Clinical Endoscopy

Correlation of Endoscopic Findings of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma with Recurrence after Complete Remission: Chang Min Lee, Dong Ho Lee, Byung Kyu Ahn, Jae Jin Hwang, Hyuk Yoon, Young Soo Park, Cheol Min Shin, Nayoung Kim; Clin Endosc 2017;50(1):51-57. Published online March 24, 2016; DOI: https://doi.org/10.5946/ce.2016.015

Background
/Aims: In gastric mucosa-associated lymphoid tissue (MALT) lymphoma, the clinical significance of various endoscopic findings has not yet been determined. This study aimed to compare the time to complete remission (CR) and relapse-free survival (RFS) in gastric MALT lymphoma based on endoscopic findings.
Methods
In this single-center retrospective cohort study, the medical records of 122 consecutive adult patients with gastric MALT lymphoma were collected over a period of 12 years. CR was defined by the absence of macroscopic or microscopic features of lymphoma on two subsequent follow-ups. Relapse was clinically defined by a positive endoscopic biopsy after CR.
Results
The median time to CR did not differ significantly between treatment methods. However, it was significantly longer in the group with polypoid endoscopic appearance than in the groups with diffuse infiltration or ulceration (7.83, 3.43, and 3.10 months, respectively; p=0.003). Six patients relapsed after CR. Kaplan-Meier analysis showed that RFS differed significantly between groups based on Ann Arbor staging, treatment methods, and initial endoscopic findings.
Conclusions
In gastric MALT lymphoma, the endoscopically defined polypoid type was characterized by a longer duration to CR, with a higher likelihood of recurrence, compared to the endoscopically defined diffuse infiltration or ulceration types.

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Sang Kil Lee
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Duodenal Mucosa-Associated Lymphoid Tissue Lymphomas: Two Cases and the Evaluation of Endoscopic Ultrasonography: Su Jin Kim, Hyung Wook Kim, Choel Woong Choi, Jong Kun Ha, Young Mi Hong, Jin Hyun Park, Soo Bum Park, Dae Hwan Kang; Clin Endosc 2013;46(5):563-567. Published online September 30, 2013; DOI: https://doi.org/10.5946/ce.2013.46.5.563

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Mucosa-associated lymphoid tissue lymphoma mainly arises in the stomach, with fewer than 30% arising in the small intestine. We describe here two cases of primary duodenal mucosa-associated lymphoid tissue lymphoma which were evaluated by endoscopic ultrasonography. A 52-year-old man underwent endoscopy due to abdominal pain, which demonstrated a depressed lesion on duodenal bulb. Endoscopic ultrasonographic finding was hypoechoic lesion invading the submucosa. The other case was a previously healthy 51-year-old man. Endoscopy showed a whitish granular lesion on duodenum third portion. Endoscopic ultrasonography image was similar to the first case, whereas abdominal computed tomography revealed enlargement of multiple lymph nodes. The first case was treated with eradication of Helicobacter pylori, after which the mucosal change and endoscopic ultrasound finding were normalized in 7 months. The second case was treated with cyclophosphamide, vincristine, prednisolone, and rituximab every 3 weeks. After 6 courses of chemotherapy, the patient achieved complete remission.

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Abdulla Alabed, Faisal Abubaker, Omar Sharif, Alddana Zayed, Eman Aljufairi
ACG Case Reports Journal.2024; 11(7): e01438. CrossRef
Review of lymphoma in the duodenum: An update of diagnosis and management
Masaya Iwamuro, Takehiro Tanaka, Hiroyuki Okada
World Journal of Gastroenterology.2023; 29(12): 1852. CrossRef
Synchronous duodenal mucosa-associated lymphoid tissue lymphoma and gastric cancer
Keiichiro Yokota, Tsutomu Namikawa, Masahiro Maeda, Nobuhisa Tanioka, Jun Iwabu, Sunao Uemura, Masaya Munekage, Hiromichi Maeda, Hiroyuki Kitagawa, Michiya Kobayashi, Kazuhiro Hanazaki
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Early, Isolated Duodenal Mucosa-Associated Lymphoid Tissue Lymphoma Presenting without Symptoms or Grossly Apparent Endoscopic Lesions and Diagnosed by Random Duodenal Biopsies
Mihajlo Gjeorgjievski, Issa Makki, Pradeep Khanal, Mitual B. Amin, Ann Marie Blenc, Tusar Desai, Mitchell S. Cappell
Case Reports in Gastroenterology.2016; 10(2): 323. CrossRef

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Two Cases of Diffuse Large B-Cell Lymphomas in the Cervical Lymph Nodes in Patients with Low-Grade Gastric Marginal Zone B-Cell Lymphoma (MALT Lymphoma): Ji Hoon Jung, Hwoon-Yong Jung, Hwan Yoon, Jae Kwang Lee, Ji Hoon Kang, Sung Jin Jeon, Young-Su Park, Jin-Ho Kim; Clin Endosc 2013;46(3):288-292. Published online May 31, 2013; DOI: https://doi.org/10.5946/ce.2013.46.3.288

Abstract PDF PubReader ePub

It is well known that gastric mucosa-associated lymphoid tissue (MALT) lymphomas are associated with Helicobacter pylori infection and have a good prognosis. However, although rare, these low-grade lymphomas transform to the high-grade diffuse large B-cell lymphomas (DLBCLs) which are thought to be the important cause of death in patients with MALT lymphoma. We report two cases of DLBCLs in the cervical lymph nodes that occurred 10 years and 1.5 years after diagnosing low-grade gastric MALT lymphomas.

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Primary Pulmonary Diffuse Large B Cell Non-Hodgkin’s Lymphoma: A Case Report and Literature Review
Ziqiang Zhu, Wei Liu, Omar Mamlouk, James E. O'Donnell, Debabrata Sen, Boris Avezbakiyev
American Journal of Case Reports.2017; 18: 286. CrossRef

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