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Original Article
Expression of MUC5AC and Trefoil Peptide 1 (TFF1) in the Subtypes of Intestinal Metaplasia
Joo-Yong Song, Byung-Wook Kim, Ah-Won Lee, Kyo-Young Lee, In-Sik Chung, Bo-In Lee, Hwang Choi, Jeong-Seon Ji, Hiun-Suk Chae, Kyu-Yong Choi
Clin Endosc 2012;45(2):151-154.   Published online June 30, 2012
DOI: https://doi.org/10.5946/ce.2012.45.2.151
AbstractAbstract PDFPubReaderePub
Background/Aims

Alterations of the expression pattern of mucins and trefoil peptides have been described in gastric adenocarcinomas and in their precursor lesions. The aim of this study was to determine the progression patterns of intestinal metaplasia (IM) subtypes by analyzing the expression patterns of TFF1 and MUC5AC in different subtypes of IM of the stomach.

Methods

Endoscopic gastric biopsies of the antrum and body were obtained from patients with dyspepsia and endoscopic IM. Alcian blue/periodic acid-Schiff staining and the high iron diamine technique were used to classify the subtypes of IM. Immunoreactivity for MUC5AC and TFF1 was estimated in different types of IM.

Results

IM was detected in 128 samples from 80 patients; type I was found in 48 samples, type II was found in 37 samples, and type III was found in 43 samples. There was a gradual decrease in MUC5AC and TFF1 expression during the progression of IM from type I to type III via the type II intermediate.

Conclusions

This downregulation of MUC5AC and TFF1 expression may challenge the sequential progression of IM from type I to type III via the type II intermediate, and it might be associated with gastric carcinogenesis.

Citations

Citations to this article as recorded by  
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    Cancer Discovery.2024; 14(5): 766.     CrossRef
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  • Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer
    Ivonne Lozano-Pope, Arnika Sharma, Michael Matthias, Kelly S. Doran, Marygorret Obonyo
    BMC Cancer.2017;[Epub]     CrossRef
  • The changes in MUC5AC expression in gastric cancer before and after Helicobacter pylori eradication
    Ding Shi, Xin-min Qiu, Xing-jun Yan
    Clinics and Research in Hepatology and Gastroenterology.2014; 38(2): 235.     CrossRef
  • Pathophysiology and Epidemiology of Intestinal Metaplasia
    Joon Sung Kim, Byung-Wook Kim
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2013; 13(2): 73.     CrossRef
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