, Sun Gyo Lim, Sung Jae Shin, Kee Myung Lee, Choong-Kyun Noh
    Clinical Endoscopy.2025; 58(6): 871.     CrossRef
  • Endoscopic Resection of Rectal Neuroendocrine Tumors: Pathologic Risk Stratification and Surveillance Strategies
    Ji Eun Kim
    Journal of Digestive Cancer Research.2025; 13(3): 228.     CrossRef
  • Treatment strategy and post‐treatment management of colorectal neuroendocrine tumor
    Masau Sekiguchi, Takahisa Matsuda, Yutaka Saito
    DEN Open.2024;[Epub]     CrossRef
  • Comparison of endoscopic resection therapies for rectal neuroendocrine tumors
    Meijiao Lu, Hongxia Cui, Mingjie Qian, Yating Shen, Jianhong Zhu
    Minimally Invasive Therapy & Allied Technologies.2024; 33(4): 207.     CrossRef
  • Effective utilization of polypectomy in endoscopic salvage treatment of rectal neuroendocrine tumors: a retrospective cohort study
    Yeonuk Ju, Jun woo Bong, Chinock Cheong, Sanghee Kang, Byung wook Min, Sun il Lee
    Annals of Surgical Treatment and Research.2024; 107(3): 151.     CrossRef
  • A Review of Colonoscopy in Intestinal Diseases
    Seung Hong, Dong Baek
    Diagnostics.2023; 13(7): 1262.     CrossRef
  • Treatment of localized well-differentiated rectal neuroendocrine tumors: A focused review
    Shigenobu Emoto, Hiroaki Nozawa, Kazuhito Sasaki, Koji Murono, Hiroyuki Matsuzaki, Yuichiro Yokoyama, Shinya Abe, Yuzo Nagai, Yuichiro Yoshioka, Takahide Shinagawa, Hirofumi Sonoda, Soichiro Ishihara
    Formosan Journal of Surgery.2023; 56(3): 73.     CrossRef
  • Clinical application of endoscopic ultrasonography in the management of rectal neuroendocrine tumors
    Soo-Young Na, Seong Jung Kim, Hyoun Woo Kang
    International Journal of Gastrointestinal Intervention.2023; 12(3): 105.     CrossRef
  • Endoscopic submucosal dissection coupled with �modified clip coupled with elastic ring� traction removing rectal neuroendocrine tumor
    Jing Zhou, Li-Sheng Wang, De-Feng Li, Rui-Yue Shi
    Revista Española de Enfermedades Digestivas.2023;[Epub]     CrossRef
  • 13,496 View
  • 423 Download
  • 29 Web of Science
  • 32 Crossref
Close layer
Current Treatment Strategy for Superficial Nonampullary Duodenal Epithelial Tumors
Tetsuya Suwa, Kohei Takizawa, Noboru Kawata, Masao Yoshida, Yohei Yabuuchi, Yoichi Yamamoto, Hiroyuki Ono
Clin Endosc 2022;55(1):15-21.   Published online September 29, 2021
DOI: https://doi.org/10.5946/ce.2021.141
AbstractAbstract PDF
Endoscopic submucosal dissection (ESD) is the standard treatment method for esophageal, gastric, and colorectal cancers. However, it has not been standardized for duodenal lesions because of its high complication rates. Recently, minimally invasive and simple methods such as cold snare polypectomy and underwater endoscopic mucosal resection have been utilized more for superficial nonampullary duodenal epithelial tumors (SNADETs). Although the rate of complications associated with duodenal ESD has been gradually decreasing because of technical advancements, performing ESD for all SNADETs is unnecessary. As such, the appropriate treatment plan for SNADETs should be chosen according to the lesion type, patient condition, and endoscopist’s skill.

Citations

Citations to this article as recorded by  
  • Efficacy and safety of cold snare polypectomy using a spike snare for duodenal adenomas : an observational study
    Soo Bin Synn, Su Jin Kim
    Journal of Innovative Medical Technology.2026; 4(1): 20.     CrossRef
  • Clinical Outcomes of Underwater Endoscopic Submucosal Dissection for Duodenal Tumors: A Systematic Review and Meta‐Analysis
    Kumiko Kirita, Teppei Akimoto, Yasunori Sato, Motoki Sasaki, Maya Ishizawa, Mai Owada, Ai Katsumi, Yuki Kubo, Misaki Sugawara, Rei Mizobe, Shoma Murata, Yuri Imura, Hinako Sakurai, Anna Tojo, Kurato Miyazaki, Teppei Masunaga, Mari Mizutani, Yusaku Takator
    Digestive Endoscopy.2026;[Epub]     CrossRef
  • Endoscopic Resection for Superficial Non-Ampullary Duodenal Epithelial Tumors
    Hye Kyung Jeon, Gwang Ha Kim
    Gut and Liver.2025; 19(1): 19.     CrossRef
  • Utility of underwater endoscopic mucosal resection combined with a protruding anchor by saline injection for superficial non-ampullary duodenal tumors: a retrospective study in Japan
    Yoshie Nomoto, Satoshi Shinozaki, Yoshimasa Miura, Hiroyuki Osawa, Yuji Ino, Tomonori Yano, Nikolaos Lazaridis, Hironori Yamamoto
    Clinical Endoscopy.2025; 58(4): 561.     CrossRef
  • Management of Adverse Events Related to Endoscopic Resection for Superficial Non-Ampullary Duodenal Epithelial Tumors
    Osamu Dohi, Tomoko Ochiai, Mayuko Seya, Katsuma Yamauchi, Naoto Iwai, Reo Kobayashi, Ryohei Hirose, Elsayed Ghoneem, Ken Inoue, Naohisa Yoshida
    Digestion.2025; 107(3): 261.     CrossRef
  • Endoscopic diagnosis and treatment of superficial nonampullary duodenal epithelial neoplasms: Current status and future perspectives
    Yu Zhang, Man-Li Cui, Ming-Xin Zhang, Chao Sun
    World Chinese Journal of Digestology.2025; 33(8): 609.     CrossRef
  • Current Management of Duodenal Neoplasia: Endoscopic Treatment for Large Superficial Non-Ampullary Duodenal Epithelial Tumor
    Kurato Miyazaki, Naohisa Yahagi, Motohiko Kato
    Digestion.2025; 107(3): 282.     CrossRef
  • Reply to the comments on ‘Utility of underwater endoscopic mucosal resection combined with a protruding anchor by saline injection for superficial non-ampullary duodenal tumors: a retrospective study in Japan'
    Hironori Yamamoto, Yoshie Nomoto, Satoshi Shinozaki, Yoshimasa Miura, Hiroyuki Osawa
    Clinical Endoscopy.2025; 58(6): 953.     CrossRef
  • International Digestive Endoscopy Network consensus on the management of antithrombotic agents in patients undergoing gastrointestinal endoscopy
    Seung Joo Kang, Chung Hyun Tae, Chang Seok Bang, Cheol Min Shin, Young-Hoon Jeong, Miyoung Choi, Joo Ha Hwang, Yutaka Saito, Philip Wai Yan Chiu, Rungsun Rerknimitr, Christopher Khor, Vu Van Khien, Kee Don Choi, Ki-Nam Shim, Geun Am Song, Oh Young Lee
    Clinical Endoscopy.2024; 57(2): 141.     CrossRef
  • IDEN Consensus on Management of Antithrombotic Agents in Patients Undergoing Gastrointestinal Endoscopy
    Seung Joo Kang, Chung Hyun Tae, Chang Seok Bang, Cheol Min Shin, Young-Hoon Jeong, Miyoung Choi, Joo Ha Hwang, Yutaka Saito, Philip Wai Yan Chiu, Rungsun Rerknimitr, Christopher Khor, Vu Van Khien, Kee Don Choi, Ki-Nam Shim, Geun Am Song, Oh Young Lee
    The Korean Journal of Gastroenterology.2024; 83(6): 217.     CrossRef
  • International Digestive Endoscopy Network Consensus on the Management of Antithrombotic Agents in Patients Undergoing Gastrointestinal Endoscopy
    Seung Joo Kang, Chung Hyun Tae, Chang Seok Bang, Cheol Min Shin, Young-Hoon Jeong, Miyoung Choi, Joo Ha Hwang, Yutaka Saito, Philip Wai Yan Chiu, Rungsun Rerknimitr, Christopher Khor, Vu Van Khien, Kee Don Choi, Ki-Nam Shim, Geun Am Song, Oh Young Lee
    Gut and Liver.2024; 18(5): 764.     CrossRef
  • A method of “Noninjecting Resection using Bipolar Soft coagulation mode; NIRBS” for superficial non-ampullary duodenal epithelial tumor: a pilot study
    Mitsuo Tokuhara, Yasushi Sano, Yoshifumi Watanabe, Hidetoshi Nakata, Hiroko Nakahira, Shingo Furukawa, Takuya Ohtsu, Naohiro Nakamura, Takashi Ito, Ikuko Torii, Takeshi Yamashina, Masaaki Shimatani, Makoto Naganuma
    BMC Gastroenterology.2024;[Epub]     CrossRef
  • Underwater Endoscopic Mucosal Resection Versus Conventional Endoscopic Mucosal Resection for Superficial Non-ampullary Duodenal Epithelial Tumors ≤20 mm
    Zhikun Yin, Ji Li, Weilin Yang, Weifeng Huang, Dong Xu, Xiaoyi Lei, Jinyan Zhang
    Journal of Clinical Gastroenterology.2023; 57(9): 928.     CrossRef
  • Long-term outcomes of endoscopic resection for duodenal neuroendocrine tumors
    Kiyoun Yi, Gwang Ha Kim, Su Jin Kim, Cheol Woong Choi, Moon Won Lee, Bong Eun Lee, Geun Am Song
    Scientific Reports.2023;[Epub]     CrossRef
  • Endoscopic management of NADTs
    Enrique Pérez-Cuadrado-Robles, Pierre H. Deprez
    Endoscopy International Open.2022; 10(06): E733.     CrossRef
  • Duodenaladenome und -karzinome: chirurgische Therapiekonzepte
    Michael Ghadimi, Jochen Gaedcke
    Allgemein- und Viszeralchirurgie up2date.2022; 16(03): 257.     CrossRef
  • Issues and Prospects of Current Endoscopic Treatment Strategy for Superficial Non-Ampullary Duodenal Epithelial Tumors
    Tetsuya Suwa, Masao Yoshida, Hiroyuki Ono
    Current Oncology.2022; 29(10): 6816.     CrossRef
  • Duodenaladenome und -karzinome: chirurgische Therapiekonzepte
    Michael Ghadimi, Jochen Gaedcke
    Onkologie up2date.2022; 4(04): 325.     CrossRef
  • 11,510 View
  • 441 Download
  • 14 Web of Science
  • 18 Crossref
Close layer
Original Articles
Endoscopic Suturing for the Prevention and Treatment of Complications Associated with Endoscopic Mucosal Resection of Large Duodenal Adenomas
Jaeil Chung, Kelly Wang, Alexander Podboy, Srinivas Gaddam, Simon K. Lo
Clin Endosc 2022;55(1):95-100.   Published online March 3, 2021
DOI: https://doi.org/10.5946/ce.2020.281
AbstractAbstract PDF
Background
/Aims: Endoscopic mucosal resection (EMR) is the primary treatment for duodenal adenomas; however, it is associated with a high risk of perforation and bleeding, especially with larger lesions. The goal of this study was to demonstrate the feasibility and safety of endoscopic suturing (ES) for the closure of mucosal defects after duodenal EMR.
Methods
Consecutive adult patients who underwent ES of large mucosal defects after EMR of large (>2 cm) duodenal adenomas were retrospectively enrolled. The OverStitch ES system was employed for closing mucosal defects after EMR. Clinical outcomes and complications, including delayed bleeding and perforation, were documented.
Results
During the study period, ES of mucosal defects was performed in seven patients in eight sessions (six for prophylaxis and two for the treatment of perforation). All ES sessions were technically successful. No early or delayed post-EMR bleeding was recorded. In addition, no clinically obvious duodenal stricture or recurrence was encountered on endoscopic follow-up evaluation, and no patients required subsequent surgical intervention.
Conclusions
ES for the prevention and treatment of duodenal perforation after EMR is technically feasible, safe, and effective. ES should be considered an option for preventing or treating perforations associated with EMR of large duodenal adenomas.

Citations

Citations to this article as recorded by  
  • Application of Plan-Do-Check-Act cycle based on software, hardware, environment, liveware model in preventing infection after endoscopic mucosal resection
    Wen Li, Chun Liu, Hai-Yan Zhang
    World Journal of Gastrointestinal Surgery.2026;[Epub]     CrossRef
  • Management of non-ampullary duodenal adenomas
    Gaurav B Nigam, Yash Kanani, Amol Bapaye, Pradeep Mundre
    Frontline Gastroenterology.2026; 17(e1): e48.     CrossRef
  • Free‐Hand Endoscopic Full‐Thickness Resection for Duodenal Subepithelial Lesions
    Peirong Xu, Zuqiang Liu, Li Wang, Yifan Qu, Chenchao Xu, Anyi Xiang, Wei Su, Tao Tan, Jiyuan Zhang, Lu Yao, Meidong Xu, Yunshi Zhong, Quanlin Li, Pinghong Zhou, Hao Hu
    Journal of Gastroenterology and Hepatology.2025; 40(4): 907.     CrossRef
  • Endoscopic Resection for Superficial Non-Ampullary Duodenal Epithelial Tumors
    Hye Kyung Jeon, Gwang Ha Kim
    Gut and Liver.2025; 19(1): 19.     CrossRef
  • Adaption of novel clip-closure technique for large mucosal defects after EMR of a colon laterally spreading tumor using standard hemostatic clips
    Hannah Saven, Andrew Canakis, Raymond E. Kim
    VideoGIE.2024; 9(1): 42.     CrossRef
  • Stapfer I and II duodenal perforations after endoscopic procedures: how surgical delay impacts outcomes
    Quentin Chenevas-Paule, Anaïs Palen, Marc Giovannini, Jacques Ewald, Jean Philippe Ratone, Fabrice Caillol, Solène Hoibian, Yanis Dahel, Olivier Turrini, Jonathan Garnier
    Surgical Endoscopy.2024; 38(11): 6614.     CrossRef
  • Through-the-scope suture closure of nonampullary duodenal endoscopic mucosal resection defects: a retrospective multicenter cohort study
    Jose Antonio Almario, Linda Y. Zhang, Jonathan Cohen, Gregory B. Haber, Hemchand Ramberan, Andrew C. Storm, Stuart Gordon, Jeffrey M. Adler, Heiko Pohl, Alexander Schlachterman, Anand Kumar, Shailendra Singh, Bashar Qumseya, Peter V. Draganov, Nikhil A. K
    Endoscopy.2023; 55(09): 865.     CrossRef
  • Double-scope technique to recover from hand-suturing trouble in the duodenum
    Leonardo Yoshio Sato, Yoshitaka Hata, Mitsuru Esaki, Eikichi Ihara, Shiho Tajiri, Tomohiko Moriyama, Yosuke Minoda
    Endoscopy.2023; 55(S 01): E1193.     CrossRef
  • Initial multicenter experience using a novel endoscopic tack and suture system for challenging GI defect closure and stent fixation (with video)
    Tala Mahmoud, Louis M. Wong Kee Song, Stavros N. Stavropoulos, Tarek H. Alansari, Hemchand Ramberan, Norio Fukami, Neil B. Marya, Prashanth Rau, Christopher Marshall, Bachir Ghandour, Michael Bejjani, Mouen A. Khashab, Gregory B. Haber, Hiroyuki Aihara, M
    Gastrointestinal Endoscopy.2022; 95(2): 373.     CrossRef
  • Endoscopic management of non-ampullary duodenal adenomas
    Maxime Amoyel, Arthur Belle, Marion Dhooge, Einas Abou Ali, Rachel Hallit, Frederic Prat, Anthony Dohan, Benoit Terris, Stanislas Chaussade, Romain Coriat, Maximilien Barret
    Endoscopy International Open.2022; 10(01): E96.     CrossRef
  • Outcomes of endoscopic mucosal resection for large superficial non-ampullary duodenal adenomas
    Maxime Amoyel, Arthur Belle, Marion Dhooge, Einas Abou Ali, Anna Pellat, Rachel Hallit, Benoit Terris, Frédéric Prat, Stanislas Chaussade, Romain Coriat, Maximilien Barret
    Scientific Reports.2022;[Epub]     CrossRef
  • Effectiveness and safety of endoscopic resection for duodenal gastrointestinal stromal tumors: A single center analysis
    Zhen-Zhen Wang, Xiao-Dan Yan, Hai-Deng Yang, Xin-Li Mao, Yue Cai, Xin-Yu Fu, Shao-Wei Li
    World Journal of Gastrointestinal Endoscopy.2022; 14(11): 684.     CrossRef
  • 8,600 View
  • 215 Download
  • 10 Web of Science
  • 12 Crossref
Close layer
Efficacy of Underwater Endoscopic Mucosal Resection for Superficial Non-Ampullary Duodenal Epithelial Tumor
Masanori Furukawa, Akira Mitoro, Takahiro Ozutumi, Yukihisa Fujinaga, Keisuke Nakanishi, Koh Kitagawa, Soichiro Saikawa, Sinya Sato, Yasuhiko Sawada, Hiroaki Takaya, Kosuke Kaji, Hideto Kawaratani, Tadashi Namisaki, Kei Moriya, Takemi Akahane, Junichi Yamao, Hitoshi Yoshiji
Clin Endosc 2021;54(3):371-378.   Published online February 18, 2021
DOI: https://doi.org/10.5946/ce.2020.147
AbstractAbstract PDF
Background
/Aims: Endoscopic resection (ER) for superficial non-ampullary duodenal epithelial tumors (SNADETs) is challenging. Conventional endoscopic mucosal resection (CEMR) is also problematic due to the anatomical features of the duodenum. We compared the safety and efficacy of underwater endoscopic mucosal resection (UEMR) with those of CEMR through a retrospective analysis.
Methods
Altogether, 44 consecutive patients with 46 SNADETs underwent ER (18 CEMR cases and 28 UEMR cases) between January 2016 and October 2019. We investigated the proportions of en bloc resection, R0 resection, complications, resection time, and total procedure time and compared the outcomes of patients from the CEMR group with those of patients from the UEMR group.
Results
The median tumor size was 8.0 mm (range, 2.0–20.0 mm). The UEMR group showed a higher proportion of en bloc resection (96.4% vs. 72.2%, p<0.05) and significantly lower median resection time and total procedure time (4 min vs. 9.5 min, p<0.05 and 13 min vs. 19 min, p<0.05; respectively) than the CEMR group. No complications were observed. However, two patients treated with piecemeal resection in the CEMR group had residual tumors.
Conclusions
UEMR is a feasible therapeutic option for SNADETs. It can be recommended as a standard treatment.

Citations

Citations to this article as recorded by  
  • High Rates of Defect Closure After Resection of Large Nonpedunculated Colorectal Lesions Using a Through‐The‐Scope Clip With Anchor Prongs
    Daniel von Renteln, Douglas K. Rex, Heiko Pohl, Nikhil A. Kumta, Shannon Chan, Marvin Ryou, Zaheer Nabi, Ping Hong Zhou, Haruhiro Inoue, Joyce A. Peetermans, Matthew J. Rousseau, Jeffrey D. Mosko
    United European Gastroenterology Journal.2026;[Epub]     CrossRef
  • Overtube Use Reduces the Incidence of Aspiration Pneumonia Following Gastric Endoscopic Submucosal Dissection: A Large, Single‐Center Japanese Experience
    Satoshi Iwai, Yukihisa Fujinaga, Hitoshi Mori, Masayoshi Takami, Jun‐ichi Hanatani, Hiroyuki Masuda, Akihiko Shibamoto, Shohei Asada, Yuki Tsuji, Shinya Sato, Norihisa Nishimura, Koh Kitagawa, Kosuke Kaji, Tadashi Namisaki, Akira Mitoro, Hitoshi Yoshiji
    DEN Open.2026;[Epub]     CrossRef
  • Underwater Versus Conventional EMR for Superficial Nonampullary Duodenal Tumors ≤20 mm
    Abdallfatah Abdallfatah, Samaa Daoud, Ahmed W. Hageen, Donia T. Mahdy, Hazem Abosheaisha, Douglas G. Adler
    Journal of Clinical Gastroenterology.2026; 60(6): 490.     CrossRef
  • Predictors of local recurrence and piecemeal resection in duodenal underwater endoscopic mucosal resection
    Daisuke Minezaki, Teppei Akimoto, Motoki Sasaki, Shoma Murata, Yuri Imura, Anna Tojo, Hinako Sakurai, Kentaro Iwata, Kurato Miyazaki, Teppei Masunaga, Mari Mizutani, Kumiko Kirita, Koshiro Tsutsumi, Michiko Nishikawa, Yusaku Takatori, Shintaro Kawasaki, N
    iGIE.2026; 5(2): 151.     CrossRef
  • Diving Deep – Making It Safer: Underwater ESD for Large Duodenal LST Polyp
    Z Barić, I Skrlec, M Omae, K Grubelic Ravić
    Endoscopy.2026; 58(S 03): S760.     CrossRef
  • Endoscopic Diagnosis and Treatment for Superficial Non‐Ampullary Duodenal Epithelial Tumors
    Masao Yoshida
    Digestive Endoscopy.2026;[Epub]     CrossRef
  • Underwater Endoscopic Mucosal Resection Vs Conventional Endoscopic Mucosal Resection for Superficial Nonampullary Duodenal Epithelial Tumors in the Western Setting
    Rui Morais, José Amorim, Renato Medas, Bernardo Sousa-Pinto, João Santos-Antunes, Romain Legros, Jérémie Albouys, Frédéric Moll, Margarida Marques, Filipe Vilas-Boas, Eduardo Rodrigues-Pinto, Irene Gullo, Fátima Carneiro, Elisa Gravito Soares, Pedro Amaro
    Clinical Gastroenterology and Hepatology.2025; 23(1): 79.     CrossRef
  • Endoscopic Resection for Superficial Non-Ampullary Duodenal Epithelial Tumors
    Hye Kyung Jeon, Gwang Ha Kim
    Gut and Liver.2025; 19(1): 19.     CrossRef
  • Clinical outcomes of endoscopic mucosal resection for large superficial nonampullary duodenal epithelial tumor: a single-center study
    Federico Barbaro, Luigi Giovanni Papparella, Michele Francesco Chiappetta, Tommaso Schepis, Rossella Maresca, Livio Enrico Del Vecchio, Cristina Ciuffini, Silvia Pecere, Lucio Petruzziello, Guido Costamagna, Cristiano Spada
    European Journal of Gastroenterology & Hepatology.2025; 37(4): 439.     CrossRef
  • Comparison of the resection depth between endoscopic mucosal resection and underwater endoscopic mucosal resection for superficial non‐ampullary duodenal epithelial tumors: A retrospective study
    Toshiki Horii, Yohei Harada, Gen Kitahara, Takuya Wada, Akinori Watanabe, Kenji Ishido, Hisatomo Ikehara, Chika Kusano
    DEN Open.2025;[Epub]     CrossRef
  • Tip‐In Underwater Endoscopic Mucosal Resection for Superficial Nonampullary Duodenal Epithelial Tumors ≤ 20 mm
    Tomoya Ueda, Shunsuke Yoshii, Kazuki Matsuyama, Yasuhiro Tani, Yoshiaki Ando, Gentaro Tanabe, Yuta Fujimoto, Noriaki Ito, Nobutoshi Tsukuda, Muneshin Morita, Minoru Kato, Takashi Kanesaka, Satoki Shichijo, Sachiko Yamamoto, Koji Higashino, Noriya Uedo, To
    Journal of Gastroenterology and Hepatology.2025; 40(10): 2540.     CrossRef
  • Management of Adverse Events Related to Endoscopic Resection for Superficial Non-Ampullary Duodenal Epithelial Tumors
    Osamu Dohi, Tomoko Ochiai, Mayuko Seya, Katsuma Yamauchi, Naoto Iwai, Reo Kobayashi, Ryohei Hirose, Elsayed Ghoneem, Ken Inoue, Naohisa Yoshida
    Digestion.2025; 107(3): 261.     CrossRef
  • Current Management of Duodenal Neoplasia: Endoscopic Treatment for Large Superficial Non-Ampullary Duodenal Epithelial Tumor
    Kurato Miyazaki, Naohisa Yahagi, Motohiko Kato
    Digestion.2025; 107(3): 282.     CrossRef
  • Comparison of Therapeutic Outcomes between Underwater EMR and Cap-Assisted EMR for Superficial Non-Ampullary Duodenal Epithelial Tumors Measuring 6–20 mm
    Eri Nishikawa, Tetsuya Yoshizaki, Erika Abe, Hiroyuki Hashimoto, Makoto Yoshiji, Shoko Matsuura, Tomonori Wada, Yuta Higasa, Hiroshi Tanabe, Shinya Hoki, Ryosuke Ishida, Ryosuke Hori, Tatsuya Nakai, Chise Ueda, Satoshi Urakami, Hirofumi Abe, Madoka Takao,
    Digestion.2025; : 1.     CrossRef
  • Conventional versus underwater endoscopic resection for superficial non-ampullary duodenal epithelial tumours
    Hajime Miyazaki, Osamu Dohi, Tsugitaka Ishida, Mayuko Seya, Katsuma Yamauchi, Hayato Fukui, Takeshi Yasuda, Takuma Yoshida, Naoto Iwai, Toshifumi Doi, Ryohei Hirose, Ken Inoue, Akihito Harusato, Naohisa Yoshida, Kazuhiko Uchiyama, Tomohisa Takagi, Takeshi
    Japanese Journal of Clinical Oncology.2024; 54(2): 137.     CrossRef
  • Can underwater endoscopic mucosal resection be an alternative to conventional endoscopic mucosal resection for superficial non‐ampullary duodenal epithelial tumors?
    Hidenori Tanaka, Yuji Urabe, Hiroki Takemoto, Kazuki Ishibashi, Hirona Konishi, Yuka Matsubara, Yudai Takehara, Shin Morimoto, Fumiaki Tanino, Noriko Yamamoto, Hajime Teshima, Junichi Mizuno, Issei Hirata, Hirosato Tamari, Akiyoshi Tsuboi, Ken Yamashita,
    DEN Open.2024;[Epub]     CrossRef
  • Underwater Techniques in Gastrointestinal Endoscopy: Diving into the Depths
    Sandro Sferrazza, Giulio Calabrese, Roberta Maselli, Rui Morais, Antonio Facciorusso, Georgios Mavrogenis, Roberto Di Mitri, Alessandro Repici, Marcello Maida
    Cancers.2024; 16(20): 3535.     CrossRef
  • Underwater versus conventional endoscopic mucosal resection for superficial non-ampullary duodenal epithelial tumors ≤20mm: A systematic review and meta-analysis
    Xiu-He Lv, Rong Luo, Qing Lu, Kai Deng, Jin-Lin Yang
    Digestive and Liver Disease.2023; 55(6): 714.     CrossRef
  • Underwater Versus Conventional Endoscopic Mucosal Resection for Superficial Non-ampullary Duodenal Epithelial Tumors: A Systematic Review and Meta-Analysis
    Jae Gon Lee, Sang Pyo Lee, Hyun Joo Jang, Sea Hyub Kae
    Digestive Diseases and Sciences.2023; 68(4): 1482.     CrossRef
  • A feasibility study comparing gel immersion endoscopic resection and underwater endoscopic mucosal resection for superficial nonampullary duodenal epithelial tumors
    Akihiro Miyakawa, Toshio Kuwai, Yukie Sakuma, Manabu Kubota, Akira Nakamura, Ei Itobayashi, Haruhisa Shimura, Yoshio Suzuki, Kenji Shimura
    Endoscopy.2023; 55(03): 261.     CrossRef
  • Underwater Endoscopic Mucosal Resection Versus Conventional Endoscopic Mucosal Resection for Superficial Non-ampullary Duodenal Epithelial Tumors ≤20 mm
    Zhikun Yin, Ji Li, Weilin Yang, Weifeng Huang, Dong Xu, Xiaoyi Lei, Jinyan Zhang
    Journal of Clinical Gastroenterology.2023; 57(9): 928.     CrossRef
  • Efficacy and safety of underwater endoscopic mucosal resection for ≤20 mm superficial non-ampullary duodenal epithelial tumors: Systematic review and meta-analysis
    Jixiang Liu, Shaojie Duan, Yichong Wang, Hongye Peng, Youjia Kong, Shukun Yao
    Frontiers in Medicine.2023;[Epub]     CrossRef
  • Underwater versus conventional EMR for nonpedunculated colorectal lesions: a randomized clinical trial
    Luciano Lenz, Bruno Martins, Gustavo Andrade de Paulo, Fabio Shiguehissa Kawaguti, Elisa Ryoka Baba, Ricardo Sato Uemura, Carla Cristina Gusmon, Sebastian Naschold Geiger, Renata Nobre Moura, Caterina Pennacchi, Marcelo Simas de Lima, Adriana Vaz Safatle-
    Gastrointestinal Endoscopy.2023; 97(3): 549.     CrossRef
  • Endoscopic resection of superficial non‐ampullary duodenal epithelial tumor
    Motohiko Kato, Takanori Kanai, Naohisa Yahagi
    DEN Open.2022;[Epub]     CrossRef
  • The Application of Underwater Endoscopic Mucosal Resection for Nonampullary Duodenal Adenomas
    Xiu-He Lv, Jin-Lin Yang
    Clinical Gastroenterology and Hepatology.2022; 20(8): 1884.     CrossRef
  • Utility of underwater EMR for nonpolypoid superficial nonampullary duodenal epithelial tumors ≤20 mm
    Kenichiro Okimoto, Daisuke Maruoka, Tomoaki Matsumura, Kengo Kanayama, Naoki Akizue, Yuki Ohta, Takashi Taida, Keiko Saito, Yosuke Inaba, Yohei Kawasaki, Makoto Arai, Jun Kato, Naoya Kato
    Gastrointestinal Endoscopy.2022; 95(1): 140.     CrossRef
  • Reply
    Yasushi Yamasaki, Noriya Uedo
    Clinical Gastroenterology and Hepatology.2022; 20(8): 1884.     CrossRef
  • Appropriate selection of endoscopic resection for superficial nonampullary duodenal adenomas in association with recurrence
    Kenichiro Okimoto, Daisuke Maruoka, Tomoaki Matsumura, Kengo Kanayama, Naoki Akizue, Yuki Ohta, Takashi Taida, Keiko Saito, Yosuke Inaba, Yohei Kawasaki, Jun Kato, Naoya Kato
    Gastrointestinal Endoscopy.2022; 95(5): 939.     CrossRef
  • Reply to Lv and Yang
    Motohiko Kato, Yoji Takeuchi, Shu Hoteya, Tsuneo Oyama, Satoru Nonaka, Shoichi Yoshimizu, Naomi Kakushima, Ken Ohata, Hironori Yamamoto, Yuko Hara, Hisashi Doyama, Osamu Dohi, Yasushi Yamasaki, Hiroya Ueyama, Kengo Takimoto, Koichi Kurahara, Tomoaki Tashi
    Endoscopy.2022; 54(05): 523.     CrossRef
  • Endoscopic treatment selection for superficial duodenal tumors: pay attention to small lesions
    Xiu-He Lv, Jin-Lin Yang
    Endoscopy.2022; 54(05): 522.     CrossRef
  • Resectability of underwater endoscopic mucosal resection for duodenal tumor: A single‐center, retrospective pilot study
    Yosuke Toya, Masaki Endo, Masanao Yamazato, Shun Yamada, Tomo Kumei, Minami Hirai, Makoto Eizuka, Toshifumi Morishita, Risaburo Akasaka, Shunichi Yanai, Noriyuki Uesugi, Tamotsu Sugai, Takayuki Matsumoto
    Journal of Gastroenterology and Hepatology.2021; 36(11): 3191.     CrossRef
  • 8,716 View
  • 191 Download
  • 31 Web of Science
  • 31 Crossref
Close layer
Diode Laser—Can It Replace the Electrical Current Used in Endoscopic Submucosal Dissection?
Yunho Jung, Gwang Ho Baik, Weon Jin Ko, Bong Min Ko, Seong Hwan Kim, Jin Seok Jang, Jae-Young Jang, Wan-Sik Lee, Young Kwan Cho, Sun Gyo Lim, Hee Seok Moon, In Kyung Yoo, Joo Young Cho
Clin Endosc 2021;54(4):555-562.   Published online January 13, 2021
DOI: https://doi.org/10.5946/ce.2020.229
AbstractAbstract PDFSupplementary Material
Background
/Aims: A new medical fiber-guided diode laser system (FDLS) is expected to offer high-precision cutting with simultaneous hemostasis. Thus, this study aimed to evaluate the feasibility of using the 1,940-nm FDLS to perform endoscopic submucosal dissection (ESD) in the gastrointestinal tract of an animal model.
Methods
In this prospective animal pilot study, gastric and colorectal ESD using the FDLS was performed in ex vivo and in vivo porcine models. The completeness of en bloc resection, the procedure time, intraprocedural bleeding, histological injuries to the muscularis propria (MP) layer, and perforation were assessed.
Results
The en bloc resection and perforation rates in the ex vivo study were 100% (10/10) and 10% (1/10), respectively; those in the in vivo study were 100% (4/4) and 0% for gastric ESD and 100% (4/4) and 25% (1/4) for rectal ESD, respectively. Deep MP layer injuries tended to occur more frequently in the rectal than in the gastric ESD cases, and no intraprocedural bleeding occurred in either group.
Conclusions
The 1,940-nm FDLS was capable of yielding high en bloc resection rates without intraprocedural bleeding during gastric and colorectal ESD in animal models.

Citations

Citations to this article as recorded by  
  • Sequential injection-electrocoagulation vs. traditional electrocoagulation haemostasis during endoscopic submucosal dissection: a randomized controlled trial
    Zi-yi Ma, Zhen Yang, Jia Liu, Xue Peng, Xu-biao Nie, Pai-pai Qi, Quan-bing Jiang, Wei-Hao Kok, En Liu, Chao-qiang Fan
    Surgical Endoscopy.2025; 39(7): 4633.     CrossRef
  • Thermal Ablation (Laser vs. Argon Plasma Coagulation) for the Treatment of Excessive Dynamic Airway Collapse: An in vivo Study in Bama Miniature Pigs
    Faming Liu, Jiyang Li, Ting Wang, Bing Xue, Yishan Lv, Jie Zhang, Felix J.F. Herth
    Respiration.2025; 105(2): 294.     CrossRef
  • Use of Diode Laser in Hysteroscopy for the Management of Intrauterine Pathology: A Systematic Review
    Andrea Etrusco, Giovanni Buzzaccarini, Antonio Simone Laganà, Vito Chiantera, Salvatore Giovanni Vitale, Stefano Angioni, Maurizio Nicola D’Alterio, Luigi Nappi, Felice Sorrentino, Amerigo Vitagliano, Tommaso Difonzo, Gaetano Riemma, Liliana Mereu, Alessa
    Diagnostics.2024; 14(3): 327.     CrossRef
  • Recent advances in endoscopic management of gastric neoplasms
    Hira Imad Cheema, Benjamin Tharian, Sumant Inamdar, Mauricio Garcia-Saenz-de-Sicilia, Cem Cengiz
    World Journal of Gastrointestinal Endoscopy.2023; 15(5): 319.     CrossRef
  • Safety and efficacy of dual emission endoscopic laser treatment in patients with upper or lower gastrointestinal vascular lesions causing chronic anemia: results from the first multicenter cohort study
    Gian Eugenio Tontini, Lorenzo Dioscoridi, Alessandro Rimondi, Paolo Cantù, Flaminia Cavallaro, Aurora Giannetti, Luca Elli, Luca Pastorelli, Francesco Pugliese, Massimiliano Mutignani, Maurizio Vecchi
    Endoscopy International Open.2022; 10(04): E386.     CrossRef
  • 7,726 View
  • 166 Download
  • 6 Web of Science
  • 5 Crossref
Close layer
Case Reports
Successful Endoscopic Resection of Residual Colonic Mucosa-Associated Lymphoid Tissue Lymphoma after Polypectomy
Jeongmin Choi
Clin Endosc 2021;54(5):759-762.   Published online November 6, 2020
DOI: https://doi.org/10.5946/ce.2020.233
AbstractAbstract PDF
Mucosa-associated lymphoid tissue (MALT) lymphomas are typically found in the stomach, while colonic MALT lymphoma is rarely found. Considering its rarity, definitive treatment of colonic MALT lymphoma has not been established. Different from that in the stomach, Helicobacter pylori infection might play a minor role while determining the treatment of colonic MALT lymphoma. If colonic MALT lymphoma is localized, treatment options are surgical resection, radiation, endoscopic resection, or combination therapy. Here, we report a case of residual colonic MALT lymphoma after endoscopic mucosal resection, which was a 1.5-cm-sized tumor confined to the superficial wall of the rectum. The lesion was successfully treated using the endoscopic submucosal dissection technique. The patient remained disease-free for 4 years. This case provides rationale for endoscopic submucosal dissection treatment as a salvage therapy for residual tumors in properly selected patients with colonic MALT lymphoma.

Citations

Citations to this article as recorded by  
  • Risk-stratified clinical management of primary colorectal mucosa-associated lymphoid tissue lymphoma based on endoscopic morphology
    Kyoung Wan Kim, Minjee Kim, Sung Noh Hong, Dong Kyung Chang, Young Ho Kim, Eun Ran Kim, Ji Eun Kim
    Scandinavian Journal of Gastroenterology.2026; : 1.     CrossRef
  • A 12 mm-sized rectal subepithelial tumor: uncommon, but one you must know
    Seong-Jung Kim, Jun Lee
    Clinical Endoscopy.2025; 58(3): 485.     CrossRef
  • A rare cause of hematochezia: colonic extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALToma): A case report and literature review
    Chien-Hung Lu, Wei-Yu Kao, Chun-Chao Chang, Yu-An Kan
    Medicine.2023; 102(21): e33869.     CrossRef
  • Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma in the Gastrointestinal Tract in the Modern Era
    Eri Ishikawa, Masanao Nakamura, Akira Satou, Kazuyuki Shimada, Shotaro Nakamura
    Cancers.2022; 14(2): 446.     CrossRef
  • Successful Endoscopic Resection of Primary Rectal Mucosa-Associated Lymphoid Tissue Lymphoma by Endoscopic Submucosal Dissection: A Case Report
    Jian Han, Zhe Zhu, Chao Zhang, Hua-ping Xie
    Frontiers in Medicine.2021;[Epub]     CrossRef
  • 7,841 View
  • 122 Download
  • 6 Web of Science
  • 5 Crossref
Close layer
Underwater Endoscopic Mucosal Resection without Submucosal Injection Facilitates En bloc Resection of Colon Adenomas Extending into a Diverticulum
Yoshikazu Hayashi, Masahiro Okada, Takaaki Morikawa, Tatsuma Nomura, Hisashi Fukuda, Takahito Takezawa, Alan Kawarai Lefor, Hironori Yamamoto
Clin Endosc 2021;54(3):436-440.   Published online November 6, 2020
DOI: https://doi.org/10.5946/ce.2020.168
AbstractAbstract PDFSupplementary Material
Superficial colonic neoplasms sometimes extend into a diverticulum. Conventional endoscopic mucosal resection of these lesions is considered challenging because colonic diverticula do not have a muscularis propria and are deeply inverted. Even if the solution is carefully injected below the mucosa at the bottom of the diverticulum, the mucosa is rarely elevated from the diverticular orifice, and it is usually just narrowed. Although endoscopic submucosal dissection or full-thickness resection with an over-the-scope clip device enables the complete resection of these lesions, it is still challenging, time consuming and expensive. Underwater endoscopic mucosal resection without submucosal injection (UEMR) is an innovative technique enabling en bloc resection of superficial colon lesions. We report three patients with colon adenomas extending into a diverticulum treated with successful UEMR. UEMR enabled rapid and safe en bloc resection of colon lesions extending into a diverticulum.

Citations

Citations to this article as recorded by  
  • Efficacy and safety of underwater endoscopic mucosal resection (UEMR) for non-pedunculated colorectal polyps: a prospective study IN Vietnam
    Tran Kinh Thanh, Nguyen Trong Man Dat, Huynh Dao Nhat Huy, Tran Vy Thao, Phi Duong Nguyen
    Cancer Treatment and Research Communications.2026; 48: 101290.     CrossRef
  • Underwater endoscopic mucosal resection for colorectal lesions: Can it be an “Underwater” revolution?
    Yoji Takeuchi, Satoki Shichijo, Noriya Uedo, Ryu Ishihara
    DEN Open.2022;[Epub]     CrossRef
  • 7,600 View
  • 150 Download
  • 2 Web of Science
  • 2 Crossref
Close layer
Review
Photodynamic Therapy for Esophageal Cancer
Takahiro Inoue, Ryu Ishihara
Clin Endosc 2021;54(4):494-498.   Published online May 19, 2020
DOI: https://doi.org/10.5946/ce.2020.073
AbstractAbstract PDF
Photodynamic therapy, a curative local treatment for esophageal squamous cell carcinoma, involves a photosensitizing drug (photosensitizer) with affinity for tumors and a photodynamic reaction triggered by laser light. Previously, photodynamic therapy was used to treat superficial esophageal squamous cell carcinoma judged to be difficult to undergo endoscopic resection. Recently, photodynamic therapy has mainly been performed for local failure after chemoradiotherapy. Although surgery is the most promising treatment for local failure after chemoradiotherapy, its morbidity and mortality rates are high. Endoscopic resection is feasible for local failure after chemoradiotherapy but requires advanced skills, and its indication is limited to within the submucosal layer by depth. Photodynamic therapy is less invasive than surgery and has a wider indication than endoscopic resection. Porfimer sodium (a first-generation photosensitizer) causes a high frequency of side effects related to photosensitivity and requires the long-term sunshade period. Talaporfin (a second-generation photosensitizer) requires a much shorter sun-shade period than porfimer sodium. Photodynamic therapy will profoundly change treatment strategies for local failure after chemoradiotherapy.

Citations

Citations to this article as recorded by  
  • Platinum‐Based Azadipyrromethane Complexes for Targeted Cancer Phototherapy: Synthesis, Properties, and Therapeutic Application
    Cagla Sevinc, Sule Ozer, Ercan Cacan, Nihal Deligonul
    ChemPhotoChem.2026;[Epub]     CrossRef
  • Heme as activator and target for artemisinin: Towards multiple pharmacological bioactivity
    Pan Zhu, Xinyi Sun, Yuting Fang, Yufei Li, Liang Guo
    Biochemistry and Biophysics Reports.2026; 45: 102398.     CrossRef
  • Endoscopic submucosal dissection: Challenges, innovations, and the road ahead
    Miltiadis K Moutzoukis, Anastasios Manolakis, Andreas Kapsoritakis, Dimitrios Christodoulou, Konstantinos Argyriou
    World Journal of Gastrointestinal Endoscopy.2026;[Epub]     CrossRef
  • The application of nanoparticle-mediated siRNA delivery systems in ovarian cancer
    Xueqian Qian, Yi Yuan, Yaning Zhang, Zemin Dou, Chengjin Gao, Yangyang Han
    Cancer Gene Therapy.2026; 33(5): 624.     CrossRef
  • Endoscopic Salvage Following Radiotherapy for Oesophageal Cancer: A Systematic Review
    H.L. Keenan, R.A. Brooks, C.M. Jones
    Clinical Oncology.2026; 58: 104304.     CrossRef
  • An optical coherence tomography study of a photoactive Pt(iv) prodrug in oesophageal tissue
    Huayun Shi, Muktesh Mohan, Kanwarpal Singh, Peter J. Sadler
    RSC Advances.2025; 15(5): 3168.     CrossRef
  • Hollow nanosystem-boosting synergistic effects between photothermal therapy and chemodynamic therapy via self-supplied hydrogen peroxide and relieved hypoxia
    Yunji Sun, Lixiao Zhen, Lin Xu, Peipei Li, Chao Zhang, Yang Zhang, Yisheng Zhao, Benkang Shi
    Biomaterials Science.2025; 13(7): 1784.     CrossRef
  • Conceptual expansion of photomedicine for spatiotemporal treatment methods
    P. K. Hashim, Ashwin T. Shaji, Ammathnadu S. Amrutha, Shifa Ahmad
    RSC Medicinal Chemistry.2025; 16(6): 2360.     CrossRef
  • Cell death mechanisms induced by gold nano-immunoconjugates-mediated photodynamic therapy against human oesophageal cancer stem cells
    Onyisi Christiana Didamson, Rahul Chandran, Heidi Abrahamse
    Frontiers in Immunology.2025;[Epub]     CrossRef
  • Aluminium phthalocyanine-mediated photodynamic therapy induces ATM-related DNA damage response and apoptosis in human oesophageal cancer cells
    Onyisi Christiana Didamson, Rahul Chandran, Heidi Abrahamse
    Frontiers in Oncology.2024;[Epub]     CrossRef
  • An Ailment with Which I Will Contend: A Narrative Review of 5000 Years of Esophagogastric Cancers and Their Treatments, with Special Emphasis on Recent Advances in Immunotherapeutics
    C. Beau Hilton, Steven Lander, Michael K. Gibson
    Cancers.2024; 16(3): 618.     CrossRef
  • Western outcomes of circumferential endoscopic submucosal dissection for early esophageal squamous cell carcinoma
    Enrique Rodríguez de Santiago, Laurelle van Tilburg, Pierre H. Deprez, Mathieu Pioche, Roos E. Pouw, Michael J. Bourke, Stefan Seewald, Bas L.A.M. Weusten, Jeremie Jacques, Sara Leblanc, Pedro Barreiro, Arnaud Lemmers, Adolfo Parra-Blanco, Ricardo Küttner
    Gastrointestinal Endoscopy.2024; 99(4): 511.     CrossRef
  • Interventional gastroenterology in oncology
    Vaibhav Wadhwa, Nicole Patel, Dheera Grover, Faisal S. Ali, Nirav Thosani
    CA: A Cancer Journal for Clinicians.2023; 73(3): 286.     CrossRef
  • Utilizing 4D Printing to Design Smart Gastroretentive, Esophageal, and Intravesical Drug Delivery Systems
    Dina B. Mahmoud, Michaela Schulz‐Siegmund
    Advanced Healthcare Materials.2023;[Epub]     CrossRef
  • Recent Advances in Green Metallic Nanoparticles for Enhanced Drug Delivery in Photodynamic Therapy: A Therapeutic Approach
    Alexander Chota, Blassan P. George, Heidi Abrahamse
    International Journal of Molecular Sciences.2023; 24(5): 4808.     CrossRef
  • Amino Acid Derivatives of Chlorin-e6—A Review
    Maria da Graça H. Vicente, Kevin M. Smith
    Molecules.2023; 28(8): 3479.     CrossRef
  • Stimuli-responsive heparin-drug conjugates co-assembled into stable nanomedicines for cancer therapy
    Zaixiang Fang, Ling Lin, Zhiqian Li, Lei Gu, Dayi Pan, Yunkun Li, Jie Chen, Haitao Ding, Xiaohe Tian, Qiyong Gong, Kui Luo
    Acta Biomaterialia.2023;[Epub]     CrossRef
  • Idarubicin and IR780 co-loaded PEG-b-PTMC nanoparticle for non-Hodgkin’s lymphoma therapy by photothermal/photodynamic strategy
    Shanshan Weng, Luqi Pan, Dawei Jiang, Wenxia Xie, Zhiyuan Zhang, Changcan Shi, Bin Liang, Shenghao Wu
    Materials & Design.2023; 230: 112008.     CrossRef
  • Protein Photodamaging Activity and Photocytotoxic Effect of an Axial-Connecting Phosphorus(V)porphyrin Trimer
    Kazutaka Hirakawa, Naoki Kishimoto, Yoshinobu Nishimura, Yuko Ibuki, Masaaki Fuki, Shigetoshi Okazaki
    Chemical Research in Toxicology.2023;[Epub]     CrossRef
  • Nanomedicine in Clinical Photodynamic Therapy for the Treatment of Brain Tumors
    Hyung Shik Kim, Dong Yun Lee
    Biomedicines.2022; 10(1): 96.     CrossRef
  • Poly(styrene-co-maleic acid) Micelle of Photosensitizers for Targeted Photodynamic Therapy, Exhibits Prolonged Singlet Oxygen Generating Capacity and Superior Intracellular Uptake
    Gahininath Yadavrao Bharate, Haibo Qin, Jun Fang
    Journal of Personalized Medicine.2022; 12(3): 493.     CrossRef
  • Deep-Learning for the Diagnosis of Esophageal Cancers and Precursor Lesions in Endoscopic Images: A Model Establishment and Nationwide Multicenter Performance Verification Study
    Eun Jeong Gong, Chang Seok Bang, Kyoungwon Jung, Su Jin Kim, Jong Wook Kim, Seung In Seo, Uhmyung Lee, You Bin Maeng, Ye Ji Lee, Jae Ick Lee, Gwang Ho Baik, Jae Jun Lee
    Journal of Personalized Medicine.2022; 12(7): 1052.     CrossRef
  • Palliation of Malignant Dysphagia: Dilation, Stents, Cryoablation or PDT: The GI Perspective
    Daniel J. Ellis, Nisa M. Kubiliun, Anna Tavakkoli
    Foregut: The Journal of the American Foregut Society.2022; 2(2): 186.     CrossRef
  • Palliation of Malignant Dysphagia: Dilation, Stents, Cryoablation or Photodynamic Therapy—A Surgical Perspective
    Uzma Rahman, Olugbenga T. Okusanya
    Foregut: The Journal of the American Foregut Society.2022; 2(2): 180.     CrossRef
  • Endoscopic Treatment for Disease Persistence/Recurrence after Definitive Chemoradiotherapy for Esophageal Cancer
    Prabin Sharma, Rani Modayil, Stavros N. Stavropoulos
    Foregut: The Journal of the American Foregut Society.2022; 2(2): 132.     CrossRef
  • Targeted chemo-photodynamic therapy toward esophageal cancer by GSH-sensitive theranostic nanoplatform
    Guodong Ren, ZiCheng Wang, Yafei Tian, Jinyao Li, Yingyu Ma, Liang Zhou, Chengwu Zhang, Lixia Guo, Haipeng Diao, Lihong Li, Li Lu, Sufang Ma, Zhifang Wu, Lili Yan, Wen Liu
    Biomedicine & Pharmacotherapy.2022; 153: 113506.     CrossRef
  • Therapeutic effects of in-vivo radiodynamic therapy (RDT) for lung cancer treatment: a combination of 15MV photons and 5-aminolevulinic acid (5-ALA)
    Dae-Myoung Yang, Dusica Cvetkovic, Lili Chen, C-M Charlie Ma
    Biomedical Physics & Engineering Express.2022; 8(6): 065031.     CrossRef
  • Laser induced thermotherapy of multiple actinic keratosis
    Tatiana Evgenievna Sukhova, Yulia Vladimirovna Molochkova, Anna Igorevna Pronina
    Russian Journal of Skin and Venereal Diseases.2022; 25(3): 181.     CrossRef
  • Novel sulfonamide porphyrin TBPoS-2OH used in photodynamic therapy for malignant melanoma
    Zhaohai Pan, Jiaojiao Fan, Qi Xie, Xin Zhang, Wen Zhang, Qing Ren, Minjing Li, Qiusheng Zheng, Jun Lu, Defang Li
    Biomedicine & Pharmacotherapy.2021; 133: 111042.     CrossRef
  • Photodynamic Therapy—An Up-to-Date Review
    Adelina-Gabriela Niculescu, Alexandru Mihai Grumezescu
    Applied Sciences.2021; 11(8): 3626.     CrossRef
  • Targeted Photodynamic Diagnosis and Therapy for Esophageal Cancer: Potential Role of Functionalized Nanomedicine
    Onyisi Christiana Didamson, Heidi Abrahamse
    Pharmaceutics.2021; 13(11): 1943.     CrossRef
  • 13,368 View
  • 320 Download
  • 27 Web of Science
  • 31 Crossref
Close layer
Original Article
Efficacy and Safety of Complete Endoscopic Resection of Colorectal Neoplasia Using a Stepwise Endoscopic Protocol with SOUTEN, a Novel Multifunctional Snare
Shinji Yoshii, Marina Kubo, Mio Matsumoto, Takefumi Kikuchi, Yasunari Takakuwa
Clin Endosc 2020;53(2):206-212.   Published online February 27, 2020
DOI: https://doi.org/10.5946/ce.2019.117
AbstractAbstract PDFSupplementary Material
Background
/Aims: A multifunctional snare SOUTEN has a sharp tip at the top of the snare loop that enables incision of the mucosa, dissection of the submucosal layer, and snaring of lesion. This study assessed the efficacy and safety of complete endoscopic resection of colorectal neoplasia using SOUTEN.
Methods
We analyzed the rates of gross en bloc resection and complete resections of 108 consecutive tumors from 69 patients resected by precutting endoscopic mucosal resection (precutting), hybrid endoscopic submucosal dissection (hybrid), or conventional endoscopic submucosal dissection (conventional) using SOUTEN.
Results
Out of the 108 tumors, 50 were resected by precutting, 27 were resected by hybrid after attempting precutting, and the remaining 31 were resected by conventional after attempting precutting and hybrid resections. The median tumor sizes were 14.5 mm for precutting, 16.4 mm for hybrid, and 21.1 mm for conventional. The success rate of gross en bloc resection and histological complete resection were 100% and 94.0% for precutting, 96.4% and 96.4% for hybrid, and 100% and 100% for conventional method, respectively. No procedure-related complication occurred.
Conclusions
By using SOUTEN, precutting and hybrid were successfully performed on 10–30 mm tumors with a shorter procedure time than conventional without major complications.

Citations

Citations to this article as recorded by  
  • Comparison of precut endoscopic mucosal resection and endoscopic submucosal dissection in the management of colorectal polyps: a systematic review and meta-analysis
    Aamir Saeed, Saira Yousuf, Ahmad Zain, Muhammad Kashif, Sultan Mahmood, Umar Hayat, Azizullah Beran, Nasir Saleem, Yasi Xiao, Anand Kumar, Alexander Schlachterman, Thomas Kowalski, Mark Radlinski, Thiruvengadam Muniraj, Faisal Kamal
    European Journal of Gastroenterology & Hepatology.2026; 38(6): 699.     CrossRef
  • The efficacy and safety of precutting-endoscopic mucosal resection for colorectal tumors: a systematic review and meta-analysis
    Yi Chen, Zhengjie Wu
    Minimally Invasive Therapy & Allied Technologies.2025; 34(3): 177.     CrossRef
  • Precut mucosectomy versus endoscopic resection techniques for colorectal lesions sized 10–30 mm: meta-analysis and systematic review
    Miriam Chinzon, Mateus Bond Boghossian, Matheus de Oliveira Veras, Evellin Souza Valentim dos Santos, Daryl Ramai, Larissa Mercadante de Assis, Vitor Hernandes Lopes, Nelson Miyajima, Wanderley Marques Bernardo, Eduardo Guimarães Hourneaux de Moura
    Surgical Endoscopy.2025; 39(9): 5506.     CrossRef
  • Safety and efficacy of hybrid versus conventional endoscopic submucosal dissection for removal of gastrointestinal lesions: A meta-analysis
    Adnan Bhat, Allah Dad, Kinza Bakht, Muhammad Arham, Humza Saeed, Zahra Ali, Faseeh Haider, Saniya Ishtiaq, Anchit Chauhan, Danyal Bakht, Adil Ahmed, Ali Naseem, Imran Ali Reshi, Dennis Yang, Peter Vassilev Draganov
    International Journal of Gastrointestinal Intervention.2025; 14(4): 134.     CrossRef
  • Hybrid Endoscopic Resection With Endo-knife and Snare for Colorectal Lesions: A Systematic Review and Meta-analysis
    Shinji Yoshii, Takefumi Kikuchi, Yuki Hayashi, Masahiro Nojima, Hiro-o Yamano, Hiroshi Nakase
    Techniques and Innovations in Gastrointestinal Endoscopy.2023; 25(2): 135.     CrossRef
  • Standard Endoscopic Mucosal Resection vs Precutting Endoscopic Mucosal Resection Using Novel Disk-Tip Snare for Colorectal Lesions
    Naohisa Yoshida, Ken Inoue, Hikaru Hashimoto, Reo Kobayashi, Yuri Tomita, Satoshi Sugino, Ryohei Hirose, Osamu Dohi, Yukiko Morinaga, Yutaka Inada, Takaaki Murakami, Yoshito Itoh
    Digestive Diseases and Sciences.2023; 68(5): 2030.     CrossRef
  • Outpatient hybrid endoscopic submucosal dissection with SOUTEN for early gastric cancer, followed by endoscopic suturing of the mucosal defect: A case report
    Renma Ito, Kazuhiro Miwa, Yutaka Matano
    World Journal of Gastrointestinal Surgery.2023; 15(8): 1831.     CrossRef
  • Understanding hybrid endoscopic submucosal dissection subtleties
    João Paulo de Souza Pontual, Alexandre Moraes Bestetti, Diogo Turiani Hourneaux de Moura
    Clinical Endoscopy.2023; 56(6): 738.     CrossRef
  • A knife plus a snare, but how will it fare?
    Kavel Visrodia, Amrita Sethi
    Gastrointestinal Endoscopy.2021; 93(3): 679.     CrossRef
  • Freestyle endoscopic submucosal dissection using a multifunctional snare
    Jun Arimoto, Hideyuki Chiba, Naoya Okada, Hiroki Kuwabara, Michiko Nakaoka
    VideoGIE.2021; 6(11): 501.     CrossRef
  • 8,295 View
  • 146 Download
  • 9 Web of Science
  • 10 Crossref
Close layer
Focused Review Series: Cutting Edge of Advanced Therapeutic Endoscopy
Present Status of Endoscopic Submucosal Dissection for Non-Ampullary Duodenal Epithelial Tumors
Naomi Kakushima, Masao Yoshida, Yohei Yabuuchi, Noboru Kawata, Kohei Takizawa, Yoshihiro Kishida, Sayo Ito, Kenichiro Imai, Kinichi Hotta, Hirotoshi Ishiwatari, Hiroyuki Matsubayashi, Hiroyuki Ono
Clin Endosc 2020;53(6):652-658.   Published online January 15, 2020
DOI: https://doi.org/10.5946/ce.2019.184
AbstractAbstract PDF
Prediction of histology by endoscopic examination is important in the clinical management of non-ampullary duodenal epithelial tumors (NADETs), including adenoma and adenocarcinoma. The use of a simple scoring system based on the findings of white-light endoscopy or magnified endoscopy with narrow-band imaging is useful to differentiate between Vienna category 3 (C3) and C4/5 lesions. Less invasive endoscopic resection procedures, such as cold snare polypectomy, are quick to perform and convenient for small (<10 mm) C3 lesions. Neoplasms with higher grade histology, such as C4/5 lesions, should be treated by endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), or surgery. Although EMR often requires piecemeal resection, the complication rate is acceptable. Excellent complete resection rates could be achieved by ESD; however, it remains a challenging method considering the high risk of complications. Shielding or closure of the ulcer after ESD is effective at decreasing the risk of delayed bleeding and perforation. Laparoscopic endoscopic cooperative surgery is an ideal treatment with a high rate of en bloc resection and a low rate of complications, although it is limited to high-volume centers. Patients with NADETs could benefit from a multidisciplinary approach to stratify the optimal treatment based on endoscopic diagnoses.

Citations

Citations to this article as recorded by  
  • Outpatient endoscopic submucosal dissection for non-ampullary duodenal lesions: a single-center experience at a U.S. tertiary referral center
    Abdulrahman Qatomah, Daryl Ramai, Aishah Qatomah, Hiroyuki Aihara
    Surgical Endoscopy.2026; 40(3): 2136.     CrossRef
  • Clinical Outcomes of Underwater Endoscopic Submucosal Dissection for Duodenal Tumors: A Systematic Review and Meta‐Analysis
    Kumiko Kirita, Teppei Akimoto, Yasunori Sato, Motoki Sasaki, Maya Ishizawa, Mai Owada, Ai Katsumi, Yuki Kubo, Misaki Sugawara, Rei Mizobe, Shoma Murata, Yuri Imura, Hinako Sakurai, Anna Tojo, Kurato Miyazaki, Teppei Masunaga, Mari Mizutani, Yusaku Takator
    Digestive Endoscopy.2026;[Epub]     CrossRef
  • Risk factors for delayed bleeding after endoscopic resection of non-ampullary duodenal epithelial tumors and the effectiveness of complete mucosal closure in high-risk patients
    Kohei Shigeta, Masao Yoshida, Yoichi Yamamoto, Yuki Maeda, Noboru Kawata, Kazunori Takada, Kenichiro Imai, Kinichi Hotta, Junya Sato, Hirotoshi Ishiwatari, Hiroyuki Matsubayashi, Hiroyuki Ono
    Surgical Endoscopy.2025; 39(2): 1025.     CrossRef
  • Endoscopic Resection for Superficial Non-Ampullary Duodenal Epithelial Tumors
    Hye Kyung Jeon, Gwang Ha Kim
    Gut and Liver.2025; 19(1): 19.     CrossRef
  • Current Management of Duodenal Neoplasia: Endoscopic Treatment for Large Superficial Non-Ampullary Duodenal Epithelial Tumor
    Kurato Miyazaki, Naohisa Yahagi, Motohiko Kato
    Digestion.2025; 107(3): 282.     CrossRef
  • The Characteristics and Treatment Outcomes of 71 Duodenal Brunner’s Gland Adenomas with Endoscopic Submucosal Dissection
    Ying Xiang, Jinyan Liu, Nan ya Wang, Dehua Tang, Lei Wang, Ping xiao Zou, Guifang Xu, Qin Huang
    Digestive Diseases.2023; 41(6): 852.     CrossRef
  • Endoscopic diagnosis and treatment of superficial non-ampullary duodenal epithelial tumors: A review
    Zheng Zhao, Yue Jiao, Shuyue Yang, Anni Zhou, Guiping Zhao, Shuilong Guo, Peng Li, Shutian Zhang
    Journal of Translational Internal Medicine.2023; 11(3): 206.     CrossRef
  • Current Treatment Strategy for Superficial Nonampullary Duodenal Epithelial Tumors
    Tetsuya Suwa, Kohei Takizawa, Noboru Kawata, Masao Yoshida, Yohei Yabuuchi, Yoichi Yamamoto, Hiroyuki Ono
    Clinical Endoscopy.2022; 55(1): 15.     CrossRef
  • Rapid and chronological expression of angiogenetic genes is a major mechanism involved in cell sheet transplantation in a rat gastric ulcer model
    Shun Yamaguchi, Miki Higashi, Kengo Kanetaka, Yasuhiro Maruya, Shinichiro Kobayashi, Keiichi Hashiguchi, Masaaki Hidaka, Kazuhiko Nakao, Susumu Eguchi
    Regenerative Therapy.2022; 21: 372.     CrossRef
  • Survival comparison between endoscopic and surgical resection for non-ampullary duodenal neuroendocrine tumor (1–2 cm)
    Jiebin Xie, Yuan Zhang, Ming He, Xu Liu, Pin Xie, Yueshan Pang
    Scientific Reports.2022;[Epub]     CrossRef
  • Efficacy, feasibility, and safety of endoscopic double closure in the GI tract
    Ahmad M. Al-Taee, Kohtaro Ooka, Gregory B. Haber, Jonathan Cohen
    iGIE.2022; 1(1): 19.     CrossRef
  • Current endoscopic diagnosis treatment strategy for superficial nonampullary duodenal tumours
    Aichun Li, Jianwei Shen
    European Journal of Medical Research.2022;[Epub]     CrossRef
  • The incidence of non‐ampullary duodenal cancer in Japan: The first analysis of a national cancer registry
    Masao Yoshida, Yohei Yabuuchi, Naomi Kakushima, Motohiko Kato, Mikitaka Iguchi, Yorimasa Yamamoto, Kengo Kanetaka, Toshio Uraoka, Mitsuhiro Fujishiro, Masayuki Sho
    Journal of Gastroenterology and Hepatology.2021; 36(5): 1216.     CrossRef
  • White light and/or magnifying endoscopy with narrow band imaging for superficial nonampullary duodenal epithelial tumors
    Naomi Kakushima, Masao Yoshida, Kohei Takizawa, Yohei Yabuuchi, Noboru Kawata, Yoshihiro Kishida, Sayo Ito, Kenichiro Imai, Kinichi Hotta, Hirotoshi Ishiwatari, Hiroyuki Matsubayashi, Hiroyuki Ono
    Scandinavian Journal of Gastroenterology.2021; 56(2): 211.     CrossRef
  • Endoscopic management of superficial nonampullary duodenal tumors: European Society of Gastrointestinal Endoscopy (ESGE) Guideline
    Geoffroy Vanbiervliet, Alan Moss, Marianna Arvanitakis, Urban Arnelo, Torsten Beyna, Olivier Busch, Pierre H. Deprez, Lumir Kunovsky, Alberto Larghi, Gianpiero Manes, Bertrand Napoleon, Kumanan Nalankilli, Manu Nayar, Enrique Pérez-Cuadrado-Robles, Stefan
    Endoscopy.2021; 53(05): 522.     CrossRef
  • Endoscopic Treatment for Superficial Nonampullary Duodenal Tumors
    Hyo-Joon Yang
    The Korean Journal of Gastroenterology.2021; 77(4): 164.     CrossRef
  • Duodenal endoscopic submucosal dissection: Is it ready for primetime? (with video)
    Sergey V. Kantsevoy
    Gastrointestinal Endoscopy.2020; 91(5): 1138.     CrossRef
  • Life on a knife edge: the optimal approach to the management of perforations during endoscopic submucosal dissection (ESD)
    Shria Kumar, Young Hoon Youn, Jeffrey H. Lee
    Expert Review of Gastroenterology & Hepatology.2020; 14(10): 965.     CrossRef
  • Tapering body stiffness shortens upper gastrointestinal examination via transoral insertion with ultrathin endoscope
    Satoshi Ono, Shun Ito, Kyohei Maejima, Shosuke Hosaka, Kiyotaka Umeki, Shin-ichiro Sato
    Endoscopy International Open.2020; 08(12): E1748.     CrossRef
  • 12,330 View
  • 278 Download
  • 19 Web of Science
  • 19 Crossref
Close layer
Case Report
A Case of Concurrent Ampullary Adenoma and Gangliocytic Paraganglioma at the Minor Papilla Treated with Endoscopic Resection
Jun Kwon Ko, Do Hyun Park, Hee Sang Hwang
Clin Endosc 2019;52(4):382-386.   Published online April 12, 2019
DOI: https://doi.org/10.5946/ce.2018.198
AbstractAbstract PDF
A gangliocytic paraganglioma is a benign tumor of the digestive system with a very low incidence. The tumor is histopathologically characterized by a triphasic pattern consisting of epithelioid, ganglion, and spindle-shaped Schwann cells. In most cases, it occurs in the second portion of the duodenum near the ampulla of Vater. We report a case of a gangliocytic paraganglioma occurring at the minor duodenal papilla (a rare location) with a concurrent adenoma of the ampulla of Vater. Both lesions were treated simultaneously using endoscopic resection. Additionally, we have presented a literature review.

Citations

Citations to this article as recorded by  
  • En bloc resection of intestinal-type adenoma extending to the minor duodenal papilla by underwater endoscopic mucosal resection with a forward-viewing endoscope
    Risa Nakamura, Yoshitaka Nawata, Tomoaki Naka, Kimihiro Igarashi, Toru Okuzono, Mareyuki Endo, Tomoki Matsuda
    Clinical Journal of Gastroenterology.2026;[Epub]     CrossRef
  • Endoscopic treatment for tumors of the minor duodenal papilla: a case series and literature review
    Jilong Wang, Kuiliang Liu, Bing Yue, Muchen Ren, Fujing Lv, Yongjun Wang, Peng Li, Shutian Zhang
    The Egyptian Journal of Internal Medicine.2025;[Epub]     CrossRef
  • Ampullary composite gangliocytoma/neuroma and neuroendocrine tumor management
    Elias Karam, Marcus Hollenbach, Christian Heise, Einas Abou Ali, Aiste Gulla, Francesco Auriemma, Benoît Terris, François R Souche, Charles de Ponthaud, Thomas Hank, Fabrice Caillol, Rami Rhaiem, Alain Sauvanet, Bertrand Napoléon, Sara Regner, Sébastien G
    Endocrine-Related Cancer.2025;[Epub]     CrossRef
  • Estrategia de manejo quirúrgico en tumores de bajo potencial maligno de localización ampular. Presentación de un caso de paraganglioma gangliocítico
    Victoria Lucas Guerrero, Anna González Costa, Andreu Romaguera Monzonis, Natalia Bejarano González, Francisco García Borobia
    Cirugía Española.2021; 99(8): 621.     CrossRef
  • Endoscopic Mucosal Resection of Adenocarcinoma at the Minor Duodenal Papilla: A Case Report and Suggestions for the Optimal Treatment Strategy
    Takao Sato, Ryota Sagami, Hidefumi Nishikiori, Hiroaki Tsuji, Keiji Sato, Tsutomu Daa, Kazunari Murakami
    Internal Medicine.2021; 60(16): 2593.     CrossRef
  • Surgical management strategy in ampullary tumors with low malignant potential: Presentation of a patient with a gangliocytic paraganglioma
    Victoria Lucas Guerrero, Anna González Costa, Andreu Romaguera Monzonis, Natalia Bejarano González, Francisco García Borobia
    Cirugía Española (English Edition).2021; 99(8): 621.     CrossRef
  • 7,591 View
  • 109 Download
  • 5 Web of Science
  • 6 Crossref
Close layer
Focused Review Series: Endoscopic Submucosal Dissection for Undifferentiated-Type Early Gastric Cancers
Risk Factors for Lymph Node Metastasis in Undifferentiated-Type Gastric Carcinoma
Myeong-Cherl Kook
Clin Endosc 2019;52(1):15-20.   Published online January 25, 2019
DOI: https://doi.org/10.5946/ce.2018.193
AbstractAbstract PDF
Undifferentiated-type carcinoma has a high incidence of lymph node metastasis. The independent risk factors for lymph node metastasis in undifferentiated-type carcinoma are invasion depth, tumor size, lymphovascular invasion, and presence of ulcer. In the cases that meet the curative resection criteria, no lymph node metastasis was observed in the Japanese studies, but some metastases were observed in Korean studies. After performing curative endoscopic submucosal dissection, the survival rate is similar to that of gastrectomy. The discrepancy between endoscopy and pathology is high in undifferentiated-type carcinoma. The tumor size in endoscopy is a significant risk factor for non-curative resection, and when the tumor size is small, the non-curative resection rate is significantly reduced. Lymphovascular invasion can be assessed in pathologic examination and D2-40 stain is helpful. The presence of ulcer should be determined by pathology, but ulcer’s omission in pathology report makes the analysis difficult. Undifferentiatedtype carcinomas with differentiated-type components show higher lymph node metastasis rate than that of pure undifferentiatedtype carcinomas. The lymph node metastasis rate of signet ring cell type is lower than that of other undifferentiated-type carcinomas and is similar to differentiated-type carcinomas. The application of these additional histologic findings may improve the indication of endoscopic submucosal dissection.

Citations

Citations to this article as recorded by  
  • Risk Factors for Metastasis and Prognosis in Non‐Curative Resection After Endoscopic Submucosal Dissection for Undifferentiated‐Type Early Gastric Cancer in a Nationwide Cohort in Japan
    Kazuo Shiotsuki, Kohei Takizawa, Akifumi Notsu, Waku Hatta, Hirotada Akiho, Masao Yoshida, Yusuke Horiuchi, Takashi Kanesaka, Seiichiro Abe, Masahiro Tajika, Yohei Furumoto, Osamu Dohi, Shinichiro Shinzaki, Junichi Kodaira, Hiroyuki Hisada, Tetsuya Sumiyo
    Digestive Endoscopy.2026;[Epub]     CrossRef
  • Metastases from gastric cancer presenting as colorectal lesions: a report of two cases and systematic review
    VL Fretwell, EG Kane, S MacPherson, P Skaife
    The Annals of The Royal College of Surgeons of England.2025; 107(1): 76.     CrossRef
  • Korean Practice Guidelines for Gastric Cancer 2024: An Evidence-based, Multidisciplinary Approach (Update of 2022 Guideline)
    In-Ho Kim, Seung Joo Kang, Wonyoung Choi, An Na Seo, Bang Wool Eom, Beodeul Kang, Bum Jun Kim, Byung-Hoon Min, Chung Hyun Tae, Chang In Choi, Choong-kun Lee, Ho Jung An, Hwa Kyung Byun, Hyeon-Su Im, Hyung-Don Kim, Jang Ho Cho, Kyoungjune Pak, Jae-Joon Kim
    Journal of Gastric Cancer.2025; 25(1): 5.     CrossRef
  • Nomogram for pre-procedural prediction of lymph node metastasis in patients with submucosal early gastric cancer
    Wenhao Yu, Zijie Xu, Ben Li, Mengli Zi, Jun Ren, Wei Wang, Qiannan Sun, Qi Zhang, Daorong Wang
    Surgical Endoscopy.2025; 39(3): 1661.     CrossRef
  • Endoscopic Submucosal Dissection (ESD) of Upper Gastrointestinal Carcinomas: An Integrated Clinical and Pathological Perspective
    Alexander Ziachehabi, Maximilian Worm, Drolaiz H. W. Liu, Philipp Pimingstorfer, Rupert Langer
    Journal of Clinical Medicine.2025; 14(24): 8817.     CrossRef
  • Korean Practice Guidelines for Gastric Cancer 2022: An Evidence-based, Multidisciplinary Approach
    Tae-Han Kim, In-Ho Kim, Seung Joo Kang, Miyoung Choi, Baek-Hui Kim, Bang Wool Eom, Bum Jun Kim, Byung-Hoon Min, Chang In Choi, Cheol Min Shin, Chung Hyun Tae, Chung sik Gong, Dong Jin Kim, Arthur Eung-Hyuck Cho, Eun Jeong Gong, Geum Jong Song, Hyeon-Su Im
    Journal of Gastric Cancer.2023; 23(1): 3.     CrossRef
  • Predictive factors of lymphatic metastasis and evaluation of the Japanese treatment guidelines for endoscopic resection of early gastric cancer in a high-volume center in Perú
    Oscar Paredes, Carlos Baca, Renier Cruz, Kori Paredes, Carlos Luque-Vasquez, Iván Chavez, Luis Taxa, Eloy Ruiz, Francisco Berrospi, Eduardo Payet
    Heliyon.2023; 9(5): e16293.     CrossRef
  • Multi-Scale Hybrid Vision Transformer for Learning Gastric Histology: AI-Based Decision Support System for Gastric Cancer Treatment
    Yujin Oh, Go Eun Bae, Kyung-Hee Kim, Min-Kyung Yeo, Jong Chul Ye
    IEEE Journal of Biomedical and Health Informatics.2023; 27(8): 4143.     CrossRef
  • Physalin B inhibits cell proliferation and induces apoptosis in undifferentiated human gastric cancer HGC‐27 cells
    Chunsheng Fang, Cunte Chen, Yanjun Yang, Kehan Li, Rili Gao, Dandan Xu, Youxue Huang, Zheng Chen, Zhuandi Liu, Shaohua Chen, Xibao Yu, Yangqiu Li, Chengwu Zeng
    Asia-Pacific Journal of Clinical Oncology.2022; 18(3): 224.     CrossRef
  • Endoscopic submucosal dissection for papillary early gastric carcinoma: Insights from a large-scale analysis of post-gastrectomy pathology specimens
    Jung Hwan Lee, Ju Yeon Oh, Young-Il Kim, Jong Yeul Lee, Chan Gyoo Kim, Il Ju Choi, Keun Won Ryu, Young-Woo Kim, Soo-Jeong Cho
    Medicine.2022; 101(50): e32085.     CrossRef
  • Impact of the Interval between Previous Endoscopic Exam and Diagnosis on the Mortality and Treatment Modality of Undifferentiated-Type Gastric Cancer
    Ayoung Lee, Hyunsoo Chung, Hyuk-Joon Lee, Soo-Jeong Cho, Jue Lie Kim, Hye Seong Ahn, Yun-Suhk Suh, Seong-Ho Kong, Hwi Nyeong Choe, Han-Kwang Yang, Sang Gyun Kim
    Journal of Gastric Cancer.2021; 21(2): 203.     CrossRef
  • Deep Learning for Automatic Subclassification of Gastric Carcinoma Using Whole-Slide Histopathology Images
    Hyun-Jong Jang, In-Hye Song, Sung-Hak Lee
    Cancers.2021; 13(15): 3811.     CrossRef
  • Adenocarcinoma indiferenciado como factor predictor de metástasis ganglionares en cáncer gástrico
    Ana María García, William Sánchez
    Revista Colombiana de Cirugía.2021; 36(4): 620.     CrossRef
  • Sex-specific differences in risk factors of lymph node metastasis in patients with early gastric cancer
    Eun Sook Ryu, Seung Jun Chang, Jungsuk An, Jun-Young Yang, Jun-Won Chung, Yoon Jae Kim, Kyoung Oh Kim, Dong Kyun Park, Kwang An Kwon, Seungyoon Nam, Woon Kee Lee, Jung Ho Kim, Masaru Katoh
    PLOS ONE.2019; 14(10): e0224019.     CrossRef
  • Feasibility of endoscopic treatment and predictors of lymph node metastasis in early gastric cancer
    Yu-Ning Chu, Ya-Nan Yu, Xue Jing, Tao Mao, Yun-Qing Chen, Xiao-Bin Zhou, Wen Song, Xian-Zhi Zhao, Zi-Bin Tian
    World Journal of Gastroenterology.2019; 25(35): 5344.     CrossRef
  • 10,371 View
  • 132 Download
  • 16 Web of Science
  • 15 Crossref
Close layer
Strategy for Curative Endoscopic Resection of Undifferentiated-Type Early Gastric Cancer
Jie-Hyun Kim
Clin Endosc 2019;52(1):9-14.   Published online January 24, 2019
DOI: https://doi.org/10.5946/ce.2018.199
AbstractAbstract PDF
Endoscopic resection (ER) of undifferentiated-type early gastric cancer (UD-EGC) has a lower curative resection (CR) rate than differentiated-type EGC. However, if UD-EGC is curatively resected using ER, long-term outcomes can be favorable. Thus, the strategy for CR by ER is important in UD-EGC. To achieve CR in UD-EGC, biological behaviors including tumor growth patterns must be considered. This review aims to describe what is important for curative ER of UD-EGC.

Citations

Citations to this article as recorded by  
  • Long-term outcomes of endoscopic resection followed by additional surgery after non-curative resection in undifferentiated-type early gastric cancer: a nationwide multi-center study
    Jie-Hyun Kim, Young-Il Kim, Ji Yong Ahn, Woon Geon Shin, Hyo-Joon Yang, Su Youn Nam, Byung-Hoon Min, Jae-Young Jang, Joo Hyun Lim, Wan Sik Lee, Bong Eun Lee, Moon Kyung Joo, Jae Myung Park, Hang Lak Lee, Tae-Geun Gweon, Moo In Park, Jeongmin Choi, Chung H
    Surgical Endoscopy.2022; 36(3): 1847.     CrossRef
  • Diffuse-type Gastric Cancer
    Jie-Hyun Kim
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2022; 22(1): 11.     CrossRef
  • The future of endoscopic resection for early gastric cancer
    Raquel Ortigão, Diogo Libânio, Mário Dinis‐Ribeiro
    Journal of Surgical Oncology.2022; 125(7): 1110.     CrossRef
  • Therapeutic approach to non-curative resection after endoscopic treatment in early gastric cancer
    Eun Jeong Gong, Chang Seok Bang
    Journal of the Korean Medical Association.2022; 65(5): 284.     CrossRef
  • Establishing Machine Learning Models to Predict Curative Resection in Early Gastric Cancer with Undifferentiated Histology: Development and Usability Study
    Chang Seok Bang, Ji Yong Ahn, Jie-Hyun Kim, Young-Il Kim, Il Ju Choi, Woon Geon Shin
    Journal of Medical Internet Research.2021; 23(4): e25053.     CrossRef
  • Risk Factors and Clinical Outcomes of Non-Curative Resection in Patients with Early Gastric Cancer Treated with Endoscopic Submucosal Dissection: A Retrospective Multicenter Study in Korea
    Si Hyung Lee, Min Cheol Kim, Seong Woo Jeon, Kang Nyeong Lee, Jong Jae Park, Su Jin Hong
    Clinical Endoscopy.2020; 53(2): 196.     CrossRef
  • 9,708 View
  • 194 Download
  • 6 Web of Science
  • 6 Crossref
Close layer
Case Report
Strongyloidiasis Presenting as Yellowish Nodules in Colonoscopy of an Immunocompetent Patient
Hannah Ra, Jun-Won Chung, Dong Hae Chung, Jung Ho Kim, Yoon Jae Kim, Kyoung Oh Kim, Kwang An Kwon, Dong Kyun Park
Clin Endosc 2019;52(1):80-82.   Published online August 30, 2018
DOI: https://doi.org/10.5946/ce.2018.078
AbstractAbstract PDF
Strongyloides stercoralis is endemic to tropical and subtropical regions, and infections are usually asymptomatic. However, immunocompromised patients, such as those receiving immunosuppressive therapy, high-dose steroids, or chemotherapy, can develop fatal hyperinfections. An 84-year-old man without any symptoms was diagnosed with strongyloidiasis during a regular screening colonoscopy. His medical history only involved a gastric endoscopic submucosal dissection for early gastric cancer 6 months previously. Few cases have been published about asymptomatic strongyloidiasis diagnosed in an immunocompetent host via endoscopic mucosal resection with characteristic colonoscopic findings. We report a case of colon-involved asymptomatic strongyloidiasis with specific colonic findings of yellowish-white nodules. This finding may be an important marker of S. stercoralis infection, which could prevent hyperinfections.

Citations

Citations to this article as recorded by  
  • Severe strongyloidiasis: a systematic review and meta-analysis of 339 cases
    Olga C Rojas, Alexandra M Montoya, Hiram Villanueva-Lozano, Diego Carrion-Alvarez
    Transactions of The Royal Society of Tropical Medicine and Hygiene.2023; 117(10): 682.     CrossRef
  • Seropositivity Rates of Strongyloides stercoralis Antibody in the Southeastern Region of Republic of Korea: A Single-Center Retrospective Study
    Taehwa Kim, Seungjin Lim
    The Korean Journal of Parasitology.2022; 60(3): 181.     CrossRef
  • A Rare Cause of Pedunculated Polyps Caused by Strongyloides
    Omer Yousaf, Arisha Carreon, Ibrahim Mohsin
    European Journal of Case Reports in Internal Medicine.2022;[Epub]     CrossRef
  • Phylogenetic Positioning of a Strongyloides stercoralis Isolate Recovered from a Korean Patient and Comparison with Other Asian Isolates
    Jaeho Bae, Mi Jin Jeong, Dong hoon Shin, Hyun Woo Kim, Sung Ho Ahn, Jun Ho Choi, Hak Sun Yu
    The Korean Journal of Parasitology.2020; 58(6): 689.     CrossRef
  • 9,235 View
  • 127 Download
  • 3 Web of Science
  • 4 Crossref
Close layer
Original Article
Factors Affecting Endoscopic Curative Resection of Gastric Cancer in the Population-Based Screening Era
Yoon Gwon Mun, Myung-Gyu Choi, Chul-Hyun Lim, Han Hee Lee, Dong Hoon Kang, Jae Myung Park, Kyo Young Song
Clin Endosc 2018;51(5):478-484.   Published online June 1, 2018
DOI: https://doi.org/10.5946/ce.2018.006
AbstractAbstract PDF
Background
/Aims: Since population-based screening for gastric cancer in Korea was implemented, endoscopic treatment of early gastric cancer has become increasingly popular. This study investigates factors affecting endoscopic curative resection of early gastric cancer in population-based screening for gastric cancer.
Methods
We retrospectively reviewed data of patients with newly diagnosed gastric cancer who underwent treatment at Seoul St. Mary’s Hospital. All patients completed questionnaires about clinical information, including interval between surveillance tests for gastric cancer.
Results
Of 469 gastric cancer patients, 147 (31.3%) had undergone curative endoscopic resection, 260 (55.4%) had undergone curative surgical resection, and 62 (13.3%) underwent non-curative resection or were in an inoperable state. Patients with curative endoscopic resection had fewer alarm symptoms/signs than other groups. In multivariate analysis, regular surveillance endoscopy was the only factor predicting curative endoscopic resection (odds ratio [OR], 6.099; 95% confidence interval [CI], 2.532–14.933). In addition, patients undergoing gastric cancer screening had a significantly higher rate of endoscopic curative resection compared with subjects who had never been screened. (1-year interval: OR, 49.969; 95% CI, 6.340–393.827, 2-year interval: OR, 15.283; 95% CI, 1.833–127.406, over 2-year interval: OR, 10.651; 95% CI, 1.248–90.871). Shorter screening test intervals were associated with higher rates of endoscopic curative resection.
Conclusions
Regular surveillance testing was the independent factor predicting curative endoscopic resection of gastric cancer.

Citations

Citations to this article as recorded by  
  • A model established using marital status and other factors from the Surveillance, Epidemiology, and End Results database for early stage gastric cancer
    Lixiang Zhang, Baichuan Zhou, Panquan Luo, Aman Xu, Wenxiu Han, Zhijian Wei
    Journal of Investigative Medicine.2022; 70(6): 1373.     CrossRef
  • Risk Factors and Clinical Outcomes of Non-Curative Resection in Patients with Early Gastric Cancer Treated with Endoscopic Submucosal Dissection: A Retrospective Multicenter Study in Korea
    Si Hyung Lee, Min Cheol Kim, Seong Woo Jeon, Kang Nyeong Lee, Jong Jae Park, Su Jin Hong
    Clinical Endoscopy.2020; 53(2): 196.     CrossRef
  • The More, the Better: Is This True in Endoscopy for Gastric Cancer Screening?
    Seong Woo Jeon
    Clinical Endoscopy.2018; 51(5): 402.     CrossRef
  • 8,725 View
  • 114 Download
  • 4 Web of Science
  • 3 Crossref
Close layer
Review
Closing the Gaps: Endoscopic Suturing for Large Submucosal and Full-Thickness Defects
Keshav Kukreja, Suma Chennubhotla, Bharat Bhandari, Ankit Arora, Shashideep Singhal
Clin Endosc 2018;51(4):352-356.   Published online March 5, 2018
DOI: https://doi.org/10.5946/ce.2017.117
AbstractAbstract PDF
This article is a systematic review of relevant literature on endoscopic suturing as a primary closure technique for large submucosal and full-thickness defects after endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), and endoscopic full-thickness resection (EFTR). A comprehensive literature search was conducted through 2016 by using PubMed, to find peer-reviewed original articles. The specific factors considered were the procedural indications and details, success rates, clinical outcomes including complications, and study limitations. Six original articles were included in the final review: two with non-human subjects and four with human subjects. The mean success rate of endoscopic suturing was 97.4% (100% for human subjects and 95.4% for non-human subjects). The procedural time ranged from 7 to 89 min. The average size and depth of lesions were 2.71 cm (3.74 cm [human] and 1.96 cm [non-human]) and 1.52 cm, respectively. The technique itself had no reported impact on mortality. In conclusion, endoscopic suturing is a minimally invasive technique for the primary closure of defects caused by EMR, ESD, and EFTR, with a high success and low complication rate.

Citations

Citations to this article as recorded by  
  • Endoscopic Suturing for Defect Closure in the Upper Gastrointestinal Tract: A Retrospective Cohort Study
    Apostolis Papaefthymiou, Nasar Aslam, Benjamin Norton, Andrea Telese, Charles Murray, Alberto Murino, Gavin Johnson, Roberto Simons-Linares, Rehan Haidry
    Gastrointestinal Disorders.2025; 7(2): 29.     CrossRef
  • Endoscopic closure for mucosal defects after endoscopic resection of gastrointestinal tumors
    Gwang Ha Kim
    Journal of Innovative Medical Technology.2025; 3(2): 50.     CrossRef
  • Endoscopic Management of Bariatric Surgery Complications
    Abhishek Shenoy, Allison R. Schulman
    Gastrointestinal Endoscopy Clinics of North America.2024; 34(4): 655.     CrossRef
  • Colon Sparing Endoscopic Full-Thickness Resection for Advanced Colorectal Lesions: Is It Time for Global Adoption?
    Zhong-Wei Wu, Chao-Hui Ding, Yao-Dong Song, Zong-Chao Cui, Xiu-Qian Bi, Bo Cheng
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Application of a traction metal clip with a fishhook-like device in wound sutures after endoscopic resection
    Wang Fangjun, Leng Xia, Gao Yi, Shen Xiuyun, Wang Wenping, Liu Huamin, Liu Pengfei
    Clinical Endoscopy.2022; 55(4): 525.     CrossRef
  • On the Track of New Endoscopic Alternatives for the Treatment of Selected Gastric GISTs—A Pilot Study
    Artur Raiter, Katarzyna M. Pawlak, Katarzyna Kozłowska-Petriczko, Jan Petriczko, Joanna Szełemej, Anna Wiechowska-Kozłowska
    Medicina.2021; 57(6): 625.     CrossRef
  • Complications of the Use of the OverStitch Endoscopic Suturing System
    Jessica X. Yu, Allison R. Schulman
    Gastrointestinal Endoscopy Clinics of North America.2020; 30(1): 187.     CrossRef
  • Resection of the gastric submucosal tumor (G-SMT) originating from the muscularis propria layer: comparison of efficacy, patients’ tolerability, and clinical outcomes between endoscopic full-thickness resection and surgical resection
    Sha Liu, Xinxin Zhou, YongXing Yao, Keda Shi, Mosang Yu, Feng Ji
    Surgical Endoscopy.2020; 34(9): 4053.     CrossRef
  • Valuing innovative endoscopic techniques: prophylactic clip closure after endoscopic resection of large colon polyps
    Eric D. Shah, Heiko Pohl, Douglas K. Rex, Michael B. Wallace, Seth D. Crockett, Shannon J. Morales, Linda A. Feagins, Ryan Law
    Gastrointestinal Endoscopy.2020; 91(6): 1353.     CrossRef
  • Optimal Endoscopic Resection Technique for Selected Gastric GISTs. The Endoscopic Suturing System Combined with ESD—a New Alternative?
    Katarzyna M. Pawlak, Artur Raiter, Katarzyna Kozłowska-Petriczko, Joanna Szełemej, Jan Petriczko, Katarzyna Wojciechowska, Anna Wiechowska-Kozłowska
    Journal of Clinical Medicine.2020; 9(6): 1776.     CrossRef
  • Life on a knife edge: the optimal approach to the management of perforations during endoscopic submucosal dissection (ESD)
    Shria Kumar, Young Hoon Youn, Jeffrey H. Lee
    Expert Review of Gastroenterology & Hepatology.2020; 14(10): 965.     CrossRef
  • Endoscopic submucosal dissection: an update on tools and accessories
    Christopher Harlow, Arun Sivananthan, Lakshmana Ayaru, Kinesh Patel, Ara Darzi, Nisha Patel
    Therapeutic Advances in Gastrointestinal Endoscopy.2020; 13: 263177452095722.     CrossRef
  • Endoscopic foregut surgery and interventions: The future is now. The state-of-the-art and my personal journey
    Kenneth J Chang
    World Journal of Gastroenterology.2019; 25(1): 1.     CrossRef
  • Management of colonoscopic perforation
    Carey Wickham, Kasim L. Mirza, Sang W. Lee
    Seminars in Colon and Rectal Surgery.2019; 30(3): 100686.     CrossRef
  • Potential role of new technological innovations in non-variceal hemorrhage
    David Friedel
    World J Gastrointest Endosc.2019; 11(8): 472.     CrossRef
  • Endoscopic full-thickness resection for treating small tumors originating from the muscularis propria in the gastric fundus: An improvement in technique over 15 years
    Nan Ge, Jin-Long Hu, Fei Yang, Fan Yang, Si-Yu Sun
    World Journal of Gastrointestinal Oncology.2019; 11(11): 1054.     CrossRef
  • Endoscopic full-thickness resection for treating small tumors originating from the muscularis propria in the gastric fundus: An improvement in technique over 15 years
    Nan Ge, Jin-Long Hu, Fei Yang, Fan Yang, Si-Yu Sun
    World Journal of Gastrointestinal Oncology.2019; 11(11): 1054.     CrossRef
  • 9,907 View
  • 176 Download
  • 14 Web of Science
  • 17 Crossref
Close layer
Focused Review Series: Endoscopic approaches to Neuroendocrine Tumors
Diagnosis and Management of Rectal Neuroendocrine Tumors
Shreya Chablaney, Zachary A. Zator, Nikhil A. Kumta
Clin Endosc 2017;50(6):530-536.   Published online November 30, 2017
DOI: https://doi.org/10.5946/ce.2017.134
AbstractAbstract PDF
The incidence of rectal neuroendocrine tumors (NETs) has increased by almost ten-fold over the past 30 years. There has been a heightened awareness of the malignant potential of rectal NETs. Fortunately, many rectal NETs are discovered at earlier stages due to colon cancer screening programs. Endoscopic ultrasound is useful in assessing both residual tumor burden after retrospective diagnosis and tumor characteristics to help guide subsequent management. Current guidelines suggest endoscopic resection of rectal NETs ≤10 mm as a safe therapeutic option given their low risk of metastasis. Although a number of endoscopic interventions exist, the best technique for resection has not been identified. Endoscopic submucosal dissection (ESD) has high complete and en-bloc resection rates, but also an increased risk of complications including perforation. In addition, ESD is only performed at tertiary centers by experienced advanced endoscopists. Endoscopic mucosal resection has been shown to have variable complete resection rates, but modifications to the technique such as the addition of band ligation have improved outcomes. Prospective studies are needed to further compare the available endoscopic interventions, and to elucidate the most appropriate course of management of rectal NETs.

Citations

Citations to this article as recorded by  
  • Sometimes less is less: endoscopic submucosal resection with band ligation of rectal neuroendocrine tumors with and without submucosal injection
    Luis F. Lara
    Gastrointestinal Endoscopy.2026; 103(2): 343.     CrossRef
  • Comparison of endoscopic mucosal resection combined with band ligation versus endoscopic submucosal dissection for small rectal neuroendocrine tumors (≤ 10 mm): a systematic review and meta-analysis
    Yan Deng, Ting Zhang, Lidan Yang, Wenquan Yi
    BMC Gastroenterology.2026;[Epub]     CrossRef
  • Clinical Outcomes of Peptide Receptor Radionuclide Therapy in Japanese Patients with Metastatic Rectal Neuroendocrine Tumors
    Takeshi Iizuka, Noritoshi Kobayashi, Damian Wild, Felix Kaul, Hiroaki Suzuki, Kengo Maehara, Naoki Okubo, Sho Tsuyuki, Shoko Takano, Yusuke Kurita, Masato Yoneda, Yasushi Ichikawa
    Cancers.2026; 18(8): 1268.     CrossRef
  • Recent updates on the endoscopic treatment of rectal neuroendocrine tumor
    Sunghyeok Ryou, Kwangwoo Nam
    Intestinal Research.2026; 24(2): 208.     CrossRef
  • Case Report: Transrectal contrast-enhanced ultrasonography on preoperative evaluation of rectal neuroendocrine tumors: a 17-case preliminary study
    Jigang Jing, Yuting Wu, Hua Zhuang
    Frontiers in Surgery.2026;[Epub]     CrossRef
  • Stratification of risk for lymph node metastasis and long-term oncologic outcomes in patients initially treated by endoscopic resection for rectal neuroendocrine tumors
    Sung Sil Park, Byung Chang Kim, Dong-eun Lee, Hee Jin Chang, Kyung Su Han, Bun Kim, Chang Won Hong, Dae Kyung Sohn, Dong Woon Lee, Kiho You, Sung Chan Park, Jae Hwan Oh
    Gastrointestinal Endoscopy.2025; 101(6): 1222.     CrossRef
  • Risk factors for lateral pelvic lymph node metastasis in patients with rectal neuroendocrine tumors: a systematic review and meta-analysis
    Ziyue Chen, Dajian Zhu
    Frontiers in Oncology.2025;[Epub]     CrossRef
  • Rectal large cell neuroendocrine carcinoma
    Panagiotis Alexandros Drakos, Antonia A Prountzopoulou, Efrossini Totskas, Konstantinos Stamou
    Oxford Medical Case Reports.2025;[Epub]     CrossRef
  • Long-term outcome of grade 1 rectal neuroendocrine tumor ≤1 cm after incomplete endoscopic resection
    Jong Sun Park, Hye Lynn Jeon, Bumhee Park, Jong Hoon Park, Gil Ho Lee, Sun Gyo Lim, Sung Jae Shin, Kee Myung Lee, Choong-Kyun Noh
    Clinical Endoscopy.2025; 58(6): 871.     CrossRef
  • Endoscopic ultrasonography (EUS)-guided SSTR PET/CT imaging in the management of patients with small (<2 cm) gastrointestinal neuroendocrine neoplasms: A multicenter study
    Xiang Li, Yirong Wang, Fang Xie, Haojun Chen, Ming Han, Zefei Zhang, Xiang Zhou, Sihao Jia, Herui Li, Jing Wang, Fei Kang
    The EANM Journal.2025; 1: 100012.     CrossRef
  • Artificial intelligence-assisted diagnosis of rectal neuroendocrine tumors during white-light endoscopy
    Ke Liu, Zhen-Yu Wang, Li-Zhi Yi, Feng Li, Shun-Hui He, Xi-Gang Zhang, Chun-Xiao Lai, Zhi-Jian Li, Lin Qiu, Rui-Ya Zhang, Wen Wu, Yu Lin, Hui Yang, Gui-Ming Liu, Quan-Sheng Guan, Zhi-Fang Zhao, Li-Ming Cheng, Jie Dai, Yang Bai, Fang Xie, Meng-Nan Zhang, Su
    World Journal of Gastroenterology.2025;[Epub]     CrossRef
  • Endoscopic Resection of Rectal Neuroendocrine Tumors: Pathologic Risk Stratification and Surveillance Strategies
    Ji Eun Kim
    Journal of Digestive Cancer Research.2025; 13(3): 228.     CrossRef
  • Risk Factor Analysis of Lymph Node Metastasis for Rectal Neuroendocrine Tumors: Who Needs a Radical Resection in Rectal Neuroendocrine Tumors Sized 1–2 cm?
    Jin Sun Choi, Min Jung Kim, Rumi Shin, Ji Won Park, Seung Chul Heo, Seung-Yong Jeong, Kyu Joo Park, Seung-Bum Ryoo
    Annals of Surgical Oncology.2024; 31(4): 2414.     CrossRef
  • Clinicopathologic and Endosonographic Characteristics of Colon Subepithelial Tumors Discovered Incidentally
    Aryoung Kim, Sung Noh Hong, Dong Kyung Chang, Young-Ho Kim, Ji Eun Kim, Eun Ran Kim
    Diagnostics.2024; 14(5): 551.     CrossRef
  • Impact of grade on workup of rectal neuroendocrine tumors: a retrospective cohort study
    Akie Watanabe, Sabrina Rai, Lily Yip, Carl J. Brown, Jonathan M. Loree, Heather C. Stuart
    World Journal of Surgical Oncology.2024;[Epub]     CrossRef
  • The role of endoscopic ultrasonography for diagnosis of residual rectal neuroendocrine tumor
    Seong-Jung Kim, Jun Lee, Gang-Woo Kim, So Yeong Kim
    Surgical Endoscopy.2024; 38(8): 4260.     CrossRef
  • Surgery Prolongs Five-Year Survival for Nonmetastatic Colon Neuroendocrine Tumors
    Venu G. Bangla, Armon Panahi, Ava Adler, Celia M. Divino
    World Journal of Colorectal Surgery.2024; 13(3): 71.     CrossRef
  • Rare Case of Well-differentiated Neuroendocrine Tumor of Rectum
    Vineeth Venkata Damera, Naveen Kumar Kosinipalli, Vijayalakshmi Seetha, Bushra Tahseen
    Indian Journal of Colo-Rectal Surgery.2024; 7(2): 28.     CrossRef
  • Rectal tonsil: a diagnostic dilemma
    Katie Wang, Munyaradzi G. Nyandoro, Benhur Amanuel, Abraham Jacob
    ANZ Journal of Surgery.2023; 93(4): 1056.     CrossRef
  • Rectal neuroendocrine tumours and the role of emerging endoscopic techniques
    Eoin Keating, Gayle Bennett, Michelle A Murray, Sinead Ryan, John Aird, Donal B O'Connor, Dermot O'Toole, Conor Lahiff
    World Journal of Gastrointestinal Endoscopy.2023; 15(5): 368.     CrossRef
  • Efficacy of endoscopic mucosal resection versus endoscopic submucosal dissection for rectal neuroendocrine tumors ≤10mm: a systematic review and meta-analysis
    Ce Zhou, Furong Zhang, Yinghua We
    Annals of Saudi Medicine.2023; 43(3): 179.     CrossRef
  • Cap-Assisted Endoscopic Mucosal Resection for Rectal Neuroendocrine Tumors: An Effective Option
    Mafalda João, Susana Alves, Miguel Areia, Luís Elvas, Daniel Brito, Sandra Saraiva, Raquel Martins, Ana Teresa Cadime
    GE - Portuguese Journal of Gastroenterology.2023; 30(2): 107.     CrossRef
  • Efficacy and safety of ligation-assisted endoscopic submucosal resection combined with endoscopic ultrasonography for treatment of rectal neuroendocrine tumors
    Dazhou Li, Jiao Xie, Donggui Hong, Gang Liu, Rong Wang, Chuanshen Jiang, Zhou Ye, Binbin Xu, Wen Wang
    Scandinavian Journal of Gastroenterology.2022; 57(6): 734.     CrossRef
  • Assessment of the Risk of Nodal Involvement in Rectal Neuroendocrine Neoplasms: The NOVARA Score, a Multicentre Retrospective Study
    Angela Dalia Ricci, Sara Pusceddu, Francesco Panzuto, Fabio Gelsomino, Sara Massironi, Claudio Giovanni De Angelis, Roberta Modica, Gianluca Ricco, Martina Torchio, Maria Rinzivillo, Natalie Prinzi, Felice Rizzi, Giuseppe Lamberti, Davide Campana
    Journal of Clinical Medicine.2022; 11(3): 713.     CrossRef
  • Risk Factors for Lymph Node Metastasis and Oncologic Outcomes in Small Rectal Neuroendocrine Tumors with Lymphovascular Invasion
    Seung-Joo Nam, Byung Chang Kim, Hee Jin Chang, Han Ho Jeon, Junho Kim, Su Young Kim
    Gut and Liver.2022; 16(2): 228.     CrossRef
  • Current status of surgical management of patients with gastroenteropancreatic neuroendocrine neoplasms
    Rafał Stankiewicz, Michał Grąt
    World Journal of Gastrointestinal Surgery.2022; 14(4): 276.     CrossRef
  • Gastroenteropancreatic Neuroendocrine Tumors
    Conrad J. Fernandes, Galen Leung, Jennifer R. Eads, Bryson W. Katona
    Gastroenterology Clinics of North America.2022; 51(3): 625.     CrossRef
  • Practical approach to linear endoscopic ultrasound examination of the rectum and anal canal
    Hussein Hassan Okasha, Katarzyna M. Pawlak, Amr Abou-elmagd, Ahmed El-Meligui, Hassan Atalla, Mohamed O. Othman, Sameh Abou Elenin, Ahmed Alzamzamy, Reem Ezzat Mahdy
    Endoscopy International Open.2022; 10(10): E1417.     CrossRef
  • Neuroendocrine Carcinoma of the Anus and Rectum: Patient Characteristics and Treatment Options
    Benjamin E. Ueberroth, Alex J. Liu, Jason S. Starr, Timothy J. Hobday, Jonathan B. Ashman, Nitin Mishra, Tanios S. Bekaii-Saab, Thorvardur R. Halfdanarson, M. Bassam Sonbol
    Clinical Colorectal Cancer.2021; 20(2): e139.     CrossRef
  • Endoscopic resection is more effective than biopsy or EUS to detect residual rectal neuroendocrine tumor
    Matthew W. Stier, Christopher G. Chapman, Steven Shamah, Kianoush Donboli, Lindsay Yassan, Irving Waxman, Uzma D. Siddiqui
    Endoscopy International Open.2021; 09(01): E4.     CrossRef
  • Comparison of endoscopic submucosal dissection and transanal endoscopic microsurgery for T1 rectal neuroendocrine tumors: a propensity score-matched study
    Sung Sil Park, Byung Chang Kim, Dong-eun Lee, Kyung Su Han, Bun Kim, Chang Won Hong, Dae Kyung Sohn
    Gastrointestinal Endoscopy.2021; 94(2): 408.     CrossRef
  • Rectal carcinoid tumour presenting as polyp: a challenge in management in rural settings
    Feras Alnimri, Michelle W. Ng, Prasenjit Modak
    ANZ Journal of Surgery.2021; 91(6): 1318.     CrossRef
  • Anchoring the snare tip is a feasible endoscopic mucosal resection method for small rectal neuroendocrine tumors
    Jeongseok Kim, Jisup Kim, Eun Hye Oh, Nam Seok Ham, Sung Wook Hwang, Sang Hyoung Park, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Seung-Mo Hong, Dong-Hoon Yang
    Scientific Reports.2021;[Epub]     CrossRef
  • Tumor grade 2 as the independent predictor for lymph node metastasis in 10–20 mm sized rectal neuroendocrine tumor
    Byung-Soo Park, Sung Hwan Cho, Gyung Mo Son, Hyun Sung Kim, Su Jin Kim, Su Bum Park, Cheol Woong Choi, Hyung Wook Kim, Dong Hoon Shin
    Korean Journal of Clinical Oncology.2021; 17(1): 37.     CrossRef
  • Synchronous multiple primary malignant neoplasms: a case report of malignant peritoneal mesothelioma and neuroendocrine rectal tumor
    Oleksandr Bondar, Sergiі Chetverikov, Viacheslav Maksymovskyi, Dmytro Atanasov, Mykhailo Chetverikov, Valeriia Chetverikova-Ovchynnyk
    EUREKA: Health Sciences.2021; (4): 81.     CrossRef
  • Colorectal endoscopic full‐thickness resection: Initial experience from a tertiary centre in Singapore
    Chin Kimg Tan, James Weiquan Li, Lai Mun Wang, Andrew Boon Eu Kwek, Tiing Leong Ang
    GastroHep.2021; 3(5): 298.     CrossRef
  • Endoscopic submucosal dissection versus endoscopic mucosal resection for rectal carcinoid tumor. A meta‐analysis and meta‐regression with single‐arm analysis
    Jie Ning Yong, Xiong Chang Lim, Kameswara Rishi Yeshayahu Nistala, Lincoln Kai En Lim, Grace En Hui Lim, Jingxuan Quek, Hui Yu Tham, Neng Wei Wong, Ker‐Kan Tan, Choon Seng Chong
    Journal of Digestive Diseases.2021; 22(10): 562.     CrossRef
  • Nodal metastases in small rectal neuroendocrine tumours
    Sarah O’Neill, Amyn Haji, Suzanne Ryan, Dominique Clement, Konstantinos Sarras, Bu Hayee, Nicola Mulholland, John K. Ramage, Rajaventhan Srirajaskanthan
    Colorectal Disease.2021; 23(12): 3173.     CrossRef
  • A case of a rectal adenocarcinoma mimicking a neuroendocrine tumor in the background mucosa of amoebic colitis
    Shun Ito, Satoshi Ono, Akihiro Kobayashi, Kyohei Maejima, Shosuke Hosaka, Kiyotaka Umeki, Shin-ichiro Sato, Satoshi Wakasugi, Kenji Ogata
    Clinical Journal of Gastroenterology.2020; 13(4): 552.     CrossRef
  • Low-grade Rectal Neuroendocrine Tumor Recurring as Multiple Hepatic Metastasis after Complete Endoscopic Removal: A Case Report
    Ik Hyun Jo, Kang-Moon Lee, Dae Bum Kim, Ji Min Lee
    The Korean Journal of Gastroenterology.2020; 76(5): 251.     CrossRef
  • Incomplete cold snare polypectomy for rectal carcinoid tumour
    Yuichiro Hirai, Toshihiro Nishizawa, Toshio Uraoka
    Arab Journal of Gastroenterology.2019; 20(1): 59.     CrossRef
  • Endoscopic Resection of a Rectal Neuroendocrine Tumor: Hybrid Endoscopic Submucosal Dissection
    Marta Gravito-Soares, Elisa Gravito-Soares, Pedro Amaro, Inês Cunha, João Fraga, Luís Tomé
    GE - Portuguese Journal of Gastroenterology.2019; 26(2): 131.     CrossRef
  • Incidental diagnosis of very small rectal neuroendocrine neoplasms: when should endoscopic submucosal dissection be performed? A single ENETS centre experience
    Nico Pagano, Claudio Ricci, Nicole Brighi, Carlo Ingaldi, Francesco Pugliese, Donatella Santini, Davide Campana, Cristina Mosconi, Valentina Ambrosini, Riccardo Casadei
    Endocrine.2019; 65(1): 207.     CrossRef
  • Neuroendocrine regulation of cholangiocarcinoma: A status quo review
    Meng Sha, Jie Cao, Han-yong Sun, Ying Tong, Qiang Xia
    Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2019; 1872(1): 66.     CrossRef
  • Analysis of 72 patients with colorectal high-grade neuroendocrine neoplasms from three Chinese hospitals
    Zhi-Jie Wang, Ke An, Rui Li, Wei Shen, Man-Dula Bao, Jin-Hua Tao, Jia-Nan Chen, Shi-Wen Mei, Hai-Yu Shen, Yun-Bin Ma, Fu-Qiang Zhao, Fang-Ze Wei, Qian Liu
    World Journal of Gastroenterology.2019; 25(34): 5197.     CrossRef
  • Management of Gastrointestinal Neuroendocrine Tumors
    Rongzhi Wang, Rui Zheng-Pywell, H Alexander Chen, James A Bibb, Herbert Chen, J Bart Rose
    Clinical Medicine Insights: Endocrinology and Diabetes.2019;[Epub]     CrossRef
  • Proper Treatment Option for Small Rectal Neuroendocrine Tumors Using Precut Endoscopic Mucosal Resection
    Seun Ja Park
    Clinical Endoscopy.2017; 50(6): 516.     CrossRef
  • 29,997 View
  • 435 Download
  • 46 Web of Science
  • 47 Crossref
Close layer
Case Report
Endoscopic Treatment of Jejunal Heterotopic Gastric Mucosa that Caused Recurrent Intussusception
Ke Ryun Ahn, Ja Seol Koo, Hwan Il Kim, Ji Hye Kim, Jee Hyun Lee, Seung Young Kim, Sung Woo Jung, Sang Woo Lee
Clin Endosc 2017;50(6):605-608.   Published online October 18, 2017
DOI: https://doi.org/10.5946/ce.2017.026
AbstractAbstract PDF
Heterotopic gastric mucosa (HGM) is a rare anomaly in the small bowel and may be the cause of intussusception when it gets a lead point in the jejunum. All cases of intussusception due to intestinal HGM have been treated with surgical resection. A 5-year-old girl presented with chief complaints of vomiting and abdominal pain for 2 weeks. A computed tomography scan of the abdomen showed intussusception at the proximal jejunal loops. Three air reductions and one saline reduction were attempted without success. She continued to be symptomatic, and endoscopic evaluation was performed. Enteroscopy revealed some variable-sized polypoid mucosal lesions with erosions on the proximal jejunum. Endoscopic mucosal resection was performed using a snare. The resected tissues histologically showed a hyperplastic polyp arising from the HGM. Her symptoms did not recur within 1 year after the treatment. Our case showed that enteroscopy could be useful for the diagnosis and management of jejunal intussusception caused by HGM.

Citations

Citations to this article as recorded by  
  • Endoscopic Mucosal Resection in Children
    David S. Vitale, Kelly Wang, Laith H. Jamil, Kenneth H. Park, Quin Y. Liu
    Journal of Pediatric Gastroenterology and Nutrition.2022; 74(1): 20.     CrossRef
  • Life-threatening gastrointestinal bleeding caused by jejunal heterotopic gastric mucosa in an adult dog: a rare case report
    Roxana Merca, Barbara Richter
    BMC Veterinary Research.2022;[Epub]     CrossRef
  • Rare polypoid gastric mucosa induced small bowel intussusception in a toddler
    Brianna M. Bowman, Suy sen Hung Fong, Joel M. Prince, Subhasis Misra, Thomas Abbruzzese, Drew Rideout
    Journal of Pediatric Surgery Case Reports.2022; 87: 102476.     CrossRef
  • Intraoperative Endoscopy in Transient Adult Jejunojejunal Intussusception
    Takeshi Okamoto, Hidekazu Suzuki, Katsuyuki Fukuda, Yoshihiro Moriwaki
    Case Reports in Gastrointestinal Medicine.2021; 2021: 1.     CrossRef
  • Heterotopic Gastric Mucosa in Adolescent Girl
    Esra Polat, Rahşan Özcan, Nuray Kepil, Mine Güllüoğlu, Sevinç Kalin
    Journal of Pediatric Gastroenterology and Nutrition.2020;[Epub]     CrossRef
  • Jejunal Polyps out of Place: A Case of Gastric Heterotopia of the Jejunum
    Siri A. Urquhart, Nayantara Coelho-Prabhu
    Case Reports in Gastrointestinal Medicine.2020; 2020: 1.     CrossRef
  • Heterotopic Gastric Mucosa Presenting as Lower Gastrointestinal Bleeding: An Unusual Case Report
    Syed Muhammad Ali, Ayman Abdelhafiz Ahmed, Leena Amin Hussain Saaid, Gihan Mustafa Kamal Mohamed, Amjad Ali Shah, Mohannad Al-Tarakji, Zia Aftab, Inamulla, Sameera Rashid, Paola De Nardi
    Case Reports in Surgery.2019;[Epub]     CrossRef
  • 9,717 View
  • 148 Download
  • 7 Web of Science
  • 7 Crossref
Close layer
Original Article
Efficacy of Precut Endoscopic Mucosal Resection for Treatment of Rectal Neuroendocrine Tumors
Hoonsub So, Su Hyun Yoo, Seungbong Han, Gwang-un Kim, Myeongsook Seo, Sung Wook Hwang, Dong-Hoon Yang, Jeong-Sik Byeon
Clin Endosc 2017;50(6):585-591.   Published online October 12, 2017
DOI: https://doi.org/10.5946/ce.2017.039
AbstractAbstract PDF
Background
/Aims: Endoscopic resection is the first-line treatment for rectal neuroendocrine tumors (NETs) measuring <1 cm and those between 1 and 2 cm in size. However, conventional endoscopic resection cannot achieve complete resection in all cases. We aimed to analyze clinical outcomes of precut endoscopic mucosal resection (EMR-P) used for the management of rectal NET.
Methods
EMR-P was used to treat rectal NET in 72 patients at a single tertiary center between 2011 and 2015. Both, circumferential precutting and EMR were performed with the same snare device in all patients. Demographics, procedural details, and histopathological features were reviewed for all cases.
Results
Mean size of the tumor measured endoscopically was 6.8±2.8 mm. En bloc and complete resection was achieved in 71 (98.6%) and 67 patients (93.1%), respectively. The mean time required for resection was 9.0±5.6 min. Immediate and delayed bleeding developed in six (8.3%) and 4 patients (5.6%), respectively. Immediate bleeding observed during EMR-P was associated with the risk of delayed bleeding.
Conclusions
Both, the en bloc and complete resection rates of EMR-P in the treatment of rectal NETs using the same snare for precutting and EMR were noted to be high. The procedure was short and safe. EMR-P may be a good treatment choice for the management of rectal NETs.

Citations

Citations to this article as recorded by  
  • Recent updates on the endoscopic treatment of rectal neuroendocrine tumor
    Sunghyeok Ryou, Kwangwoo Nam
    Intestinal Research.2026; 24(2): 208.     CrossRef
  • Comparison between ligation-assisted and precutting endoscopic mucosal resection for small rectal neuroendocrine tumors: a CHASID study
    Sunghyeok Ryou, Yunho Jung, Dae Sung Kim, Hee Seok Moon, Hoon Sup Koo, Hyun Deok Shin, Ki Bae Bang, Kyu Chan Huh
    The Korean Journal of Internal Medicine.2026; 41(3): 432.     CrossRef
  • Efficacy, Safety and Oncological Outcomes of Minimally Invasive Approaches (EMR, ESD and TAMIS) for Early Rectal Tumors: A Systematic Review and Meta-Analysis
    Mariam Hussain, Fatima Kayali, Abdelaziz O Surkhi, Roy Shartouni, Thurkga Moothathamby, Ahmed Akmal, Rohan Vyas, Leen Ammari, Ibrahim Sharaf, Mona Jaffar-Karballai, Mohamed Refaie, Yousif Jubouri, Matti Jubouri, Mohamad Bashir, Ali Murtada
    Medical Devices: Evidence and Research.2026; Volume 19: 1.     CrossRef
  • Modified endoscopic mucosal resection versus endoscopic submucosal dissection for rectal neuroendocrine tumors ≤10 mm: a systematic review and meta-analysis of randomized controlled trials
    Ke Pang, Lujing Ying, Hemiao Xu, Yabing Wang, Wangyang Chen, Daiyu Yang, Qiming Xiao, Shuai Li, Rutong Li, Hongwei Wang, Jingchao Gao, Peiyu Zhang, Jun Li, Kun He, Qiang Wang, Dong Wu
    Digestive and Liver Disease.2026;[Epub]     CrossRef
  • Risk factors for residual tumors in histologically incompletely resected rectal neuroendocrine tumors
    Jung-Bin Park, Ga Hee Kim, Minjun Kim, Seung Wook Hong, Sung Wook Hwang, Sang Hyoung Park, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Seok-Byung Lim, Seung-Mo Hong, Dong-Hoon Yang
    Digestive and Liver Disease.2025; 57(7): 1473.     CrossRef
  • Submucosal saline injection and mini-probe endoscopic ultrasound to assess endoscopic resectability of colorectal subepithelial tumors
    Jung-Bin Park, Ji Eun Baek, June Hwa Bae, Seung Wook Hong, Sung Wook Hwang, Sang Hyoung Park, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Dong-Hoon Yang
    The Korean Journal of Internal Medicine.2025; 40(4): 592.     CrossRef
  • Precut mucosectomy versus endoscopic resection techniques for colorectal lesions sized 10–30 mm: meta-analysis and systematic review
    Miriam Chinzon, Mateus Bond Boghossian, Matheus de Oliveira Veras, Evellin Souza Valentim dos Santos, Daryl Ramai, Larissa Mercadante de Assis, Vitor Hernandes Lopes, Nelson Miyajima, Wanderley Marques Bernardo, Eduardo Guimarães Hourneaux de Moura
    Surgical Endoscopy.2025; 39(9): 5506.     CrossRef
  • Safety and Efficacy of Simplified EMR Versus ESD for Rectal Neuroendocrine Tumors ≤ 10 Mm: A Retrospective Cohort Study
    Linfeng Zou, Long Zou, Yingyun Yang, Weixun Zhou, Xi Wu, Tao Guo, Qingwei Jiang, Yunlu Feng, Shengyu Zhang, Qiang Wang, Aiming Yang
    Journal of Clinical Medicine.2025; 14(17): 6125.     CrossRef
  • Endoscopic mucosal resection using anchored snare Tip-in versus precut technique for small rectal neuroendocrine tumors
    Seung Wook Hong, Dong-Hoon Yang, Yoo Jin Lee, Dong Hoon Baek, Jaeyoung Chun, Hyun Gun Kim, Sung Joo Kim, Seung-Mo Hong, Dae-Seong Myung
    The Korean Journal of Internal Medicine.2024; 39(2): 238.     CrossRef
  • Risk Factors for Lymph Node Metastasis and Oncologic Outcomes in Small Rectal Neuroendocrine Tumors with Lymphovascular Invasion
    Seung-Joo Nam, Byung Chang Kim, Hee Jin Chang, Han Ho Jeon, Junho Kim, Su Young Kim
    Gut and Liver.2022; 16(2): 228.     CrossRef
  • EMR-P for small rectal neuroendocrine tumors: is it a preferred treatment?
    Zhaohui Liu, Chunsi Zheng, Shihua Ding, Chong Chen, Jingbo Yang, Ruinuan Wu, Dayong Sun
    Scandinavian Journal of Gastroenterology.2022; 57(12): 1503.     CrossRef
  • Recurrence after endoscopic resection of small rectal neuroendocrine tumors: a retrospective cohort study
    Sukit Pattarajierapan, Supakij Khomvilai
    Annals of Coloproctology.2022; 38(3): 216.     CrossRef
  • Endoscopic treatment for rectal neuroendocrine tumor: which method is better?
    Seung Min Hong, Dong Hoon Baek
    Clinical Endoscopy.2022; 55(4): 496.     CrossRef
  • Diagnosis, treatment, and current concepts in the endoscopic management of gastroenteropancreatic neuroendocrine neoplasms
    Giuseppe Iabichino, Milena Di Leo, Monica Arena, Giovanni Giuseppe Rubis Passoni, Elisabetta Morandi, Francesca Turpini, Paolo Viaggi, Carmelo Luigiano, Luca De Luca
    World Journal of Gastroenterology.2022; 28(34): 4943.     CrossRef
  • Comparison of conventional and modified endoscopic mucosal resection methods for the treatment of rectal neuroendocrine tumors
    Hee Sung Lee, Hee Seok Moon, In Sun Kwon, Jae Ho Park, Ju Seok Kim, Sun Hyung Kang, Eaum Seok Lee, Seok Hyun Kim, Jae Kyu Sung, Byung Seok Lee, Hyun Yong Jeong
    Surgical Endoscopy.2021; 35(11): 6055.     CrossRef
  • Diagnosis and Management of Rectal Neuroendocrine Tumors (NETs)
    Francesco Maione, Alessia Chini, Marco Milone, Nicola Gennarelli, Michele Manigrasso, Rosa Maione, Gianluca Cassese, Gianluca Pagano, Francesca Paola Tropeano, Gaetano Luglio, Giovanni Domenico De Palma
    Diagnostics.2021; 11(5): 771.     CrossRef
  • Anchoring the snare tip is a feasible endoscopic mucosal resection method for small rectal neuroendocrine tumors
    Jeongseok Kim, Jisup Kim, Eun Hye Oh, Nam Seok Ham, Sung Wook Hwang, Sang Hyoung Park, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Seung-Mo Hong, Dong-Hoon Yang
    Scientific Reports.2021;[Epub]     CrossRef
  • Safety and efficacy of tip‐in endoscopic mucosal resection for large sessile colorectal polyps: A single‐center experience in Taiwan
    Chung‐Ying Lee, Ming‐Yao Chen, Hwai‐Jeng Lin, Hsi‐Yuan Chien
    Advances in Digestive Medicine.2020; 7(2): 58.     CrossRef
  • Incidental diagnosis of very small rectal neuroendocrine neoplasms: when should endoscopic submucosal dissection be performed? A single ENETS centre experience
    Nico Pagano, Claudio Ricci, Nicole Brighi, Carlo Ingaldi, Francesco Pugliese, Donatella Santini, Davide Campana, Cristina Mosconi, Valentina Ambrosini, Riccardo Casadei
    Endocrine.2019; 65(1): 207.     CrossRef
  • Clinical outcomes of endoscopic mucosal resection for rectal neuroendocrine tumor
    Jihye Kim, Jee Hyun Kim, Joo Young Lee, Jaeyoung Chun, Jong Pil Im, Joo Sung Kim
    BMC Gastroenterology.2018;[Epub]     CrossRef
  • Proper Treatment Option for Small Rectal Neuroendocrine Tumors Using Precut Endoscopic Mucosal Resection
    Seun Ja Park
    Clinical Endoscopy.2017; 50(6): 516.     CrossRef
  • 13,463 View
  • 263 Download
  • 22 Web of Science
  • 21 Crossref
Close layer
Review
Metachronous Gastric Cancer Following Curative Endoscopic Resection of Early Gastric Cancer
Seiichiro Abe, Ichiro Oda, Takeyoshi Minagawa, Masau Sekiguchi, Satoru Nonaka, Haruhisa Suzuki, Shigetaka Yoshinaga, Amit Bhatt, Yutaka Saito
Clin Endosc 2018;51(3):253-259.   Published online September 18, 2017
DOI: https://doi.org/10.5946/ce.2017.104
AbstractAbstract PDF
This review article summarizes knowledge about metachronous gastric cancer (MGC) occurring after curative endoscopic resection (ER) of early gastric cancer (EGC), treatment outcomes of patients who developed MGC, and efficacy of Helicobacter pylori eradication to prevent MGC. The incidence of MGC following curative ER increases over time and is higher than in patients undergoing gastrectomy. Increasing age and multifocal EGC are independent risk factors for developing MGC. An MGC following curative ER is usually a small (<20 mm) and differentiated intramucosal cancer. Most MGC lesions are found at an early stage on semiannual or annual surveillance endoscopy and are successfully treated by further ER, with excellent long-term outcomes. Eradication of H. pylori may reduce the risk of MGC following ER of EGC, but further prospective studies with long-term outcomes are required. Surveillance endoscopy following gastric ER should be continued indefinitely, due to the risk of MGC even after successful H. pylori eradication. Risk stratification and tailored endoscopic surveillance schedules need to be developed.

Citations

Citations to this article as recorded by  
  • White Globe Appearance Is an Endoscopic Predictor of Metachronous Multiple Gastric Cancers
    Manami Utsunomiya, Hiroyoshi Nakanishi, Naohiro Yoshida, Saori Miyajima, Azusa Kawasaki, Shigenori Wakita, Yosuke Kito, Kunihiro Tsuji, Haruhiko Shugo, Shigetsugu Tsuji, Sho Tsuyama, Kazuyoshi Katayanagi, Hiroshi Minato, Hisashi Doyama
    DEN Open.2027;[Epub]     CrossRef
  • Risk factors associated with non-curative resection and metachronous cancer after endoscopic submucosal dissection in patients with ulcerative early gastric cancer
    Yiping Xin, Yuning Chu, Qi Zhang, Xiaoyan Yin, Tao Mao, Xiaoyu Li
    European Journal of Medical Research.2026;[Epub]     CrossRef
  • Bile Reflux is a Risk Factor for Metachronous Development in Patients with Early Gastric Cancer
    Hiroki Murai, Takuya Yamada, Yukihiro Kusumoto, Akane Namiki, Naoko Hayata, Akino Okamoto, Munehiro Ashida, Takafumi Tanimoto, Kohsaku Ohnishi, Tomohide Kurahashi, Motohiro Hirao, Atsushi Hosui, Naoki Hiramatsu
    Endoscopy International Open.2026;[Epub]     CrossRef
  • Management of Gastric Precancerous Lesions and Early Cancer: Practice-Oriented Answers to Clinical Questions
    Cecilia Capelli, Alberto Gattuso, Roberta Grosso, Marco Di Marco, Leonardo Frazzoni
    Cancers.2026; 18(14): 2276.     CrossRef
  • Incidence of Metachronous Gastric Cancer After Endoscopic Submucosal Dissection in Helicobacter pylori-uninfected Early Gastric Cancer
    Yusuke Kawai, Junnosuke Hayasaka, Yorinari Ochiai, Junji Tanaka, Minoru Oda, Hiroshi Yamato, Yugo Suzuki, Yutaka Mitsunaga, Hiroyuki Odagiri, Akira Matsui, Shu Hoteya
    Digestive Diseases and Sciences.2026;[Epub]     CrossRef
  • AGA Clinical Practice Update on Screening and Surveillance in Individuals at Increased Risk for Gastric Cancer in the United States: Expert Review
    Shailja C. Shah, Andrew Y. Wang, Michael B. Wallace, Joo Ha Hwang
    Gastroenterology.2025; 168(2): 405.     CrossRef
  • Gastric remnant cancer: a comprehensive narrative review from carcinogenesis to treatment
    José Darío Portillo-Miño, Sandra Cifuentes, Javier Morales, Melissa Bastidas, William Otero, Paulo Pimentel de Assumpção, Gonzalo Latorre, Megan Neumann, Arnoldo Riquelme
    Revista de Gastroenterología del Perú.2025; 45(3): 282.     CrossRef
  • Impact of endoscopy intervals on metachronous gastric cancer after endoscopic submucosal dissection: Comparison between 1 year and half‐a‐year
    Yuichiro Ozeki, Kingo Hirasawa, Atsushi Sawada, Ryosuke Ikeda, Masafumi Nishio, Takehide Fukuchi, Ryosuke Kobayashi, Chiko Sato, Shin Maeda
    Digestive Endoscopy.2024; 36(3): 332.     CrossRef
  • High risk of multiple gastric cancers in Japanese individuals with Lynch syndrome
    Nobuhiko Kanaya, Thijs A. van Schaik, Hideki Aoki, Yumiko Sato, Fumitaka Taniguchi, Kunitoshi Shigeyasu, Kokichi Sugano, Kiwamu Akagi, Hideyuki Ishida, Kohji Tanakaya
    Annals of Gastroenterological Surgery.2024; 8(6): 1008.     CrossRef
  • Clinical outcomes of ablation of gastric dysplasia with argon plasma coagulation
    Mi Jin Oh, Sang Gyun Kim, Jiyoon Kim, Yun Suk Na, Seunghan Lee, Junhee Lee, Bokyung Kim, Hyunsoo Chung, Soo-Jeong Cho, Miquel Vall-llosera Camps
    PLOS ONE.2024; 19(7): e0306934.     CrossRef
  • Optimal Surveillance of Metachronous Gastric Lesion after Endoscopic Resection of Early Gastric Cancer
    Dong Chan Joo, Gwang Ha Kim
    Gut and Liver.2024; 18(5): 781.     CrossRef
  • Latest guideline of endoscopic submucosal dissection of early gastric cancer may not be suitable for Chinese patients: retrospective study findings from two centers
    Yu Mei, Jianpeng Gao, Benyan Zhang, Tienan Feng, Wei Wu, Zhenggang Zhu, Zhenglun Zhu
    Surgical Endoscopy.2024; 38(11): 6726.     CrossRef
  • Risk assessment of metachronous gastric cancer development using OLGA and OLGIM systems after endoscopic submucosal dissection for early gastric cancer: a long-term follow-up study
    Yun Suk Na, Sang Gyun Kim, Soo-Jeong Cho
    Gastric Cancer.2023; 26(2): 298.     CrossRef
  • Metachronous lesions after gastric endoscopic submucosal dissection: first assessment of the FAMISH prediction score
    Andreia Rei, Raquel Ortigão, Mariana Pais, Luís P. Afonso, Pedro Pimentel-Nunes, Mário Dinis-Ribeiro, Diogo Libânio
    Endoscopy.2023; 55(10): 909.     CrossRef
  • Variation in the rate of detection of minute and small early gastric cancers at diagnostic endoscopy may reflect the performance of individual endoscopists
    Daisuke Murakami, Masayuki Yamato, Yuji Amano, Takayoshi Nishino, Makoto Arai
    BMJ Open Gastroenterology.2023; 10(1): e001143.     CrossRef
  • Decision to perform additional surgery after non-curative endoscopic submucosal dissection for gastric cancer based on the risk of lymph node metastasis: a long-term follow-up study
    Seunghan Lee, Sang Gyun Kim, Soo-Jeong Cho
    Surgical Endoscopy.2023; 37(10): 7738.     CrossRef
  • Helicobacter pylori Eradication Can Reverse Rho GTPase Expression in Gastric Carcinogenesis
    Jue Lie Kim, Sang Gyun Kim, Enerelt Natsagdorj, Hyunsoo Chung, Soo-Jeong Cho
    Gut and Liver.2023; 17(5): 741.     CrossRef
  • Risk assessment of metachronous gastric cancer after endoscopic submucosal dissection based on endoscopic intestinal metaplasia
    Chino Iizuka, Soichiro Sue, Sho Onodera, Aya Ikeda, Ryosuke Ikeda, Yoshihiro Goda, Kuniyasu Irie, Hiroaki Kaneko, Shin Maeda
    JGH Open.2023; 7(11): 783.     CrossRef
  • Second gastric cancer after curative endoscopic resection of differentiated-type early gastric cancer: post-hoc analysis of a single-arm confirmatory trial
    Masao Yoshida, Kohei Takizawa, Noriaki Hasuike, Hiroyuki Ono, Narikazu Boku, Tomohiro Kadota, Junki Mizusawa, Ichiro Oda, Naohiro Yoshida, Yusuke Horiuchi, Kingo Hirasawa, Yoshinori Morita, Yoshinobu Yamamoto, Manabu Muto, Masao Yoshida, Kohei Takizawa, H
    Gastrointestinal Endoscopy.2022; 95(4): 650.     CrossRef
  • Therapeutic approach to non-curative resection after endoscopic treatment in early gastric cancer
    Eun Jeong Gong, Chang Seok Bang
    Journal of the Korean Medical Association.2022; 65(5): 284.     CrossRef
  • Assessment of Outcomes From 1-Year Surveillance After Detection of Early Gastric Cancer Among Patients at High Risk in Japan
    Yoshinobu Yamamoto, Naohiro Yoshida, Tomonori Yano, Takahiro Horimatsu, Noriya Uedo, Noboru Kawata, Hiromitsu Kanzaki, Shinichiro Hori, Kenshi Yao, Seiichiro Abe, Chikatoshi Katada, Chizu Yokoi, Ken Ohata, Hisashi Doyama, Kenichi Yoshimura, Hideki Ishikaw
    JAMA Network Open.2022; 5(8): e2227667.     CrossRef
  • Management of patients with multiple primary сancer in the practice of a modern oncologist. Case report and literature review
    D. A. Khlanta, G. P. Gens
    Siberian journal of oncology.2022; 21(4): 147.     CrossRef
  • Assigning a different endoscopist for each annual follow-up may contribute to improved gastric cancer detection rates
    Shuhei Unno, Kimihiro Igarashi, Hiroaki Saito, Dai Hirasawa, Toru Okuzono, Yukari Tanaka, Masato Nakahori, Tomoki Matsuda
    Endoscopy International Open.2022; 10(10): E1333.     CrossRef
  • Statistical proof of Helicobacter pylori eradication in preventing metachronous gastric cancer after endoscopic resection in an East Asian population
    Mohsen Karbalaei, Masoud Keikha
    World Journal of Gastrointestinal Surgery.2022; 14(8): 867.     CrossRef
  • Follow-up after endoscopic resection for early gastric cancer in 3 French referral centers
    Bernadette de Rauglaudre, Mathieu Pioche, Fabrice Caillol, Jean-Philippe Ratone, Anna Pellat, Romain Coriat, Jerôme Rivory, Thomas Lambin, Laetitia Dahan, Marc Giovanini, Maximilien Barret
    iGIE.2022; 1(1): 49.     CrossRef
  • Documento de posicionamiento de la AEG, la SEED y la SEAP sobre cribado de cáncer gástrico en poblaciones con baja incidencia
    Joaquín Cubiella, Ángeles Pérez Aisa, Miriam Cuatrecasas, Pilar Díez Redondo, Gloria Fernández Esparrach, José Carlos Marín-Gabriel, Leticia Moreira, Henar Núñez, M. Luisa Pardo López, Enrique Rodríguez de Santiago, Pedro Rosón, José Miguel Sanz Anquela,
    Gastroenterología y Hepatología.2021; 44(1): 67.     CrossRef
  • Incidence of metachronous cancer after endoscopic submucosal dissection: a comparison between undifferentiated-type and differentiated-type early gastric cancer
    Mitsuaki Ishioka, Toshiyuki Yoshio, Yuji Miyamoto, Ken Namikawa, Yoshitaka Tokai, Shoichi Yoshimizu, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiaki Hirasawa, Tomohiro Tsuchida, Junko Fujisaki
    Gastrointestinal Endoscopy.2021; 93(3): 557.     CrossRef
  • Gastric cancer screening in low incidence populations: Position statement of AEG, SEED and SEAP
    Joaquin Cubiella, Ángeles Pérez Aisa, Miriam Cuatrecasas, Pilar Díez Redondo, Gloria Fernández Esparrach, José Carlos Marín-Gabriel, Leticia Moreira, Henar Núñez, M. Luisa Pardo López, Enrique Rodríguez de Santiago, Pedro Rosón, José Miguel Sanz Anquela,
    Gastroenterología y Hepatología (English Edition).2021; 44(1): 67.     CrossRef
  • Molecular risk markers related to local tumor recurrence at histological margin-free endoscopically resected early gastric cancers: A pilot study
    Ho Suk Kang, Mi Jung Kwon, Premi Haynes, Yan Liang, Yuqi Ren, Hyun Lim, Jae Seung Soh, Nan Young Kim, Hye Kyung Lee
    Pathology - Research and Practice.2021; 222: 153434.     CrossRef
  • Characteristics of metachronous gastric neoplasms after curative endoscopic submucosal dissection for early gastric neoplasms
    Shan-Shan Xu, Ning-Li Chai, Xiao-Wei Tang, En-Qiang Linghu, Sha-Sha Wang, Bao Li
    Chinese Medical Journal.2021; 134(21): 2603.     CrossRef
  • Consenso mexicano sobre detección y tratamiento del cáncer gástrico incipiente
    M.E. Icaza-Chávez, M.A. Tanimoto, F.M. Huerta-Iga, J.M. Remes-Troche, R. Carmona-Sánchez, A. Ángeles-Ángeles, F.J. Bosques-Padilla, J.M. Blancas-Valencia, G. Grajales-Figueroa, O.V. Hernández-Mondragón, A.I. Hernández-Guerrero, M.A. Herrera-Servín, F.D. H
    Revista de Gastroenterología de México.2020; 85(1): 69.     CrossRef
  • The Mexican consensus on the detection and treatment of early gastric cancer
    M.E. Icaza-Chávez, M.A. Tanimoto, F.M. Huerta-Iga, J.M. Remes-Troche, R. Carmona-Sánchez, A. Ángeles-Ángeles, F.J. Bosques-Padilla, J.M. Blancas-Valencia, G. Grajales-Figueroa, O.V. Hernández-Mondragón, A.I. Hernández-Guerrero, M.Á. Herrera-Servín, F.D. H
    Revista de Gastroenterología de México (English Edition).2020; 85(1): 69.     CrossRef
  • Long‐term follow up of serum pepsinogens in patients with gastric cancer or dysplasia after Helicobacter pylori eradication
    Gitark Noh, Nayoung Kim, Yonghoon Choi, Hye Seung Lee, Young Jae Hwang, Hee Jin Kim, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee
    Journal of Gastroenterology and Hepatology.2020; 35(9): 1540.     CrossRef
  • Metachronous Gastric Cancer: Another Hurdle for Successful Endoscopic Treatment for Early Gastric Cancer?
    Moon Won Lee, Gwang Ha Kim
    Gut and Liver.2020; 14(2): 145.     CrossRef
  • Clinical Outcomes of Metachronous Gastric Cancer after Endoscopic Resection for Early Gastric Cancer
    Jue Lie Kim, Sang Gyun Kim, Jung Kim, Jae Yong Park, Hyo-Joon Yang, Hyun Ju Kim, Hyunsoo Chung
    Gut and Liver.2020; 14(2): 190.     CrossRef
  • Chemoprevention of gastric cancer development afterHelicobacter pylorieradication therapy in an East Asian population: Meta-analysis
    Mitsushige Sugimoto, Masaki Murata, Yoshio Yamaoka
    World Journal of Gastroenterology.2020; 26(15): 1820.     CrossRef
  • Multifocal early gastric cancer in a patient with atrophic gastritis and pernicious anemia
    Tommaso Zurleni, Michele Altomare, Giovanni Serio, Filippo Catalano
    International Journal of Surgery Case Reports.2020; 72(C): 433.     CrossRef
  • Impact of the timing of Helicobacter pylori eradication on the risk of development of metachronous lesions after treatment of early gastric cancer: a population-based cohort study
    Hyun Ju Kim, Yun Jin Kim, Seung In Seo, Woon Geon Shin, Chan Hyuk Park
    Gastrointestinal Endoscopy.2020; 92(3): 613.     CrossRef
  • Gastric cancer prevention strategies: A global perspective
    Leonardo Henry Eusebi, Andrea Telese, Giovanni Marasco, Franco Bazzoli, Rocco Maurizio Zagari
    Journal of Gastroenterology and Hepatology.2020; 35(9): 1495.     CrossRef
  • Metachronous Gastric Cancer Occurring after Endoscopic Resection of Early Gastric Cancer
    Gwang Ha Kim
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2020; 20(4): 295.     CrossRef
  • Somatic alterations and mutational burden are potential predictive factors for metachronous development of early gastric cancer
    Kazuhiro Sakuta, Yu Sasaki, Yasuhiko Abe, Hidenori Sato, Masakuni Shoji, Takao Yaoita, Makoto Yagi, Naoko Mizumoto, Yusuke Onozato, Takashi Kon, Ayumi Koseki, Sonoko Sato, Ryoko Murakami, Yuki Miyano, Yoshiyuki Ueno
    Scientific Reports.2020;[Epub]     CrossRef
  • Clinicopathologic Characteristics of Patients with Gastric Superficial Neoplasia and Risk Factors for Multiple Lesions after Endoscopic Submucosal Dissection in a Western Country
    Gisela Brito-Gonçalves, Diogo Libânio, Pedro Marcos, Inês Pita, Rui Castro, Inês Sá, Mário Dinis-Ribeiro, Pedro Pimentel-Nunes
    GE - Portuguese Journal of Gastroenterology.2020; 27(2): 76.     CrossRef
  • Helicobacter pylori status and risks of metachronous recurrence after endoscopic resection of early gastric cancer: a systematic review and meta-analysis
    Shiyu Xiao, Sizhu Li, Liya Zhou, Wenjun Jiang, Jinzhe Liu
    Journal of Gastroenterology.2019; 54(3): 226.     CrossRef
  • Helicobacter pylori Eradication for Metachronous Gastric Cancer: An Unsuitable Methodology Impeding Broader Clinical Usage
    Alexios-Fotios A. Mentis, Efthimios Dardiotis
    Frontiers in Oncology.2019;[Epub]     CrossRef
  • Common Locations of Gastric Cancer: Review of Research from the Endoscopic Submucosal Dissection Era
    Su Jin Kim, Cheol Woong Choi
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • UEG Week 2019 Poster Presentations

    United European Gastroenterology Journal.2019; 7(S8): 189.     CrossRef
  • Helicobacter pylori Infection following Endoscopic Resection of Early Gastric Cancer
    Lan Li, Chaohui Yu
    BioMed Research International.2019; 2019: 1.     CrossRef
  • Prophylaxis and early diagnosis of stomach cancer
    I. G. Bakulin, S. S. Pirogov, N. V. Bakulina, E. A. Stadnik, N. N. Golubev
    Dokazatel'naya gastroenterologiya.2018; 7(2): 44.     CrossRef
  • Linked Color Imaging and Blue Laser Imaging for Upper Gastrointestinal Screening
    Hiroyuki Osawa, Yoshimasa Miura, Takahito Takezawa, Yuji Ino, Tsevelnorov Khurelbaatar, Yuichi Sagara, Alan Kawarai Lefor, Hironori Yamamoto
    Clinical Endoscopy.2018; 51(6): 513.     CrossRef
  • 14,726 View
  • 311 Download
  • 43 Web of Science
  • 49 Crossref
Close layer
Original Article
Therapeutic Outcomes of Endoscopic Resection of Early Gastric Cancer with Undifferentiated-Type Histology: A Korean ESD Registry Database Analysis
Chang Seok Bang, Jae Myung Park, Gwang Ho Baik, Jong Jae Park, Moon Kyung Joo, Jae Young Jang, Seong Woo Jeon, Suck Chei Choi, Jae Kyu Sung, Kwang Bum Cho
Clin Endosc 2017;50(6):569-577.   Published online July 25, 2017
DOI: https://doi.org/10.5946/ce.2017.017
AbstractAbstract PDF
Background
/Aims: To assess the therapeutic outcomes of endoscopic resection (ER) of early gastric cancer (EGC) with undifferentiated-type histology.
Methods
Cases of ER of EGC with undifferentiated-type histology in the Korean endoscopic submucosal dissection (ESD) registry database were identified and reviewed. The immediate outcomes, including en bloc resection, complete resection, and curative resection rates, and long-term outcomes, including recurrence and survival rates, were extracted and analyzed.
Results
From 2006 to 2015, 275 EGCs with undifferentiated-type histology from 275 patients were identified. The immediate outcomes were as follows: en bloc resection rate: 92.4%; complete resection rate: 80%; and curative resection rate: 36.4%. Compared to patients with lesions that were beyond the expanded indication, those with expanded indication lesions showed better therapeutic outcomes. There was no difference in immediate outcomes between patients with poorly differentiated adenocarcinoma (PDC) and signet ring cell carcinoma (SRC). However, compared to ER of SRC, ER of PDC had a stronger association with submucosal invasion (41.9% vs. 23.6%, p=0.003). With regard to long-term outcomes, there was no difference between lesions with curative and non-curative resections in the recurrence and mortality rates. These rates also did not differ between PDC and SRC (median follow up: 3.96 years).
Conclusions
ER confined to expanded indication lesions can be considered for treatment of EGC with undifferentiated-type histology.

Citations

Citations to this article as recorded by  
  • Risk factors associated with non-curative resection and metachronous cancer after endoscopic submucosal dissection in patients with ulcerative early gastric cancer
    Yiping Xin, Yuning Chu, Qi Zhang, Xiaoyan Yin, Tao Mao, Xiaoyu Li
    European Journal of Medical Research.2026;[Epub]     CrossRef
  • Long-term outcomes after non-curative endoscopic submucosal dissection for undifferentiated early gastric cancer: a multicenter retrospective study
    Zhi-Yu Xiang, Yun Wang, Hunter Wang, Guo-Liang Ye, Wen-Kai Ni, Rui-Ying Jing, Hai-Han Xu, Wei Su, Rong-Dan Lu, Sai-Yan Bian, Wen-Jie Zheng, Michael Bourke, Ping-Hong Zhou, Yao-Yao Gong, Sheng-Li Lin
    Surgical Endoscopy.2026; 40(7): 5878.     CrossRef
  • A Rare Case of Primary Gastric Signet Ring Cell Carcinoma: a Review of Guidelines for the Management of Gastric Cancer
    Ronald Mauricio Blanco Montecino, Mikhail Sukhorosl, Mayi Ann Francis, Neeraj Kancherla, Ogbonnaya Akuma, Nkiruka Lauretta Nwangene, Shreyas Nandyal, Rohan Raj, Chinaza Mercy Akuma, Tamer Zahdeh, Sharanya Kaushik, Adil M. Khan
    Indian Journal of Surgical Oncology.2024; 15(1): 153.     CrossRef
  • Update on Endoscopic Diagnosis and Treatment of Early Gastric Signet Ring Cell Carcinoma
    鹏齐 陈
    Advances in Clinical Medicine.2024; 14(03): 922.     CrossRef
  • Advances in Endoscopic Detection and Therapeutic Strategies for Early Gastric Signet Ring Cell Carcinoma
    Jiahui Xu, Fan Yin, Mengyu Cao, Linlin Ren, Shidong Wang, Congcong Min, Xiaoyu Li, Zibin Tian, Tao Mao
    Nature Cell and Science.2024; 2(1): 10.     CrossRef
  • An artificial intelligence system for comprehensive pathologic outcome prediction in early gastric cancer through endoscopic image analysis (with video)
    Seunghan Lee, Jiwoon Jeon, Jinbae Park, Young Hoon Chang, Cheol Min Shin, Mi Jin Oh, Su Hyun Kim, Seungkyung Kang, Su Hee Park, Sang Gyun Kim, Hyuk-Joon Lee, Han-Kwang Yang, Hey Seung Lee, Soo-Jeong Cho
    Gastric Cancer.2024; 27(5): 1088.     CrossRef
  • Endoscopic Resection of Undifferentiated Early Gastric Cancer
    Yuichiro Hirai, Seiichiro Abe, Mai Ego Makiguchi, Masau Sekiguchi, Satoru Nonaka, Haruhisa Suzuki, Shigetaka Yoshinaga, Yutaka Saito
    Journal of Gastric Cancer.2023; 23(1): 146.     CrossRef
  • Update on diagnosis and treatment of early signet-ring cell gastric carcinoma: A literature review
    Yun-He Tang, Lin-Lin Ren, Tao Mao
    World Journal of Gastrointestinal Endoscopy.2023; 15(4): 240.     CrossRef
  • Clinical Features of Gastric Signet Ring Cell Cancer: Results from a Systematic Review and Meta-Analysis
    Mariagiulia Dal Cero, Maria Bencivenga, Drolaiz H. W. Liu, Michele Sacco, Mariella Alloggio, Kelly G. P. Kerckhoffs, Federica Filippini, Luca Saragoni, Mar Iglesias, Anna Tomezzoli, Fátima Carneiro, Heike I. Grabsch, Giuseppe Verlato, Lorena Torroni, Guil
    Cancers.2023; 15(21): 5191.     CrossRef
  • Long-term outcomes of endoscopic resection followed by additional surgery after non-curative resection in undifferentiated-type early gastric cancer: a nationwide multi-center study
    Jie-Hyun Kim, Young-Il Kim, Ji Yong Ahn, Woon Geon Shin, Hyo-Joon Yang, Su Youn Nam, Byung-Hoon Min, Jae-Young Jang, Joo Hyun Lim, Wan Sik Lee, Bong Eun Lee, Moon Kyung Joo, Jae Myung Park, Hang Lak Lee, Tae-Geun Gweon, Moo In Park, Jeongmin Choi, Chung H
    Surgical Endoscopy.2022; 36(3): 1847.     CrossRef
  • Diffuse-type Gastric Cancer
    Jie-Hyun Kim
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2022; 22(1): 11.     CrossRef
  • Endoscopic submucosal dissection for early signet ring cell gastric cancer: A systematic review and meta-analysis
    Chun-Yan Weng, Shao-Peng Sun, Chang Cai, Jing-Li Xu, Bin Lv
    World Journal of Clinical Cases.2022; 10(20): 6915.     CrossRef
  • Clinico-pathologic determinants of non-e-curative outcome following en-bloc endoscopic submucosal dissection in patients with early gastric neoplasia
    Kidane Siele Embaye, Chao Zhang, Matiwos Araya Ghebrehiwet, Zhihao Wang, Fengdi Zhang, Liwei Liu, Shenghui Qin, Lingzhi Qin, Jun Wang, Xi Wang
    BMC Cancer.2021;[Epub]     CrossRef
  • Factors associated with overall survival in early gastric cancer patients who underwent additional surgery after endoscopic submucosal dissection
    Zhi Zheng, Fan-Di Bu, Hao Chen, Jie Yin, Rui Xu, Jun Cai, Jun Zhang, Hong-Wei Yao, Zhong-Tao Zhang
    World Journal of Clinical Cases.2021; 9(10): 2192.     CrossRef
  • Long-Term Outcomes of Endoscopic Submucosal Dissection of Undifferentiated-Type Early Gastric Cancer
    Chang Seok Bang
    Clinical Endoscopy.2021; 54(2): 143.     CrossRef
  • Establishing Machine Learning Models to Predict Curative Resection in Early Gastric Cancer with Undifferentiated Histology: Development and Usability Study
    Chang Seok Bang, Ji Yong Ahn, Jie-Hyun Kim, Young-Il Kim, Il Ju Choi, Woon Geon Shin
    Journal of Medical Internet Research.2021; 23(4): e25053.     CrossRef
  • Результаты проксимальной резекции желудка в зависимости от методов реконструкции желудочно-кишечного тракта
    Виктория Эдуардовна Тишакова , Дмитрий Валерьевич Ручкин , Александр Анатольевич Грицкевич , Николай Алексеевич Ефименко
    Естественные и Технические Науки.2021; (№11): 198.     CrossRef
  • Protocol for expanded indications of endoscopic submucosal dissection for early gastric cancer in China: a multicenter, ambispective, observational, open-cohort study
    Zhi Zheng, Jie Yin, Ziyu Li, Yingjiang Ye, Bo Wei, Xin Wang, Yantao Tian, Mengyi Li, Qian Zhang, Na Zeng, Rui Xu, Guangyong Chen, Jie Zhang, Peng Li, Jun Cai, Hongwei Yao, Jun Zhang, Zhongtao Zhang, Shutian Zhang
    BMC Cancer.2020;[Epub]     CrossRef
  • Regional Lymph Node Dissection as an Additional Treatment Option to Endoscopic Resection for Expanded Indications in Gastric Cancer: a Prospective Cohort Study
    Ho Seok Seo, Han Mo Yoo, Yoon Ju Jung, Sung Hak Lee, Jae Myung Park, Kyo Young Song, Eun Sun Jung, Myung-Gyu Choi, Cho Hyun Park
    Journal of Gastric Cancer.2020; 20(4): 442.     CrossRef
  • Effect of ilaprazole on the healing of endoscopic submucosal dissection-induced gastric ulcer: randomized-controlled, multicenter study
    Chang Seok Bang, Woon Geon Shin, Seung In Seo, Min Ho Choi, Hyun Joo Jang, Se Woo Park, Sea Hyub Kae, Young Joo Yang, Suk Pyo Shin, Gwang Ho Baik, Hak Yang Kim
    Surgical Endoscopy.2019; 33(5): 1376.     CrossRef
  • Effect of age on the clinical outcomes of patients with early gastric cancer with undifferentiated-type histology
    Jeung Hui Pyo, Hyuk Lee, Yang Won Min, Byung-Hoon Min, Jun Haeng Lee, Kyoung-Mee Kim, Heejin Yoo, Kyunga Kim, Yoon-Ho Choi, Jae J. Kim, Sung Kim
    Surgery.2019; 165(4): 802.     CrossRef
  • Long-term clinical outcomes of endoscopic vs. surgical resection for early gastric cancer with undifferentiated histology
    Joo Hyun Lim, Jung Kim, Sang Gyun Kim, Hyunsoo Chung
    Surgical Endoscopy.2019; 33(11): 3589.     CrossRef
  • Pitfalls in the Interpretation of Publications about Endoscopic Submucosal Dissection of Early Gastric Cancer with Undifferentiated-Type Histology
    Chang Seok Bang, Gwang Ho Baik
    Clinical Endoscopy.2019; 52(1): 30.     CrossRef
  • Strategy for Curative Endoscopic Resection of Undifferentiated-Type Early Gastric Cancer
    Jie-Hyun Kim
    Clinical Endoscopy.2019; 52(1): 9.     CrossRef
  • Risk Factors for Lymph Node Metastasis in Undifferentiated-Type Gastric Carcinoma
    Myeong-Cherl Kook
    Clinical Endoscopy.2019; 52(1): 15.     CrossRef
  • Is Radical Surgery Necessary for All Patients Diagnosed as Having Non-Curative Endoscopic Submucosal Dissection?
    Si Hyung Lee, Byung Sam Park
    Clinical Endoscopy.2019; 52(1): 21.     CrossRef
  • Characteristics of proximal early gastric cancer differentiating distal early gastric cancer
    Jin Sung Koh, Moon Kyung Joo, Jong-Jae Park, Beom Jae Lee, Hoon Jai Chun, Sang Woo Lee, You-Jin Jang, Young-Jae Mok, Masaru Katoh
    PLOS ONE.2019; 14(9): e0223284.     CrossRef
  • Usefulness of histologic differences and perivascular infiltration for preoperative T staging of advanced gastric cancer using computed tomography
    Ji Youn Kim, Woo-Suk Chung, Hyeun Jin Lee, Ji Hae An, Jang Shin Son
    Japanese Journal of Radiology.2019; 37(12): 817.     CrossRef
  • Mixed poorly differentiated adenocarcinoma in undifferentiated-type early gastric cancer predicts endoscopic noncurative resection
    Yusuke Horiuchi, Junko Fujisaki, Noriko Yamamoto, Naoki Ishizuka, Masami Omae, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Yorimasa Yamamoto, Masatsugu Nagahama, Hiroshi Takahashi, Tomohiro Tsuchida
    Gastric Cancer.2018; 21(4): 689.     CrossRef
  • Self-expandable metal stents in patients with postoperative delayed gastric emptying after distal gastrectomy
    Seung Han Kim, Bora Keum, Hyuk Soon Choi, Eun Sun Kim, Yeon Seok Seo, Yoon Tae Jeen, Hong Sik Lee, Hoon Jai Chun, Soon Ho Um, Chang Duck Kim, Sungsoo Park
    World Journal of Gastroenterology.2018; 24(40): 4578.     CrossRef
  • Endoscopic Resection of Early Gastric Cancer with Undifferentiated-Type Histology
    Jie-Hyun Kim
    Clinical Endoscopy.2017; 50(6): 511.     CrossRef
  • 11,074 View
  • 353 Download
  • 30 Web of Science
  • 31 Crossref
Close layer
Focused Review Series: Endoscopic Accessories Used for ESDs
History and Development of Accessories for Endoscopic Submucosal Dissection
Bong Min Ko
Clin Endosc 2017;50(3):219-223.   Published online May 31, 2017
DOI: https://doi.org/10.5946/ce.2017.078
AbstractAbstract PDF
Endoscopic submucosal dissection (ESD) procedure is composed of circumferential mucosal incision and submucosal dissection. A variety of endoscopic accessories are required to perform mucosal incision and submucosal dissection safely. As a result of the improvements in ESD devices and peripheral equipment and development of the ESD technique, ESD procedures have been performed extensively worldwide. Here I review the history of the development of accessories used in performing ESD procedures.

Citations

Citations to this article as recorded by  
  • The Current Landscape of Endoscopic Submucosal Training in the United States
    Mike T. Wei, Shai Friedland, Joo Ha Hwang
    Current Gastroenterology Reports.2025;[Epub]     CrossRef
  • Endoscopic Submucosal Dissection with Rubber Bands and Clips Compared to Conventional Endoscopic Submucosal Dissection: A Systematic Review and Meta-Analysis
    Abdelaziz A. Awad, Hazem Abosheaishaa, Malak A. Hassan, Mohamed Mahmoud Marey, Ahmed Bahnasy, Rashad G. Mohamed, Menna A. Keshk, Yousef Radwan Alnomani, Manar A. Balouz, Ahmed Abdelgayed M Hussein, Fatma S. Mohamed, Mohammed A. Alaeb, Mohamed S. Sharaf, O
    Digestive Diseases and Sciences.2025; 70(8): 2823.     CrossRef
  • A novel model of dual-network composite hydrogels for application in endoscopic submucosal dissection
    Fei Zhao, YunFang Bai, JunJie Wu, ZhiHao Zhu, JinLei Mao, Aikebaier Aili, HongRun Gu, ShiJie Yu, ZhiFei Wang
    BMC Gastroenterology.2025;[Epub]     CrossRef
  • Advanced endoscopic resection for early gastrointestinal cancers in India: Challenges and opportunities await!
    Sridhar Sundaram, Akhil Mahajan, Prachi Patil
    Indian Journal of Gastroenterology.2024; 43(5): 866.     CrossRef
  • Experience in the development of various devices for therapeutic endoscopy
    Do Hoon Kim
    Journal of Innovative Medical Technology.2024; 2(2): 35.     CrossRef
  • Settings of a novel electrosurgical generator to enable efficient and safe submucosal endoscopic procedures
    Salmaan Jawaid, Tara Keihanian, Mai Khalaf, Margarita Riojas-Barrett, Wesam Abdeljaber, Michael Mercado, Noor Zabad, Mohamed O. Othman
    Endoscopy International Open.2023; 11(08): E743.     CrossRef
  • Design and validation of performance-oriented injectable chitosan thermosensitive hydrogels for endoscopic submucosal dissection
    Jia Liu, Panxianzhi Ni, Yi Wang, Zhengkui Zhou, Junlin Li, Tianxu Chen, Tun Yuan, Jie Liang, Yujiang Fan, Jing Shan, Xiaobin Sun, Xingdong Zhang
    Biomaterials Advances.2023; 146: 213286.     CrossRef
  • Efficacy and Safety of ClearCut™ Knife H-type in Endoscopic Submucosal Dissection for Gastric Neoplasms: A Multicenter, Randomized Trial
    Eun Jeong Gong, Hyun Lim, Sang Jin Lee, Do Hoon Kim
    Journal of Gastric Cancer.2023; 23(3): 451.     CrossRef
  • Understanding hybrid endoscopic submucosal dissection subtleties
    João Paulo de Souza Pontual, Alexandre Moraes Bestetti, Diogo Turiani Hourneaux de Moura
    Clinical Endoscopy.2023; 56(6): 738.     CrossRef
  • The application of endoscopic loop ligation in defect repair following endoscopic full-thickness resection of gastric submucosal tumors originating from the muscularis propria layer
    Guoxiang Wang, Yanli Xiang, Yangde Miao, Honggang Wang, Meidong Xu, Guang Yu
    Scandinavian Journal of Gastroenterology.2022; 57(1): 119.     CrossRef
  • A Novel Knife for Endoscopic Submucosal Dissection in Early Gastric Cancer
    Seokin Kang, Jeong Hoon Lee
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2022; 22(1): 3.     CrossRef
  • The Efficacy of a Novel Type of Integrated Knife for Endoscopic Submucosal Dissection in Early Gastric Cancer
    Eun Ju Choe, Han Ho Jeon, Yong Suk Cho, Sun Young Won, Jeong Hun Seo, Jong Won Choi, Chun Kyon Lee, Byung Kyu Park, Yong Kang Lee
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2022; 22(1): 50.     CrossRef
  • The future of endoscopic resection for early gastric cancer
    Raquel Ortigão, Diogo Libânio, Mário Dinis‐Ribeiro
    Journal of Surgical Oncology.2022; 125(7): 1110.     CrossRef
  • Comparison between a novel core knife and the conventional IT knife 2 for endoscopic submucosal dissection of gastric mucosal lesions
    Myeongsoon Park, Jin Wook Lee, Dong Woo Shin, Jungseok Kim, Yoo Jin Lee, Ju Yup Lee, Kwang Bum Cho
    Clinical Endoscopy.2022; 55(6): 767.     CrossRef
  • Snare Tip Is an Alternative Tool for Colorectal Endoscopic Submucosal Dissection
    Chih-Chien Wu, Min-Chi Chang, Ming-Hung Lee, Chiao-Hui Hsu, Chao-Wen Hsu
    Diseases of the Colon & Rectum.2021; 64(2): 241.     CrossRef
  • Lactobionic acid-modified chitosan thermosensitive hydrogels that lift lesions and promote repair in endoscopic submucosal dissection
    Panxianzhi Ni, Renpeng Li, Sheng Ye, Jing Shan, Tun Yuan, Jie Liang, Yujiang Fan, Xingdong Zhang
    Carbohydrate Polymers.2021; 263: 118001.     CrossRef
  • Chitosan thermosensitive hydrogels based on lyophilizate powders demonstrate significant potential for clinical use in endoscopic submucosal dissection procedures
    Panxianzhi Ni, Sheng Ye, Renpeng Li, Jing Shan, Tun Yuan, Jie Liang, Yujiang Fan, Xingdong Zhang
    International Journal of Biological Macromolecules.2021; 184: 593.     CrossRef
  • Diode Laser—Can It Replace the Electrical Current Used in Endoscopic Submucosal Dissection? (with Video)
    Yunho Jung, Gwang Ho Baik, Weon Jin Ko, Bong Min Ko, Seong Hwan Kim, Jin Seok Jang, Jae-Young Jang, Wan-Sik Lee, Young Kwan Cho, Sun Gyo Lim, Hee Seok Moon, In Kyung Yoo, Joo Young Cho
    Clinical Endoscopy.2021; 54(4): 555.     CrossRef
  • Review on colorectal endoscopic submucosal dissection focusing on the technical aspect
    Tak Lit Derek Fung, Chi Woo Samuel Chow, Pak Tat Chan, Kam Hung Kwok
    Surgical Endoscopy.2020; 34(9): 3766.     CrossRef
  • Determining the Safety and Effectiveness of Electrocautery Enhanced Scissors for Peroral Endoscopic Myotomy (with Video)
    Kelly E. Hathorn, Walter W. Chan, Hiroyuki Aihara, Christopher C. Thompson
    Clinical Endoscopy.2020; 53(4): 443.     CrossRef
  • Long-Term Outcomes and Prognostic Factors of Endoscopic Submucosal Dissection for Early Gastric Cancer in Patients Aged ≥75 Years
    Jin Won Chang, Da Hyun Jung, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee
    Cancers.2020; 12(11): 3222.     CrossRef
  • 12,612 View
  • 292 Download
  • 18 Web of Science
  • 21 Crossref
Close layer
Accessory Devices Frequently Used for Endoscopic Submucosal Dissection
Hyuk Soon Choi, Hoon Jai Chun
Clin Endosc 2017;50(3):224-233.   Published online May 31, 2017
DOI: https://doi.org/10.5946/ce.2017.070
AbstractAbstract PDF
Endoscopic submucosal dissection (ESD) is increasingly being considered an essential component of treatment for early gastrointestinal cancers and subepithelial tumors. The ESD technique owes its popularity to the development of sophisticated instruments used for ESD. With an increase in the number of ESD procedures performed, there is rapid development in the number and types of endoscopic accessory devices used for such procedures. Despite the large numbers of new devices developed and marketed, the use of ESD instruments and accessory devices is largely determined by individual preferences and experiences. Accessory devices frequently used during ESD are important tools for ESD techniques. Each instrument possesses characteristic advantages and disadvantages associated with its use, and no one instrument is superior in all respects to others. In this article, we review the characteristics of endoscopic electrical knives, cap and hood, and hemostatic devices commonly used in ESD.

Citations

Citations to this article as recorded by  
  • Effect of crosslinking densities on decanoyl-group modified Alaska pollock gelatin microparticles as tissue-adhesive hemostatic powders
    Hatsune Nishino, Shima Ito, Hiyori Komatsu, Satsuki Minamisakamoto, Yasuko Kobayashi, Shiharu Watanabe, Akihiro Nishiguchi, Tetsushi Taguchi
    Biomaterials Advances.2026; 180: 214534.     CrossRef
  • Developing and operating a high-quality endoscopic resection unit: insights from western institutions
    Samer Al-Dury, Sinan Sharba, Yahya Al Hammada, Noora Alzadjali, Noor Mohammed
    Best Practice & Research Clinical Gastroenterology.2026; : 102132.     CrossRef
  • A new hemostatic device for gastric endoscopic submucosal dissection: a prospective randomized controlled trial comparing Coajet and Hemograsper in Korea
    Sang Un Kim, Seong Woo Jeon
    Clinical Endoscopy.2025; 58(4): 552.     CrossRef
  • Robot versus conventional ESD for colonic lesions: results from a randomising model trial
    Daniel Szvarca, Trent Walradt, Hiroyuki Aihara, Christopher C Thompson
    Gut.2025; : gutjnl-2025-336937.     CrossRef
  • Evaluation of a new motorized endoscope versus conventional endoscopy: a single-center, single-blind, randomized controlled trial
    Seoyeon Lee, Gihong Park, Mi Jin Oh, Ji Kon Ryu, Hyunsoo Chung
    Scientific Reports.2025;[Epub]     CrossRef
  • Endoscopic Resection of Early Luminal Cancer
    Hyuk Soon Choi, Joo Ha Hwang
    Gastrointestinal Endoscopy Clinics of North America.2024; 34(1): 51.     CrossRef
  • Endoscopic Submucosal Dissection: A Safe and Effective Alternative to Surgical Intervention for Esophageal Hemangioma
    Lu Zhongsheng, Dou Yan, Reem Ezzat, Mu Chen, Yuan Jing, Mohamed El-Kassas, Ahmed Tawheed, Ahmad Madkour
    Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2024; 34(2): 124.     CrossRef
  • Improved hydration property of tissue adhesive/hemostatic microparticle based on hydrophobically-modified Alaska pollock gelatin
    Shima Ito, Kazuhiro Nagasaka, Hiyori Komatsu, Debabrata Palai, Akihiro Nishiguchi, Tetsushi Taguchi
    Biomaterials Advances.2024; 159: 213834.     CrossRef
  • Is there a best choice of equipment for colorectal endoscopic submucosal dissection?
    Francesco Cocomazzi, Sonia Carparelli, Nunzia Labarile, Antonio Capogreco, Marco Gentile, Roberta Maselli, Jahnvi Dhar, Jayanta Samanta, Alessandro Repici, Cesare Hassan, Francesco Perri, Antonio Facciorusso
    Expert Review of Medical Devices.2024; 21(7): 561.     CrossRef
  • Endoscopic Management of Complex Colorectal Polyps: Current Insights and Future Trends
    Rupinder Mann, Mahesh Gajendran, Chandraprakash Umapathy, Abhilash Perisetti, Hemant Goyal, Shreyas Saligram, Juan Echavarria
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • How to Incorporate Advanced Tissue Resection Techniques in Your Institution
    Alessandro Repici, Roberta Maselli, Cesare Hassan
    Gastroenterology.2022; 162(7): 1825.     CrossRef
  • Preparation and ex vivo investigation of an injectable microparticulate formulation for gastrointestinal mucosa polyp resection
    Cristina Moles-Aranda, Noelia Pérez-González, Ana C. Calpena-Campmany, María J. Martín-Villena, Francisco J. Otero-Espinar, Patricia Severino, Eliana B. Souto, José A. Morales-Molina, Beatriz Clares-Naveros
    European Journal of Pharmaceutics and Biopharmaceutics.2022; 178: 25.     CrossRef
  • Comparison between a novel core knife and the conventional IT knife 2 for endoscopic submucosal dissection of gastric mucosal lesions
    Myeongsoon Park, Jin Wook Lee, Dong Woo Shin, Jungseok Kim, Yoo Jin Lee, Ju Yup Lee, Kwang Bum Cho
    Clinical Endoscopy.2022; 55(6): 767.     CrossRef
  • The Mettle to Use the Petals: Using Over-the-Scope Rings to Optimize Endoscopic Submucosal Dissection
    Mike T. Wei, George Triadafilopoulos, Shai Friedland
    Digestive Diseases and Sciences.2021; 66(4): 989.     CrossRef
  • Successful Endoscopic Resection of Residual Colonic Mucosa-Associated Lymphoid Tissue Lymphoma after Polypectomy
    Jeongmin Choi
    Clinical Endoscopy.2021; 54(5): 759.     CrossRef
  • Endoscopic submucosal dissection: an update on tools and accessories
    Christopher Harlow, Arun Sivananthan, Lakshmana Ayaru, Kinesh Patel, Ara Darzi, Nisha Patel
    Therapeutic Advances in Gastrointestinal Endoscopy.2020; 13: 263177452095722.     CrossRef
  • Advanced Colonic Polypectomy
    Ipek Sapci, Emre Gorgun
    Surgical Clinics of North America.2020; 100(6): 1079.     CrossRef
  • Endoscopic Submucosal Dissection Using Endoscopic Robot: Endoscopist’s Future Destination
    Hang Lak Lee
    Gut and Liver.2019; 13(4): 381.     CrossRef
  • A Pilot Study of Endoscopic Submucosal Dissection Using an Endoscopic Assistive Robot in a Porcine Stomach Model
    Byung Gon Kim, Hyuk Soon Choi, Sei Hoon Park, Jun Ho Hong, Jung Min Lee, Seung Han Kim, Hoon Jai Chun, Daehie Hong, Bora Keum
    Gut and Liver.2019; 13(4): 402.     CrossRef
  • Self-expandable metal stents in patients with postoperative delayed gastric emptying after distal gastrectomy
    Seung Han Kim, Bora Keum, Hyuk Soon Choi, Eun Sun Kim, Yeon Seok Seo, Yoon Tae Jeen, Hong Sik Lee, Hoon Jai Chun, Soon Ho Um, Chang Duck Kim, Sungsoo Park
    World Journal of Gastroenterology.2018; 24(40): 4578.     CrossRef
  • 16,284 View
  • 338 Download
  • 19 Web of Science
  • 20 Crossref
Close layer
Original Articles
Endoscopic Mucosal Resection with Circumferential Mucosal Incision for Colorectal Neoplasms: Comparison with Endoscopic Submucosal Dissection and between Two Endoscopists with Different Experiences
Dong-Hoon Yang, Min-Seob Kwak, Sang Hyoung Park, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Hyun Gun Kim, Shai Friedland
Clin Endosc 2017;50(4):379-387.   Published online March 7, 2017
DOI: https://doi.org/10.5946/ce.2016.058
AbstractAbstract PDF
Background
/Aims: Endoscopic mucosal resection with circumferential mucosal incision (CMI-EMR) may offer benefits comparable to those of endoscopic submucosal dissection (ESD), while requiring less technical proficiency than ESD.
Methods
We retrospectively compared the outcomes of CMI-EMR (n=34) and size-matched ESD (n=102), which were performed by a Korean endoscopist for colorectal epithelial lesions of 20–35 mm. Procedural parameters of CMI-EMRs performed by an American ESD novice ((n=30) were compared with those performed by the Korean endoscopist.
Results
The lesion size was 22.3±3.9 mm and 22.9±2.4 mm in the CMI-EMR and size-matched ESD groups, respectively (p=0.730). The resection time was 12.7±7.0 minutes in the CMI-EMR group and 45.6±30.1 minutes in the ESD group (p<0.001). The en bloc resection rate was 94.1% in the CMI-EMR group and 100% in the ESD group (p=0.061). There were no differences in the en bloc resection and complication rates of CMI-EMRs between a Korean and an American endoscopist.
Conclusions
For the treatment of moderate-size colorectal lesions, CMI-EMR showed a trend toward lower en bloc resection rate, but required shorter procedure time than ESD. CMI-EMR outcomes were similar when performed by a Korean ESD expert and an American ESD novice.

Citations

Citations to this article as recorded by  
  • Comparison of precut endoscopic mucosal resection and endoscopic submucosal dissection in the management of colorectal polyps: a systematic review and meta-analysis
    Aamir Saeed, Saira Yousuf, Ahmad Zain, Muhammad Kashif, Sultan Mahmood, Umar Hayat, Azizullah Beran, Nasir Saleem, Yasi Xiao, Anand Kumar, Alexander Schlachterman, Thomas Kowalski, Mark Radlinski, Thiruvengadam Muniraj, Faisal Kamal
    European Journal of Gastroenterology & Hepatology.2026; 38(6): 699.     CrossRef
  • Pre-snaring endoscopic mucosal resection: a simplified alternative to precutting technique for large sessile serrated lesions
    Pan Xu, LiYun Fu, Wan Zhou
    Endoscopy.2026; 58(S 02): E631.     CrossRef
  • Endoscopic mucosal resection with a circumferential incision in the removal of colon neoplasms. Results of a randomized trial.
    E. U. Abdulzhalieva, A. A. Likutov, V. V. Veselov, D. A. Mtvralashvili, O. M. Yugai, E. A. Khomyakov, S. V. Chernyshov, O. I. Sushkov
    Koloproktologia.2024; 23(1): 21.     CrossRef
  • Approaches and considerations in the endoscopic treatment of T1 colorectal cancer
    Yunho Jung
    The Korean Journal of Internal Medicine.2024; 39(4): 563.     CrossRef
  • Hybrid Endoscopic Resection With Endo-knife and Snare for Colorectal Lesions: A Systematic Review and Meta-analysis
    Shinji Yoshii, Takefumi Kikuchi, Yuki Hayashi, Masahiro Nojima, Hiro-o Yamano, Hiroshi Nakase
    Techniques and Innovations in Gastrointestinal Endoscopy.2023; 25(2): 135.     CrossRef
  • Multicenter evaluation of recurrence in endoscopic submucosal dissection and endoscopic mucosal resection in the colon: A Western perspective
    Mike T Wei, Margaret J Zhou, Andrew A Li, Andrew Ofosu, Joo Ha Hwang, Shai Friedland
    World Journal of Gastrointestinal Endoscopy.2023; 15(6): 458.     CrossRef
  • Comparison of precutting endoscopic mucosal resection and endoscopic submucosal dissection for large (20–30 mm) flat colorectal lesions
    Chang Kyo Oh, Young Wook Cho, In Hyoung Choi, Han Hee Lee, Chul‐Hyun Lim, Jin Su Kim, Bo‐In Lee, Young‐Seok Cho
    Journal of Gastroenterology and Hepatology.2022; 37(3): 568.     CrossRef
  • A systematic review and meta-analysis of endoscopic mucosal resection vs endoscopic submucosal dissection for colorectal sessile/non-polypoid lesions
    Endrit Shahini, Roberto Passera, Giacomo Lo Secco, Alberto Arezzo
    Minimally Invasive Therapy & Allied Technologies.2022; 31(6): 835.     CrossRef
  • Endoscopic mucosal resection with a circumferential incision in the removal of colorectal neoplasms (preliminary results of the prospective randomized study)
    A. U. Abdulzhalieva, A. A. Likutov, D. A. Mtvralashvili, V. V. Veselov, Yu. E. Vaganov, S. V. Chernyshov, O. A. Mainovskaya, O. I. Sushkov
    Koloproktologia.2022; 21(4): 21.     CrossRef
  • Efficacy and Safety of Complete Endoscopic Resection of Colorectal Neoplasia Using a Stepwise Endoscopic Protocol with SOUTEN, a Novel Multifunctional Snare
    Shinji Yoshii, Marina Kubo, Mio Matsumoto, Takefumi Kikuchi, Yasunari Takakuwa
    Clinical Endoscopy.2020; 53(2): 206.     CrossRef
  • Tip-in versus conventional endoscopic mucosal resection for flat colorectal neoplasia 10 mm or larger in size
    Soo Min Noh, Jin Yong Kim, Jae Cheol Park, Eun Hye Oh, Jeongseok Kim, Nam Seok Ham, Sung Wook Hwang, Sang Hyoung Park, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Dong-Hoon Yang
    International Journal of Colorectal Disease.2020; 35(7): 1283.     CrossRef
  • Long‐term clinical outcomes of endoscopic submucosal dissection for colorectal neoplasia with or without the hybrid technique
    DU Kang, JC Park, SW Hwang, SH Park, DH Yang, KJ Kim, BD Ye, SJ Myung, SK Yang, JS Byeon
    Colorectal Disease.2020; 22(12): 2008.     CrossRef
  • Pyogenic Liver Abscess Caused by Endoscopic Submucosal Dissection for Early Colon Cancer
    Joon Seop Lee, Yong Hwan Kwon
    Clinical Endoscopy.2019; 52(6): 620.     CrossRef
  • Endoscopic submucosal dissection in the West: Current status and future directions
    Michael X. Ma, Michael J. Bourke
    Digestive Endoscopy.2018; 30(3): 310.     CrossRef
  • Introduction of endoscopic submucosal dissection in the West
    David Friedel, Stavros Nicholas Stavropoulos
    World Journal of Gastrointestinal Endoscopy.2018; 10(10): 225.     CrossRef
  • Filling the Technical Gap between Standard Endoscopic Mucosal Resection and Full Endoscopic Submucosal Dissection for 20–35 mm Sized Colorectal Neoplasms
    Sung Noh Hong
    Clinical Endoscopy.2017; 50(4): 313.     CrossRef
  • 12,776 View
  • 253 Download
  • 16 Web of Science
  • 16 Crossref
Close layer
Use of a Double-Channel Gastroscope Reduces Procedural Time in Large Left-Sided Colonic Endoscopic Mucosal Resections
Evangelos Voudoukis, Georgios Tribonias, Aikaterini Tavernaraki, Angeliki Theodoropoulou, Emmanouil Vardas, Konstantina Paraskeva, Gregorios Chlouverakis, Gregorios A. Paspatis
Clin Endosc 2015;48(2):136-141.   Published online March 27, 2015
DOI: https://doi.org/10.5946/ce.2015.48.2.136
AbstractAbstract PDF
Background/Aims

Endoscopic mucosal resection (EMR) of large colorectal lesions is associated with increased procedural time. The objective of this study was to evaluate the effect of double-channel gastroscope (DCG) use on the procedural time of EMRs in the rectosigmoid area.

Methods

All EMRs for sessile or flat rectosigmoid lesions ≥2 cm performed between July 2011 and September 2012 were retrospectively analyzed.

Results

There were 55 lesions ≥2 cm in the rectosigmoid area in 55 patients, of which 26 were removed by EMR using a DCG (DC group) and 29 by using an ordinary colonoscope or gastroscope (OS group). The mean size of the removed polyps, morphology, adverse effects, and other parameters were similar between the two groups. The mean procedural time was significantly lower in the DC group than in the OS group (24.4±18.3 minutes vs. 36.3±24.4 minutes, p=0.015). Moreover, in a subgroup of patients with polyps >40 mm, the statistical difference in the mean procedural time between the DC and OS groups was even more pronounced (33±21 minutes vs. 58.7±20.6 minutes, p=0.004).

Conclusions

Our data suggest that the use of a DCG in the resection of large nonpedunculated rectosigmoid lesions significantly reduces the procedural time.

Citations

Citations to this article as recorded by  
  • Dual Channel Endoscopic Mucosal Resection
    Julia T. Saraidaridis, Racquel S. Gaetani, Peter W. Marcello
    Clinics in Colon and Rectal Surgery.2024; 37(05): 295.     CrossRef
  • Endoscopic management of difficult laterally spreading tumors in colorectum
    Edgar Castillo-Regalado, Hugo Uchima
    World Journal of Gastrointestinal Endoscopy.2022; 14(3): 113.     CrossRef
  • A Critical Review of Post Endoscopic Sub-Mucosal Dissection (ESD) Delayed Bleeding Risk Factors
    Bilal Khan, Bilquis Nawabi, Daniya Sivakumar, Said Maisam Shuoa, Ruihua Shi
    Open Journal of Gastroenterology.2020; 10(06): 166.     CrossRef
  • Novel technique for endoscopic en bloc resection (EMR+) – Evaluation in a porcine model
    Benjamin Meier, Andreas Wannhoff, Christoph Klinger, Karel Caca
    World Journal of Gastroenterology.2019; 25(28): 3764.     CrossRef
  • Endoscopic mucosal resection and endoscopic submucosal dissection for colorectal lesions: A systematic review
    Antonella De Ceglie, Cesare Hassan, Benedetto Mangiavillano, Takahisa Matsuda, Yutaka Saito, Lorenzo Ridola, Pradeep Bhandari, Federica Boeri, Massimo Conio
    Critical Reviews in Oncology/Hematology.2016; 104: 138.     CrossRef
  • Is the Double Channel Gastroscope Useful in Endoscopic Mucosal Resection for Large Sessile Colon Polyps?
    Kwang An Kwon
    Clinical Endoscopy.2015; 48(2): 89.     CrossRef
  • 9,857 View
  • 65 Download
  • 6 Web of Science
  • 6 Crossref
Close layer
Endoscopic Mucosal Resection with Circumferential Incision for the Treatment of Large Sessile Polyps and Laterally Spreading Tumors of the Colorectum
Young Mi Hong, Hyung Wook Kim, Su Bum Park, Cheol Woong Choi, Dae Hwan Kang
Clin Endosc 2015;48(1):52-58.   Published online January 31, 2015
DOI: https://doi.org/10.5946/ce.2015.48.1.52
AbstractAbstract PDF
Background/Aims

Endoscopic mucosal resection (EMR) is the standard treatment for colorectal polyps such as adenomas and early cancers with no risk of lymph node metastasis. However, endoscopic resection of large colorectal polyps (≥20 mm diameter) is difficult to perform. We evaluated the clinical outcomes of EMR with circumferential incision (EMR-CI) for the resection of large sessile polyps (Is) and laterally spreading tumors (LSTs) in the colorectum.

Methods

Between February 2009 and March 2011, we resected 80 large colorectal polyps by EMR-CI. We retrospectively investigated the en bloc resection rate, histologic complete resection rate, recurrence rate, and complications.

Results

The median polyp size was approximately 25 mm (range, 20 to 50), and the morphologic types included Is (13 cases), LST-granular (37 cases), and LST-nongranular (30 cases). The en bloc and complete histologic resection rates were 66.3% and 45.0%, respectively. The recurrence rate was 0% (median follow-up duration, 23 months), and perforation occurred in five cases (6.3%).

Conclusions

EMR-CI is an effective treatment modality for 20 to 30 mm-sized colorectal polyps, and may be considered as a second line therapeutic option if ESD is difficult.

Citations

Citations to this article as recorded by  
  • Comparing Precutting Endoscopic Mucosal Resection Using Snare-Tip and Endoscopic Submucosal Dissection Knife for Large Nonpedunculated Colorectal Polyps: A Randomized Controlled Trial
    Chang Kyo Oh, Young Wook Cho, Young-Seok Cho
    American Journal of Gastroenterology.2026; 121(2): 345.     CrossRef
  • Structured Cap-assisted Margin Assessment Reduces Residual Neoplasia after Colorectal Polypectomy: A Prospective Multicentre Proof-of-Concept Study
    Alexander Huelsen, Timothy Willis, Prabha Ketheson, Caroline Cooper, Jennifer Borowsky, Sooraj Pillay, Ian Paul Hughes, Zaki Hamarneh
    Endoscopy International Open.2026;[Epub]     CrossRef
  • Efficacy of Hybrid Endoscopic Submucosal Dissection to Ensure Adequate Submucosal Layer for T1b Colorectal Carcinomas of 20-30 mm in Diameter
    Yudai Takehara, Ken Yamashita, Shin Morimoto, Fumiaki Tanino, Noriko Yamamoto, Yuki Kamigaichi, Hidenori Tanaka, Hidehiko Takigawa, Yuji Urabe, Toshio Kuwai, Koji Arihiro, Shiro Oka
    Journal of the Anus, Rectum and Colon.2025; 9(3): 292.     CrossRef
  • Hybrid endoscopic submucosal dissection as a salvage option for difficult colorectal conventional endoscopic submucosal dissection
    Shin Morimoto, Hidenori Tanaka, Yudai Takehara, Noriko Yamamoto, Fumiaki Tanino, Yuki Kamigaichi, Ken Yamashita, Hidehiko Takigawa, Ryo Yuge, Yuji Urabe, Shiro Oka
    Surgical Endoscopy.2024; 38(1): 222.     CrossRef
  • Endoscopic resection of large non-pedunculated colorectal polyps: current standards of treatment
    Mahsa Taghiakbari, Dong Hyun Danny Kim, Roupen Djinbachian, Daniel von Renteln
    eGastroenterology.2024; 2(2): e100025.     CrossRef
  • Hybrid Endoscopic Resection With Endo-knife and Snare for Colorectal Lesions: A Systematic Review and Meta-analysis
    Shinji Yoshii, Takefumi Kikuchi, Yuki Hayashi, Masahiro Nojima, Hiro-o Yamano, Hiroshi Nakase
    Techniques and Innovations in Gastrointestinal Endoscopy.2023; 25(2): 135.     CrossRef
  • Endoscopic Submucosal Dissection, Endoscopic Mucosal Resection, and Transanal Minimally Invasive Surgery for the Management of Rectal and Anorectal Lesions: A Narrative Review
    Pedro Moreira, Pedro Cardoso, Guilherme Macedo, João Santos-Antunes
    Journal of Clinical Medicine.2023; 12(14): 4777.     CrossRef
  • Indications and outcomes of colorectal hybrid endoscopic submucosal dissection: a large multicenter 10-year study
    Yuki Okamoto, Shiro Oka, Shinji Tanaka, Shinji Nagata, Masaki Kunihiro, Toshio Kuwai, Yuko Hiraga, Seiji Onogawa, Takeshi Mizumoto, Hideharu Okanobu, Morihisa Akagi, Kazuaki Chayama
    Surgical Endoscopy.2022; 36(3): 1894.     CrossRef
  • Comparison of precutting endoscopic mucosal resection and endoscopic submucosal dissection for large (20–30 mm) flat colorectal lesions
    Chang Kyo Oh, Young Wook Cho, In Hyoung Choi, Han Hee Lee, Chul‐Hyun Lim, Jin Su Kim, Bo‐In Lee, Young‐Seok Cho
    Journal of Gastroenterology and Hepatology.2022; 37(3): 568.     CrossRef
  • Cap-assisted EMR versus standard inject and cut EMR for treatment of large colonic laterally spreading tumors: a randomized multicenter study (with videos)
    Massimo Conio, Raffaele Manta, Rosa Angela Filiberti, Todd H. Baron, Luigi Pasquale, Mario Marini, Antonella De Ceglie
    Gastrointestinal Endoscopy.2022; 96(5): 829.     CrossRef
  • Endoscopic techniques to reduce recurrence rates after colorectal EMR: systematic review and meta-analysis
    Gijs Kemper, Ayla S. Turan, Erik J. Schoon, Ruud W. M. Schrauwen, Ludger S. M. Epping, Christian Gerges, Torsten Beyna, Horst Neuhaus, Ufuk Gündug, Peter D. Siersema, Erwin J. M. van Geenen
    Surgical Endoscopy.2021; 35(10): 5422.     CrossRef
  • Indications and outcomes of endoscopic resection for non-pedunculated colorectal lesions: A narrative review
    Endrit Shahini, Diogo Libânio, Giacomo Lo Secco, Antonio Pisani, Alberto Arezzo
    World Journal of Gastrointestinal Endoscopy.2021; 13(8): 275.     CrossRef
  • Endoscopic mucosal resection versus endoscopic submucosal dissection for colorectal laterally spreading tumors: a meta-analysis
    Hongjing Zhao, Jie Yin, Cuiying Ji, Xin Wang, Na Wang
    Revista Española de Enfermedades Digestivas.2020;[Epub]     CrossRef
  • A Critical Review of Post Endoscopic Sub-Mucosal Dissection (ESD) Delayed Bleeding Risk Factors
    Bilal Khan, Bilquis Nawabi, Daniya Sivakumar, Said Maisam Shuoa, Ruihua Shi
    Open Journal of Gastroenterology.2020; 10(06): 166.     CrossRef
  • Efficacy of hybrid endoscopic submucosal dissection (ESD) as a rescue treatment in difficult colorectal ESD cases
    Koichi Okamoto, Naoki Muguruma, Kaizo Kagemoto, Yasuhiro Mitsui, Daisaku Fujimoto, Shinji Kitamura, Tetsuo Kimura, Masahiro Sogabe, Hiroshi Miyamoto, Tetsuji Takayama
    Digestive Endoscopy.2017; 29(S2): 45.     CrossRef
  • Endoscopic Mucosal Resection with Circumferential Mucosal Incision for Colorectal Neoplasms: Comparison with Endoscopic Submucosal Dissection and between Two Endoscopists with Different Experiences
    Dong-Hoon Yang, Min-Seob Kwak, Sang Hyoung Park, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Hyun Gun Kim, Shai Friedland
    Clinical Endoscopy.2017; 50(4): 379.     CrossRef
  • Local recurrence and subsequent endoscopic treatment after endoscopic piecemeal mucosal resection with or without precutting in the colorectum
    Myeongsook Seo, Eun Mi Song, Gwang Un Kim, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Kyung-Jo Kim, Byong Duk Ye, Seung-Jae Myung, Suk-Kyun Yang, Jeong-Sik Byeon
    Intestinal Research.2017; 15(4): 502.     CrossRef
  • How to deal with large colorectal polyps
    Selvi Thirumurthi, Gottumukkala S. Raju
    Current Opinion in Gastroenterology.2016; 32(1): 26.     CrossRef
  • Endoscopic mucosal resection and endoscopic submucosal dissection for colorectal lesions: A systematic review
    Antonella De Ceglie, Cesare Hassan, Benedetto Mangiavillano, Takahisa Matsuda, Yutaka Saito, Lorenzo Ridola, Pradeep Bhandari, Federica Boeri, Massimo Conio
    Critical Reviews in Oncology/Hematology.2016; 104: 138.     CrossRef
  • Should antibiotics be administered after endoscopic mucosalresection in patients with colon polyps?
    Zhimeng SHI, Hui QIU, Huangang LIU, Honggang YU
    TURKISH JOURNAL OF MEDICAL SCIENCES.2016; 46: 1486.     CrossRef
  • Endoscopic Approach for Superficial Colorectal Neoplasms
    Jun-feng Xu, Lang Yang, Peng Jin, Jian-qiu Sheng
    Gastrointestinal Tumors.2016; 3(2): 69.     CrossRef
  • Many Options to Manage Laterally Spreading Tumors
    Dong Kyung Chang
    Clinical Endoscopy.2015; 48(1): 4.     CrossRef
  • 13,677 View
  • 131 Download
  • 27 Web of Science
  • 22 Crossref
Close layer
Focused Review Series: Endoscopic and Molecular Imaging of Premalignant GI Lesions, Part II
Histopathology in Barrett Esophagus and Barrett Esophagus-Related Dysplasia
Andrea Grin, Catherine J. Streutker
Clin Endosc 2014;47(1):31-39.   Published online January 24, 2014
DOI: https://doi.org/10.5946/ce.2014.47.1.31
AbstractAbstract PDF

Pathologic specimens, both biopsies and endoscopic mucosal resections, for Barrett esophagus and Barrett-associated dysplasia and malignancy are common for pathologists in North America, and the incidence in South Asian countries seems to be increasing. Dysplasia and malignancy arising in intestinalized gastric-type mucosa raises issues in the interpretation of dysplasia and the evaluation of the depth of invasion of malignancies that are not seen in squamous dysplasia and squamous cell carcinoma. We review the North American approach to these lesions.

Citations

Citations to this article as recorded by  
  • Associations Between Non-Genetic Risk Factors and DNA Methylation Alterations in Barrett’s Esophagus and Its Progression to Esophageal Adenocarcinoma
    Nastaran Riahi Dehkordi, Kristi Kruusmaa, Kausilia K. Krishnadath, Arianna Bertossi
    International Journal of Molecular Sciences.2025; 26(23): 11704.     CrossRef
  • Complete circumferential endoscopic submucosal dissection for early Barrett’s neoplasia
    Douglas Motomura, Robert Bechara
    Gastrointestinal Endoscopy.2024; 99(3): 337.     CrossRef
  • Barrett's esophagus: The pathomorphological and molecular genetic keystones of neoplastic progression
    Ksenia S. Maslyonkina, Alexandra K. Konyukova, Darya Y. Alexeeva, Mikhail Y. Sinelnikov, Liudmila M. Mikhaleva
    Cancer Medicine.2022; 11(2): 447.     CrossRef
  • Matrix metalloproteinase (MMP)-7 in Barrett's esophagus and esophageal adenocarcinoma: expression, metabolism, and functional significance
    Hanan M. Garalla, Nantaporn Lertkowit, Laszlo Tiszlavicz, Zita Reisz, Chris Holmberg, Rob Beynon, Deborah Simpson, Akos Varga, Jothi Dinesh Kumar, Steven Dodd, David Mark Pritchard, Andrew R. Moore, András I. Rosztóczy, Tibor Wittman, Alec Simpson, Graham
    Physiological Reports.2018; 6(10): e13683.     CrossRef
  • A Comparison Study of Esophageal Findings on 18F-FDG PET/CT and Esophagogastroduodenoscopy
    KwanHyeong Jo, Soyoung Kim, Jongtae Cha, Sang Hyun Hwang, Narae Lee, Mijin Yun, Won Jun Kang
    Nuclear Medicine and Molecular Imaging.2016; 50(2): 123.     CrossRef
  • 19,617 View
  • 220 Download
  • 10 Web of Science
  • 5 Crossref
Close layer
Case Reports
Endoscopic Treatment of Duodenal Neuroendocrine Tumors
Sang Ho Kim, Chang Hwan Park, Ho Seok Ki, Chung Hwan Jun, Seon Young Park, Hyun Soo Kim, Sung Kyu Choi, Jong Sun Rew
Clin Endosc 2013;46(6):656-661.   Published online November 19, 2013
DOI: https://doi.org/10.5946/ce.2013.46.6.656
AbstractAbstract PDF

Duodenal neuroendocrine tumors (NETs) are rare neoplasms. In this study, the medical records of 14 patients with duodenal NETs diagnosed at Chonnam National University Hospital from July 2001 to August 2011 were reviewed and analyzed retrospectively. Four patients were diagnosed in the first 5 years, and 10 patients were diagnosed in the latter 5 years of the study. Ten of 12 patients (83.3%) who underwent endoscopic biopsy were confirmed to have NET before resection. Endoscopic resection was performed in 12 patients, surgical resection in one patient, and regular follow-up in one patient who refused resection. None of the patients showed recurrence or distant metastasis. Duodenal NETs are increasingly observed and are mostly detected during screening upper gastrointestinal endoscopy. Careful endoscopic examination and biopsy can improve the diagnostic yield of NETs. Most well-differentiated, nonfunctional duodenal NETs that are limited to the mucosa/submucosa can be treated effectively with endoscopic resection.

Citations

Citations to this article as recorded by  
  • Real-world outcomes of duodenal endoscopic submucosal dissection and endoscopic full-thickness resection: predictors of adverse events and the role of a structured closure approach (with video)
    Mohan Kumar Ramchandani, Priscilla Vanesa Lopez, Sundeep Lakhtakia, Pradev Inavolu, Aniruddha Singh, Santosh Darisetty, Anuradha Sekaran, Hardik Rughwani, Sara Teles de Campos, Partha Pal, Zaheer Nabi, Nitin Jagtap, Shujaath Asif, Nikitha Boddu, Guduru Ve
    Gastrointestinal Endoscopy.2026;[Epub]     CrossRef
  • Prevalence and risk factors for lymph node metastasis in duodenal neuroendocrine tumors: a systematic review and meta-analysis
    Yohei Ogata, Waku Hatta, Takeshi Kanno, Yutaka Hatayama, Masahiro Saito, Xiaoyi Jin, Tomoyuki Koike, Akira Imatani, Yuhong Yuan, Atsushi Masamune
    Journal of Gastroenterology.2025; 60(6): 673.     CrossRef
  • Approach to upper gastrointestinal subepithelial lesions
    Shrihari Anil Anikhindi, Rajesh Puri, Noriya Uedo, Kamlesh Taori, Anil Arora
    Expert Review of Gastroenterology & Hepatology.2025; 19(7): 789.     CrossRef
  • Endoscopic management of gastric, duodenal and rectal NETs: Position paper from the Italian Association for Neuroendocrine Tumors (Itanet), Italian Society of Gastroenterology (SIGE), Italian Society of Digestive Endoscopy (SIED)
    Francesco Panzuto, Maria Caterina Parodi, Gianluca Esposito, Sara Massironi, Alberto Fantin, Renato Cannizzaro, Massimo Milione, Claudio Giovanni De Angelis, Bruno Annibale
    Digestive and Liver Disease.2024; 56(4): 589.     CrossRef
  • Conventional endoscopic mucosal resection versus modified endoscopic mucosal resection for duodenal neuroendocrine tumor
    Jin Hee Noh, Do Hoon Kim, Kwangbeom Park, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Wook Jung, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
    Surgical Endoscopy.2023; 37(5): 3884.     CrossRef
  • The meaning of R1 resection after endoscopic removal of gastric, duodenal and rectal neuroendocrine tumors
    Gianluca Esposito, Elisabetta Dell’Unto, Irene Ligato, Matteo Marasco, Francesco Panzuto
    Expert Review of Gastroenterology & Hepatology.2023; 17(8): 785.     CrossRef
  • Duodenal neuroendocrine tumors: Short-term outcomes of endoscopic submucosal dissection performed in the Western setting
    Sunil Gupta, Puja Kumar, Rocio Chacchi, Alberto Murino, Edward J Despott, Arnaud Lemmers, Mathieu Pioche, Michael J. Bourke
    Endoscopy International Open.2023; 11(11): E1099.     CrossRef
  • Management of Duodenal Neuroendocrine Tumors: Surgical versus Endoscopic Mucosal Resection
    Catherine G. Tran, Scott K. Sherman, Mohammed O. Suraju, Apoorve Nayyar, Henning Gerke, Rami G. El Abiad, Chandrikha Chandrasekharan, Po Hien Ear, Thomas M. O’Dorisio, Joseph S. Dillon, Andrew M. Bellizzi, James R. Howe
    Annals of Surgical Oncology.2022; 29(1): 75.     CrossRef
  • Endoscopic mucosal resection using a ligation device for duodenal neuroendocrine tumors: a simple method
    Yasuhiro Inokuchi, Kei Hayashi, Yoshihiro Kaneta, Yoichiro Okubo, Mamoru Watanabe, Mitsuhiro Furuta, Nozomu Machida, Shin Maeda
    Therapeutic Advances in Gastrointestinal Endoscopy.2022;[Epub]     CrossRef
  • Survival and Disease Recurrence in Patients with Duodenal Neuroendocrine Tumours—A Single Centre Cohort
    Oddry Folkestad, Hans H. Wasmuth, Patricia Mjønes, Reidun Fougner, Øyvind Hauso, Reidar Fossmark
    Cancers.2021; 13(16): 3985.     CrossRef
  • Comparison of endoscopic resection techniques for duodenal neuroendocrine tumors: systematic review
    Helcio Pedrosa Brito, Isabela Trindade Torres, Karine Corcione Turke, Artur Adolfo Parada, Jaques Waisberg, Ricardo Vieira Botelho
    Endoscopy International Open.2021; 09(08): E1214.     CrossRef
  • The Role of Endoscopy in Small Bowel Neuroendocrine Tumors
    Ji Yoon Yoon, Nikhil A. Kumta, Michelle Kang Kim
    Clinical Endoscopy.2021; 54(6): 818.     CrossRef
  • Systematic review: management of localised low‐grade upper gastrointestinal neuroendocrine tumours
    Klaire Exarchou, Nathan Howes, David Mark Pritchard
    Alimentary Pharmacology & Therapeutics.2020; 51(12): 1247.     CrossRef
  • Duodenal Neuroendocrine Tumour Resection with a New Duodenal Full-Thickness Resection Device
    João Cortez-Pinto, Susana Mão de Ferro, Joana Castela, Isabel Claro, Paula Chaves, António Dias Pereira
    GE - Portuguese Journal of Gastroenterology.2020; 27(4): 290.     CrossRef
  • Development and Validation of Prognostic Nomograms for Patients with Duodenal Neuroendocrine Neoplasms
    Shenghong Sun, Wei Wang, Chiyi He
    Medical Science Monitor.2020;[Epub]     CrossRef
  • Endoscopic Resection of Duodenal Carcinoid Tumors
    Nadim Mahmud, Yutaka Tomizawa, Kristen Stashek, Bryson W. Katona, Gregory G. Ginsberg, David C. Metz
    Pancreas.2019; 48(1): 60.     CrossRef
  • Neuroendocrine Carcinoma of Duodenum—an Uncommon Tumour at an Unusual Site
    Palki Dewan, Shubha P. Bhat, H. L. Kishan Prasad, Rajesh Ballal, K. Sajitha
    Indian Journal of Surgical Oncology.2019; 10(1): 199.     CrossRef
  • Non-functional duodenal neuroendocrine carcinoma: a rare cause of diabetes mellitus
    Chad Bisambar, Andrew Collier, Fraser Duthie, Carron Meney
    Endocrinology, Diabetes & Metabolism Case Reports.2018;[Epub]     CrossRef
  • 13,784 View
  • 95 Download
  • 18 Crossref
Close layer
Successful Endoscopic Mucosal Resection of a Low Esophageal Carcinoid Tumor
Chang Sup Lim, Seun Ja Park, Moo In Park, Won Moon, Hyung Hun Kim, Jun Sik Lee, Bong Jin Kim, Dong Young Ku
Clin Endosc 2013;46(5):576-578.   Published online September 30, 2013
DOI: https://doi.org/10.5946/ce.2013.46.5.576
AbstractAbstract PDF

Esophageal carcinoid tumors remain some of the rarest of all carcinoid tumors, with only several cases previously reported in the literature. The endoscopic mucosal resection of selected carcinoid tumors has been shown to be a valid, safe, and effective method of treatment. Endoscopic ultrasonography is the technique of choice to select patients eligible for endoscopic resection. Here, we report successful endoscopic mucosal resection of a low esophageal carcinoid tumor and review the relevant literature. The present case is the first reported case of esophageal carcinoid tumor in Korea.

Citations

Citations to this article as recorded by  
  • Unraveling the characteristics of early esophageal neuroendocrine carcinoma using multi-model endoscopy: A retrospective study of serial cases
    Tian Jin, Yu-Wei Zhou, Pei-Sen Sun, Yue Huang, Jian-Guo Gao, Xi Jin
    World Journal of Gastrointestinal Oncology.2025;[Epub]     CrossRef
  • Role of Advanced Gastrointestinal Endoscopy in the Comprehensive Management of Neuroendocrine Neoplasms
    Harishankar Gopakumar, Vinay Jahagirdar, Jagadish Koyi, Dushyant Singh Dahiya, Hemant Goyal, Neil R. Sharma, Abhilash Perisetti
    Cancers.2023; 15(16): 4175.     CrossRef
  • Contemporary outcomes of esophageal and gastroesophageal junction neuroendocrine tumors
    Lauren M Poston, Shreya Gupta, Christine E Alvarado, Jillian Sinopoli, Leonidas T Vargas, Philip A Linden, Christopher W Towe
    Diseases of the Esophagus.2023;[Epub]     CrossRef
  • A rare rarity: Neuroendocrine tumor of the esophagus
    Elisa Giannetta, Valentina Guarnotta, Francesca Rota, Federica de Cicco, Federica Grillo, Annamaria Colao, Antongiulio Faggiano
    Critical Reviews in Oncology/Hematology.2019; 137: 92.     CrossRef
  • Incidental neuroendocrine tumor of the esophagus: A case report and review of the literature
    Sarah K. Findeis, Atin Agarwal
    Human Pathology: Case Reports.2019; 16: 100294.     CrossRef
  • A 13-year time trend analysis of 3724 small bowel video capsule endoscopies and a forecast model during the financial crisis in Greece
    Konstantinos Triantafyllou, Paraskevas Gkolfakis, Nikos Viazis, Panagiotis Tsibouris, Athanasios Tsigaridas, Periklis Apostolopoulos, John Anastasiou, Eleni Hounda, Ioannis Skianis, Konstantina Katopodi, Xhoela Ndini, George Alexandrakis, Demetrios G. Kar
    European Journal of Gastroenterology & Hepatology.2017; 29(2): 185.     CrossRef
  • NASPGHAN Capsule Endoscopy Clinical Report
    Joel A. Friedlander, Quin Y. Liu, Benjamin Sahn, Koorosh Kooros, Catharine M. Walsh, Robert E. Kramer, Jenifer R. Lightdale, Julie Khlevner, Mark McOmber, Jacob Kurowski, Matthew J. Giefer, Harpreet Pall, David M. Troendle, Elizabeth C. Utterson, Herbert
    Journal of Pediatric Gastroenterology and Nutrition.2017; 64(3): 485.     CrossRef
  • Quality Indicators for Small Bowel Capsule Endoscopy
    Ki-Nam Shim, Seong Ran Jeon, Hyun Joo Jang, Jinsu Kim, Yun Jeong Lim, Kyeong Ok Kim, Hyun Joo Song, Hyun Seok Lee, Jae Jun Park, Ji Hyun Kim, Jaeyoung Chun, Soo Jung Park, Dong-Hoon Yang, Yang Won Min, Bora Keum, Bo-In Lee
    Clinical Endoscopy.2017; 50(2): 148.     CrossRef
  • Primary neuroendocrine neoplasm of the esophagus – Report of 14 cases from a single institute and review of the literature
    Francisco TUSTUMI, Flavio Roberto TAKEDA, Rodrigo Hideki UEMA, Guilherme Luiz Stelko PEREIRA, Rubens Antonio Aissar SALLUM, Ivan CECCONELLO
    Arquivos de Gastroenterologia.2017; 54(1): 4.     CrossRef
  • A Simple Evaluation Tool (ET-CET) Indicates Increase of Diagnostic Skills From Small Bowel Capsule Endoscopy Training Courses
    J.G. Albert, O. Humbla, M.E. McAlindon, C. Davison, U. Seitz, C. Fraser, F. Hagenmüller, E. Noetzel, C. Spada, M.E. Riccioni, J. Barnert, N. Filmann, M. Keuchel
    Medicine.2015; 94(43): e1941.     CrossRef
  • Training in Video Capsule Endoscopy
    Cary G. Sauer, Steven H. Erdman
    Journal of Pediatric Gastroenterology and Nutrition.2015; 61(4): 381.     CrossRef
  • Endoscopic resection using band ligation for esophageal SMT in less than 10 mm
    Joung Boom Hong
    World Journal of Gastroenterology.2015; 21(10): 2982.     CrossRef
  • 8,162 View
  • 53 Download
  • 12 Crossref
Close layer
Special Issue Article of IDEN 2013
Tips and Tricks for Better Endoscopic Treatment of Colorectal Tumors: Usefulness of Cap and Band in Colorectal Endoscopic Mucosal Resection
Seun Ja Park
Clin Endosc 2013;46(5):492-494.   Published online September 30, 2013
DOI: https://doi.org/10.5946/ce.2013.46.5.492
AbstractAbstract PDF

Endoscopic mucosal resection (EMR) is an endoscopic alternative to surgical resection of mucosal and submucosal neoplastic lesions. Prior to the development of knives, EMR could be performed with accessories to elevate the lesion. After the development of various knives, en bloc resection was possible without other accessories. So, recently, simple snaring without suction or endoscopic submucosal dissection using knife in the epithelial lesions such as adenoma or early mucosal cancer has been performed. However, for easy and complete resection of subepithelial lesions such as carcinoid tumor, a few accessories are needed. Complete resection of rectal carcinoid tumors is difficult to achieve with conventional endoscopic resection techniques because these tumors often extend into the submucosa. The rate of positive resection margin for tumor is lower in the group of EMR using a cap (EMR-C) or EMR with a ligation device (EMR-L) than conventional EMR group. EMR-C and EMR-L (or endoscopic submucosal resection with a ligation device) may be a superior method to conventional EMR for removing small rectal carcinoid tumors.

Citations

Citations to this article as recorded by  
  • Multimodal Pressure-Actuated System Toward Adaptive Anchoring Within Complex Human Lumen
    Hao Liu, Yuchen Tang, Chongyang Wang, Yongming Yang, Mengyuan Liu, Lianqing Liu
    Soft Robotics.2026; 13(1): 100.     CrossRef
  • Risk Factors for Perforation in Endoscopic Treatment for Early Colorectal Cancer: A Nationwide ENTER-K Study
    Ik Hyun Jo, Hyun Gun Kim, Young-Seok Cho, Hyun Jung Lee, Eun Ran Kim, Yoo Jin Lee, Sung Wook Hwang, Kyeong-Ok Kim, Jun Lee, Hyuk Soon Choi, Yunho Jung, Chang Mo Moon
    Gut and Liver.2025; 19(1): 95.     CrossRef
  • Optimal endoscopic resection method based on vertical margin distance for small rectal neuroendocrine tumors: Propensity score-matched study
    Jianning Liu, Weihua Yu, Peng Liu, Hao Tian, Lihong Gan, Kaige Zhang, Hui Chen, Nian Fang
    Endoscopy International Open.2025;[Epub]     CrossRef
  • Investigation of the efficacy and safety of endoscopic wide band resection in the treatment of colorectal polyps
    Ufuk Kutluana
    European Journal of Gastroenterology & Hepatology.2025; 37(11): 1213.     CrossRef
  • Research Progress of Endoscopic Treatment of Colorectal Polyps
    隆毅 潘
    Advances in Clinical Medicine.2024; 14(01): 1010.     CrossRef
  • Clinicopathological characteristics of rectal multiple neuroendocrine neoplasms and literature review
    Xiuli Zheng, Mingli Wu, Shengmian Li, Limian Er, Huiyan Deng, Shuo Guo, Zhihuan Liu
    BMC Surgery.2023;[Epub]     CrossRef
  • Comparison between endoscopic mucosal resection with a cap and endoscopic submucosal dissection for rectal neuroendocrine tumors
    Xiuli Zheng, Mingli Wu, Huihui Shi, Limian Er, Kan Wang, Ying Cao, Shengmian Li
    BMC Surgery.2022;[Epub]     CrossRef
  • Indications and outcomes of endoscopic resection for non-pedunculated colorectal lesions: A narrative review
    Endrit Shahini, Diogo Libânio, Giacomo Lo Secco, Antonio Pisani, Alberto Arezzo
    World Journal of Gastrointestinal Endoscopy.2021; 13(8): 275.     CrossRef
  • Proper Treatment Option for Small Rectal Neuroendocrine Tumors Using Precut Endoscopic Mucosal Resection
    Seun Ja Park
    Clinical Endoscopy.2017; 50(6): 516.     CrossRef
  • Endoscopic management of mucosal lesions in the gastrointestinal tract
    Wei-Chung Chen, Michael B. Wallace
    Expert Review of Gastroenterology & Hepatology.2016; 10(4): 481.     CrossRef
  • Pneumothorax, pneumomediastinum, pneumoperitoneum and extensive subcutaneous emphysema resulting from endoscopic mucosal resection secondary to colonoscopy: A case report
    JUN YANG, WEI QING LIU, JIAN DONG, ZHENG QI WEN, ZHU ZHU, WEN LIANG LI
    Oncology Letters.2016; 11(4): 2763.     CrossRef
  • Highlights of International Digestive Endoscopy Network 2013
    Kwang An Kwon, Il Ju Choi, Eun Young Kim, Seok Ho Dong, Ki Baik Hahm
    Clinical Endoscopy.2013; 46(5): 425.     CrossRef
  • 8,712 View
  • 93 Download
  • 12 Crossref
Close layer
Case Report
Endoscopic Resection of Hypopharyngeal Squamous Cell Carcinoma
Gene Hyun Bok, Won Young Cho, Joo Young Cho, So Young Jin, Ji Ho Ahn, Chang Gyun Chun, Tae Hee Lee, Hyun Gun Kim
Clin Endosc 2013;46(2):189-192.   Published online March 31, 2013
DOI: https://doi.org/10.5946/ce.2013.46.2.189
AbstractAbstract PDF

Hypopharyngeal cancers are often diagnosed at an advanced stage and have a poor prognosis. Even when they are diagnosed at an operable stage, surgery often results in substantial morbidity and decreased patients' quality of life. Although the endoscopic diagnosis of early hypopharyngeal cancer is difficult, recent developments in advanced imaging endoscopy have enabled easier diagnosis of these lesions. Endoscopic resection of early hypopharyngeal cancer is a potential minimally invasive treatment that can preserve the function and quality of life of patients. Reports of this procedure are limited, however. We report a case of hypopharygeal cancer treated with endoscopic resection.

Citations

Citations to this article as recorded by  
  • Identify metabolism-related genes IDO1, ALDH2, NCOA2, SLC7A5, SLC3A2, LDHB, and HPRT1 as potential prognostic markers and correlate with immune infiltrates in head and neck squamous cell carcinoma
    Ce Li, Shuai Chen, Wenming Jia, Wenming Li, Dongmin Wei, Shengda Cao, Ye Qian, Rui Guan, Heng Liu, Dapeng Lei
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Endoscopic resection for superficial hypopharyngeal/laryngeal cancer and clinical pathway options
    Wei‐Chen Huang, Li‐Hsiang Cheng, Tien‐Yu Huang, Yu‐Lueng Shih, Wei‐Kuo Chang, Tsai‐Yuan Hsieh, Peng‐Jen Chen
    Advances in Digestive Medicine.2019; 6(3): 123.     CrossRef
  • MG132 reverse the malignant characteristics of hypopharyngeal cancer
    JUKE MA, LIANG YU, JIAJUN TIAN, YAKUI MU, ZHENGHUA LV, JIDONG ZOU, JIANFENG LI, HAIBO WANG, WEI XU
    Molecular Medicine Reports.2014; 9(6): 2587.     CrossRef
  • 10,077 View
  • 69 Download
  • 3 Crossref
Close layer
Is Endoscopic Resection Currently Available in Non-tertiary or Non-academic Hospitals?
Seong Woo Jeon, M.D., Min Kyu Jung, M.D., Sung Kook Kim, M.D., Tae Nyeun Kim, M.D.*, Byung Ik Jang, M.D.*, Si Hyung Lee, M.D.*, Kyeong Ok Kim, M.D.*, Eun Soo Kim, M.D.†, Kwang Bum Cho, M.D.†, Kyung Sik Park, M.D.†
Korean J Gastrointest Endosc 2010;41(6):338-343.   Published online December 30, 2010
AbstractAbstract PDF
Background
/Aims: Endoscopic mucosal resection (EMR) has been gaining popularity with the advances in the technique and the accumulating experience. The objectives of this study are to assess the current situation of endoscopic resection (ER) in primary clinics and community-based hospitals and to suggest an affordable training program.
Methods
A questionnaire about the indications to perform ER for gastric or colonic lesions was sent to the doctors working in the non-tertiary hospitals by mail. Results: The responders who were performing EMR or polypectomy for gastric lesions accounted for 43% (31/72) and 44.8% (47/101), respectively, of the total responders. The percentage of responders who had experience with performing EMR or polypectomy for colonic lesions accounted for 56.6% (30/53) and 87.3% (62/71), respectively, of the total responders. The indication for ER for treating gastric and colonic lesions was restricted to the size of 1∼2 cm irrespective of the type or location of lesion. Most of the responders assumed that ER should be performed in their clinics and they wanted to have a chance to improve these techniques.
Conclusions
The infrastructure for therapeutic endoscopy, such as ER, should be progressively expanded. Therefore, well designed schematic training programs are currently needed to advance using ER more commonly in clinical practice. (Korean J Gastrointest Endosc 2010;41:338-343)
  • 2,652 View
  • 11 Download
Close layer
Three Cases of Endoscopic Mucosal Resection of Rectal Carcinoid Tumor by Band Ligation and the Snare Resection Technique
Young Hwa Jo, M.D., Ji Hun Roh, M.D., Dong Young Goo, M.D., Jae Hoon Yoo, M.D., Ki Soo Kim, M.D., Young Min Shin, M.D., Sung Hoon Kim, M.D. and Ji Eun Park, M.D.
Korean J Gastrointest Endosc 2010;41(1):45-51.   Published online July 31, 2010
AbstractAbstract PDF
Many reports have shown that endoscopic polypectomy or endoscopic mucosal resection can successfully remove tumor less than 1.0 cm in size. However, most carcinoid tumors in the rectum occur in the submucosal layer so that the entire tumor cannot be completely removed via endoscopic polypectomy or endoscopic mucosal resection. Endoscopic mucosal resection can also cause perforation of the intestinal wall and bleeding. Due to these reasons, instead of these two conventional methods, endoscopic mucosal resection using a ligation device is currently being used for the treatment of rectal carcinoid tumor. Recent studies that used this method have reported that endoscopic mucosal resection of rectal carcinoid tumor by band ligation and the snare resection technique is safe with minimal complications and this is quite useful to completely remove rectal carcinoid tumor. (Korean J Gastrointest Endosc 2010;41:45-51)
  • 2,662 View
  • 15 Download
Close layer
A Case of Early-stage Squamous Cell Carcinoma of the Anal Canal Diagnosed by Endoscopic Mucosal Resection
Soo Woong Kim, M.D., Jae Myung Cha, M.D., Joung Il Lee, M.D., Kwang Ro Joo, M.D., Sung Won Jung, M.D., Hyun Phil Shin, M.D., Yu Jin Suh, M.D. and Jun Uk Lim, M.D.
Korean J Gastrointest Endosc 2010;40(5):329-333.   Published online May 30, 2010
AbstractAbstract PDF
In the past, abdominoperineal resection was routinely performed for anal canal cancer, yet it is now known that squamous cell carcinoma of the anal canal has a favorable prognosis and it rarely requires radical surgery. Furthermore, T1 anal cancer, which represents about 10% of all anal canal cancers, has an excellent prognosis. Endoscopic mucosal resection (EMR), which has been used for removal of early-stage adenocarcinoma of the rectum, has not been reported as a treatment option for squamous cell carcinoma of the anal canal because making the endoscopic diagnosis of early-stage anal canal cancer is very difficult. We have experienced a case of early-stage squamous cell carcinoma of the anal canal that was identified without symptoms during routine screening colonoscopy and it was removed by EMR. As far as we know, it is the first case of early-stage anal canal cancer that was diagnosed and treated by endoscopic mucosal resection. (Korean J Gastrointest Endosc 2010;40:329-333)
  • 2,744 View
  • 11 Download
Close layer
A Case of Primary Duodenal Adenocarcinoma Treated by Endoscopic Mucosal Resection
Kun Hyung Cho, M.D., Jae Young Jang, M.D., Ji-Yun Kim, M.D., HyunJin Park, M.D., Nam Sook Park, M.D., Jeung Eun Park, M.D., Seong Dong Sohn, M.D. and Yun Hwa Kim, M.D.*
Korean J Gastrointest Endosc 2010;40(3):186-189.   Published online March 30, 2010
AbstractAbstract PDF
Primary nonampullary duodenal adenocarcinoma is an extremely rare disease. In the past, almost all duodenal adenocarcinomas were detected at an advanced stage. Yet recently, an increased number of case reports of early duodenal adenocarcinoma has coincided with the advances in the field of endoscopy, and there has also been an increased number of case reports of duodenal adenocarcinoma treated by endoscopic mucosal resection. We report here on a case of primary nonampullary duodenal adenocarcinoma that was treated by endoscopic mucosal resection, and there has been no recurrence for over 3 years, as assessed by endoscopic examination. (Korean J Gastrointest Endosc 2010;40:186-189)
  • 3,399 View
  • 9 Download
Close layer
Endoscopic Submucosal Dissection for Colorectal Tumors
Sang Un Park, M.D. and Dong Kyung Chang, M.D.
Korean J Gastrointest Endosc 2010;40(3):145-156.   Published online March 30, 2010
AbstractAbstract PDF
Because screening gastrointestinal endoscopies have been widely performed recently, diagnosis rates of early stage cancer have been increasing rapidly. This trend has also led to advances in therapeutic endoscopy, which is less invasive than surgery. The state-of-the-art technique, endoscopic submucosal dissection (ESD), allows more favorable outcomes than conventional endoscopic mucosal resection (EMR) regarding en-bloc resection of the lesion, irrespective of the size of the lesion. ESD has already been established as the standard therapeutic option for neoplastic lesions in the upper gastrointestinal tract. However, the use of ESD for colorectal lesions is not yet established because of the unique pathological, organ specific characteristics of colonic lesions. Moreover, endoscopists are required to have higher qualifications to perform ESD and tend to cause complications more frequently. Nevertheless, it is obvious that ESD has a therapeutic advantage for certain colonic lesions and enables endoscopists to achieve a higher en-bloc resection rate, resulting in enhanced curability and more accurate histopathological assessment. Recent development of a special colonoscope for ESD and refinement of devices such as surgical knives and traction systems are expected to overcome some limitations of ESD and a standard protocol will be available in the near future. In this review, we will discuss the current status and future prospects of colorectal ESD. (Korean J Gastrointest Endosc 2010;40:145-156)
  • 3,077 View
  • 22 Download
Close layer
Duodenal Carcinoid Tumor Treated by Endoscopic Mucosal Resection
Jong Hak Choi, M.D., In Do Song, M.D., In Soo Oh, M.D., Beom Jin Kim, M.D., Hyoung Chul Oh, M.D., Jeong Wook Kim, M.D. and Jae Gyu Kim, M.D.
Korean J Gastrointest Endosc 2010;40(1):36-40.   Published online January 30, 2010
AbstractAbstract PDF
Duodenal carcinoid tumors are rare, and they represent only 2.0∼8.9% of all gastrointestinal carcinoid tumors in the western countries. Duodenal carcinoid tumors have previously been treated by surgical resection. The recently recommended treatment for a carcinoid tumor smaller than 1 cm in diameter is endoscopic resection. We experienced a case of a duodenal carcinoid tumor in a 56 year-old man who presented with upper abdominal pain. On the endoscopic examination, a 6 mm sized polypoid lesion with a central depression was noticed on the duodenal bulb. The biopsy confirmed the diagnosis of carcinoid tumor. The endoscopic ultrasound probe showed a hypoechoic tumor that was confined to the submocosal layer. The tumor was completely resected by an endoscopic mucosal resection technique and using a transparent cap. (Korean J Gastrointest Endosc 2010;40:36-40)
  • 2,845 View
  • 15 Download
Close layer
Successful Treatment of Gastric Hamartomatous Polyp with Hemorrhage by Endoscopic Mucosal Resection
Jung Min Lee, M.D., Ji Hoon Baek, M.D., Hye Mi Kang, M.D., Byeng Do Min, M.D., Sang Hoon Park, M.D., Ji Woong Kim, M.D., Jin Woong Cho, M.D. and Myoung Jin Ju, M.D.*
Korean J Gastrointest Endosc 2009;39(5):300-303.   Published online November 30, 2009
AbstractAbstract PDF
Hamartomatous polyp is an uncommon lesion. Most of the gastric hamartomatous polyps occur in patients in their 40s because of polyposis coli. Gastric hamartomaotus polyps are usually asymptomatic, but they occasionally manifest with hematemesis or anemia. If they are congenital, then sessile polyps in children should be observed with some measurable frequency. However, many reports have revealed that if the polyp size is big and the risk of rebleeding is high, then ESD or surgical resection can be used to completely remove them. An inverted gastric hamartomatous polyp may have an early gastric cancer component. We report here on an unusual polyp in a 14-years male who presented with hematemesis. Those were about two 3 cm sized large polyps at the proximal antrum and mid body of the stomach, respectively. The polyps were successfully removed by an endoscopic mucosal resection and the lesions were diagnosed as gastric harmatomas. (Korean J Gastrointest Endosc 2009;39:300-303)
  • 2,961 View
  • 16 Download
Close layer
Periampullary Gangliocytic Paraganglioma Successfully Treated by Endoscopic Mucosal Resection
Seon Young Park, M.D., Young A Song, M.D., Nam Chul Jin, M.D., Jun Ho Cho, M.D., Young Eun Joo, M.D., Hyun Soo Kim, M.D., Sung Kyu Choi, M.D. and Jong Sun Rew, M.D.
Korean J Gastrointest Endosc 2009;39(2):97-102.   Published online August 30, 2009
AbstractAbstract PDF
Gangliocytic paraganglioma is a rare tumor that occurs nearly exclusively in the second portion of the duodenum. This tumor is usually considered to be benign. So, endoscopic resection may be the best procedure to facilitate the diagnosis and for treatment to avoid an unnecessary, invasive operation. To the best of our knowledge, this is the first report of a periampullary gangliocytic paraganglioma that was successfully treated by endoscopic mucosal resection in Korea. We report here a case of a 45-year-old man who was found to have a periampullary gangliocytic paraganglioma. This tumor was adequately treated by endoscopic mucosal resection. (Korean J Gastrointest Endosc 2009;39:97-102)
  • 2,947 View
  • 13 Download
Close layer
Close layer
TOP