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4 "Hypereosinophilic syndrome"
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Case Report
A Hypereosinophilic Syndrome Presenting as Eosinophilic Colitis
Young Woo Jeon, Su Jin Hong, Hwa Jong Kim, Jae Pil Han, Hee Kyung Kim, Bong Min Ko, Sung Kyu Park, Moon Sung Lee
Clin Endosc 2012;45(4):444-447.   Published online November 30, 2012
DOI: https://doi.org/10.5946/ce.2012.45.4.444
AbstractAbstract PDFPubReaderePub

Hypereosinophilic syndrome (HES) has three defining features: marked hypereosinophilia for at least 6 months, no confirmed etiology for the eosinophilia, and eosinophilia-related symptoms or organ dysfunction. However, a shorter period of hypereosinophilia with symptoms requiring eosinophil-lowering therapy is also acceptable. We report a case of HES presenting as eosinophilic colitis. Although hypereosinophilia was present for 3 months, this patient needed to be treated with eosionphil-lowering therapy for severe hematochezia. After systemic corticosteroid therapy, symptoms caused by organ involvement were dramatically improved.

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  • Hyper-eosinophilic syndrome: An uncommon cause of chronic abdominal pain in an elderly male
    Dibya L Praharaj, Bipadabhanjan Mallick, Preetam Nath, Sarat C Panigrahi, Anil C Anand, Rajkumar Sharma
    Tropical Doctor.2021; 51(4): 640.     CrossRef
  • Platelet-derived growth factor receptor-alpha-positive myeloid neoplasm presenting as eosinophilic gastrointestinal disease
    Gregory M. Constantine, JeanAnne Ware, Thomas Brown, Lauren Thumm, Natasha Kamal, Sheila Kumar, David Kleiner, Irina Maric, Amy D. Klion
    The Journal of Allergy and Clinical Immunology: In Practice.2020; 8(6): 2089.     CrossRef
  • Gastrointestinal Manifestations of Hypereosinophilic Syndromes and Mast Cell Disorders: a Comprehensive Review
    Vivian C. Nanagas, Anna Kovalszki
    Clinical Reviews in Allergy & Immunology.2019; 57(2): 194.     CrossRef
  • Hypereosinophilic Syndrome Presenting as Intussusception in Adults
    Nuri Chon, WooJung Kim, Sang Young Park, Kwang Hyun Kim
    Korean Journal of Medicine.2014; 87(5): 585.     CrossRef
  • Syndrome hyperéosinophilique de type myéloprolifératif révélé par une ascite : à propos d’un cas
    M. Boudabbous, H. Mnif, H. Bellaj, K. Yaïch, L. Chtourou, L. Mnif, A. Amouri, N. Tahri
    Journal Africain d'Hépato-Gastroentérologie.2014; 8(2): 89.     CrossRef
  • Recurrent cutaneous necrotizing eosinophilic vasculitis: a case report and review of the literature
    Wenfei Li, Wang Cao, Haiyan Song, Yanxia Ciu, Xianmei Lu, Furen Zhang
    Diagnostic Pathology.2013;[Epub]     CrossRef
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Two Cases of Eosinophilic Gastroenteritis and One Case of Hypereosinophilic
Il Young You, M.D., Min Ok Kim, M.D., Ji Young Chai, M.D., Eui Sil Hong, M.D., Hee Bok Chae, M.D., Seon Mee Park, M.D., Mi Kyung Kim, M.D, Sei Jin Youn, M.D., Lee Chan Jang, M.D.* and Ro Hyun Sung, M.D.
Korean J Gastrointest Endosc 2003;27(1):31-37.   Published online July 30, 2003
AbstractAbstract PDF
Eosinophilic gastroenteritis is a rare disorder of unknown origin that is pathologically characterized by marked infiltration of eosinophils in the wall of the gastrointestinal tracts. Eosinophilic gastroenteritis is often classified according to the layer of the bowel wall involved. We experienced two cases of eosinophilic gastroenteritis. One case having whole small bowel wall involvement resulting in small bowel obstruction and eosinophilic ascites underwent bowel resection followed by oral steroid treatment. The other case having mucosal layer involvement with chronic diarrhea and hypoalbuminemia was treated with oral corticosteroid and responded dramatically. In addition, we report one case of hypereosinophilic syndrome involving the gastrointestinal tracts. The patient presented with abdominal pain, ascites, and urticaria. and also showed good response to oral steroid. (Korean J Gastrointest Endosc 2003;27:31⁣37)
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특발성 과호산구 증후군 환자에서 발생한 장 폐색증 1 예 ( A Case of Idiopathic Hypereosinophilic Syndrome Accompanied with Intestinal Obstruction )
Korean J Gastrointest Endosc 2001;23(4):245-250.   Published online November 30, 2000
AbstractAbstract PDF
The idiopathic hypereosinophlic syndrome (HES) is a disease defined by three diagnostic criteria, first, sustained blood eosinophilia is greater than 1,500/mm3 present for longer than 6 months, second, other apparent etiologies for eosinophilia must be absent, including parasitic infection and allergic disease, third, patients must have signs and symptoms of organ involvement. It is associated with cytotoxic granule proteins released by mature eosinophils. HES mainly affects cardiovascular, neurologic, pulmonary system, liver and apleen while low incidence of gastrointestinal involvement is found, and the development of severe complications such as intestinal obstruction after peritonitis or intestinal perforation is extremely rare. We have experienced a case of HES involving hepatic and digestive system, 39 year old man patient who was operated due to intestinal obstruction that was followed by HES, so we report this case with a review of the literature. (Korean J Gastrointest Endosc 2001;23:245-250)
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증례 : 식도 위장관 ; 호산구성 장염으로 나타난 과호산구 증후군 1예 ( Case Reports : Esophagus , Stomach & Intestine ; A Case of Eosinophilic Colitis as a Complication of the Hypereosinophilic Syndrome )
Korean J Gastrointest Endosc 1998;18(3):417-425.   Published online November 30, 1997
AbstractAbstract PDF
The hypereosinophilic syndrome (HES) is a leukoproliferative disorder, marked by a sustained overproduction of eosinophils and a predilection to damage specific organs. There are several diagnostic criteria. First, the patient must sustained blood eosinophilia of greater than 1,500/mm3, for longer than 6 months. Secondly, other apparent etiologies for eosinophilia must be absent, ineluding parasitic infections and allergic diseases. Thirdly, the patient must have signs and symptoms of organ involvement. Cardiac and neurologic diseases, frequent in HES, are major causes of morbidity and mortality. The damage to the heart and nervous system is due to thrombosis and fibrosis. Gastrointestinal tract involvement can accompany HES, but severe eosinophilic colitis was very rarely described in association with this syndrome. In this report, we present a patient with HES and eosinophilic colitis who was successfully treated with steroids. (Korean J Gastrointest Endosc 18: 417-423, 1998)
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