Skip Navigation
Skip to contents

Clin Endosc : Clinical Endoscopy



Page Path
HOME > Search
4 "Gel"
Article category
Publication year
Systematic Review and Meta-analysis
Systematic review of self-assembling peptides as topical agents for treatment and prevention of gastrointestinal bleeding
Andrei Voiosu, Monica State, Victor Drăgan, Sergiu Văduva, Paul Bălănescu, Radu Bogdan Mateescu, Theodor Voiosu
Received July 4, 2023  Accepted September 30, 2023  Published online May 24, 2024  
DOI:    [Epub ahead of print]
Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReaderePub
/Aims: Gastrointestinal bleeding is a significant and potentially lethal event. We aimed to review the efficiency and safety of self-assembling peptides for the treatment and prevention of gastrointestinal tract bleeding.
We conducted a systematic search for studies describing the endoscopic use of self-assembling peptides for treatment or prevention of bleeding in the gastrointestinal tract in a parallel, independent fashion. The primary outcomes were rates of successful initial hemostasis, delayed bleeding, and rebleeding. The secondary outcomes were adverse events and ease and volume of gel used.
Seventeen studies were analyzed. Overall success rate of self-assembling peptides in gastrointestinal bleeding was 87.7% (38%–100%), regardless of etiology or associated treatments. Rebleeding rate ranged from 0% to 16.2%, with a mean of 4.7%, and overall delayed bleeding rate was 5% (range, 0%–15.9%). Only three adverse events were reported in a pooled number of 815 patients. The volume of gel used varied (0.43 to 3.7 mL) according to indication and type of bleeding.
The limited available data on the use of self-assembling peptides in gastrointestinal endoscopy suggest a high efficiency and good safety profile.
  • 2,011 View
  • 75 Download
Close layer
Original Article
Usefulness of a new polyvinyl alcohol hydrogel (PVA-H)-based simulator for endoscopic submucosal dissection training: a pilot study
Dong Seok Lee, Gin Hyug Lee, Sang Gyun Kim, Kook Lae Lee, Ji Won Kim, Ji Bong Jeong, Yong Jin Jung, Hyoun Woo Kang
Clin Endosc 2023;56(5):604-612.   Published online May 18, 2023
Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReaderePub
/Aims: We developed a new endoscopic submucosal dissection (ESD) simulator and evaluated its efficacy and realism for use training endoscopists.
An ESD simulator was constructed using polyvinyl alcohol hydrogel sheets and compared to a previous ESD simulator. Between March 1, 2020, and December 30, 2021, eight expert endoscopists from three different centers analyzed the procedure-related factors of the simulator. Five trainees performed gastric ESD exercises under the guidance of these experts.
Although the two ESD simulators provided overall favorable outcomes in terms of ESD-related factors, the new simulator had several benefits, including better marking of the target lesion’s limits (p<0.001) and overall handling (p<0.001). Trainees tested the usefulness of the new ESD simulator. The complete resection rate improved after 3 ESD training sessions (9 procedures), and the perforation rate decreased after 4 sessions (12 procedures).
We have developed a new ESD simulator that can help beginners achieve a high level of technical experience before performing real-time ESD procedures in patients.


Citations to this article as recorded by  
  • There is no royal road: a shortcut for endoscopic submucosal dissection training
    Seong Woo Jeon
    Clinical Endoscopy.2023; 56(5): 590.     CrossRef
  • 2,143 View
  • 112 Download
  • 1 Web of Science
  • 1 Crossref
Close layer
Case Report
Migration of a Percutaneous Endoscopic Gastrojejunostomy Tube into the Colon with Small Intestinal Telescoping
Shinya Taki, Takao Maekita, Mayumi Sakata, Kazuhiro Fukatsu, Yoshimasa Maeda, Mikitaka Iguchi, Hidefumi Ito, Masayuki Kitano
Clin Endosc 2019;52(6):616-619.   Published online October 16, 2019
AbstractAbstract PDFPubReaderePub
Continuous duodenal levodopa/carbidopa intestinal gel delivery by a gastrostomy infusion system improves control of Parkinson’s disease. The overall complication rates of percutaneous endoscopic gastrojejunostomy were reported to be 41% and 59% for immediate and delayed adverse events, respectively. A 72-year-old woman underwent percutaneous endoscopic gastrojejunostomy using the delivery system noted above. Abdominal pain and vomiting occurred 3 months later. Esophagogastroduodenoscopy showed a longitudinal ulcer extending from the lower gastric body to the ileum end, with small intestinal telescoping. Colonoscopy showed a large bezoar of food residue that was attached around the tip of the tube, reaching the ascending colon, which may have acted as an anchor. Thus, the gastric antrum and small intestine were shortened with telescoping. This complication was resolved by crushing the bezoar with forceps during colonoscopy and can be prevented by consuming a fiber-free diet and periodic exchanges of the tube using esophagogastroduodenoscopy.


Citations to this article as recorded by  
  • Retrograde Migration of a Percutaneous Endoscopic Gastro-Jejunal Tube Into the Esophagus
    Binyamin R Abramowitz, Jude Noel, Sushil Ahlawat
    Cureus.2024;[Epub]     CrossRef
  • Weighted Tip Extensions Result in Fewer Gastrojejunostomy Tube Migrations and Increase Tube Lifespan
    Matthew A. Patetta, Kyung R. Kim, Clayton W. Commander, Peter R. Bream
    Journal of Vascular and Interventional Radiology.2023; 34(1): 124.     CrossRef
  • Parkinson hastalarında perkütan endoskopik gastrojejunostomi katateri takılan hastalarımızın takibi: Tek merkez deneyimi
    Akademik Gastroenteroloji Dergisi.2022; 21(3): 157.     CrossRef
  • 4,312 View
  • 89 Download
  • 2 Web of Science
  • 3 Crossref
Close layer
Identification of Patients More Susceptible to Severe Anal Pain after Colonoscopy and Effect of Topical Treatment of Lidocaine Gel in Reducing the Anal Pain: A Prospective, Randomized, Controlled Study (Identification and Management of Patients Susceptible to Severe Anal Pain after Colonoscopy)
Seong-Eun Kim, M.D., Sung-Ae Jung, M.D., Ki-Nam Shim, M.D., Yu Kyung Cho, M.D., Jung Mi Kwon, M.D., Chung Hyun Chun, M.D., Jeong Eun Shin, M.D. and Kwon Yoo, M.D.
Korean J Gastrointest Endosc 2003;27(6):521-526.   Published online December 30, 2003
AbstractAbstract PDF
/Aims: The aim of this study was to identify which patients are more susceptible to severe anal pain after colonoscopy and to determine the usefulness of lidocaine gel in reducing the anal pain. Methods: A prospective trial was performed with 150 consecutive outpatients who underwent a colonoscopic examination. The patients were randomized into three groups: they received topical treatment of lidocaine gel (n=48) or lubricant gel (chlorhexidine gluconate) (n=48), or no treatment (n=54) just after the procedure. Data regarding the procedures were collected and the patients were phone-interviewed on the next day. Results: Seventy of 150 (46.7%) had moderate to severe pain (VAS score≥4). A multiple regression analysis found that the presence of hemorrhoid was significantly (p<0.05) associated with severe anal pain after colonoscopy. Among three groups, there was no significant difference of the pain scores on the procedure day on the next day. However, patients' subjective evaluation about the usefulness of the gel was significantly better in the lidocaine group than in the placebo group in patients who had moderate to severe pain (79.2% vs. 43.5%, p<0.05). Conclusions: A palliative management is more required for patients who complain moderate to severe pain just after colonoscopy or those with hemorrhoid (Korean J Gastrointest Endosc 2003;27:521⁣526)
  • 2,320 View
  • 14 Download
Close layer

Clin Endosc : Clinical Endoscopy Twitter Facebook
Close layer