Clinical Endoscopy

A Case of Esophageal Squamous Cell Carcinoma in situ Arising from Esophageal Squamous Papilloma: Jae Yeong Cho, Dae Young Cheung, Tae Jung Kim, Jae Kwang Kim; Clin Endosc 2019;52(1):72-75. Published online July 18, 2018; DOI: https://doi.org/10.5946/ce.2018.058

Squamous papilloma is a common benign tumor of the esophagus. Patients with papilloma are usually asymptomatic, and they are diagnosed incidentally during esophagogastroduodenoscopy. Most papillomas are small and easily removed by forceps biopsy. Recurrence of papilloma after removal is rare. Human papilloma virus infection is supposed to play a role in the development of esophageal papilloma; however, malignant transformation of papilloma is extremely unusual. Here, we report a case of malignant transformation of esophageal squamous papilloma at the gastroesophageal junction into squamous cell carcinoma in situ, which was treated by endoscopic submucosal dissection.

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Implementación de la disección endoscópica submucosa esofágica en España: resultados del registro nacional
Enrique Rodríguez de Santiago, Alberto Herreros-de-Tejada, Eduardo Albéniz, Felipe Ramos Zabala, Gloria Fernández-Esparrach, Oscar Nogales, Pedro Rosón, Beatriz Peñas García, Hugo Uchima, Álvaro Terán, Joaquín Rodríguez Sánchez, Diego de Frutos, Sofía Par
Gastroenterología y Hepatología.2024; 47(2): 119. CrossRef
Detection of Human Papillomavirus in Squamous Papilloma of the Esophagus
Yuan Li, Fan Lin, Qing Ling, Yanmei Xiao, Xiaowei Xue, Weixun Zhou, Hanlin L. Wang
International Journal of Surgical Pathology.2024; 32(4): 748. CrossRef
Implementation of esophageal endoscopic submucosal dissection in Spain: Results from the nationwide registry
Enrique Rodríguez de Santiago, Alberto Herreros-de-Tejada, Eduardo Albéniz, Felipe Ramos Zabala, Gloria Fernández-Esparrach, Oscar Nogales, Pedro Rosón, Beatriz Peñas García, Hugo Uchima, Álvaro Terán, Joaquín Rodríguez Sánchez, Diego de Frutos, Sofía Par
Gastroenterología y Hepatología (English Edition).2024; 47(2): 119. CrossRef
Oesophageal squamous papilloma in paediatric population: a single-centre case series
Pamela Hernández-Almeida, Fabián Vásconez-Muñoz, Andrea Vásconez-Montalvo, Nelson Montalvo-Flores, Ligia Redrobán-Armendariz, Edison Aymacaña-Albán
BMJ Paediatrics Open.2023; 7(1): e001667. CrossRef
Oesophageal squamous papilloma: a rare finding on oesophago-gastro-duodenoscopy with malignant potential
Jia Xi Julian Li, Toan Pham, Graham Newstead
Journal of Surgical Case Reports.2023;[Epub] CrossRef
Esophageal papillomatosis: an exceedingly rare disease
Dandan Li, Changfeng Li, Yuxing Yan, Minya Liu
Orphanet Journal of Rare Diseases.2023;[Epub] CrossRef
Esophageal squamous papilloma: Literature review and case–control retrospective study with histopathological exam of human papillomavirus
Akram I Ahmad, Arielle Lee, Pichayut Nithagon, Omair Ayaz, Nadera Altork, Spyros Peppas, Sayel Alzraikat, Reza Ayoubi, Andrew Smith, Rachna Dhanjal, Ajay Jassal, Samantha M Rizzo, Won Kyoo Cho
JGH Open.2023; 7(10): 674. CrossRef
Rehabilitation Nursing Intervention Can Improve Dysphagia and Quality of Life of Patients Undergoing Radiotherapy for Esophageal Cancer
Xiange Zeng, Ling Li, Wenjing Wang, Lihui Zhu, Alamgeer Yuchi
Journal of Oncology.2021; 2021: 1. CrossRef
Squamous Cell Papilloma of the Oesophagus: A Human Papilloma Virus Lesion
Youssef Aladham, Omar Ahmed, Juliet Laycock
Cureus.2021;[Epub] CrossRef
A case of esophageal carcinoma due to esophageal squamous papillomatosis
E. Fraga, J. Almeida, C. Camacho, J. Simões, A. Bernardes
International Journal of Surgery Case Reports.2020; 71: 335. CrossRef
Squamous Cell Papilloma of the Esophagus: A Case Series Highlighting Endoscopic and Histologic Features
Dustin J. Uhlenhopp, Kristin M. Olson, Tagore Sunkara
Case Reports in Gastrointestinal Medicine.2020; 2020: 1. CrossRef

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Gastric Squamous Papilloma in a 52-Year-Old Female Patient: Hyung Ha Jang, Hyung Wook Kim, Su Jin Kim, Choel Woong Choi, Su Bum Park, Byeong Jun Song, Dong Hoon Shin, Dae Hwan Kang; Clin Endosc 2014;47(6):571-574. Published online November 30, 2014; DOI: https://doi.org/10.5946/ce.2014.47.6.571

Abstract PDF PubReader ePub

A papilloma is a benign epithelial lesion characterized by finger-like projections of tissue lined by an overgrowth of squamous cells and a core of connective tissue. We report a case of squamous papilloma on the cardia in a 52-year-old asymptomatic female. Endoscopy showed a 1-cm sized is polyp with hyperemic change originating from the cardia adjacent to the esophagogastric junction, the biopsy of which suggested a diagnosis of squamous papilloma. Endoscopic mucosal resection was performed to obtain a definite diagnosis and the polyp was completely removed. The histological result was compatible with squamous papilloma, and its surrounding tissues showed foveolar epithelium, which suggested a stomach origin. This is the first report of endoscopic resection of a gastric squamous papilloma. Squamous papilloma should be considered in the differential diagnosis of a gastric polyp, especially one in the cardia. As the prognostic value of a squamous papilloma is not well known, we recommend endoscopic resection to treat a gastric squamous papilloma, when possible.

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Overexpression of Neutrophil MMP-9 and HIF-1α May Contribute to the Finger-Like Projections Formation and Histo-Pathogenesis in Nasal Inverted Papilloma
Tao Li, Kai Sen Tan, Yan Yi Tu, Li Zhao, Jing Liu, Hsiao Hui Ong, De Yun Wang, Li Shi
Journal of Inflammation Research.2021; Volume 14: 2979. CrossRef

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Autosomal Dominant Inherited Cowden's Disease in a Family: Jun-Wook Ha; Clin Endosc 2013;46(1):85-90. Published online January 31, 2013; DOI: https://doi.org/10.5946/ce.2013.46.1.85

Abstract PDF PubReader ePub

Cowden's disease, also known as a kind of phosphatase and tensin homolog (PTEN) hamartoma tumor syndrome, is an uncommon autosomal dominant inherited complex disorder with various hamartomatous growths of multiple organs involving all three germ cell layers. It usually manifests with polyps throughout the gastrointestinal tract, ranging anywhere from 30% to 85%, and more common extra intestinal findings. Mucocutaneous lesions like facial trichilemmomas, acral keratoses, papillomatous papules and macrocephaly, and malignancies including breast, thyroid and endometrial carcinoma are the hallmark of the disease. Here we report on familial Cowden's diseases case of a 52-year-old male proband with mucocutaneous lesions and mutation on the PTEN gene obtained by extrapolating from gastrointestinal polyposis as a starter and his daughter who developed thyroid cancer.

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Cowden Syndrome: A Case Series Highlighting Cutaneous and Systemic Diversity
Marcus S Rossi, Jessica P Sejo, Allison Kirchner, Maria Tsoukas
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Ye-Ryeong Jung, Ji-Young Jun, Seeyoun Lee, Kum Hei Ryu, Dong Ock Lee, Yoon-Jung Chang, So-Youn Jung, Sun-Young Kong
Laboratory Medicine Online.2023; 13(3): 165. CrossRef
Colorectal polyposis as a clue to the diagnosis of Cowden syndrome: Report of two cases and literature review
Giovanni Innella, Sara Miccoli, Dora Colussi, Laura Maria Pradella, Laura Benedetta Amato, Roberta Zuntini, Nunzio Cosimo Mario Salfi, Guido Collina, Francesco Ferrara, Luigi Ricciardiello, Daniela Turchetti
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Clinical manifestations of gastrointestinal diseases in the oral cavity
Mohammad S. Al-Zahrani, Ahmed A. Alhassani, Khalid H. Zawawi
The Saudi Dental Journal.2021; 33(8): 835. CrossRef
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Syndrome In Question
Gabriela Maldonado, Juliano Peruzzo, Mariana Quirino Tubone, Clarissa Prieto Herman Reinehr, Gabriela Fortes Escobar
Anais Brasileiros de Dermatologia.2015; 90(1): 131. CrossRef

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A Case of Benign Biliary Stricture as a Complication of Photodynamic Therapy for Biliary Papillomatosis: Mun Ki Choi, M.D., Dong Uk Kim, M.D., Gwang Ha Kim, M.D., Geun Am Song, M.D., Hyung Seok Nam, M.D., Yang Seon Yi, M.D., Kang Hee Ahn, M.D. and Jung Seop Eom, M.D.; Korean J Gastrointest Endosc 2011;42(5):327-333. Published online May 28, 2011

Abstract PDF: Biliary papillomatosis is a rare disease with a high risk of recurrence and malignant transformation. Therapeutic options include partial hepatectomy, Whipple's procedure and liver transplantation. If there is no surgical option left due to several reasons, local palliative procedures such as biliary stenting and drainage for the treatment of cholestasis are considered, but tumor growth cannot be influenced. Photodynamic therapy might be a new additional, palliative option for patients with biliary papillomatosis who are not eligible for surgery. Benign biliary stricture is a rare complication of photodynamic therapy. We report here a case of a 63-year-old male who developed benign biliary stricture after photodynamic therapy using the photosensitizer photofrin. (Korean J Gastrointest Endosc 2011;42:327-333)

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A Case of Endoscopic Removal of Hypopharyngeal Papilloma under General Anesthesia with Nasotracheal Intubation: Yoon Ho Jung, M.D., Joo Young Cho, M.D., Dong Kyun Kim, M.D., Young Kwan Cho, M.D., Won Young Cho, M.D., Jin Oh Kim, M.D., Joon Seong Lee, M.D. and So Young Jin, M.D.*; Korean J Gastrointest Endosc 2010;41(2):90-93. Published online August 30, 2010

Abstract PDF: Benign tumors of the hypopharynx are uncommon and papillomas are quite rare. Papillomas grow very slowly and they are well defined, mobile and sometimes pedunculated masses. In order to minimize the patient's discomfort, many endoscopists tend to pass the scope quickly through the throat, without trying to visualize the oral and hypopharyngeal lesion. As for the treatment of hypopharyngeal lesions, cases of endoscopic treatment are rare and any guidelines have not yet been defined. We present here a case of endoscopic removal of a hypopharyngeal papilloma with the patient under general anesthesia and nasotracheal intubation. (Korean J Gastrointest Endosc 2010;41:90-93)

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A Case of Mucin-hypersecreting Gallbladder Papillary Carcinoma Manifested as Obstructive Jaundice: Ji Hoon Jung, M.D., Myung-Hwan Kim, M.D., Sang Su Lee, M.D., Chang Hee Jung, M.D., Ji Young Lee, M.D., Dong Wan Seo, M.D., Sung Goo Lee, M.D. and Gyung Yeop Gong, M.D.*; Korean J Gastrointest Endosc 2006;32(3):235-237. Published online March 30, 2006

Abstract PDF: Biliary papillomatosis (BP) is a rare disease that is classified as either the mucin-hypersecreting type or nonmucin-secreting type. Typical papillomas of the biliary tree mainly involve intrahepatic bile ducts or both intra- and extrahepatic bile ducts. The isolated involvement of the extrahepatic bile duct is rare, and there is no report of BP confined to the gallbladder in Korea. We report a case of a 50-year-old man who developed obstructive jaundice due to hypersecreted mucin from papillomas of the gallbladder. (Korean J Gastrointest Endosc 2006;32:235⁣238)

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A Case of Mucin-hypersecreting Biliary Papillomatosis ⁣Including Review of Korean Literatures⁣: Dae Kyoum Kim, M.D., Myung Hwan Kim, M.D., Kyoung Min Park, M.D., Yoon Seon Lee, M.D., Kwi Sook Choi, M.D., Hyun Soon Song, M.D., Jong Seok Bae, M.D., Hyun Jun Kim, M.D., Sang Soo Lee, M.D., Dong Wan Seo, M.D., Sung Koo Lee, M.D., Young Il Min, M.D., Youn; Korean J Gastrointest Endosc 2003;26(3):167-171. Published online March 31, 2003

Abstract PDF: The mucin-hypersecreting bile duct tumor is rare and its clinical, radiologic, and pathologic features are not well known. We report the case of mucin-hypersecreting biliary papillomatosis with malignant transformation including review of 11 korean literatures. A 65-year-old female was admitted to our hospital with fever, chills, and right upper quadrant pain. A CT scan showed marked dilatation of left intrahepatic duct with intraductal filling defects. During endoscopic retrograde cholangiograpy, mucin from the ampulla was observed and dilated common bile duct with multiple amorphous filling defects was noted. Cholangioscopy revealed muliple coral-like mucosal papillary projections with large amount of mucin in the left intrahepatic ducts. The patient underwent left lobectomy, and the biopsy revealed intraductal papillary adenocarcinoma in the background of papillary adenoma. (Korean J Gastrointest Endosc 2003;26:167⁣171)

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고도 이형성증을 동반한 식도 편평세포 유두종 1예 ( A Squamous Cell Papilloma of Esophagus Associated with Dysplasia ): Korean J Gastrointest Endosc 2000;21(6):934-937. Published online November 30, 1999

Abstract PDF: A squamous cell papilloma of esophagus is regarded as a rare tumor, and one of the distal esophagus is known to be not changed into a malignant neoplasm although squamous papilloma of the larynx, cervix and the upper esophagus may be associated with squamous cell carcinoma. We report the first case of a squamous papilloma associated with hig grade dysplasia at the lower esophagus. We think this case may have an important implication in the surveillance and management of esophageal papilloma found at endoscopy.

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65세 남자, 복부 불쾌감: Korean J Gastrointest Endosc 2000;20(5):335-336. Published online November 30, 1999

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원저 : 식도 위장관 ; 식도에서 편평세포유두종과 인유두종바이러스와의 관계 ( Original Articles : Esophagus , Stomach $ Intestine ; Correlation between Squamous Papilloma and Human Papillomavirus in Esophagus ): Korean J Gastrointest Endosc 1998;18(6):805-810. Published online November 30, 1997

Abstract PDF: Background
/Aims: Esophageal squamous papillorma is a rare benign lesion. This lesion is generally asymptomatic and solitary. Resent studies reveal the presence of human papil- lomavirus in certain cases of esophageal squamous papilloma, and human papillomavirus appears to be pathogenetically related to the esophageal squamous papilloma. The aim of this study was to evaluate the presence of human papillomavirus in esoplmgeal spuamous papilloma. Methods: In situ hybridizations and direct in situ polymerase chain reactions for human papillomavirus type 6/11 were performed on 16 paraffin embedded tissues with esophageal squamous papilloma. Results: Human papillomavirus type 6/11 was detected in 1 of 16 esophageal squamous papillomas on direct in situ polymerase chain reaction. All lesions were solitary, and 12 of 16 cases were located in distal one-third of the esophagus. Age range was 23-71 years (mean, 41 years). Conclusion: These results indicate that causal relation between human papillomavirus type 6/11 and esophageal squamous papilloma is inconspicuous. (Korean J Gastrointest Endosc 18: 805-810, 1998)

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원저 : 담도 췌장 : 담도의 다발성 유두종 9예 ( Original Articles : Biliary Tract & Pancreas ; An Analysis of Nine Cases of Multiple Biliary Papillomatosis ): Korean J Gastrointest Endosc 1998;18(5):681-689. Published online November 30, 1997

Abstract PDF: Background
and Study Aims: Multiple biliary papillomatosis (MBP) is an uncommon disease. This study was undertaken to review cases with respect to describing clinical features and characteristical cholangiographic findings, and to define the role of cholangioscopy in the diagnosis and treatment of this disorder. Patients and Methods: from 1990 to 1997, nine patients (mean age; 57.3 years, 6 men and 3 women) were diagnosed as having MBP arnong 5,361 cases of endoscopic retrograde cholangiography (ERC) conducted at our center. A retrospective analyses of the cholangiographic and cholangioscopic findings as well as clinieal features were performed.(Korean J Gastrointest Endosc 18: 681-687, 1998)

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증례 : 담도 췌장 ; 담관의 다발성 유두종에서 병발된 선암 ( Case Reports : Biliary Tract & Pancreas ; A Case of Multiple Biliary Papillomatosis with Focal Adenocarcinoma ): Korean J Gastrointest Endosc 1998;18(4):625-629. Published online November 30, 1997

Abstract PDF: Multiple biliary papillomatosis are extremely rare, fifty one cases have been reported in the literature. Clinical symptoms are associated with obsructive jaundice and cholangitis. Malignant transformation into adenocarcinoma had been described. We report a case of multiple papillomatosis in the entire biliary ductal system with malignant transformation, in which endoscopic retrograde cholangiopancreatography and peroral choledochoscopy showed multiple polypoid lesicons. The endoscopic sphincterotomy and the intraductal biopsy confirmed the histologic diagnosis of multiple papillomatosis and adenocarcinoma. (Korean J Gastrointest Endosc 18: 625-629, 1998)

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증례 : 담도 췌장 ; 담도의 다발성 유두종 1예 ( Case Reports : Biliary Tract & Pancreas ; A Case of Biliary Papillomatosis which Underwent Curative Resection ): Korean J Gastrointest Endosc 1998;18(1):111-115. Published online November 30, 1997

Abstract PDF: Biliary Papillomatosis is an extremely rare pathologic entity. Only about 40 cases of intrahepatic or diffuse intra- and extrahepatic papillomatosis have been described since the first report in 1959 by Caroli. Although this is a histologically benign lesion, its course is unfavaurable because of its tendency to extend to the entire biliary tract, high recurrence rate following local excision and the probability of progression to malignancy. We described herein a case of biliary papillomatosis associated with diffuse bile duct dilatation. The patient, a 59-year-old male, was admitted to our hospital because of right upper abdominal pain and weight loss. Cholangiogram revealed multiple round filling defects in common hepatic duct with intrahepatic bile duct dilatation. The patient underwent Whipple's operation with right lobectomy. Grossly, multiple small pin-head sized polypoid masses were seen in common bile duct, common hepatic duct and right intrahepatic duct. Microscapically, papillary epithelial hyperplasia with moderate cellular atypia was seen and there was no evidence of stromal invasion. He is healthy with a follow-up for 7 months. (Korean J Gastrointest Endosc 18: 111-114, 1998)

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원저 : 식도 유두종의 임상적 양상 ( Original Articles : Clinical Feature of Esophageal Papilloma ): Korean J Gastrointest Endosc 1995;15(1):1-5. Published online November 30, 1994

Abstract PDF: In human, Human Papilloma Virus(HPV) is associated with benign squamous tumors in a variety of body sites. But the relationship between HPV infection and malignant epithelial lesions is not clear. Esophageal squamous papilloma is relatively rare tumor but it is reported with increasing frequency recently. We reviewed twenty six patients of esophageal papilloma diagnosed by endoscopic biopsy from 1990 to 1994. The results are as follows; The peak age is fifth decade, men and women ratio is 1: 1.2. Most papillomas located in distal esophagus and have no specific symptoms related to papilloma. All case are sessile form and no malignant change in follow up endoscopy.

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