Original Articles
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Synergistic effect of independent risk factors for post-endoscopic retrograde cholangiopancreatography pancreatitis: a multicenter retrospective study in Japan
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Hirokazu Saito, Yoshihiro Kadono, Takashi Shono, Kentaro Kamikawa, Atsushi Urata, Jiro Nasu, Masayoshi Uehara, Ikuo Matsushita, Tatsuyuki Kakuma, Shunpei Hashigo, Shuji Tada
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Clin Endosc 2024;57(4):508-514. Published online April 18, 2024
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DOI: https://doi.org/10.5946/ce.2023.203
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- Background
/Aims: This study aimed to examine the synergistic effect of independent risk factors on post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP).
Methods
This multicenter retrospective study included 1,273 patients with native papillae who underwent ERCP for bile duct stones in Japan. Independent PEP risk factors were identified using univariate and multivariate analyses. Significant risk factors for PEP in the multivariate analysis were included in the final analysis to examine the synergistic effect of independent risk factors for PEP.
Results
PEP occurred in 45 of 1,273 patients (3.5%). Three factors including difficult cannulation ≥10 minutes, pancreatic injection, and normal serum bilirubin level were included in the final analysis. The incidences of PEP in patients with zero, one, two, and three factors were 0.5% (2/388), 1.9% (9/465), 6.0% (17/285), and 12.6% (17/135), respectively. With increasing risk factors for PEP, the incidence of PEP significantly increased (1 factor vs. 2 factors, p=0.006; 2 factors vs. 3 factors, p=0.033).
Conclusions
As the number of risk factors for PEP increases, the risk of PEP may not be additive; however, it may multiply. Thus, aggressive prophylaxis for PEP is strongly recommended in patients with multiple risk factors.
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Citations
Citations to this article as recorded by

- Optimal timing for discontinuation of ERCP in cases of difficult selective biliary cannulation
Han Taek Jeong, Jimin Han
Endoscopy International Open.2025;[Epub] CrossRef - Clinical outcomes of endoscopic retrograde cholangiopancreatography after Billroth II anastomosis: a comparison of gastroscope and duodenoscope
Kang Ho Lee, Gwang Hyo Yim, Jimin Han, Han Taek Jeong
BMC Gastroenterology.2025;[Epub] CrossRef - Risk factors for acute pancreatitis after endoscopic retrograde cholangiopancreatography: a retrospective single-center study
I.М. Mamontov, D.D. Rjabushhenko, Т.І. Tamm, К.О. Kramarenko, V.V. Nepomniashchyi, A.T. Ustinov
Український радіологічний та онкологічний журнал.2024; 32(3): 287. CrossRef
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Development of a predictive model for hypoxia due to sedatives in gastrointestinal endoscopy: a prospective clinical study in Korea
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Jung Wan Choe, Jong Jin Hyun, Seong-Jin Son, Seung-Hak Lee
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Clin Endosc 2024;57(4):476-485. Published online April 12, 2024
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DOI: https://doi.org/10.5946/ce.2023.198
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- Background
/Aims: Sedation has become a standard practice for patients undergoing gastrointestinal (GI) endoscopy. However, considering the serious cardiopulmonary adverse events associated with sedatives, it is important to identify patients at high risk. Machine learning can generate reasonable prediction for a wide range of medical conditions. This study aimed to evaluate the risk factors associated with sedation during GI endoscopy and develop a predictive model for hypoxia during endoscopy under sedation.
Methods
This prospective observational study enrolled 446 patients who underwent sedative endoscopy at the Korea University Ansan Hospital. Clinical data were used as predictor variables to construct predictive models using the random forest method that is a machine learning algorithm.
Results
Seventy-two of the 446 patients (16.1%) experienced life-threatening hypoxia requiring immediate medical intervention. Patients who developed hypoxia had higher body weight, body mass index (BMI), neck circumference, and Mallampati scores. Propofol alone and higher initial and total dose of propofol were significantly associated with hypoxia during sedative endoscopy. Among these variables, high BMI, neck circumference, and Mallampati score were independent risk factors for hypoxia. The area under the receiver operating characteristic curve for the random forest-based predictive model for hypoxia during sedative endoscopy was 0.82 (95% confidence interval, 0.79–0.86) and displayed a moderate discriminatory power.
Conclusions
High BMI, neck circumference, and Mallampati score were independently associated with hypoxia during sedative endoscopy. We constructed a model with acceptable performance for predicting hypoxia during sedative endoscopy.
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Citations
Citations to this article as recorded by

- Core curriculum for sedation in gastrointestinal endoscopy with a focus on practice: a proposal from the Korean Society of Gastrointestinal Endoscopy
Hong Sub Lee, Yun Jeong Lim, Jong-Jae Park
Clinical Endoscopy.2025; 58(2): 218. CrossRef
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4,419
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Prevalence and natural course of incidental gastric subepithelial tumors
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Dae-Hyuk Heo, Min A Yang, Jae Sun Song, Won Dong Lee, Jin Woong Cho
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Clin Endosc 2024;57(4):495-500. Published online March 29, 2024
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DOI: https://doi.org/10.5946/ce.2023.124
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- Background
/Aims: Gastric subepithelial tumors (SETs) are often encountered during the upper gastrointestinal endoscopic screening. We assessed the prevalence of gastric SETs and the risk factors for their progression.
Methods
We reviewed the electronic medical records of 30,754 patients who underwent upper gastrointestinal endoscopic screening at our medical center between January 2013 and December 2016.
Results
Among the 30,754 patients examined, 599 (1.94%) had gastric SETs. The prevalence increased with age and was 9.56% in patients aged ≥70 years. In total, 262 patients underwent serial endoscopy for more than 6 months. The median age was 68 years (interquartile range [IQR], 61–74), and the number of females was 167 (63.7%). During a median follow-up of 58 months (IQR, 38–75), 22 patients (8.4%) showed significant changes in tumor size. An irregular border (odds ratio, 4.623; 95% confidence interval, 1.093–19.558; p=0.037) was a significant risk factor for progression. Seven patients underwent surgical or endoscopic resections. The pathologies of gastric SETs included leiomyomas (n=3), gastrointestinal stromal tumors (n=2), and lipomas (n=2).
Conclusions
The prevalence of gastric SETs increases with age. Most gastric SETs do not progress during long-term endoscopic examinations, and the risk of an increase in size is low in asymptomatic small SETs without irregular borders.
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Citations
Citations to this article as recorded by

- Advancements in Endoscopic Treatment for Gastric Subepithelial Tumors
Osamu Goto, Kazutoshi Higuchi, Eriko Koizumi, Katsuhiko Iwakiri
Gut and Liver.2025; 19(2): 151. CrossRef - Advancements in endoscopic resection of subepithelial tumors: toward safer, recurrence-free techniques
Won Shik Kim, Moon Kyung Joo
Clinical Endoscopy.2025; 58(2): 256. CrossRef - Artificial Intelligence-Based Diagnosis of Gastric Mesenchymal Tumors Using Digital Endosonography Image Analysis
Dong Chan Joo, Gwang Ha Kim, Moon Won Lee, Bong Eun Lee, Ji Woo Kim, Kwang Baek Kim
Journal of Clinical Medicine.2024; 13(13): 3725. CrossRef
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Respiratory complications during recovery from gastrointestinal endoscopies performed by gastroenterologists under moderate sedation
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Inna Eidelman Pozin, Amir Zabida, Moshe Nadler, Guy Zahavi, Dina Orkin, Haim Berkenstadt
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Clin Endosc 2023;56(2):188-193. Published online January 10, 2023
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DOI: https://doi.org/10.5946/ce.2022.033
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- Background
/Aims: Data on the incidence of adverse respiratory events during recovery from gastrointestinal endoscopy are limited. The aim of this study was to investigate the incidence of these complications.
Methods
In this retrospective cohort study, data were obtained from the electronic records of 657 consecutive patients, who underwent gastroenterological procedures under sedation.
Results
Pulse oximetry oxygen saturation (SpO2) <90% for <60 seconds occurred in 82 patients (12.5%) and in 11 patients (1.7%), SpO2 of <90% for >60 seconds occurred in 79 patients (12.0%) and in 11 patients (1.7%), and SpO2 <75% occurred in four patients (0.6%) and in no patients during the procedure and recovery period, respectively. No major complications were noted. The occurrence of desaturation during recovery was correlated with desaturation during the procedure (p<0.001). American Society of Anesthesiologists score (odds ratio [OR], 1.867; 95% confidence interval [CI], 1.008–3.458), ischemic heart disease (OR, 1.815; 95% CI, 0.649–5.080), hypertension (OR, 1.289; 95% CI, 0.472–3.516), and diabetes mellitus (OR, 2.406; 95% CI, 0.950–6.095) increased the occurrence of desaturation during recovery.
Conclusions
We found no major complications during recovery after balanced propofol-based sedation administered by a gastroenterologist-nurse team. Patients with the identified risk predictors must be monitored carefully.
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Citations
Citations to this article as recorded by

- Core curriculum for sedation in gastrointestinal endoscopy with a focus on practice: a proposal from the Korean Society of Gastrointestinal Endoscopy
Hong Sub Lee, Yun Jeong Lim, Jong-Jae Park
Clinical Endoscopy.2025; 58(2): 218. CrossRef - Remimazolam, a novel drug, for safe and effective endoscopic sedation
Jae Min Lee, Yehyun Park, Dong Won Ahn, Jun Kyu Lee, Kwang Hyuck Lee
Clinical Endoscopy.2025; 58(3): 370. CrossRef - Development of a predictive model for hypoxia due to sedatives in gastrointestinal endoscopy: a prospective clinical study in Korea
Jung Wan Choe, Jong Jin Hyun, Seong-Jin Son, Seung-Hak Lee
Clinical Endoscopy.2024; 57(4): 476. CrossRef
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3,879
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Risk Stratification in Cancer Patients with Acute Upper Gastrointestinal Bleeding: Comparison of Glasgow-Blatchford, Rockall and AIMS65, and Development of a New Scoring System
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Matheus Cavalcante Franco, Sunguk Jang, Bruno da Costa Martins, Tyler Stevens, Vipul Jairath, Rocio Lopez, John J. Vargo, Alan Barkun, Fauze Maluf-Filho
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Clin Endosc 2022;55(2):240-247. Published online January 21, 2022
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DOI: https://doi.org/10.5946/ce.2021.115
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- Background
/Aims: Few studies have measured the accuracy of prognostic scores for upper gastrointestinal bleeding (UGIB) among cancer patients. Thereby, we compared the prognostic scores for predicting major outcomes in cancer patients with UGIB. Secondarily, we developed a new model to detect patients who might require hemostatic care.
Methods
A prospective research was performed in a tertiary hospital by enrolling cancer patients admitted with UGIB. Clinical and endoscopic findings were obtained through a prospective database. Multiple logistic regression analysis was performed to gauge the power of each score.
Results
From April 2015 to May 2016, 243 patients met the inclusion criteria. The AIMS65 (area under the curve [AUC] 0.85) best predicted intensive care unit admission, while the Glasgow-Blatchford score best predicted blood transfusion (AUC 0.82) and the low-risk group (AUC 0.92). All scores failed to predict hemostatic therapy and rebleeding. The new score was superior (AUC 0.74) in predicting hemostatic therapy. The AIMS65 (AUC 0.84) best predicted in-hospital mortality.
Conclusions
The scoring systems for prognostication were validated in the group of cancer patients with UGIB. A new score was developed to predict hemostatic therapy. Following this result, future prospective research should be performed to validate the new score.
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Citations
Citations to this article as recorded by

- Comparative diagnostic utility of Rockall and Glasgow-Blatchford scores in non-variceal upper gastrointestinal bleeding: a systematic review and meta-analysis
Landon Kozai, Arvin Tan, Kevin Nebrejas, Yoshito Nishimura
European Journal of Gastroenterology & Hepatology.2025; 37(2): 161. CrossRef - Endoscopic Management of Tumor Bleeding
Frances Dang, Marc Monachese
Gastrointestinal Endoscopy Clinics of North America.2024; 34(1): 155. CrossRef - Clinical significance of D-dimer, antithrombin III, and Helicobacter pylori infection in acute upper gastrointestinal bleeding
Cong-Biao Cheng, Na Li
World Chinese Journal of Digestology.2024; 32(7): 501. CrossRef - The Accuracy of Pre-Endoscopic Scores for Mortality Prediction in Patients with Upper GI Bleeding and No Endoscopy Performed
Sergiu Marian Cazacu, Dragoș Ovidiu Alexandru, Răzvan-Cristian Statie, Sevastița Iordache, Bogdan Silviu Ungureanu, Vlad Florin Iovănescu, Petrică Popa, Victor Mihai Sacerdoțianu, Carmen Daniela Neagoe, Mirela Marinela Florescu
Diagnostics.2023; 13(6): 1188. CrossRef - Progress in the Evaluation of Acute Upper Gastrointestinal Bleeding with AIMS65 Scoring System
莉 王
Advances in Clinical Medicine.2023; 13(05): 8163. CrossRef - Interpretations of the Role of Plasma Albumin in Prognostic Indices: A Literature Review
Kim Oren Gradel
Journal of Clinical Medicine.2023; 12(19): 6132. CrossRef
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Case Report
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Bronchoesophageal fistula in a patient with Crohn’s disease receiving anti-tumor necrosis factor therapy
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Kyunghwan Oh, Kee Don Choi, Hyeong Ryul Kim, Tae Sun Shim, Byong Duk Ye, Suk-Kyun Yang, Sang Hyoung Park
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Clin Endosc 2023;56(2):239-244. Published online December 21, 2021
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DOI: https://doi.org/10.5946/ce.2021.215
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- Tuberculosis is an adverse event in patients with Crohn’s disease receiving anti-tumor necrosis factor (TNF) therapy. However, tuberculosis presenting as a bronchoesophageal fistula (BEF) is rare. We report a case of tuberculosis and BEF in a patient with Crohn’s disease who received anti-TNF therapy. A 33-year-old Korean woman developed fever and cough 2 months after initiation of anti-TNF therapy. And the symptoms persisted for 1 months, so she visited the emergency room. Chest computed tomography was performed upon visiting the emergency room, which showed BEF with aspiration pneumonia. Esophagogastroduodenoscopy with biopsy and endobronchial ultrasound with transbronchial needle aspiration confirmed that the cause of BEF was tuberculosis. Anti-tuberculosis medications were administered, and esophageal stent insertion through endoscopy was performed to manage the BEF. However, the patient’s condition did not improve; therefore, fistulectomy with primary closure was performed. After fistulectomy, the anastomosis site healing was delayed due to severe inflammation, a second esophageal stent and gastrostomy tube were inserted. Nine months after the diagnosis, the fistula disappeared without recurrence, and the esophageal stent and gastrostomy tube were removed.
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Citations
Citations to this article as recorded by

- (Re-)introduction of TNF antagonists and JAK inhibitors in patients with previous tuberculosis: a systematic review
Thomas Theo Brehm, Maja Reimann, Niklas Köhler, Christoph Lange
Clinical Microbiology and Infection.2024; 30(8): 989. CrossRef - Azathioprine/infliximab/methylprednisolone
Reactions Weekly.2023; 1963(1): 114. CrossRef
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Original Articles
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Factors Predicting Difficult Biliary Cannulation during Endoscopic Retrograde Cholangiopancreatography for Common Bile Duct Stones
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Hirokazu Saito, Yoshihiro Kadono, Takashi Shono, Kentaro Kamikawa, Atsushi Urata, Jiro Nasu, Haruo Imamura, Ikuo Matsushita, Tatsuyuki Kakuma, Shuji Tada
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Clin Endosc 2022;55(2):263-269. Published online November 12, 2021
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DOI: https://doi.org/10.5946/ce.2021.153
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- Background
/Aims: Difficult biliary cannulation is an important risk factor for post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). Therefore, this study aimed to identify the factors that predict difficult cannulation for common bile duct stones (CBDS) to reduce the risk for PEP.
Methods
This multicenter retrospective study included 1,406 consecutive patients with native papillae who underwent ERCP for CBDS. Factors predicting difficult cannulation for CBDS were identified using univariate and multivariate analyses.
Results
Univariate analysis showed that six factors significantly predicted difficult cannulation: ERCP performed by non-expert endoscopists, low-volume center, absence of acute cholangitis, normal serum bilirubin, intradiverticular papilla, and type of major duodenal papilla. Multivariate analysis identified ERCP performed by non-expert endoscopists (odds ratio [OR], 2.5; p<0.001), low-volume center (OR, 1.6; p<0.001), intradiverticular papilla (OR, 1.3; p=0.007), normal serum bilirubin (OR, 1.3; p=0.038), and absence of acute cholangitis (OR, 1.3; p=0.049) as factors significantly predicting difficult cannulation for CBDS.
Conclusions
Initial cannulation by an experienced endoscopist, early rescue cannulation, or early takeover by an experienced endoscopist should be considered when performing ERCP for CBDS in the presence of factors predicting difficult cannulation.
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Citations
Citations to this article as recorded by

- Development of a Scoring System for Predicting the Difficulty of Bile Duct Cannulation and Selecting the Appropriate Cannulation Method
Taira Kuroda, Hideki Miyata, Kozue Kanemitsu-Okada, Emi Yanagihara, Hironobu Saneto, Taisei Murakami, Hirofumi Izumoto, Kei Onishi, Shogo Kitahata, Tomoe Kawamura, Ryuichiro Iwasaki, Fujimasa Tada, Eiji Tsubouchi, Atsushi Hiraoka, Tomoyuki Ninomiya
Digestive Diseases and Sciences.2025; 70(2): 843. CrossRef - Unsedated emergent ERCP is feasible and efficient for acute cholangitis in old patients over 80 years
Jia-Qi Xu, Yi-Fan Qu, Zhao-Chao Zhang, Shi-Yao Chen, Yun-Shi Zhong, Yi-Qun Zhang, Wei-Feng Chen, Jian-Wei Hu, Ming-Yan Cai, Li-Qing Yao, Quan-Lin Li, Ping-Hong Zhou
Surgical Endoscopy.2025; 39(5): 2847. CrossRef - Difficult biliary cannulation during endoscopic retrograde cholangiopancreatography for distal malignant biliary obstruction caused by pancreatic cancer: An observational study
Jun Noda, Yuichi Takano, Naoki Tamai, Masataka Yamawaki, Tetsushi Azami, Fumitaka Niiya, Naotaka Maruoka, Masatsugu Nagahama
DEN Open.2025;[Epub] CrossRef - Advancements in Research on Challenges in Selective Biliary Cannulation during Endoscopic Retrograde Cholangiopancreatography (ERCP)
天雨 张
Journal of Clinical Personalized Medicine.2024; 03(01): 100. CrossRef - The impact of transpancreatic precut sphincterotomy on the quality of ERCP in a low-volume setting
Wei-Chih Su, Chia-Chi Wang, Tsung-Hsien Hsiao, Hung-Da Chen, Jiann-Hwa Chen
Gastrointestinal Endoscopy.2024; 99(5): 747. CrossRef - Morphology of the papilla can predict procedural safety and efficacy of ERCP—a systematic review and meta-analysis
Edina Tari, Endre Botond Gagyi, Anett Rancz, Dániel Sándor Veres, Szilárd Váncsa, Péter Jenő Hegyi, Krisztina Hagymási, Péter Hegyi, Bálint Erőss
Scientific Reports.2024;[Epub] CrossRef - Quality Indicators of Endoscopic Retrograde Cholangiopancreatography in Korea
Hyung Ku Chon, Ki-Hyun Kim, Tae Jun Song, Dong-Won Ahn, Eaum Seok Lee, Yun Nah Lee, Yoon Suk Lee, Tae Joo Jeon, Chang Hwan Park, Kwang Bum Cho, Dong Wook Lee, Jin-Seok Park, Seung Bae Yoon, Kwang Hyun Chung, Jin Lee, Miyoung Choi
Gut and Liver.2024; 18(4): 564. CrossRef - Quality Indicators of Endoscopic Retrograde Cholangiopancreatography in Korea
Ki-Hyun Kim, Hyung Ku Chon, Tae Jun Song, Dong Won Ahn, Eaum Seok Lee, Yun Nah Lee, Yoon Suk Lee, Tae Joo Jeon, Chang Hwan Park, Kwang Bum Cho, Dong Wook Lee, Jin-Seok Park, Seung Bae Yoon, Kwang Hyung Chung, Jin Lee, Miyoung Choi
The Korean Journal of Gastroenterology.2024; 84(3): 111. CrossRef - Quality Indicators of Endoscopic Retrograde Cholangiopancreatography in Korea
Ki-Hyun Kim, Hyung Ku Chon, Tae Jun Song, Dong Won Ahn, Eaum Seok Lee, Yun Nah Lee, Yoon Suk Lee, Tae Joo Jeon, Chang Hwan Park, Kwang Bum Cho, Dong Wook Lee, Jin-Seok Park, Seung Bae Yoon, Kwang Hyung Chung, Jin Lee, Miyoung Choi
The Korean Journal of Pancreas and Biliary Tract.2024; 29(4): 144. CrossRef - En face position of the major duodenal papilla using a reopenable clip during endoscopic retrograde cholangiopancreatography
Hirokazu Saito, Akiko Ikebata, Shunpei Hashigo
Digestive Endoscopy.2023;[Epub] CrossRef - Criterios 5-5-2 de canulación biliar y complicaciones post colangiopancreatografía retrógrada endoscópica: Experiencia en un hospital de referencia, Perú
Wilmer Gustavo Quiroga Purizaca, Diego Ricardo Páucar Aguilar, Jackeline Amparo Barrientos Pérez, Isamar Benyi Gutiérrez Córdova, Renato Garrido Acedo, Daniel Andrei Vargas Blácido
Revista de Gastroenterología del Perú.2023; 43(2): e1461. CrossRef - Predictive factors of difficult biliary cannulation: An experience of a tunisian tertiary center
K. Ben Abdallah, L. Hamzaoui, M. Mahmoudi, I. Cherif, A. Ben Mohamed, M. Yakoubi, A. Khsiba, M. Medhioub, M.M. Azouz
Heliyon.2022; 8(12): e12526. CrossRef
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Cholecystitis after Placement of Covered Self-Expandable Metallic Stents in Patients with Distal Malignant Biliary Obstructions
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Masafumi Watanabe, Kosuke Okuwaki, Jun Woo, Mitsuhiro Kida, Hiroshi Imaizumi, Tomohisa Iwai, Hiroshi Yamauchi, Toru Kaneko, Rikiya Hasegawa, Takahiro Kurosu, Naoki Minato, Hiroki Haradome, Wasaburo Koizumi
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Clin Endosc 2021;54(4):589-595. Published online November 17, 2020
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DOI: https://doi.org/10.5946/ce.2020.136
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- Background
/Aims: Cholecystitis can occur after the placement of covered self-expandable metallic stents for distal malignant biliary obstructions. We aimed to identify risk factors for cholecystitis following covered self-expandable metallic stent placement.
Methods
We investigated risk factors related to cholecystitis following covered self-expandable metallic stent placement in 118 patients with distal malignant biliary obstructions between January 1, 2015 and April 30, 2019. Endoscopic assessments and tumor invasion to the arteries feeding the gallbladder were determined by a pancreaticobiliary endoscopist and a radiologist, respectively.
Results
The median patient age was 72 years (men, 61.0%). The flow of the contrast agent into the gallbladder and tumor involvement in the orifice of the cystic duct were observed in 35 (29.7%) and 35 (29.7%) patients, respectively. During the observation period (median, 179 days), cholecystitis occurred in 18 (15.3%) patients. Multivariate analysis revealed the flow of the contrast agent into the gallbladder (p=0.023) and tumor involvement in the orifice of the cystic duct (p=0.005) as significant independent risk factors associated with cholecystitis.
Conclusions
The flow of the contrast agent into the gallbladder and tumor involvement in the orifice of the cystic duct are potential independent risk factors for cholecystitis following the placement of covered self-expandable metallic stents. A follow-up prospective study is warranted to validate their influence.
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Citations
Citations to this article as recorded by

- Incidence of Cholecystitis After Endoscopic Biliary Drainage Using a Low Axial Force Covered Self‐Expandable Metallic Stent in Patients With Malignant Distal Biliary Obstruction: A Multicenter Prospective Study
Naoki Minato, Kosuke Okuwaki, Masafumi Watanabe, Jun Woo, Takaaki Matsumoto, Masayoshi Tadehara, Toru Kaneko, Junro Ishizaki, Tomohisa Iwai, Hiroshi Imaizumi, Mitsuhiro Kida, Hiroki Haradome, Chika Kusano
Journal of Gastroenterology and Hepatology.2025; 40(2): 502. CrossRef - Risk Factors for Cholecystitis After Self-expandable Metallic Stent Placement for Malignant Distal Biliary Obstruction
Hashem Albunni, Azizullah Beran, Nwal Hadaki, Mark A. Gromski, Mohammad Al-Haddad
Journal of Clinical Gastroenterology.2025;[Epub] CrossRef - Fully covered metal stents as a risk factor for acute cholecystitis and cholangitis in patients with biliary stricture: A multicenter retrospective study
T Khoury, A Benson, M Moaad Farraj, M Basheer, M Mahamid, A Nubani, T Greener, N Mubariki, H Awadie, A Lisotti, W Sbeit
Endoscopy.2025; 57(S 02): S127. CrossRef - Interventional Endoscopic Ultrasonography: Advances in Application
Haidar Khan, Sharon Slomovich, Neal C. Shah, Frank Gress
Journal of Clinical Medicine.2025; 14(10): 3286. CrossRef - Adverse events of self-expandable metal stent placement for malignant distal biliary obstruction: a large multicenter study
Takashi Tamura, Takuo Yamai, Norimitsu Uza, Tomoaki Yamasaki, Atsuhiro Masuda, Fumimasa Tomooka, Hirotsugu Maruyama, Minoru Shigekawa, Takeshi Ogura, Katsutoshi Kuriyama, Masanori Asada, Hisakazu Matsumoto, Mamoru Takenaka, Koichiro Mandai, Yui Osaki, Ken
Gastrointestinal Endoscopy.2024; 99(1): 61. CrossRef - Fully covered versus partially covered self-expandable metal stents for palliation of distal malignant biliary obstruction: a systematic review and meta-analysis
Giuseppe Vanella, Chiara Coluccio, Alessandro Cucchetti, Roberto Leone, Giuseppe Dell’Anna, Paolo Giuffrida, Carmela Abbatiello, Cecilia Binda, Carlo Fabbri, Paolo Giorgio Arcidiacono
Gastrointestinal Endoscopy.2024; 99(3): 314. CrossRef - Endoscopic Ultrasound–Guided vs Endoscopic Retrograde Cholangiopancreatography–Guided Biliary Drainage as Primary Approach to Malignant Distal Biliary Obstruction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Harishankar Gopakumar, Ritu Raj Singh, Vakya Revanur, Rajanikanth Kandula, Srinivas R. Puli
American Journal of Gastroenterology.2024; 119(8): 1607. CrossRef - Cholecystitis in patients with a fully covered self-expandable metal stent with and without externally anchored plastic stents
José Miguel Jiménez-Gutiérrez, Félix Téllez-Avila
Endoscopy.2024; 56(04): 317. CrossRef - Risk factors and treatment strategies for cholecystitis after metallic stent placement for malignant biliary obstruction: a multicenter retrospective study
Akihiro Matsumi, Hironari Kato, Taiji Ogawa, Toru Ueki, Masaki Wato, Masakuni Fujii, Tatsuya Toyokawa, Ryo Harada, Yuki Ishihara, Masahiro Takatani, Hirofumi Tsugeno, Naoko Yunoki, Takeshi Tomoda, Toshiharu Mitsuhashi, Motoyuki Otsuka
Gastrointestinal Endoscopy.2024; 100(1): 76. CrossRef - Intrahepatic Rupture of Acute Cholecystitis Complicated by Septic Portal Thrombosis
Mena Louis, Nathaniel Grabill, Baraa Mohamed, Firdous Khan, Joe Williams, Nelson A Royall
Cureus.2024;[Epub] CrossRef - Malignant Obstructive Jaundice ERCP Postoperative Complications Risk Factors
威 刘
Asian Case Reports in Emergency Medicine.2024; 12(04): 153. CrossRef - Covered versus uncovered double bare self-expandable metal stent for palliation of unresectable extrahepatic malignant biliary obstruction: a randomized controlled multicenter trial
Se Woo Park, Kyong Joo Lee, Moon Jae Chung, Jung Hyun Jo, Hee Seung Lee, Jeong Youp Park, Seung Woo Park, Si Young Song, Huapyong Kang, Eui Joo Kim, Yeon Suk Kim, Jae Hee Cho, Seungmin Bang
Gastrointestinal Endoscopy.2023; 97(1): 132. CrossRef - Risk factors for early and late cholecystitis after covered metal stent placement for distal biliary obstruction
Tatsuya Ishii, Tsuyoshi Hayashi, Hajime Yamazaki, Risa Nakamura, Kosuke Iwano, Ryo Ando, Haruka Toyonaga, Toshifumi Kin, Kuniyuki Takahashi, Akio Katanuma
Journal of Hepato-Biliary-Pancreatic Sciences.2023; 30(10): 1180. CrossRef - Efficacy and complications of inoperable malignant distal biliary obstruction treatment by metallic stents: fully covered or uncovered?
Jiangning Gu, Xiaoyi Guo, Yong Sun, Bin Fan, Haoran Li, Ting Luo, Haifeng Luo, Jiao Liu, Feng Gao, Yuan Gao, Guang Tan, Xiaoming Liu, Zhuo Yang
Gastroenterology Report.2022;[Epub] CrossRef - Endoscopic Management of Pancreatobiliary Malignancies
Dong Wook Lee, Eun Young Kim
Digestive Diseases and Sciences.2022; 67(5): 1635. CrossRef
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Positive Fecal Occult Blood Test is a Predictive Factor for Gastrointestinal Bleeding after Capsule Endoscopy in Patients with Unexplained Iron Deficiency Anemia: A Korean Multicenter CAPENTRY Study
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Ji Young Chang, Chang Mo Moon, Ki-Nam Shim, Dae Young Cheung, Hyun Seok Lee, Yun Jeong Lim, Seong Ran Jeon, Soo Jung Park, Kyeong Ok Kim, Hyun Joo Song, Hyun Joo Jang, Ji Hyun Kim
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Clin Endosc 2020;53(6):719-726. Published online November 6, 2020
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DOI: https://doi.org/10.5946/ce.2019.149
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Abstract
PDF
Supplementary Material
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- Background
/Aims: Capsule endoscopy (CE) is recommended as the primary method for the evaluation of unexplained anemia. This study aimed to assess the diagnostic yield of CE in patients with unexplained iron deficiency anemia (IDA) without overt bleeding, and to evaluate their long-term outcomes and related clinical factors.
Methods
Data of patients who underwent CE for the evaluation of IDA were reviewed from a CE registry in Korea. Additional clinical data were collected by the involved investigators of each hospital through a review of medical records.
Results
Among a total of 144 patients, the diagnostic yield of CE was 34%. Gastrointestinal (GI) bleeding was found in 6.3% (n=9) of the patients (occult bleeding in four patients and overt bleeding in five patients) during a mean follow-up of 17.8 months. Patients with a positive fecal occult blood test (FOBT) result at the initial diagnosis had a higher rate of GI bleeding after CE (p=0.004). In addition, a positive FOBT result was the only independent predictive factor for GI bleeding (hazard ratio, 5.30; 95% confidence interval, 1.41–19.85; p=0.013).
Conclusions
Positive FOBT is a predictive factor for GI bleeding during follow-up after CE in patients with unexplained IDA without overt bleeding. Thus, patients with positive FOBT need to be more closely followed up.
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Citations
Citations to this article as recorded by

- Faecal occult blood testing in persons aged 50–74 years with established spinal cord injury: a prospective case series
Michael Yulong Wu, Carmen Tung, McCawley Clark-Dickson, Samuel Arthurs, Steffanie Nario, Ian D. Norton
Spinal Cord Series and Cases.2025;[Epub] CrossRef - Frequency of Positive Fecal Occult Blood Test in Patients with Cirrhosis
Faisal Khan, Aliena Badshah, Durkho Atif, Muhammad Irshad
Journal of Gandhara Medical and Dental Science.2024; 12(1): 32. CrossRef - Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2022
Marco Pennazio, Emanuele Rondonotti, Edward J. Despott, Xavier Dray, Martin Keuchel, Tom Moreels, David S. Sanders, Cristiano Spada, Cristina Carretero, Pablo Cortegoso Valdivia, Luca Elli, Lorenzo Fuccio, Begona Gonzalez Suarez, Anastasios Koulaouzidis,
Endoscopy.2023; 55(01): 58. CrossRef - Predictive Model for Positive Video Capsule Endoscopy in Iron Deficiency Anemia
Shadi Hamdeh, Jihan Fathallah, Hui Zhang, Amber Charoen, Barakat Aburajab Altamimi, Florence-Damilola Odufalu, Devashree Dave, Amer El Sayed, Laura R. Glick, Scott Grisolano, Christine Hachem, Muhammad Bader Hammami, Khaldoun Haj Mahmoud, Alexander N. Lev
Digestive Diseases and Sciences.2023; 68(7): 3083. CrossRef - Predictors of Positive Video Capsule Endoscopy Findings for Chronic Unexplained Abdominal Pain: Single-Center Retrospective Study and Meta-Analysis
Wonshik Kim, Beomjae Lee, Ahyoung Yoo, Seunghan Kim, Moonkyung Joo, Jong-Jae Park
Diagnostics.2021; 11(11): 2123. CrossRef
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7,398
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139
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5
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5
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Case Report
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Acquired Hemophilia A with Gastrointestinal Bleeding
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Narae Park, Jin Seok Jang, Jae Hwang Cha
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Clin Endosc 2020;53(1):90-93. Published online July 8, 2019
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DOI: https://doi.org/10.5946/ce.2019.036
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Abstract
PDF
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ePub
- Peptic ulcer disease is the most common cause of acute gastrointestinal bleeding, followed by variceal bleeding, Mallory–Weiss syndrome, and malignancy. On the contrary, acquired hemophilia A is a very rare hemorrhagic disease, which usually manifests with musculocutaneous bleeding, caused by autoantibodies against coagulation factor VIII.
A 78-year-old man presented to the Emergency Department with melena. Dieulafoy’s lesions were observed on esophagogastroduodenoscopy, and endoscopic cauterization was performed. However, the patient complained of back pain and symptoms indicative of upper gastrointestinal bleeding. Abdominopelvic computed tomography was performed, and hematoma in the psoas muscle was detected. Antibodies against coagulation factor VIII were confirmed with a blood test, and the diagnosis of acquired hemophilia A was made. Here, we report a case of acquired hemophilia A presenting with upper gastrointestinal bleeding symptoms and present a brief review of literature.
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Citations
Citations to this article as recorded by

- Variceal hemorrhage in a patient with cirrhosis and congenital hemophilia A: A therapeutic challenge
Rafael Gregorio Peña Amaya, María del Carmen Figueredo Peña
SAGE Open Medical Case Reports.2024;[Epub] CrossRef - Acquired hemophilia A as a disease of the elderly: A comprehensive review of epidemiology, pathogenesis, and novel therapy
Andrea Lehoczki, Mónika Fekete, Gábor Mikala, Imre Bodó
GeroScience.2024; 47(1): 503. CrossRef - A case of refractory bleeding from duodenal angioectasia with acquired hemophilia A
Hiroko Abe, Masahiro Saito, Kaname Uno, Tomoyuki Koike, Satoshi Ichikawa, Masashi Saito, Takeshi Kanno, Waku Hatta, Naoki Asano, Atsushi Masamune
Clinical Journal of Gastroenterology.2023; 16(3): 355. CrossRef - C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians
Dimitra S. Mouliou
Diseases.2023; 11(4): 132. CrossRef - THE RESTRICTIVE EFFECTS OF THE COVID-19 PANDEMIC ON THE MANAGEMENT OF PLASTRON APPENDICITIS IN A KNOWN HEMOPHILIA A PATIENT
Mert Yurtsever, İrfan Arda Aykut, Beste Girgin, Berkay Aldemir, Oğuzhan Alp Öztürk, Zeliha Türkyılmaz
TURKISH MEDICAL STUDENT JOURNAL.2022; 9(3): 84. CrossRef - A rare cause of lower gastrointestinal bleeding: acquired hemophilia A
Pilar Del Pino Bellido, María Fernanda Guerra Veloz, Reyes Aparcero López
Revista Española de Enfermedades Digestivas.2021;[Epub] CrossRef - Undiagnosed Acquired Hemophilia A: Presenting as Recurrent Gastrointestinal Bleeding
Arya Mariam Roy, Aisha Siddiqui, Anand Venkata
Cureus.2020;[Epub] CrossRef
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5,961
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162
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7
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Original Article
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Predictive Factors for Inaccurate Diagnosis of Swollen Lymph Nodes in Endoscopic Ultrasound-Guided Fine Needle Aspiration
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Yuki Fujii, Yoshihide Kanno, Shinsuke Koshita, Takahisa Ogawa, Hiroaki Kusunose, Kaori Masu, Toshitaka Sakai, Keisuke Yonamine, Yujiro Kawakami, Toji Murabayashi, Fumisato Kozakai, Yutaka Noda, Hiroyuki Okada, Kei Ito
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Clin Endosc 2019;52(2):152-158. Published online January 7, 2019
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DOI: https://doi.org/10.5946/ce.2018.125
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Abstract
PDF
PubReader
ePub
- Background
/Aims: This study aimed to identify the predictive factors for inaccurate endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) diagnosis of swollen lymph nodes without rapid on-site cytopathological evaluation.
Methods
Eighty-three consecutive patients who underwent EUS-FNA for abdominal or mediastinal lymph nodes from January 2008 to June 2017 were included from a prospectively maintained EUS-FNA database and retrospectively reviewed. The sensitivity, specificity, and accuracy of EUS-FNA for the detection of neoplastic diseases were calculated. Candidate factors for inaccurate diagnosis (lymph node size and location, needle type, puncture route, number of passes, and causative disease) were evaluated by comparison between accurately diagnosed cases and others.
Results
The final diagnosis of the punctured lymph node was classified as neoplastic (65 cases: a metastatic lymph node, malignant lymphoma, or Crow-Fukase syndrome) or non-neoplastic (18 cases: a reactive node or amyloidosis). The sensitivity, specificity, and accuracy were 83%, 94%, and 86%, respectively. On multivariate analyses, small size of the lymph node was the sole predictive factor for inaccurate EUS-FNA diagnosis with a significant difference (odds ratios, 19.8; 95% confidence intervals, 3.15–124; p=0.0015).
Conclusions
The lymph node size of <16 mm was the only independent factor associated with inaccurate EUS-FNA diagnosis of swollen lymph nodes.
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Citations
Citations to this article as recorded by

- Mediastinal lymphadenopathy: Causes, symptoms and factors predicting good yield of endoscopic ultrasound-guided biopsy
Abbas A Tasneem, Nasir H Luck, Muhammed Mubarak
World Journal of Clinical Cases.2025;[Epub] CrossRef - Role of EBUS‐TBNA/EUS‐FNA and mass spectrometry for diagnosis and typing of lymph node amyloidosis: 10‐year experience in two tertiary care academic centers
Asghar Naqvi, Michael Bonert, Christian Finley, Katarzyna Czarnecka‐Kujawa, Kazuhiro Yasufuku, Joerg Schwock, Vathany Kulasingam, Rohan John, Hyang‐Mi Ko
Cancer Cytopathology.2023; 131(11): 724. CrossRef - Endoscopic Ultrasound-Guided Fine Needle Biopsy in the Diagnostic Work-Up of Deep-Seated Lymphadenopathies and Spleen Lesions: A Monocentric Experience
Flaminia Bellisario, Fabia Attili, Fabrizia Campana, Federica Borrelli de Andreis, Silvia Bellesi, Elena Maiolo, Eleonora Alma, Rosalia Malafronte, Giuseppe Macis, Luigi Maria Larocca, Salvatore Annunziata, Francesco D’Alò, Stefan Hohaus
Diagnostics.2023; 13(17): 2839. CrossRef - Lymph node FNA cytology: Diagnostic performance and clinical implications of proposed diagnostic categories
Vladislav V. Makarenko, Michelle E. DeLelys, Robert P. Hasserjian, Amy Ly
Cancer Cytopathology.2022; 130(2): 144. CrossRef - Diagnostic accuracy and clinical impact of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in Positron Emission Tomography - Computed Tomography (PET-CT)-positive mediastinal lymphadenopathies in patients with thoracic or extra-thoracic mali
Dominique Béchade, Carine Bellera, Lisa Gauquelin, Isabelle Soubeyran, Pippa McKelvie-Sebileau, Marc Debled, François Chomy, Guilhem Roubaud, Marianne Fonck, Simon Pernot, Alexandre Roch, Anne-Laure Cazeau
Clinics and Research in Hepatology and Gastroenterology.2022; 46(5): 101912. CrossRef - High Diagnostic Accuracy and Safety of Endoscopic Ultrasound-Guided Fine-Needle Aspiration in Malignant Lymph Nodes: A Systematic Review and Meta-Analysis
Linbin Chen, Yin Li, Xiaoyan Gao, Shiyong Lin, Longjun He, Guangyu Luo, Jianjun Li, Chunyu Huang, Guobao Wang, Qing Yang, Hongbo Shan
Digestive Diseases and Sciences.2021; 66(8): 2763. CrossRef - Diagnosis of Pancreatic Solid Lesions, Subepithelial Lesions, and Lymph Nodes Using Endoscopic Ultrasound
Akashi Fujita, Shomei Ryozawa, Masafumi Mizuide, Yuki Tanisaka, Tomoya Ogawa, Masahiro Suzuki, Hiromune Katsuda, Yoichi Saito, Tomoaki Tashima, Kazuya Miyaguchi, Eiichi Arai, Tomonori Kawasaki, Yumi Mashimo
Journal of Clinical Medicine.2021; 10(5): 1076. CrossRef - Primary localized gastric amyloidosis: A scoping review of the literature from clinical presentations to prognosis
Xin-Yu Lin, Dan Pan, Li-Xuan Sang, Bing Chang
World Journal of Gastroenterology.2021; 27(12): 1132. CrossRef - Comparison of Endoscopic Ultrasound-Guided Fine-Needle Aspiration and Biopsy Device for Lymphadenopathy
Yuki Tanisaka, Masafumi Mizuide, Akashi Fujita, Tomoya Ogawa, Ryuichiro Araki, Masahiro Suzuki, Hiromune Katsuda, Youichi Saito, Kazuya Miyaguchi, Tomoaki Tashima, Yumi Mashimo, Masami Yasuda, Shomei Ryozawa, Konstantinos Triantafyllou
Gastroenterology Research and Practice.2021; 2021: 1. CrossRef - How to Improve the Diagnostic Accuracy of EUS-FNA in Abdominal and Mediastinal Lymphadenopathy?
Tae Hyeon Kim
Clinical Endoscopy.2019; 52(2): 93. CrossRef
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Case Report
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Unexpected Delayed Colon Perforation after the Endoscopic Submucosal Dissection with Snaring of a Laterally Spreading Tumor
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Young Bo Ko, Jeong-Mi Lee, Wan Soo Kim, Min Seob Kwak, Ji Wan Lee, Dong Yeol Shin, Dong-Hoon Yang, Jeong-Sik Byeon
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Clin Endosc 2015;48(6):570-575. Published online November 30, 2015
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DOI: https://doi.org/10.5946/ce.2015.48.6.570
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Abstract
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- Colonic perforation may occur as a complication of diagnostic and therapeutic colonoscopy. The risk factors for perforation after colorectal endoscopic submucosal dissection (ESD) include an inexperienced endoscopist, a large tumor size, and submucosal fibrosis. The mechanisms of perforation include unintended endoscopic resection/dissection and severe thermal injury. Here, we report a case of colon perforation that occurred after ESD with snaring of a laterally spreading tumor. The perforation was completely unexpected because there were no colorectal ESD-associated risk factors for perforation, deep dissection, or severe coagulation injury in our patient.
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Citations
Citations to this article as recorded by

- Clinical outcomes and risk factors of post-polypectomy microperforation in patients with colorectal neoplasia: a case-control study
Seung Yong Shin, Min Soo Cho, Jinhoon Nam, Jie-Hyun Kim, Young Hoon Yoon, Hyojin Park, Jeonghyun Kang, Jae Jun Park
Therapeutic Advances in Gastrointestinal Endoscopy.2025;[Epub] CrossRef - Tri-Axial Force Sensor in a Soft Catheter Using Fiber Bragg Gratings for Endoscopic Submucosal Dissection
Ramzi Ben Hassen, Arnaud Lemmers, Alain Delchambre
IEEE Sensors Journal.2023; 23(20): 24626. CrossRef - Factors for conversion risk of colorectal endoscopic submucosal dissection: a multicenter study
Yuki Kamigaichi, Shiro Oka, Shinji Tanaka, Shinji Nagata, Masaki Kunihiro, Toshio Kuwai, Yuko Hiraga, Akira Furudoi, Seiji Onogawa, Hideharu Okanobu, Takeshi Mizumoto, Tomohiro Miwata, Shiro Okamoto, Kenichi Yoshimura, Kazuaki Chayama
Surgical Endoscopy.2022; 36(8): 5698. CrossRef - Life on a knife edge: the optimal approach to the management of perforations during endoscopic submucosal dissection (ESD)
Shria Kumar, Young Hoon Youn, Jeffrey H. Lee
Expert Review of Gastroenterology & Hepatology.2020; 14(10): 965. CrossRef - Delayed perforation after endoscopic resection of a colonic laterally spreading tumor: A case report and literature review
Ge-Yu-Jia Zhou, Jin-Long Hu, Sheng Wang, Nan Ge, Xiang Liu, Guo-Xin Wang, Si-Yu Sun, Jin-Tao Guo
World Journal of Clinical Cases.2020; 8(16): 3608. CrossRef - Predicting and managing complications following colonoscopy: risk factors and management of advanced interventional endoscopy with a focus on colorectal ESD
Hiroyuki Takamaru, Rina Goto, Masayoshi Yamada, Taku Sakamoto, Takahisa Matsuda, Yutaka Saito
Expert Review of Medical Devices.2020; 17(9): 929. CrossRef - Cost Analysis of Endoscopic Submucosal Dissection for the Treatment of Colorectal Lesions in China
Ning Cui, Yu Zhao, Honggang Yu
BioMed Research International.2019; 2019: 1. CrossRef - Delayed perforation after endoscopic submucosal dissection for mucosal colon cancer: A conservatively treated case
Kazumasa Kawashima, Takuto Hikichi, Tatsuo Fujiwara, Naohiko Gunji, Jun Nakamura, Ko Watanabe, Kyoko Katakura, Hiromasa Ohira
FUKUSHIMA JOURNAL OF MEDICAL SCIENCE.2018; 64(3): 157. CrossRef
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12,486
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8
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Original Article
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Evidence of the Internationalization of Clinical Endoscopy Based on Journal Metrics
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Sun Huh
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Clin Endosc 2015;48(4):317-321. Published online July 24, 2015
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DOI: https://doi.org/10.5946/ce.2015.48.4.317
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Abstract
PDF
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- Background/Aims
This study aims to verify the internationalization of Clinical Endoscopy based on journal metrics after the change to English-only in 2011. The results of this study serve as a starting point for developing strategies to develop Clinical Endoscopy into a top-tier international journal.
MethodsThe following journal metrics were analyzed from the journal's homepage or the Web of Science: the number of citable articles, number of countries of affiliation of the contributors, the number of articles supported by research grants, total citations, impact factor, citing journals, countries of citing authors, and the Hirsch index.
ResultsThe number of citable articles in 2011, 2012, 2013, and 2014 was 22, 81, 120, and 95, respectively. The authors were from 11 countries. Twenty-one out of 55 original articles were supported by research grants. The total citations in 2012, 2013, and 2014 were 2, 85, and 213, respectively. The impact factor was 0.670 in 2013 and 0.940 in 2014. The number of countries citing authors were from was 61. The Hirsch index was 6.
ConclusionsThe above results demonstrate that Clinical Endoscopy became an international journal, contributing to the propagation of valuable research results through an open access publishing model.
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Citations
Citations to this article as recorded by

- Journal metrics of Clinical and Molecular Hepatology based on the Web of Science Core Collection
Sun Huh
Clinical and Molecular Hepatology.2018; 24(2): 137. CrossRef -
Clinical and Experimental Vaccine Research's promotion to internationally competitive journal evidenced by journal metrics
Sun Huh
Clinical and Experimental Vaccine Research.2017; 6(2): 67. CrossRef - Promotion ofNeurointerventionto International Journal Based on Journal Metrics
Sun Huh
Neurointervention.2016; 11(1): 5. CrossRef - Journal of Gastric Cancer's Promotion to International Journal from the Perspective of Biliometric Analysis
Sun Huh
Journal of Gastric Cancer.2016; 16(1): 8. CrossRef -
Clinics in Orthopedic Surgery's Evolution into an International Journal Based on Journal Metrics
Sun Huh
Clinics in Orthopedic Surgery.2016; 8(2): 127. CrossRef - The Elevation ofAnnals of Rehabilitation Medicineto the Status of an International Journal After Adopting an English-Only Policy
Sun Huh
Annals of Rehabilitation Medicine.2015; 39(5): 661. CrossRef - How much is Journal of Educational Evaluation for Health Professions promoted based on journal metrics?
Sun Huh
Journal of Educational Evaluation for Health Professions.2015; 12: 57. CrossRef
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7,578
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45
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7
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Focused Review Series: Endoscopic and Molecular Imaging of Premalignant GI Lesions, Part II
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Barrett Esophagus in Asia: Same Disease with Different Pattern
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Hyun Seok Lee, Seong Woo Jeon
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Clin Endosc 2014;47(1):15-22. Published online January 24, 2014
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DOI: https://doi.org/10.5946/ce.2014.47.1.15
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Abstract
PDF
PubReader
ePub
Barrett esophagus (BE) is considered to develop as a result of chronic gastroesophageal reflux disease (GERD) and to predispose to esophageal adenocarcinoma (EAC). However, the disease pattern of BE in Asia differs from that observed in the West. For example, in the West, the prevalence rates of BE and EAC have progressively increased, whereas although the prevalence rate of GERD is increasing in Asia, the prevalence rates of BE and EAC have remained low in most Asian countries. GERD, hiatal hernia, old age, male sex, abdominal obesity (visceral obesity), smoking, alcohol consumption, and kyphosis are known risk factors for BE in Asia, and most Asian patients have short-segment BE. Helicobacter pylori infection is more prevalent in Asia than in the West. We suggest larger studies with a prospective design be conducted to elaborate further the different patterns of BE in Asia.
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Citations
Citations to this article as recorded by

- Increased Prevalence of Barrett's Esophagus in Taiwan: A Prospective Multicenter Study
Fu‐Jen Lee, Ming‐Chang Tsai, Chien‐Lin Chen, Ming‐Wun Wong, Hsu‐Heng Yen, Jeng‐Yih Wu, Chen‐Shuan Chung, Ping‐Huei Tseng, Ying‐Nan Tsai, Ming‐Tsung Hsieh, Chi‐Yang Chang
Journal of Gastroenterology and Hepatology.2025;[Epub] CrossRef - Prevalence of Barrett’s Esophagus and Esophageal Adenocarcinoma With and Without Gastroesophageal Reflux: A Systematic Review and Meta-analysis
Bibek Saha, Kornpong Vantanasiri, Babu P. Mohan, Rohit Goyal, Nikita Garg, Danielle Gerberi, John B. Kisiel, Siddharth Singh, Prasad G. Iyer
Clinical Gastroenterology and Hepatology.2024; 22(7): 1381. CrossRef - Low-grade dysplasia in Barrett's esophagus: A problematic diagnosis
Muhannad Sarem, Francisco J. Martínez Cerezo, Maria Lujan Salvia Favieres, Rodolfo Corti
Gastroenterología y Hepatología.2023; 46(8): 637. CrossRef - Low-grade dysplasia in Barrett's esophagus: A problematic diagnosis
Muhannad Sarem, Francisco J. Martínez Cerezo, Maria Lujan Salvia Favieres, Rodolfo Corti
Gastroenterología y Hepatología (English Edition).2023; 46(8): 637. CrossRef - Is There an Increasing Incidence of Gastroesophageal Junctional Adenocarcinoma and Barrett Esophagus in Asia? A Review of Diagnostic Conundrums
Phei Oon Tan, Alex Yu Sen Soh, Chika Kusano, Yeong Yeh Lee, Takuji Gotoda
Digestion.2022; 103(1): 37. CrossRef - Thailand guideline 2020 for medical management of gastroesophageal reflux disease
Monthira Maneerattanaporn, Rapat Pittayanon, Tanisa Patcharatrakul, Chalermrat Bunchorntavakul, Siam Sirinthornpanya, Panyavee Pitisuttithum, Asawin Sudcharoen, Uayporn Kaosombatwattana, Kawin Tangvoraphongchai, Reawika Chaikomin, Kamin Harinwan, Karjpong
Journal of Gastroenterology and Hepatology.2022; 37(4): 632. CrossRef - Quality indicators in esophagogastroduodenoscopy
Sang Yoon Kim, Jae Myung Park
Clinical Endoscopy.2022; 55(3): 319. CrossRef - Epidemiological Review of Gastroesophageal Junction Adenocarcinoma in Asian Countries
Noriaki Manabe, Kazuhiro Matsueda, Ken Haruma
Digestion.2022; 103(1): 29. CrossRef - Reply: Need for evidence on surveillance endoscopy in achalasia-related Barret esophagus and adenocarcinoma in Asian population
Hiroki Sato, Yuto Shimamura, Shinwa Tanaka, Hironari Shiwaku, Hitomi Minami, Chiaki Sato, Ryo Ogawa, Haruhiro Inoue
Journal of Gastroenterology.2022; 57(10): 813. CrossRef - Barrett's Esophagus
Yong Kang Lee
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2022; 22(3): 177. CrossRef - Multinational survey on the preferred approach to management of Barrett’s esophagus in the Asia-Pacific region
Guan Sen Kew, Alex Yu Sen Soh, Yeong Yeh Lee, Takuji Gotoda, Yan-Qing Li, Yan Zhang, Yiong Huak Chan, Kewin Tien Ho Siah, Daniel Tong, Simon Ying Kit Law, Andrew Ruszkiewicz, Ping-Huei Tseng, Yi-Chia Lee, Chi-Yang Chang, Duc Trong Quach, Chika Kusano, Sho
World Journal of Gastrointestinal Oncology.2021; 13(4): 279. CrossRef - Risk Prediction of Barrett’s Esophagus in a Taiwanese Health Examination Center Based on Regression Models
Po-Hsiang Lin, Jer-Guang Hsieh, Hsien-Chung Yu, Jyh-Horng Jeng, Chiao-Lin Hsu, Chien-Hua Chen, Pin-Chieh Wu
International Journal of Environmental Research and Public Health.2021; 18(10): 5332. CrossRef - Relationship between time-varying status of reflux esophagitis and Helicobacter pylori and progression to long-segment Barrett’s esophagus: time-dependent Cox proportional-hazards analysis
Genki Usui, Tomohiro Shinozaki, Toyohisa Jinno, Kazutoshi Fujibayashi, Teppei Morikawa, Toshiaki Gunji, Nobuyuki Matsuhashi
BMC Gastroenterology.2020;[Epub] CrossRef - Challenges to diagnostic standardization of Barrett's esophagus in Asia
Yu Sen Alex Soh, Yeong Yeh Lee, Takuji Gotoda, Prateek Sharma, Khek‐Yu Ho
Digestive Endoscopy.2019; 31(6): 609. CrossRef - Presence of columnar-lined esophagus is negatively associated with the presence of esophageal varices in Japanese alcoholic men
Akira Yokoyama, Kenro Hirata, Rieko Nakamura, Tai Omori, Takeshi Mizukami, Junko Aida, Katsuya Maruyama, Tetsuji Yokoyama
World Journal of Gastroenterology.2017; 23(39): 7150. CrossRef - Unchanging pattern of prevalence of esophageal cancer, overall and by histological subtype, in the endoscopy service of the main referral hospital in the central region of Rio Grande do Sul State, in Southern Brazil
R. B. Fagundes, D. de Carli, R. V. Xaubet, J. C. Cantarelli
Diseases of the Esophagus.2016; 29(6): 603. CrossRef - Dietary magnesium, calcium:magnesium ratio and risk of reflux oesophagitis, Barrett’s oesophagus and oesophageal adenocarcinoma: a population-based case–control study
Qi Dai, Marie M. Cantwell, Liam J. Murray, Wei Zheng, Lesley A. Anderson, Helen G. Coleman
British Journal of Nutrition.2016; 115(2): 342. CrossRef - A Model for Predicting the Future Risk of Incident Erosive Esophagitis in an Asymptomatic Population Undergoing Regular Check-ups
Soo Hoon Kang, Yaeji Lim, Hyuk Lee, Joungyoun Kim, Sangah Chi, Yang Won Min, Byung-Hoon Min, Jun Haeng Lee, Hee Jung Son, Seungho Ryu, Poong-Lyul Rhee, Jae J. Kim
Medicine.2016; 95(4): e2591. CrossRef - Asia-Pacific consensus on the management of gastro-oesophageal reflux disease: an update focusing on refractory reflux disease and Barrett's oesophagus
Kwong Ming Fock, Nicholas Talley, Khean Lee Goh, Kentaro Sugano, Peter Katelaris, Gerald Holtmann, John E Pandolfino, Prateek Sharma, Tiing Leong Ang, Michio Hongo, Justin Wu, Minhu Chen, Myung-Gyu Choi, Ngai Moh Law, Bor-Shyang Sheu, Jun Zhang, Khek Yu H
Gut.2016; 65(9): 1402. CrossRef - Prevalence of Barrett’s Esophagus in Asian Countries: A Systematic Review and Meta-analysis
Seiji Shiota, Siddharth Singh, Ashraf Anshasi, Hashem B. El-Serag
Clinical Gastroenterology and Hepatology.2015; 13(11): 1907. CrossRef - Association Between Alcohol Consumption and the Risk of Barrett's Esophagus
Qin Xu, Wei Guo, Xingang Shi, Wei Zhang, Tianyi Zhang, Cheng Wu, Jian Lu, Rui Wang, Yanfang Zhao, Xiuqiang Ma, Jia He
Medicine.2015; 94(32): e1244. CrossRef - Barrett's esophagus and risk of esophageal adenocarcinoma: A retrospective analysis
Hung‐Wei Wang, Chia‐Jung Kuo, Wey‐Ran Lin, Chen‐Ming Hsu, Yu‐Pin Ho, Chun‐Jung Lin, Kuang‐Hua Chen, Ming‐Yao Su, Cheng‐Tang Chiu
Advances in Digestive Medicine.2015; 2(4): 135. CrossRef - Risk factors of early proximal gastric carcinoma in Chinese diagnosed using WHO criteria
Cheng Fang, Qin Huang, Lin Lu, Jiong Shi, Qi Sun, Gui Fang Xu, Jason Gold, Hiroshi Mashimo, Xiao Ping Zou
Journal of Digestive Diseases.2015; 16(6): 327. CrossRef - Association of Visceral Fat Area, Smoking, and Alcohol Consumption with Reflux Esophagitis and Barrett's Esophagus in Japan
Juntaro Matsuzaki, Hidekazu Suzuki, Masao Kobayakawa, John M. Inadomi, Michiyo Takayama, Kanako Makino, Yasushi Iwao, Yoshinori Sugino, Takanori Kanai, Norikazu Maeda
PLOS ONE.2015; 10(7): e0133865. CrossRef
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Original Articles
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Clinical Outcomes and Risk Factors of Rebleeding Following Endoscopic Therapy for Nonvariceal Upper Gastrointestinal Hemorrhage
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Ki Tae Suk, Hyun-Soo Kim, Chang Seob Lee, Il Young Lee, Moon Young Kim, Jae Woo Kim, Soon Koo Baik, Sang Ok Kwon, Dong Ki Lee, Young Lim Ham
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Clin Endosc 2011;44(2):93-100. Published online December 31, 2011
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DOI: https://doi.org/10.5946/ce.2011.44.2.93
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Abstract
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- Background/Aims
Rebleeding after endoscopic therapy for non-variceal upper gastrointestinal hemorrhage (NGIH) is the most important predictive factor of mortality. We evaluated the risk factors of rebleeding in patients undergoing endoscopic therapy for the NGIH.
MethodsBetween January 2003 and January 2007, 554 bleeding events in 487 patients who underwent endoscopic therapy for NGIH were retrospectively enrolled. We reviewed the clinicoendoscopical characteristics of patients with rebleeding and compared them with those of patients without rebleeding.
ResultsThe incidence of rebleeding was 21.7% (n=120). In the multivariate analysis, initial hemoglobin level ≤9 g/dL (p=0.002; odds ratio [OR], 2.433), inexperienced endoscopist with less than 2 years of experience in therapeutic endoscopy (p=0.001; OR, 2.418), the need for more 15 cc of epinephrine (p=0.001; OR, 2.570), injection therapy compared to thermal and injection therapy (p=0.001; OR, 2.840), and comorbidity with chronic renal disease (p=0.004; OR, 2.908) or liver cirrhosis (p=0.010; OR, 2.870) were risk factors for rebleeding following endoscopic therapy.
ConclusionsTogether with patients with low hemoglobin level at presentation, chronic renal disease, liver cirrhosis, the need for more 15 cc of epinephrine, or therapy done by inexperienced endoscopist were risk factors for the development of rebleeding.
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- Dieulafoy’s lesion of the upper GI tract: a comprehensive nationwide database analysis
Yichen Wang, Pardeep Bansal, Si Li, Zaid Iqbal, Mahesh Cheryala, Marwan S. Abougergi
Gastrointestinal Endoscopy.2021; 94(1): 24. CrossRef - Analysis of rebleeding in cases of an upper gastrointestinal bleed in a single center series
Rita Jiménez Rosales, Juan Gabriel Martínez-Cara, Francisco Vadillo-Calles, Eva Julissa Ortega-Suazo, Patricia Abellán-Alfocea, Eduardo Redondo-Cerezo
Revista Española de Enfermedades Digestivas.2018;[Epub] CrossRef - Continuing use of antithrombotic medications for patients with bleeding gastroduodenal ulcer requiring endoscopic hemostasis: a case–control study
Keisuke Kawasaki, Shotaro Nakamura, Koichi Kurahara, Tomohiro Nagasue, Shunichi Yanai, Akira Harada, Hiroki Yaita, Tadahiko Fuchigami, Takayuki Matsumoto
Scandinavian Journal of Gastroenterology.2017; : 1. CrossRef - Multidisciplinary Approach to Refractory Upper Gastrointestinal Bleeding: Case Series of Angiographic Embolization
Ko Eun Lee, Ki-Nam Shim, Chung Hyun Tae, Min Sun Ryu, Sun Young Choi, Chang Mo Moon, Seong-Eun Kim, Hey-Kyung Jung, Sung-Ae Jung
Journal of Korean Medical Science.2017; 32(9): 1552. CrossRef - Successful Endoscopic Hemostasis Is a Protective Factor for Rebleeding and Mortality in Patients with Nonvariceal Upper Gastrointestinal Bleeding
Yong Jae Han, Jae Myung Cha, Jae Hyun Park, Jung Won Jeon, Hyun Phil Shin, Kwang Ro Joo, Joung Il Lee
Digestive Diseases and Sciences.2016; 61(7): 2011. CrossRef - Rebleeding after Initial Endoscopic Hemostasis in Peptic Ulcer Disease
Mi Jin Hong, Sun-Young Lee, Jeong Hwan Kim, In-Kyung Sung, Hyung Seok Park, Chan Sup Shim, Choon Jo Jin
Journal of Korean Medical Science.2014; 29(10): 1411. CrossRef - Chronic Kidney Disease, Hemodynamic Instability, and Endoscopic High-Risk Appearance Are Associated with 30-Day Rebleeding in Patients with Non-Variceal Upper Gastrointestinal Bleeding
Yoo Jin Lee, Eun Soo Kim, Yu Jin Hah, Kyung Sik Park, Kwang Bum Cho, Byoung Kuk Jang, Woo Jin Chung, Jae Seok Hwang
Journal of Korean Medical Science.2013; 28(10): 1500. CrossRef
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Short-term Clinical Outcomes Based on Risk Factors of Recurrence after Removing Common Bile Duct Stones with Endoscopic Papillary Large Balloon Dilatation
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Jung Ho Kim, Yeon Suk Kim, Dong Kyu Kim, Min Su Ha, Young Jun Lee, Jong Joon Lee, Sang Jin Lee, In Sik Won, Yang Suh Ku, Yun Soo Kim, Ju Hyun Kim
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Clin Endosc 2011;44(2):123-128. Published online December 31, 2011
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DOI: https://doi.org/10.5946/ce.2011.44.2.123
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Abstract
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- Background/Aims
Recurrence is an important late complication of endotherapy of bile duct stones. Endoscopic papillary large balloon dilation (EPLBD) can be used as an alternative method of removing difficult bile duct stones. The aim of this study was to evaluate short term clinical outcomes after removing common bile duct (CBD) stones using EPLBD.
MethodsA retrospective review was performed based on the medical records of 141 patients who received EPLBD, with or without endoscopic sphincterotomy, between September 2008 and February 2010. Of these, 50 patients, were enrolled in the study. Clinical and endoscopic parameters were analyzed to identify risk factors for CBD stones recurrence.
ResultsMale:Female ratio was 22:28 (mean age, 67.4±14.4 years). Recurrence rate was 24.0% (12/50). Mean follow-up period was 10.8±4.5 months. Nineteen (38.0%) had a history of surgery and 20 (40.0%) were comorbid with periampullary diverticula. Mean diameters of the stones and CBD were 13.8±4.3 mm and 20.1±7.2 mm, respectively. In univariate analysis, large CBD stones (≥12 mm) and angulated CBD (angle ≤145°) were identified as the significant predictors of recurrence. In multivariate analysis, angulated CBD (angle ≤145°) was the significant independent risk factor for recurrence.
ConclusionsClose follow-up seems necessary in patients with angulated CBD (angle ≤145°).
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- Endoscopic Papillary Large Balloon Dilatation With or Without Endoscopic Sphincterotomy in the Treatment of Common Bile Duct Stones
Jia Wang, Lichao Cao, Kuijin Xue, Peng Qi, Qingdong Mao, Mingjuan Cui, Hui Ju, Baoguo He, Bin Cao
Digestive Diseases and Sciences.2025; 70(2): 478. CrossRef - Eyelid and Parotid Gland Metastasis of Colorectal Cancer Demonstrated by 18F-FDG PET/CT
Mehmet Samsum, Nur Aydinbelge Dizdar, Alev Cinar, Ozlem Ozmen
Clinical Nuclear Medicine.2025; 50(7): e437. CrossRef - Recurrence of common bile duct stones after endoscopic clearance and its predictors: A systematic review
Marko Kozyk, Suprabhat Giri, Sidharth Harindranath, Manan Trivedi, Kateryna Strubchevska, Rakesh Kumar Barik, Sridhar Sundaram
DEN Open.2024;[Epub] CrossRef - Modern Management of Common Bile Duct Stones: Breakthroughs, Challenges, and Future Perspectives
Yanguang Sha, Zhilin Wang, Rongmei Tang, Ke Wang, Chen Xu, Guangbin Chen
Cureus.2024;[Epub] CrossRef - Risk factors and management of primary choledocholithiasis: a systematic review
Jie Zhang, Xiaofeng Ling
ANZ Journal of Surgery.2021; 91(4): 530. CrossRef - Efficacy and safety of conversion of percutaneous cholecystostomy to endoscopic transpapillary gallbladder stenting in high-risk surgical patients
Hyung Ku Chon, Chan Park, Dong Eun Park, Tae Hyeon Kim
Hepatobiliary & Pancreatic Diseases International.2021; 20(5): 478. CrossRef - Alterations of the Bile Microbiome in Recurrent Common Bile Duct Stone
Cheng Ye, Wence Zhou, Hui Zhang, Long Miao, Gen Lv, Abdelwahab Omri
BioMed Research International.2020;[Epub] CrossRef - Clinical Impact of Common Bile Duct Angulation for Recurrence of Bile Duct Stones
Se Woo Park
The Korean Journal of Gastroenterology.2020; 76(4): 177. CrossRef - Clinical Impact of Common Bile Duct Angulation on the Recurrence of Common Bile Duct Stone: A Meta-analysis and Review
Seongyul Ryu, Ik Hyun Jo, Seonhoo Kim, Yeon-Ji Kim, Woo Chul Chung
The Korean Journal of Gastroenterology.2020; 76(4): 199. CrossRef - Causes associated with recurrent choledocholithiasis following therapeutic endoscopic retrograde cholangiopancreatography: A large sample sized retrospective study
Feng Deng, Mi Zhou, Ping-Ping Liu, Jun-Bo Hong, Guo-Hua Li, Xiao-Jiang Zhou, You-Xiang Chen
World Journal of Clinical Cases.2019; 7(9): 1028. CrossRef - Japan Gastroenterological Endoscopy Society guidelines for endoscopic papillary large balloon dilation
Takao Itoi, Shomei Ryozawa, Akio Katanuma, Yoshinobu Okabe, Hironori Kato, Jun Horaguchi, Takayoshi Tsuchiya, Takuji Gotoda, Naotaka Fujita, Kenjiro Yasuda, Yoshinori Igarashi, Kazuma Fujimoto
Digestive Endoscopy.2018; 30(3): 293. CrossRef - Mid‐term outcome of endoscopic sphincterotomy combined with large balloon dilation
Fumihide Itokawa, Takao Itoi, Atsushi Sofuni, Toshio Kurihara, Takayoshi Tsuchiya, Kentaro Ishii, Shujiro Tsuji, Nobuhito Ikeuchi, Junko Umeda, Reina Tanaka, Ryosuke Tonozuka, Mitsuyoshi Honjyo, Fuminori Moriyasu, Kazuhiko Kasuya, Akihiko Tsuchida
Journal of Gastroenterology and Hepatology.2015; 30(1): 223. CrossRef - Which Is the Better Treatment for the Removal of Large Biliary Stones? Endoscopic Papillary Large Balloon Dilation versus Endoscopic Sphincterotomy
Woo Hyun Paik, Ji Kon Ryu, Jin Myung Park, Byeong Jun Song, Jaihwan Kim, Joo Kyung Park, Yong-Tae Kim
Gut and Liver.2014; 8(4): 438. CrossRef - Endoscopic papillary balloon dilation for difficult common bile duct stones: Our experience
Maddalena Zippi
World Journal of Clinical Cases.2013; 1(1): 19. CrossRef
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A Comparison of Clinical Characteristics between Medically-treated Patients and Surgically-treated Patients with Ischemic Colitis
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Nam-Chul Jin, Hyun-Soo Kim, Dae-Hyun Kim, Young-A Song, Yeon-Ju Kim, Tae-Jin Seo, Sun-Young Park, Chang-Hwan Park, Young-Eun Joo, Sung-Kyu Choi, Jong-Sun Rew
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Clin Endosc 2011;44(1):38-43. Published online September 30, 2011
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DOI: https://doi.org/10.5946/ce.2011.44.1.38
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Abstract
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- Background/Aims
Ischemic colitis (IC) is usually a self-limiting disease. But, it can cause necrosis that requires urgent surgical treatment. We sought to evaluate clinical difference in IC patients between medical and surgical treatment groups, and to identify prognostic factors for adverse outcomes.
MethodsWe conducted a retrospective analysis of clinical characteristics in patients with IC treated in Chonnam National University Hospital between May 2001 and April 2010. A total of 81 patients with IC were enrolled. We classified the patients into two groups-a medical treatment group and a surgical treatment group-and evaluated their clinical features, treatment outcomes and mortality.
ResultsAbsence of hematochezia, vomiting, abdominal tenderness, abdominal rebound tenderness, heart rate over 90 beats/min, systolic blood pressure less than 100 mm Hg, hyponatremia and increased LDH or serum creatinine level were observed more frequently in surgically-treated patients (p<0.05). Most cases in the medically-treated group resolved without complications (98.3%). But, about half of the cases (52.4%) of the surgically-treated group resolved and the mortality rate was 47.6%.
ConclusionsIn patients with ischemic colitis, several clinical factors are associated with surgical treatment. Although IC is often selflimited, our data suggests that special attention and aggressive therapy is warranted in treating these patients.
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- Congestive ischemic colitis successfully treated with anti-inflammatory therapy: A case report
Geon Woo Lee, Su Bum Park
World Journal of Clinical Cases.2024; 12(1): 142. CrossRef - Colitis isquémica. ¿La localización en el colon derecho tiene peor pronóstico?
Vincenzo Vigorita, Marta Paniagua García-Señoráns, Gianluca Pellino, Paula Troncoso Pereira, Alberto de San Ildefonso Pereira, Enrique Moncada Iribarren, Raquel Sánchez-Santos, Jose Enrique Casal Núñez
Cirugía Española.2022; 100(2): 74. CrossRef - Ischemic colitis. Does right colon location mean worst prognosis?
Vincenzo Vigorita, Marta Paniagua García-Señoráns, Gianluca Pellino, Paula Troncoso Pereira, Alberto de San Ildefonso Pereira, Enrique Moncada Iribarren, Raquel Sánchez-Santos, Jose Enrique Casal Núñez
Cirugía Española (English Edition).2022; 100(2): 74. CrossRef - Clinical characteristics and long-term outcomes of hospitalised patients with ischemic colitis with different degrees of haematochezia: a retrospective study
Qin An, Baisi- Yuan, Zhen Guo, Lin Wu, Miaofang- Yang, Shaopei- Shi, Guoxing- Tang, Fangyu- Wang
European Journal of Gastroenterology & Hepatology.2022; 34(8): 823. CrossRef - Clinical features and risk factors for ischemic colitis in young and middle-aged patients
W Cai, J Zhu, D Hu
Acta Gastro Enterologica Belgica.2022; 85(2): 283. CrossRef - Clinical impact of inferior mesenteric vein preservation during left hemicolectomy with low ligation of the inferior mesenteric artery for distal transverse and descending colon cancers: A comparative study based on computed tomography
Jung Wook Suh, Jihoon Park, Jeehye Lee, In Jun Yang, Hong-Min Ahn, Heung-Kwon Oh, Duck-Woo Kim, Sung-Bum Kang
Frontiers in Oncology.2022;[Epub] CrossRef - Development and Validation of a Risk Scoring Model for Early Prediction of Severe Colon Ischemia
Min Young Shin, Hee Seok Moon, In Sun Kwon, Jae Ho Park, Ju Seok Kim, Sun Hyung Kang, Eaum Seok Lee, Seok Hyun Kim, Jae Kyu Sung, Byung Seok Lee, Hyun Yong Jeong
Digestive Diseases and Sciences.2021; 66(11): 3993. CrossRef - Colon ischemia: A comprehensive review
Antonella Maimone, Antonella De Ceglie, Peter D. Siersema, Todd H. Baron, Massimo Conio
Clinics and Research in Hepatology and Gastroenterology.2021; 45(6): 101592. CrossRef - The Pathophysiology, Presentation and Management of Ischaemic Colitis: A Systematic Review
George Demetriou, Ahmed Nassar, Sriram Subramonia
World Journal of Surgery.2020; 44(3): 927. CrossRef - Congestive ischemic colitis occurring after resection of left colon cancer: 4 case series
Takatsugu Fujii, Shigeo Toda, Yuki Nishihara, Yusuke Maeda, Kosuke Hiramatsu, Yutaka Hanaoka, Rikiya Sato, Shuichiro Matoba, Masashi Ueno, Hiroya Kuroyanagi
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Amanda L. Nikolic, James O. Keck
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Hyun Il Seo, Kyoo-ho Choi, Koon Hee Han, Sang Jin Lee, Jong Kyu Park, Young Don Kim, Gab Jin Cheon
Gastroenterology Research and Practice.2017; 2017: 1. CrossRef - Advents in the Diagnosis and Management of Ischemic Colitis
Evangelos P. Misiakos, Dimitrios Tsapralis, Theodore Karatzas, Irene Lidoriki, Dimitrios Schizas, George S. Sfyroeras, Konstantinos G. Moulakakis, Chrysostomos Konstantos, Anastasios Machairas
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D. Sun, C. Wang, L. Yang, M. Liu, F. Chen
Colorectal Disease.2016; 18(10): 949. CrossRef - Laparoscopy rather than colonoscopy for the diagnosis and treatment of fulminant ischemic colitis
Mahmoud Othman, Nadim El-Majzoub, Ghattas Khoury, Kassem Barada
International Journal of Colorectal Disease.2014; 29(11): 1443. CrossRef - Efficacy of Pentoxifylline and Tadalafil in Rat Model of Ischemic ColITIS
Enver Reyhan, Oktay Irkorucu, Ali Surmelioglu, Selvinaz Ozkara, Kamuran Cumhur Deger, Mehmet Aziret, Hasan Erdem, Suleyman Cetinkunar, Pelin Demirturk, Ahmet Ozer Sehirli
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Muhammed Sherid, Humberto Sifuentes, Salih Samo, Samian Sulaiman, Husein Husein, Ruth Tupper, Sankara N Sethuraman, Charles Spurr, John A Vainder, Subbaramiah Sridhar
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Tomoya Tsukada
World Journal of Gastrointestinal Surgery.2012; 4(8): 203. CrossRef
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Regression of Hyperplastic Gastric Polyp after Helicobacter pylori Eradication
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Sang-Ah Lim, M.D., Jae-Won Yun, M.D., Daewoong Yoon, M.D., Wonjae Choi, M.D., Seung Han Kim, M.D., Jung Wan Choe, M.D., Mi-Na Kim, M.D., Eun Joo Kang, M.D., Jong Jae Park, M.D., Moon Kyung Joo, M.D., Beom Jae Lee, M.D., Young-Tae Bak, M.D., Sang Woo Lee,
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Korean J Gastrointest Endosc 2011;42(2):74-82. Published online February 28, 2011
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- Background/Aims: Recent studies have suggested that the eradication of Helicobacter pylori (Hp) may lead to the regression of hyperplastic polyps (HPPs) in the stomach. We evaluated the sizes of HPPs after Hp eradication and we also compared the clinical parameters between the regression and non-regression groups.
Methods: We enrolled 187 patients who had HPPs in the stomach. The polyps were measured by using biopsy forceps, and the endoscopically observed changes of the polyps were assessed by two endoscopists.
Results: Total regression was observed in 68 patients of the eradicated group and in 6 patients in the non-eradicated group (42.5% vs. 22.2%, respectively, p<0.05). The non regression rate was significantly higher for the non-eradicated group than that for the eradicated group (33% vs. 10%, respectively, p<0.05). Comparing between the regression and non-regression groups, the incidence of polyps that were smaller than 10 mm in size and sessile was significantly higher in the regression group. Hp eradication was the only significant predictor of regression.
Conclusions: Hp eradication could be a therapeutic option for Hp positive-hyperplastic gastric polyps, and especially for those that are less than 10 mm in size and sessile. (Korean J Gastrointest Endosc 2011;42:74-82)
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A Case of Simple Ulcer of the Terminal Ileum Successfully Treated by Monoclonal Antibody to Tumor Necrosis Factor-Ձ (Infliximab)
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Seok Jong Lee, M.D., Woo Chul Chung, M.D., Kang Moon Lee, M.D., You Suk Oh, M.D., Eun Jung Kim, M.D., Kang Hyun Choi, M.D. and Chang Nyol Paik, M.D.
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Korean J Gastrointest Endosc 2010;41(1):56-60. Published online July 31, 2010
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Abstract
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- Nonspecific and idiopathic ulcer of the small bowel or colon is a rare condition, and it is the so called "simple ulcer" when the patients do not have systemic symptoms of Behcet's syndrome. Differentiation of simple ulcer from intestinal Behcet's disease according to the endoscopic and pathologic findings is often impossible and the clinical course of the 2 maladies is similar. A 51-year-old man presented with low abdominal pain, and colonoscopy revealed a huge deep ulceration with an entero-enteric fistula in the terminal ileum. He was diagnosed with simple ulcer without the constitutional symptoms of Behcet's syndrome. He was refractory to conventional therapy with corticosteroids and antibiotics, and so he required surgical resection. Monoclonal antibody against tumor necrosis factor-Ձ (Infliximab) was administered at 0, 2 and 6 weeks. His symptoms were relieved after the therapy and the ulceration had completely resolved after 1 year. He was entirely asymptomatic at the 36 month follow up. (Korean J Gastrointest Endosc 2010;41:56-60)
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Clinical Characteristics of Gastrointestinal Carcinoid Tumors
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Myoung Hee Lee, M.D., Sung Jae Shin, M.D., Su Jin Jeon, M.D., Sun-Gyo Lim, M.D., Yoon Chul Lee, M.D., Jae Chul Hwang, M.D., Kee Myung Lee, M.D., Kwang Jae Lee, M.D. and Jin Hong Kim, M.D.
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Korean J Gastrointest Endosc 2010;40(6):347-351. Published online June 30, 2010
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Abstract
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- Background
/Aims: Various factors have been reported that can predict the clinical course and outcome of patients with gastrointestinal (GI) carcinoid tumors. We analyzed the clinical characteristics of GI carcinoid tumors and the factors associated with metastasis.
Methods
We retrospectively analyzed the clinical manifestations, treatment modalities and prognosis of 83 patients with GI carcinoid tumors.
Results
The mean age of the patients was 48 years old. The locations of the carcinoid tumors were rectum (n=60), stomach (n=12), duodenum (n=6), appendix (n=4) and colon (n=1). The most common symptom was non-specific (n=65, 79.5%), and the mean tumor size was 11.2 mm. The main treatment modality was endoscopic resection (n=66, 79.5%). Nine patients showed metastasis, and all of their tumors were larger than 2 cm. Univariate analysis revealed that size, ulceration and invasion of the proper muscle layer were significant factors associated with metastasis. Tumor size (p=0.001) was the only independent factor on multivariate analysis.
Conclusions
The diagnosis of small sized, asymptomatic GI carcinoid tumors has increased and endoscopic treatment was a useful modality. Tumor size was a predictive factor for metastasis. (Korean J Gastrointest Endosc 2010;40:347-351)
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Risk Factors Predicting the Development of Complication after Foreign Body Ingestion
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Sung Hoon Jung, M.D., Chang Nyol Paik, M.D., Kang Moon Lee, M.D., Woo Chul Chung, M.D., Jeong Rok Lee, M.D., U-Im Chang, M.D. and Jin Mo Yang, M.D.
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Korean J Gastrointest Endosc 2009;38(4):199-204. Published online April 30, 2009
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/Aims: Complications related to foreign body ingestion are uncommon, and especially a food bolus, but some ingested foreign bodies are associated with severe and life threatening morbidity. The aim of this study is determine the predictive risk factors for complications resulting from foreign body ingestion in patients who are without gastrointestinal tract obstruction. Methods: We retrospectively analyzed the data of 147 patients who were diagnosed with a foreign body in the GI tract without obstruction between Jan. 2000 to Aug. 2008. Results: Animal bone fragment and coin were the most common type of foreign bodies in adults and children, respectively. Multivariate analysis showed age (p=0.019), the duration of impaction (p=0.013) and the location of the impacted foreign body (p=0.011) were significant independent risk factors associated with the development of complications. Especially, the most important risk factor for children was the location of the impacted foreign body and for adults it was the duration of impaction. Conclusions: Old age, a longer duration of impaction and impaction at the upper esophageal sphincter or upper esophagus are important predictive factors of complication after foreign body ingestion in patients without gastrointestinal tract obstruction. For cases with these factors, more intensive awareness by the physician should be adapted. (Korean J Gastrointest Endosc 2009;38:199-204)
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Risk Factors for Post-ERCP Pancreatitis in Patients Pretreated with Nafamostat Mesilate
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Il Doo Kim, M.D., Dae Hwan Kang, M.D., Jin Hyun Park, M.D., Jung Ho Bae, M.D., Pyo Jun Kim, M.D., Yong Wook Kim, M.D., Cheol Woong Choi, M.D., Jae Sup Eum, M.D., Sun Mi Lee, M.D., Tae Oh Kim, M.D., Gwang Ha Kim, M.D. and Geun Am Song, M.D.
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Korean J Gastrointest Endosc 2008;37(4):265-270. Published online October 30, 2008
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- Backgound/Aims: Pancreatitis is the most common and important complication of an endoscopic retrograde cholangiopancreatography (ERCP). The aim of this study was to identify risk factors for post ERCP-pancreatitis in patients pretreated with nafamostat mesilate, a synthetic protease inhibitor. Methods: A total of 247 patients who underwent an ERCP were evaluated prospectively. Potential risk factors of post-ERCP pancreatitis in patients pretreated with nafamostat mesilate were evaluated. Results: Twenty-four patients (9.7%) and nine patients (3.6%) developed post-ERCP hyperamylasemia and pancreatitis, respectively. As determined by univariate analysis among the potential risk factors, we found a procedure time over 20 minutes, pancreatic duct cannulation over four times, prior post-ERCP pancreatitis and the absence of a common bile duct (CBD) stone as risk factors for post-ERCP hyperamylasemia. We also found a patient age under 60 years, a procedure time over 20 minutes, pancreatic duct cannulation over four times and the absence of a CBD stone as risk factors for post-ERCP pancreatitis (p<0.05). As determined by multivariate analysis, pancreatic cannulation over four times is independently associated with post-ERCP hyperamylasemia (p=0.038; OR, 5.165; 95% CI, 1.093∼24.412) and post-ERCP pancreatitis (p=0.002; OR, 33.122; 95% CI, 3.526∼311.138). Conclusions: A repeated pancreatic duct cannulation is the most important risk factor for post-ERCP pancreatitis in patients pretreated with nafamostat mesilate. (Korean J Gastrointest Endosc 2008; 37:265-270)
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Clinical Features and Prognostic Factors in Ischemic Colitis
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Sung Hoon Jung, M.D., Kang Moon Lee, M.D., Jeong Seon Ji, M.D., Woo Chul Chung, M.D., Chang Nyol Paik, M.D., Bo In Lee, M.D., Jeong Rok Lee, M.D., Hwang Choi, M.D., You Joung Kim, MPH*, Jin Mo Yang, M.D. and Kyu Yong Choi, M.D.
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Korean J Gastrointest Endosc 2008;36(6):349-353. Published online June 30, 2008
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- Background
/Aims: Ischemic colitis mainly occurs in elderly patients and encompasses a wide clinical spectrum from mild, transient to severe and gangrenous forms. Since life expectancy is now increasing, more often physicians will encounter patients with this disease entity. Our aim was to review the clinical features of ischemic colitis and to analyze the effect of clinical factors on the duration of hospital stay and evaluate predictive factors of poor prognosis. Methods: We retrospectively analyzed the medical records of 294 patients diagnosed with ischemic colitis during 10 years from March 1997 to February 2007. Results: The mean hospital stay was 12.4±6.6 days. According to the use of multiple regression analysis, age, sex, clinical symptoms, hypertension, constipation, use of laxatives or antibiotics did not affect hospital stay. Factors that significantly increased hospital stay were diabetes mellitus (p= 0.007), colonic involvement of more than three segments (p=0.009) and the presence of an ulcer on a colonoscopic finding (p=0.008). Conclusions: Diabetes mellitus, colonic involvement of more than three segments and the presence of an ulcer on a colonoscopic finding are important predictive factors of poor prognosis in patients with ischemic colitis. In cases with one of these factors, more intensive treatment options should be adapted. (Korean J Gastrointest Endosc 2008;36:349-353)
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Clinical Factors That Potentially Affect the Treatment Outcome of Helicobacter pylori Eradication Therapy with using a Standard Triple Regimen in Peptic Ulcer Patients
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Taek Man Nam, M.D., Dong Ho Lee, M.D., Kyung Phil Kang, M.D., Jung Hoon Lee, M.D., Jae Il Chung, M.D., Hyun Cheul Choi, M.D., Sang Hyub Lee, M.D., Young Soo Park, M.D., Jin Hyeok Hwang, M.D., Jin Wook Kim, M.D., Sook Hyang Jung, M.D., Nayoung Kim, M.D., H
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Korean J Gastrointest Endosc 2008;36(4):200-205. Published online April 30, 2008
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Abstract
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- Background
/Aims: Proton pump inhibitor (PPI) based triple therapy for Helicobacter pylori eradication has an approximately 20% treatment failure rate. The aim of this study is to examine the clinical factors that influence eradication of H. pylori in patients with peptic ulcers. Methods: We reviewed the medical records of 597 endoscopy-proven peptic ulcer and H. pylori-positive patients who were treated at our hospital between July 2004 and March 2007. The eradication rate and the effect of age, gender, smoking, alcohol drinking, activity and the location of ulcer and the kind of PPIs were examined. Results: 597 patients were treated with one-week triple therapy (PPI, amoxicillin 1 g, clarithromycin 500 mg all twice daily). The overall eradication rate was 80.2%. Eradication was significantly more successful in the patients with an age under 60, and in patients over 60 and who had a duodenal ulcer (83.2% vs 73.2%, respectively, p=0.005) or a gastric ulcer (82.5% vs 73.6%, respectively, p=0.041). There was no statistically significant difference according to gender, smoking, alcohol, the activity of the ulcer and the kind of PPIs. Conclusions: An age over 60 and gastric ulcer were associated with a lower H. pylori eradication rate in patients with peptic ulcers. Therefore, H. pylori eradication in old age patients and in patients with gastric ulcer should be managed differently and the treatment duration should be extended or a new treatment regime developed to overcome the lower eradication rate. (Korean J Gastrointest Endosc 2008;36:199-205)
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A Risk Factor for Wound Infection after Percutaneous Endoscopic Gastrostomy : Decreased Performance Status
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Chan Ran You, M.D., Sang Woo Kim, M.D., Chang Nyol Paik, M.D., Jae Myung Park, M.D.,Yu Kyung Cho, M.D., In Seok Lee, M.D., Myung Gyu Choi, M.D., Kyu Yong Choi, M.D. and In Sik Chung M.D.
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Korean J Gastrointest Endosc 2007;35(3):133-139. Published online September 30, 2007
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/Aims: Percutaneous endoscopic gastrostomy (PEG) has been widely used for long term enteral nutrition. The most common complication is peristomal wound infection. The aim of this study is to investigate the risk factors for peristomal wound infection after PEG. Methods: We reviewed the records of 55 patients who had undergone PEG placement at Kangnam St. Mary's hospital via the Pull-string technique. We analyzed the underlying disease, the performance status and the nutritional state of the patients to determine the risk factors for wound infection. Results: Peristomal wound infection after PEG occurred in 20 (36.4%) of the 55 patients. Methicillin resistant Staphylococcus aureus (MRSA) was the most common isolated microorganism. On univariate analysis, the underlying CNS disease, non-malignant disease and a decreased performance status (ECOG 3, 4) were correlated with wound infection. On multivariate analysis, a decreased performance status was an independent risk factor for wound infection after PEG (p=0.007, OR=6.011, CI: 1.64∼22.09). Conclusions: A decreased performance status was an independent risk factor for peristomal wound infection after PEG. (Korean J Gastrointest Endosc 2007;35:133-139)
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Risk Factors for Upper Gastrointestinal Rebleeding in Critically Ill Patients
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Seong Joon Koh, M.D., Jae Hee Cheon, M.D., Joo Sung Kim, M.D., Byong Duk Ye, M.D., Hae Yeon Kang, M.D., Bo Hyun Kim, M.D., Jeong Hoon Lee, M.D., Ki Young Yang, M.D., Sang Gyun Kim, M.D., Hyun Chae Jung, M.D. and In Sung Song, M.D.
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Korean J Gastrointest Endosc 2006;32(5):320-325. Published online May 30, 2006
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/Aims: To determine the incidence and risk factors associated with rebleeding after upper gastrointestinal bleeding (UGIB) in critically ill patients. Methods: This study retrospectively reviewed the medical records of 60 patients undergoing bedside esophagogastroduodenoscopy between April 2000 and February 2004 for UGIB that developed whilst in the intensive care unit (ICU). Results: Eight out of 60 patients died within 7 days, and an additional 7 patients died within 30 days after the initial bleeding. Two of these 15 patients (13.3%), died from GI bleeding. The 7-day and 30-day rebleeding rates were 34.6% (18/52 patients), and 51.1% (23/45 patients), respectively. Multiple logistic regression using the significant variables revealed, anemia (Hb<9.0 g/dL) and hypoalbuminemia (<3.0 g/dL) to be significant factor for 7-day rebleeding, and hypoxia (<80 mmHg), anemia (Hb<9.0 g/dL), blood transfusion (≥3 units) to be significant independent risk factor for 30-day rebleeding. Conclusions: The rebleeding rates in the ICU setting were as high as 34.6% at 7 days and 51.1% at 30 days. This suggests that the underlying conditions of the critically ill patients affect the rebleeding rate more than the endoscopic features. Therefore, adequate general ICU care including the prevention and correction of hypoxia, anemia, and hypoalbuminemia, and minimizing blood loss can reduce the risk of rebleeding after UGIB in an ICU setting. (Korean J Gastrointest Endosc 2006;32:320325)
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Risk Factors Related to Bleeding after Endoscopic Mucosal Resection of Gastric Tumors
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Young Doo Lee, M.D., Hyang Eun Seo, M.D., Seong Woo Jeon, M.D., Myung Kwon Lee, M.D., Dong Seok Lee, M.D., Ki Tae Kwon, M.D., Chang Min Cho, M.D., Won Young Tak, M.D., Young Oh Kweon, M.D., Sung Kook Kim, M.D. and Yong Hwan Choi, M.D.
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Korean J Gastrointest Endosc 2005;30(6):297-304. Published online June 30, 2005
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/Aims: Endoscopic mucosal resection (EMR) has been widely used for treatment of gastric mucosal tumors because of its relative safety and minimal invasiveness. However, the bleeding after EMR has been regarded as a major complication. Herein, we assessed the bleeding rates and risk factors related to bleeding after EMR. Methods: We retrospectively analyzed the medical records of two hundred and fortynine patients with 283 lesions who underwent EMR for flat adenoma (78.8%), hyperplastic polyp (4.9%), and early gastric cancer (16.3%) from January 1999 to August 2003. Bleeding during EMR was defined as an immediate bleeding while bleeding on follow-up day endoscopy after EMR was considered as an delayed bleeding We evaluated risk factors related to bleeding using univariate and multivariate analysis. Results: Bleeding after EMR occurred in 99 patients (35%). Immediate bleeding occurred in 31.8% and was more frequent in the case of beginners, upper part of the stomach or EMR prcedures using needle knife. Delayed bleeding occurred in 7.1% and was more frequent in the case of flat or depressed lesions, or occurrence after the incidence of immediate bleeding. Risk factors related to EMR bleeding were experience of operator (beginner vs. expert, p= 0.001), anatomical location (upper vs. lower, p=0.018), and methods of procedure (needle-knife vs. snare or band, p=0.001). Conclusions: We concluded that experience of operator, anatomical location, and method of procedure were the risk factors related to bleeding after EMR. (Korean J Gastrointest Endosc 2005;30:297304)
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내시경적 점막절제술(EMR) 시 출혈 합병증에 미치는 요인에 대한 연구
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Korean J Gastrointest Endosc 2003;27(5):339-339. Published online November 20, 2003
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A Study on Clinical Characteristics of Mallory-Weiss Syndrome with Complicated Course
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Hang Lak Lee, M.D., Dong Soo Han, M.D., Jong Pyo Kim, M.D., Jin Bae Kim, M.D., Joon Yong Park, M.D., Joo Hyun Sohn, M.D. and Joon Soo Hahm, M.D.
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Korean J Gastrointest Endosc 2003;26(6):405-409. Published online June 30, 2003
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/Aims: Mallory-Weiss syndrome is a benign and self-limiting disease, but occasionally cases with complications are encountered. The aim of this study was to identify the risk factors for complicated course and predisposing factors of Mallory-Weiss syndrome, and its associated conditions. Methods: Fifty-nine patients diagnosed as having Mallory-Weiss syndrome were subjects of this study. Patients' medical records were reviewed retrospectively. A complicated course was defined if there was a need for transfusion of >6 pints, evidence of shock, rebleeding or angiographic or surgical interventions. Results: Risk factors for a complicated Mallory-Weiss syndrome in univariate analysis were the followings; low hemoglobin, melena, presence of visible vessel or active bleeding on initial endoscopy. In multivariate analysis, the presence of visible vessel and active bleeding on initial endoscopy were the only significant risk factors. Predisposing factors of Mallory-Weiss syndrome were as follows: vomiting after alcohol intake (62.7%), vomiting without alcohol (18.6%), nausea (1%), cough (1%), seizure (1%) and unknown etiology (13.6%). Associated medical conditions were as follows: alcoholic liver disease (45.8%), hiatal hernia (27.1%) and liver cirrhosis (18.6%). Conclusions: We suggest that the presence of visible vessel and active bleeding on initial endoscopy are a independent risk factors of Mallory-Weiss syndrome with a complicated course. In such patients, aggressive treatment and careful observations are essential. (Korean J Gastrointest Endosc 2003;26:405409)
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원저 : 소화성 궤양 출혈에서 열탐침 지혈법 후 재출혈의 위험인자 (The Risk Factors for Rebleeding with Heat Probe Thermocoagulation in Bleeding Peptie Ulcer Patients
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Korean J Gastrointest Endosc 2000;20(6):431-436. Published online November 30, 1999
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/Aims: The precise rebleeding rate and risk factors of rebleeding after heat probe thermocoagulation in peptic ulcer patients with bleeding are not clear and still need to be evaluated. If we could identify the pre-dictors for rebleeding, the mortality rate might be loweted with early retreatment or surgery in these high risk group. Methods: The 94 patients in whom heat probe was applied were enrolled and the 18 patients with bleeding tendencies. Initial hemostasis was defined as hemostasis persisting for 24 hours post-treatment and permanent hemostasis as absence of bleeding for 7 days after therapy. Rebleedig was defined as oozing or spurting hemorrhage in the ulcer base and/or unstable vital signs and continuting tarry or bloody stool or hematemesis after therapy. Results: In 35 patients with active bleeding sign, initial hemostasis was obtained in 30 (85.7%) patients. After having achieved initial hemostasis, 9 (30.0%) patients rebled. In 41 ulcer patients with non-bleeding visible vessel, 40 cases (97.6%) achieved successful pre-vention of rebleeding. No evident complication was observed. With univariate analysis, bleeding ulcer patients with spurting and oozing hemorrhage had a higher re-bleeding rate than those with non-bleeding visible vessel. Conclusions: The heat probe thermocoagulaton is relative safe and effective procedure to protect bleeding in pectic ulcer patients with non-bleeding visible vessel, but insufficient to hemostasis in bleeding peptic ulcer patients with spurting or oozing in ulcer base. Spurting and oozing hemorrhage are the only risk factors of rebleeding after initial hemostasis with heat probe thermocoagulation in peptic ulcer patients with bleeding.