Clinical Endoscopy

Reviews

Comparing palliative treatment options for cholangiocarcinoma: photodynamic therapy vs. radiofrequency ablation: Tayyaba Mohammad, Michel Kahaleh; Clin Endosc 2022;55(3):347-354. Published online May 17, 2022; DOI: https://doi.org/10.5946/ce.2021.274

Referral to an endoscopist is often done once curative resection is no longer an option for cholangiocarcinoma management. In such cases, palliation has become the main objective of the treatment. Photodynamic therapy and radiofrequency ablation can be performed to achieve palliation, with both procedures associated with improved stent patency and survival. Despite the greatly increased cost and association with photosensitivity, photodynamic therapy allows transmission to the entire biliary tree. In contrast, radiofrequency ablation is cheaper and faster to apply but requires intraductal contact. This paper reviews both modalities and compares their efficacy and safety for bile duct cancer palliation.

Citations

Citations to this article as recorded by

Umbrella review of adjuvant photodynamic therapy for cholangiocarcinoma palliative treatment
Hanhan Chen, Honglin Li, Huijie Li, Zhen Zhang
Photodiagnosis and Photodynamic Therapy.2025; 51: 104472. CrossRef
Endoscopic treatment of unresectable perihilar cholangiocarcinoma: beyond biliary drainage
Di Zhang, Tianci Shen, Feng Gao, Yong Sun, Zihao Dai, Haifeng Luo, Yanan Sun, Zhuo Yang, Jiangning Gu
Therapeutic Advances in Gastroenterology.2025;[Epub] CrossRef
Current interventional options for palliative care for patients with advanced-stage cholangiocarcinoma
Maryam Makki, Malak Bentaleb, Mohammed Abdulrahman, Amal Abdulla Suhool, Salem Al Harthi, Marcelo AF Ribeiro Jr
World Journal of Clinical Oncology.2024; 15(3): 381. CrossRef
Gallengangskarzinome – up to date in Diagnostik und Therapie
Lukas Perkhofer, Juliane Schütz
Gastroenterologie up2date.2024; 20(03): 253. CrossRef
Endoskopisch gesteuerte Diagnostik und Therapie von Cholangiokarzinomen
Ulrike Denzer, Alexander Dechêne
Die Gastroenterologie.2023; 18(1): 16. CrossRef
Recent Updates on Local Ablative Therapy Combined with Chemotherapy for Extrahepatic Cholangiocarcinoma: Photodynamic Therapy and Radiofrequency Ablation
Tadahisa Inoue, Masashi Yoneda
Current Oncology.2023; 30(2): 2159. CrossRef
Role of radiofrequency ablation in advanced malignant hilar biliary obstruction
Mamoru Takenaka, Tae Hoon Lee
Clinical Endoscopy.2023; 56(2): 155. CrossRef
Impact of endobiliary radiofrequency ablation on survival of patients with unresectable cholangiocarcinoma: a narrative review
Elena Di Girolamo, Andrea Belli, Alessandro Ottaiano, Vincenza Granata, Valentina Borzillo, Luca Tarotto, Fabiana Tatangelo, Raffaele Palaia, Corrado Civiletti, Mauro Piccirillo, Valentina D’Angelo, Francesco Fiore, Pietro Marone, Guglielmo Nasti, Frances
Frontiers in Oncology.2023;[Epub] CrossRef
Thermal ablative therapies in the gastrointestinal tract
Hendrik Manner
Current Opinion in Gastroenterology.2023; 39(5): 370. CrossRef
Photodynamic Therapy: From the Basics to the Current Progress of N-Heterocyclic-Bearing Dyes as Effective Photosensitizers
Eurico Lima, Lucinda V. Reis
Molecules.2023; 28(13): 5092. CrossRef
Balloon‐assisted laser application for endoscopic treatment of biliary stricture
Seonghee Lim, Van Gia Truong, Seok Jeong, Jiho Lee, Byeong‐il Lee, Hyun Wook Kang
Lasers in Surgery and Medicine.2023; 55(10): 912. CrossRef
Emerging Systemic Therapies in Advanced Unresectable Biliary Tract Cancer: Review and Canadian Perspective
Vincent C. Tam, Ravi Ramjeesingh, Ronald Burkes, Eric M. Yoshida, Sarah Doucette, Howard J. Lim
Current Oncology.2022; 29(10): 7072. CrossRef

4,619 View
234 Download
10 Web of Science
12 Crossref

Photodynamic Therapy for Esophageal Cancer: Takahiro Inoue, Ryu Ishihara; Clin Endosc 2021;54(4):494-498. Published online May 19, 2020; DOI: https://doi.org/10.5946/ce.2020.073

Abstract PDF PubReader ePub

Photodynamic therapy, a curative local treatment for esophageal squamous cell carcinoma, involves a photosensitizing drug (photosensitizer) with affinity for tumors and a photodynamic reaction triggered by laser light. Previously, photodynamic therapy was used to treat superficial esophageal squamous cell carcinoma judged to be difficult to undergo endoscopic resection. Recently, photodynamic therapy has mainly been performed for local failure after chemoradiotherapy. Although surgery is the most promising treatment for local failure after chemoradiotherapy, its morbidity and mortality rates are high. Endoscopic resection is feasible for local failure after chemoradiotherapy but requires advanced skills, and its indication is limited to within the submucosal layer by depth. Photodynamic therapy is less invasive than surgery and has a wider indication than endoscopic resection. Porfimer sodium (a first-generation photosensitizer) causes a high frequency of side effects related to photosensitivity and requires the long-term sunshade period. Talaporfin (a second-generation photosensitizer) requires a much shorter sun-shade period than porfimer sodium. Photodynamic therapy will profoundly change treatment strategies for local failure after chemoradiotherapy.

Citations

Citations to this article as recorded by

An optical coherence tomography study of a photoactive Pt(iv) prodrug in oesophageal tissue
Huayun Shi, Muktesh Mohan, Kanwarpal Singh, Peter J. Sadler
RSC Advances.2025; 15(5): 3168. CrossRef
Hollow nanosystem-boosting synergistic effects between photothermal therapy and chemodynamic therapy via self-supplied hydrogen peroxide and relieved hypoxia
Yunji Sun, Lixiao Zhen, Lin Xu, Peipei Li, Chao Zhang, Yang Zhang, Yisheng Zhao, Benkang Shi
Biomaterials Science.2025; 13(7): 1784. CrossRef
Conceptual expansion of photomedicine for spatiotemporal treatment methods
P. K. Hashim, Ashwin T. Shaji, Ammathnadu S. Amrutha, Shifa Ahmad
RSC Medicinal Chemistry.2025;[Epub] CrossRef
Aluminium phthalocyanine-mediated photodynamic therapy induces ATM-related DNA damage response and apoptosis in human oesophageal cancer cells
Onyisi Christiana Didamson, Rahul Chandran, Heidi Abrahamse
Frontiers in Oncology.2024;[Epub] CrossRef
An Ailment with Which I Will Contend: A Narrative Review of 5000 Years of Esophagogastric Cancers and Their Treatments, with Special Emphasis on Recent Advances in Immunotherapeutics
C. Beau Hilton, Steven Lander, Michael K. Gibson
Cancers.2024; 16(3): 618. CrossRef
Western outcomes of circumferential endoscopic submucosal dissection for early esophageal squamous cell carcinoma
Enrique Rodríguez de Santiago, Laurelle van Tilburg, Pierre H. Deprez, Mathieu Pioche, Roos E. Pouw, Michael J. Bourke, Stefan Seewald, Bas L.A.M. Weusten, Jeremie Jacques, Sara Leblanc, Pedro Barreiro, Arnaud Lemmers, Adolfo Parra-Blanco, Ricardo Küttner
Gastrointestinal Endoscopy.2024; 99(4): 511. CrossRef
Interventional gastroenterology in oncology
Vaibhav Wadhwa, Nicole Patel, Dheera Grover, Faisal S. Ali, Nirav Thosani
CA: A Cancer Journal for Clinicians.2023; 73(3): 286. CrossRef
Utilizing 4D Printing to Design Smart Gastroretentive, Esophageal, and Intravesical Drug Delivery Systems
Dina B. Mahmoud, Michaela Schulz‐Siegmund
Advanced Healthcare Materials.2023;[Epub] CrossRef
Recent Advances in Green Metallic Nanoparticles for Enhanced Drug Delivery in Photodynamic Therapy: A Therapeutic Approach
Alexander Chota, Blassan P. George, Heidi Abrahamse
International Journal of Molecular Sciences.2023; 24(5): 4808. CrossRef
Amino Acid Derivatives of Chlorin-e6—A Review
Maria da Graça H. Vicente, Kevin M. Smith
Molecules.2023; 28(8): 3479. CrossRef
Stimuli-responsive heparin-drug conjugates co-assembled into stable nanomedicines for cancer therapy
Zaixiang Fang, Ling Lin, Zhiqian Li, Lei Gu, Dayi Pan, Yunkun Li, Jie Chen, Haitao Ding, Xiaohe Tian, Qiyong Gong, Kui Luo
Acta Biomaterialia.2023;[Epub] CrossRef
Idarubicin and IR780 co-loaded PEG-b-PTMC nanoparticle for non-Hodgkin’s lymphoma therapy by photothermal/photodynamic strategy
Shanshan Weng, Luqi Pan, Dawei Jiang, Wenxia Xie, Zhiyuan Zhang, Changcan Shi, Bin Liang, Shenghao Wu
Materials & Design.2023; 230: 112008. CrossRef
Protein Photodamaging Activity and Photocytotoxic Effect of an Axial-Connecting Phosphorus(V)porphyrin Trimer
Kazutaka Hirakawa, Naoki Kishimoto, Yoshinobu Nishimura, Yuko Ibuki, Masaaki Fuki, Shigetoshi Okazaki
Chemical Research in Toxicology.2023;[Epub] CrossRef
Nanomedicine in Clinical Photodynamic Therapy for the Treatment of Brain Tumors
Hyung Shik Kim, Dong Yun Lee
Biomedicines.2022; 10(1): 96. CrossRef
Poly(styrene-co-maleic acid) Micelle of Photosensitizers for Targeted Photodynamic Therapy, Exhibits Prolonged Singlet Oxygen Generating Capacity and Superior Intracellular Uptake
Gahininath Yadavrao Bharate, Haibo Qin, Jun Fang
Journal of Personalized Medicine.2022; 12(3): 493. CrossRef
Deep-Learning for the Diagnosis of Esophageal Cancers and Precursor Lesions in Endoscopic Images: A Model Establishment and Nationwide Multicenter Performance Verification Study
Eun Jeong Gong, Chang Seok Bang, Kyoungwon Jung, Su Jin Kim, Jong Wook Kim, Seung In Seo, Uhmyung Lee, You Bin Maeng, Ye Ji Lee, Jae Ick Lee, Gwang Ho Baik, Jae Jun Lee
Journal of Personalized Medicine.2022; 12(7): 1052. CrossRef
Palliation of Malignant Dysphagia: Dilation, Stents, Cryoablation or PDT: The GI Perspective
Daniel J. Ellis, Nisa M. Kubiliun, Anna Tavakkoli
Foregut: The Journal of the American Foregut Society.2022; 2(2): 186. CrossRef
Palliation of Malignant Dysphagia: Dilation, Stents, Cryoablation or Photodynamic Therapy—A Surgical Perspective
Uzma Rahman, Olugbenga T. Okusanya
Foregut: The Journal of the American Foregut Society.2022; 2(2): 180. CrossRef
Endoscopic Treatment for Disease Persistence/Recurrence after Definitive Chemoradiotherapy for Esophageal Cancer
Prabin Sharma, Rani Modayil, Stavros N. Stavropoulos
Foregut: The Journal of the American Foregut Society.2022; 2(2): 132. CrossRef
Targeted chemo-photodynamic therapy toward esophageal cancer by GSH-sensitive theranostic nanoplatform
Guodong Ren, ZiCheng Wang, Yafei Tian, Jinyao Li, Yingyu Ma, Liang Zhou, Chengwu Zhang, Lixia Guo, Haipeng Diao, Lihong Li, Li Lu, Sufang Ma, Zhifang Wu, Lili Yan, Wen Liu
Biomedicine & Pharmacotherapy.2022; 153: 113506. CrossRef
Therapeutic effects of in-vivo radiodynamic therapy (RDT) for lung cancer treatment: a combination of 15MV photons and 5-aminolevulinic acid (5-ALA)
Dae-Myoung Yang, Dusica Cvetkovic, Lili Chen, C-M Charlie Ma
Biomedical Physics & Engineering Express.2022; 8(6): 065031. CrossRef
Laser induced thermotherapy of multiple actinic keratosis
Tatiana Evgenievna Sukhova, Yulia Vladimirovna Molochkova, Anna Igorevna Pronina
Russian Journal of Skin and Venereal Diseases.2022; 25(3): 181. CrossRef
Novel sulfonamide porphyrin TBPoS-2OH used in photodynamic therapy for malignant melanoma
Zhaohai Pan, Jiaojiao Fan, Qi Xie, Xin Zhang, Wen Zhang, Qing Ren, Minjing Li, Qiusheng Zheng, Jun Lu, Defang Li
Biomedicine & Pharmacotherapy.2021; 133: 111042. CrossRef
Photodynamic Therapy—An Up-to-Date Review
Adelina-Gabriela Niculescu, Alexandru Mihai Grumezescu
Applied Sciences.2021; 11(8): 3626. CrossRef
Targeted Photodynamic Diagnosis and Therapy for Esophageal Cancer: Potential Role of Functionalized Nanomedicine
Onyisi Christiana Didamson, Heidi Abrahamse
Pharmaceutics.2021; 13(11): 1943. CrossRef

8,612 View
285 Download
18 Web of Science
25 Crossref

Focused Review Series: Advanced Endoscopic Treatment for Pancreaticobiliary Diseases

Endoscopic Ablation Therapy for Biliopancreatic Malignancies: Jason Roque, Shiaw-Hooi Ho, Nageshwar Reddy, Khean-Lee Goh; Clin Endosc 2015;48(1):15-19. Published online January 31, 2015; DOI: https://doi.org/10.5946/ce.2015.48.1.15

Abstract PDF PubReader ePub

Biliopancreatic malignancies such as cholangiocarcinoma (CCA) has notoriously been diagnosed late. As such most therapy have been palliative in nature. Cholangioscopy allows for an earlier diagnosis to be made. Brachytherapy with the insertion of catheter with iridium-132 seeds, percutaneously or through endoscopic retrograde cholangiopancreatography (ERCP) was the earliest ablative techniques used. It has been shown to have a beneficial effect only in prolonging survival. Photodynamic therapy (PDT) has also been used for several years. stenting with PDT versus stenting alone for unresectable CCA showed a marked survival benefit with the addition of PDT. However the most exciting endoscopic ablative modality appears to be intraductal radiofrequency ablation using the Habib catheter and device. Several case series have shown the effectiveness of this technique in ablating tumors. This technique is evolving and coupled with early diagnosis of CCA through cholangioscopy will allow for a curative therapy. The crux to the effective treatment of early cancerous lesions in the bile or pancreatic duct is the early diagnosis of such lesions. Effective endoscopic ablative therapy is now available with the advent of radiofrequency ablation probes that can be passed through the duodenoscope via ERCP.

Citations

Citations to this article as recorded by

Clinical and cost effectiveness of endoscopic bipolar radiofrequency ablation for the treatment of malignant biliary obstruction: a systematic review
Fiona Beyer, Stephen Rice, Giovany Orozco-Leal, Madeleine Still, Hannah O’Keefe, Nicole O’Connor, Akvile Stoniute, Dawn Craig, Stephen Pereira, Louise Carr, John Leeds
Health Technology Assessment.2023; : 1. CrossRef
Impact of endobiliary radiofrequency ablation on survival of patients with unresectable cholangiocarcinoma: a narrative review
Elena Di Girolamo, Andrea Belli, Alessandro Ottaiano, Vincenza Granata, Valentina Borzillo, Luca Tarotto, Fabiana Tatangelo, Raffaele Palaia, Corrado Civiletti, Mauro Piccirillo, Valentina D’Angelo, Francesco Fiore, Pietro Marone, Guglielmo Nasti, Frances
Frontiers in Oncology.2023;[Epub] CrossRef
Endoscopic Management of Pancreatobiliary Malignancies
Dong Wook Lee, Eun Young Kim
Digestive Diseases and Sciences.2022; 67(5): 1635. CrossRef
Survival Benefit of Intraductal Radiofrequency Ablation for Malignant Biliary Obstruction: A Systematic Review with MetaAnalysis
Byung Hyo Cha, Myoung-Jin Jang, Sang Hyub Lee
Clinical Endoscopy.2021; 54(1): 100. CrossRef
Biliary endoscopy in the management of primary sclerosing cholangitis and its complications
Brian M. Fung, James H. Tabibian
Liver Research.2019; 3(2): 106. CrossRef
Diagnostic and therapeutic single-operator cholangiopancreatoscopy with SpyGlassDS™: results of a multicenter retrospective cohort study
Felicia Turowski, Ulrich Hügle, Arno Dormann, Matthias Bechtler, Ralf Jakobs, Uwe Gottschalk, Ellen Nötzel, Dirk Hartmann, Albrecht Lorenz, Frank Kolligs, Wilfried Veltzke-Schlieker, Andreas Adler, Olaf Becker, Bertram Wiedenmann, Nataly Bürgel, Hanno Trö
Surgical Endoscopy.2018; 32(9): 3981. CrossRef
Klinischer Stellenwert der modularen Cholangioskopie
C. Bojarski, F. Turowski
Der Gastroenterologe.2017; 12(3): 202. CrossRef
Radiofrequency ablation for management of malignant biliary obstruction: a single-center experience and review of the literature
Amit Kumar Dutta, Umesh Basavaraju, Laura Sales, John Samuel Leeds
Expert Review of Gastroenterology & Hepatology.2017; 11(8): 779. CrossRef
Endoluminal Nd:YAG laser application in ex vivo biliary porcine tissue
Roberta Rea, Francesco Maria Di Matteo, Margareth Martino, Monica Pandolfi, Paola Saccomandi, Carla Rabitti, Anna Crescenzi, Guido Costamagna
Lasers in Medical Science.2017; 32(6): 1411. CrossRef
Endoscopic management of hilar stricture
Abhishek Gulati, Payal Thakkar, Shyam Thakkar
Techniques in Gastrointestinal Endoscopy.2016; 18(2): 67. CrossRef
Advances in Therapeutic Cholangioscopy
Tomazo Antonio Prince Franzini, Renata Nobre Moura, Eduardo Guimarães Hourneaux de Moura
Gastroenterology Research and Practice.2016; 2016: 1. CrossRef
Review of endoscopic radiofrequency in biliopancreatic tumours with emphasis on clinical benefits, controversies and safety
María-Victoria Alvarez-Sánchez, Bertrand Napoléon
World Journal of Gastroenterology.2016; 22(37): 8257. CrossRef
Aktuelle Therapiekonzepte für lokale Cholangiokarzinome
D. Seehofer, T.B. Brunner, H. Wege
Der Onkologe.2015; 21(11): 1054. CrossRef

8,170 View
100 Download
15 Web of Science
13 Crossref

Original Article

Photodynamic Therapy in Unresectable Cholangiocarcinoma: Not for the Uncommitted: Jayant P. Talreja, Marisa DeGaetani, Kristi Ellen, Timothy Schmitt, Monica Gaidhane, Michel Kahaleh; Clin Endosc 2013;46(4):390-394. Published online July 31, 2013; DOI: https://doi.org/10.5946/ce.2013.46.4.390

Abstract PDF PubReader ePub

Background/Aims

Photodynamic therapy (PDT) in unresectable cholangiocarcinoma has been associated with improved survival. We report a single tertiary care center experience over the past 6 years.

Methods

Fifty-five patients with unresectable cholangiocarcinoma received PDT between 2004 and 2010. Plastic stents were placed after PDT to prevent cholangitis.

Results

Twenty-seven patients (49%) showed Bismuth type IV, 22 (41%) showed Bismuth type III, and six (10%) showed Bismuth type I and II. Twenty patients (37%) received chemotherapy and radiation therapy, five (9%) received chemotherapy only; and one (2%) received radiation therapy only. Mean number of PDT sessions was 1.9±1.5 sessions (range, 1 to 9). Mean survival duration was 293±266 days (median, 190; range, 25 to 1,332). PDT related complications included three (5%) facial burn, three (5%) photosensitivity, and two (3%) rash. Kaplan-Meier analysis comparing the survival means of patients who received PDT and chemotherapy/radiation therapy (median survival 257 days; 95% confidence interval [CI], 166 to 528) versus who received PDT only (median survival 183 days; 95% CI, 129 to 224) showed no significant difference (log-rank p=0.20).

Conclusions

PDT has a measurable impact on survival in unresectable cholangiocarcinoma but requires aggressive stenting posttherapy.

Citations

Citations to this article as recorded by

Ablation Therapy of the Biliary Tree
Marina Kim, Darshan Parekh, Michel Kahaleh
Journal of Clinical Gastroenterology.2024;[Epub] CrossRef
Ablative Therapy in Non-HCC Liver Malignancy
Tyler P. Robinson, Travis Pebror, Matthew E. Krosin, Leonidas G. Koniaris
Cancers.2023; 15(4): 1200. CrossRef
Benefits and safety of photodynamic therapy in patients with hilar cholangiocarcinoma: A meta-analysis
Pengcheng Chen, Ting Yang, Peidong Shi, Jiangbo Shen, Qingchun Feng, Jingen Su
Photodiagnosis and Photodynamic Therapy.2022; 37: 102712. CrossRef
Photodynamic Therapy (PDT), Radiofrequency Ablation (RFA) With Biliary Stents in Palliative Treatment of Unresectable Extrahepatic Cholangiocarcinoma
Babu P. Mohan, Saurabh Chandan, Shahab R. Khan, Lena L. Kassab, Suresh Ponnada, Everson L.A. Artifon, Jose P. Otoch, Stephanie McDonough, Douglas G. Adler
Journal of Clinical Gastroenterology.2022; 56(2): e153. CrossRef
Comparing palliative treatment options for cholangiocarcinoma: photodynamic therapy vs. radiofrequency ablation
Tayyaba Mohammad, Michel Kahaleh
Clinical Endoscopy.2022; 55(3): 347. CrossRef
New approach to the treatment of cancer of large duodenal papilla and extrahepatic bile ducts with photodynamic therapy
E. P. Stranadko, A. V. Baranov, V. A. Duvansky, A. I. Lobakov, V. A. Morokhotov, M. V. Riabov
Experimental and Clinical Gastroenterology.2022; (5): 78. CrossRef
Endoscopic palliation of malignant biliary obstruction
Andrew Canakis, Michel Kahaleh
World Journal of Gastrointestinal Endoscopy.2022; 14(10): 581. CrossRef
Endoscopic Retrograde Cholangiopancreatography-Guided Ablation for Cholangiocarcinoma
Ross C.D. Buerlein, Andrew Y. Wang
Gastrointestinal Endoscopy Clinics of North America.2019; 29(2): 351. CrossRef
Photodynamic Therapy Plus Chemotherapy Compared with Photodynamic Therapy Alone in Hilar Nonresectable Cholangiocarcinoma
Robert Wentrup, Nicola Winkelmann, Andrey Mitroshkin, Matthias Prager, Winfried Voderholzer, Guido Schachschal, Christian J, rgensen, Carsten B, ning
Gut and Liver.2016;[Epub] CrossRef
Efficacy and safety of photodynamic therapy for unresectable cholangiocarcinoma: A meta-analysis
Yi Lu, Lei Liu, Jia-chuan Wu, Li-ke Bie, Biao Gong
Clinics and Research in Hepatology and Gastroenterology.2015; 39(6): 718. CrossRef
Biliary Tumor Ablation with Photodynamic Therapy and Radiofrequency Ablation
Ioana Smith, Michel Kahaleh
Gastrointestinal Endoscopy Clinics of North America.2015; 25(4): 793. CrossRef
The Role of Endoscopy in the Diagnosis and Management of Cholangiocarcinoma
Ajaypal Singh, Uzma D. Siddiqui
Journal of Clinical Gastroenterology.2015; 49(9): 725. CrossRef
Role of photodynamic therapy and intraductal radiofrequency ablation in cholangiocarcinoma
Janaki Patel, Nada Rizk, Michel Kahaleh
Best Practice & Research Clinical Gastroenterology.2015; 29(2): 309. CrossRef
Impact of Radiofrequency Ablation on Malignant Biliary Strictures: Results of a Collaborative Registry
Reem Z. Sharaiha, Amrita Sethi, Kristen R. Weaver, Tamas A. Gonda, Raj J. Shah, Norio Fukami, Prashant Kedia, Nikhil A. Kumta, Carlos M. Rondon Clavo, Michael D. Saunders, Jorge Cerecedo-Rodriguez, Paola Figueroa Barojas, Jessica L. Widmer, Monica Gaidhan
Digestive Diseases and Sciences.2015; 60(7): 2164. CrossRef
Randomised phase II trial of photodynamic therapy plus oral fluoropyrimidine, S-1, versus photodynamic therapy alone for unresectable hilar cholangiocarcinoma
Do Hyun Park, Sang Soo Lee, So Eun Park, Jae Lyun Lee, Jun Ho Choi, Hee Jung Choi, Ji Woong Jang, Hyoung Jung Kim, Jun Bum Eum, Dong-Wan Seo, Sung Koo Lee, Myung-Hwan Kim, Jung Bok Lee
European Journal of Cancer.2014; 50(7): 1259. CrossRef
Is There Any Evidence for a Role of Local Treatment in Cholangiocarcinoma?
Arndt Vogel, Oliver Dudeck
Visceral Medicine.2014; 30(4): 254. CrossRef

7,530 View
66 Download
16 Crossref

Focused Review Series: Photodynamic Therapy

Current Status of Photodynamic Therapy for Bile Duct Cancer: Tae Yoon Lee, Young Koog Cheon, Chan Sup Shim; Clin Endosc 2013;46(1):38-44. Published online January 31, 2013; DOI: https://doi.org/10.5946/ce.2013.46.1.38

Abstract PDF PubReader ePub

The most common form in bile duct cancers is a highly desmoplastic cancer with a growth pattern characterized by periductal extension and infiltration. The prognosis of bile duct cancers, especially hilar cholangiocarcinoma, is limited by tumor spread along the biliary tree leading to refractory obstructive cholestasis, cholangitis, and liver failure. Although biliary endoprosthesis improves occlusion rates and reduces the number of therapeutic interventions, median survival time is not ameliorated. Photodynamic therapy (PDT) is a local photochemical tumor treatment that consists of a photosensitizing agent in combination with laser irradiation of a distinct wavelength. Tumor ablation with PDT combined with biliary stenting reduces cholestasis and significantly improves median survival time in selected patients with bile duct cancers.

Citations

Citations to this article as recorded by

The Photosensitizer Temoporfin (mTHPC) – Chemical, Pre‐clinical and Clinical Developments in the Last Decade†‡
Arno Wiehe, Mathias O. Senge
Photochemistry and Photobiology.2023; 99(2): 356. CrossRef
Inhibition of hypoxia-inducible factor 1 by acriflavine renders glioblastoma sensitive for photodynamic therapy
Shuai Ma, Fang Wang, Jiawei Dong, Nan Wang, Shengzhong Tao, Jianyang Du, Shaoshan Hu
Journal of Photochemistry and Photobiology B: Biology.2022; 234: 112537. CrossRef
Extrahepatic cholangiocarcinoma: Current status of endoscopic approach and additional therapies
Alina Ioana Tantau, Alina Mandrutiu, Anamaria Pop, Roxana Delia Zaharie, Dana Crisan, Carmen Monica Preda, Marcel Tantau, Voicu Mercea
World Journal of Hepatology.2021; 13(2): 166. CrossRef
Investigated spectral-fluorescent properties of endogenous porphyrins of the wild boar hepatobiliary system optimize the diagnostics and treatment of cholangiocarcinoma with FD and PDT
Artem Shiryaev, Polina Alekseeva, Kanamat Efendiev, Dmitry Yakovlev, Arkadii Moskalev, Elizaveta Kozlikina, Pavel Kharnas, Igor Reshetov, Vladimir Levkin, Victor Loschenov
Optical Engineering.2020; 59(06): 1. CrossRef
New approaches to diagnostics and treatment of cholangiocellular cancer based on photonics methods
Dmitry V. Yakovlev, Dina S. Farrakhova, Artem A. Shiryaev, Kanamat T. Efendiev, Maxim V. Loschenov, Liana M. Amirkhanova, Dmitry O. Kornev, Vladimir V. Levkin, Igor V. Reshetov, Victor B. Loschenov
Frontiers of Optoelectronics.2020; 13(4): 352. CrossRef
Therapy for hilar cholangiocarcinoma
D. Yu. Frantsev, O. N. Sergeeva, B. I. Dolgushin
Siberian journal of oncology.2019; 18(1): 103. CrossRef
Combined treatment of nonresectable cholangiocarcinoma complicated by obstructive jaundice
A.A. Shiryaev, G.Kh. Musaev, V.V. Levkin, I.V. Reshetov, M.V. Loshchenov, P.M. Alekseeva, V.V. Volkov, K.G. Linkov, V.I. Makarov, I.O. Shchekoturov, A.V. Borodkin, V.B Loschenov
Photodiagnosis and Photodynamic Therapy.2019; 26: 218. CrossRef
Local Therapy in Advanced Cholangiocarcinoma: A Review of Current Endoscopic, Medical, and Oncologic Treatment Options
Carlo Felix Maria Jung, Julie Lavole, Maximilien Barret, Einas Abou Ali, Lola-Jade Palmieri, Solene Dermine, Amélie Barré, Stanislas Chaussade, Romain Coriat
Oncology.2019; 97(4): 191. CrossRef
Electrochemotherapy of cholangiocellular carcinoma at hepatic hilum: A feasibility study
Luciano Tarantino, Giuseppina Busto, Aurelio Nasto, Riccardo Aurelio Nasto, Paolo Tarantino, Raffaele Fristachi, Luigi Cacace, Sara Bortone
European Journal of Surgical Oncology.2018; 44(10): 1603. CrossRef
Clinico-pathological factors and prognosis scale for portal cholangiocarcinoma
Yu. O. Zharikov, Yu. A. Kovalenko, A. A. Olifir, D. V. Kalinin, A. V. Czhao
Khirurgiya. Zhurnal im. N.I. Pirogova.2017; (1): 27. CrossRef
Comprehensive high-throughput image analysis for therapeutic efficacy of architecturally complex heterotypic organoids
Anne-Laure Bulin, Mans Broekgaarden, Tayyaba Hasan
Scientific Reports.2017;[Epub] CrossRef
Redox-Responsive Nanophotosensitizer Composed of Chlorin e6-Conjugated Dextran for Photodynamic Treatment of Colon Cancer Cells
Chong Woo Chu, Je Ho Ryu, Young-IL Jeong, Tae Won Kwak, Hye Lim Lee, Hyun Yul Kim, Gyung Mo Son, Hyung Wook Kim, Dae Hwan Kang
Journal of Nanomaterials.2016; 2016: 1. CrossRef
Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy
M. Broekgaarden, R. van Vught, S. Oliveira, R. C. Roovers, P. M. P. van Bergen en Henegouwen, R. J. Pieters, T. M. Van Gulik, E. Breukink, M. Heger
Nanoscale.2016; 8(12): 6490. CrossRef
Endoscopic management of hilar stricture
Abhishek Gulati, Payal Thakkar, Shyam Thakkar
Techniques in Gastrointestinal Endoscopy.2016; 18(2): 67. CrossRef
Short-term effects and adverse events of endoscopically applied radiofrequency ablation appear to be comparable with photodynamic therapy in hilar cholangiocarcinoma
A Schmidt, M Bloechinger, A Weber, J Siveke, S von Delius, C Prinz, W Schmitt, RM Schmid, B Neu
United European Gastroenterology Journal.2016; 4(4): 570. CrossRef
Resectable Cholangiocarcinoma: Reviewing the Role of Adjuvant Strategies
E. Una Cidon
Clinical Medicine Insights: Oncology.2016;[Epub] CrossRef
Radiological interventions in malignant biliary obstruction
Kumble Seetharama Madhusudhan, Shivanand Gamanagatti, Deep Narayan Srivastava, Arun Kumar Gupta
World Journal of Radiology.2016; 8(5): 518. CrossRef
Inhibition of hypoxia inducible factor 1 and topoisomerase with acriflavine sensitizes perihilar cholangiocarcinomas to photodynamic therapy
Ruud Weijer, Mans Broekgaarden, Massis Krekorian, Lindy K. Alles, Albert C. van Wijk, Claire Mackaaij, Joanne Verheij, Allard C. van der Wal, Thomas M. van Gulik, Gert Storm, Michal Heger
Oncotarget.2016; 7(3): 3341. CrossRef
Efficacy and safety of photodynamic therapy for unresectable cholangiocarcinoma: A meta-analysis
Yi Lu, Lei Liu, Jia-chuan Wu, Li-ke Bie, Biao Gong
Clinics and Research in Hepatology and Gastroenterology.2015; 39(6): 718. CrossRef
Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies
Mans Broekgaarden, Ruud Weijer, Thomas M. van Gulik, Michael R. Hamblin, Michal Heger
Cancer and Metastasis Reviews.2015; 34(4): 643. CrossRef
Biliary Tumor Ablation with Photodynamic Therapy and Radiofrequency Ablation
Ioana Smith, Michel Kahaleh
Gastrointestinal Endoscopy Clinics of North America.2015; 25(4): 793. CrossRef
Nanoparticulate carriers for photodynamic therapy of cholangiocarcinoma: In vitro comparison of various polymer-based nanoparticles
Jonas Grünebaum, Judith Söbbing, Dennis Mulac, Klaus Langer
International Journal of Pharmaceutics.2015; 496(2): 942. CrossRef
Improve bile duct-targeted drug delivery and therapeutic efficacy for cholangiocarcinoma by cucurbitacin B loaded phospholipid complex modified with berberine hydrochloride
Ling Cheng, Ping-hua Xu, Bao-de Shen, Gang Shen, Juan-juan Li, Ling Qiu, Chao-yong Liu, Hai-long Yuan, Jin Han
International Journal of Pharmaceutics.2015; 489(1-2): 148. CrossRef
Role of photodynamic therapy and intraductal radiofrequency ablation in cholangiocarcinoma
Janaki Patel, Nada Rizk, Michel Kahaleh
Best Practice & Research Clinical Gastroenterology.2015; 29(2): 309. CrossRef
Systemic therapy of cholangiocarcinoma: From chemotherapy to targeted therapies
N. Schweitzer, A. Vogel
Best Practice & Research Clinical Gastroenterology.2015; 29(2): 345. CrossRef
Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells
Ruud Weijer, Mans Broekgaarden, Rowan F. van Golen, Esther Bulle, Esther Nieuwenhuis, Aldo Jongejan, Perry D. Moerland, Antoine H. C. van Kampen, Thomas M. van Gulik, Michal Heger
BMC Cancer.2015;[Epub] CrossRef
Endoscopic and Percutaneous Approaches to the Treatment of Biliary Tract and Primary Liver Tumors
Kevin N. Shah, Bryan M. Clary
Surgical Oncology Clinics of North America.2014; 23(2): 207. CrossRef
Palliation: Hilar cholangiocarcinoma
Mahesh Kr Goenka, Usha Goenka
World Journal of Hepatology.2014; 6(8): 559. CrossRef
Ursodeoxycholic acid-conjugated chitosan for photodynamic treatment of HuCC-T1 human cholangiocarcinoma cells
Hye Myeong Lee, Young-Il Jeong, Do Hyung Kim, Tae Won Kwak, Chung-Wook Chung, Cy Hyun Kim, Dae Hwan Kang
International Journal of Pharmaceutics.2013; 454(1): 74. CrossRef

9,929 View
103 Download
29 Crossref

A Case of Benign Biliary Stricture as a Complication of Photodynamic Therapy for Biliary Papillomatosis: Mun Ki Choi, M.D., Dong Uk Kim, M.D., Gwang Ha Kim, M.D., Geun Am Song, M.D., Hyung Seok Nam, M.D., Yang Seon Yi, M.D., Kang Hee Ahn, M.D. and Jung Seop Eom, M.D.; Korean J Gastrointest Endosc 2011;42(5):327-333. Published online May 28, 2011

Abstract PDF: Biliary papillomatosis is a rare disease with a high risk of recurrence and malignant transformation. Therapeutic options include partial hepatectomy, Whipple's procedure and liver transplantation. If there is no surgical option left due to several reasons, local palliative procedures such as biliary stenting and drainage for the treatment of cholestasis are considered, but tumor growth cannot be influenced. Photodynamic therapy might be a new additional, palliative option for patients with biliary papillomatosis who are not eligible for surgery. Benign biliary stricture is a rare complication of photodynamic therapy. We report here a case of a 63-year-old male who developed benign biliary stricture after photodynamic therapy using the photosensitizer photofrin. (Korean J Gastrointest Endosc 2011;42:327-333)

2,177 View
5 Download

The Long-term Outcome and Predictors for Increased Survival after PDT for Hilar Cholangiocarcinoma: Ji Ho Ahn, M.D., Young Koog Cheon, M.D., Young Deok Cho, M.D., Hyun Jong Choi, M.D., Jong Ho Moon, M.D., Tae Hoon Lee, M.D., Sang Heum Park, M.D. and Chan Sup Shim, M.D.*; Korean J Gastrointest Endosc 2011;42(1):6-10. Published online January 30, 2011

Abstract PDF

Background/Aims: Photodynamic therapy (PDT) has a promising effect on nonresectable cholangiocarcinoma (CC) but its long term data is not yet available. This study examined the long term outcome and factors associated with increased survival after performing PDT for hilar cholangiocarcinoma.

Methods: A list of 393 patients with a diagnosis of hilar CC was retrieved from the database of Soonchunhyang University Hospital (Seoul, Korea) and these patients were seen from January 1, 2001, to April 1, 2010. We retrospectively reviewed the records of 74 patients who underwent PDT in addition to biliary stenting with/without chemoradiation.

Results: The median overall survival from the date of diagnosis to death or to the last follow-up was 11.7 months (range: 2.2∼78.4). After performing PDT, a complete remission was observed in 1.3% (1/74) of the patients who had a superficial depth of tumor without lymph node involvement. On multivariate analysis using the Cox regression model, increasing the time to treatment after the diagnosis was a statistically significant predictor of shorter survival after PDT [Odds ratio: 3.25, 95% confidence interval (CI): 1.90∼4.71, p=0.034].

Conclusions: Although PDT does not prevent progression of CC, it appears to control the cholestasis. The early treatment of PDT after the diagnosis showed a survival benefit for patients with advanced hilar CC. (Korean J Gastrointest Endosc 2011;42:6-10)

1,859 View
15 Download

A Case of Early Esophageal Cancer Treated by Photodynamic Therapy in a Patient with Liver Cirrhosis Accompanied by Esophageal Varix: Yoon Yung Chung, M.D., Woo Chul Chung, M.D., U-Im Chang, M.D., Ju Hyun Oak, M.D., Yeon Oh Jeong, M.D., Min Ju Kim, M.D., Chang Nyol Paik, M.D. and Kang-Moon Lee, M.D.; Korean J Gastrointest Endosc 2010;41(5):298-302. Published online November 30, 2010

Abstract PDF: Photodynamic therapy (PDT) is a non-invasive treatment for cancer that works through a photochemical effect after the administration of a photosensitizer. At first, PDT had been used for the relief of obstructive symptoms caused by exophytic esophageal cancer or for control of tumor overgrowth. Recently, several investigators have reported the use of PDT in early esophageal cancer with encouraging results. This report describes a case of a 52-year-old man with early esophageal cancer, who had a long history of liver cirrhosis with esophageal varix. The patient was treated successfully with PDT using porfimer sodium as the photosensitizer. PDT is an alternative to surgical treatment of early esophageal cancer, especially in patients with liver cirrhosis. (Korean J Gastrointest Endosc 2010;41:298-302)

2,099 View
10 Download

A Case of Photodynamic Therapy after Endoscopic Submucosal Dissection for the Treatment of Early Gastric Cancer that Mimicked Submucosal Tumor: Woo Seok Choi, M.D., Jong-Jae Park, M.D., Bum Jae Lee, M.D., Jain Park, M.D., Sung-Ho Kim, M.D., Eunhye Lim, M.D., Jae Seon Kim, M.D. and Young-Tae Bak, M.D.; Korean J Gastrointest Endosc 2008;37(6):424-428. Published online December 30, 2008

Abstract PDF: Several cases of photodynamic therapy (PDT) for the curative treatment of early gastric cancer have recently been reported. However, PDT has been performed in only limited cases because it is impossible to determine the pathologic subtype or stage of the malignant lesion after the procedure. Nevertheless, PDT combined with endoscopic submucosal dissection (ESD) is expected to enhance the accuracy of the pathologic assessment and enable more effective, safe treatment for early gastric cancer. Furthermore, PDT may exert a complementary and synergetic effect on ESD for the atypical forms of early gastric cancer. From this background, we report here on a case of early gastric cancer that mimicked submucosal tumor, and this was removed by ESD, and then this was followed by adjuvant PDT. The patient had a high risk for operation due to his old age and comorbidity. After the procedure, he achieved complete remission and he is currently under follow up: he is without recurrence of tumor one year after ESD. (Korean J Gastrointest Endosc 2008;37:424-428)

2,197 View
5 Download

A Case of Photodynamic Therapy as a Curative Treatment of Early Esophageal Cancer: Chang Nyol Paik, M.D., Myung Gyu Choi, M.D., Kye Weol Kim, M.D., In Seok Lee, M.D., Jung Hwan Oh, M.D., Jae Myung Park, M.D., Joon Wook Lee, M.D., Yu Kyung Cho, M.D., Sang Woo Kim, M.D. and In Sik Chung, M.D.; Korean J Gastrointest Endosc 2006;33(1):37-41. Published online July 30, 2006

Abstract PDF: Although the surgical treatment of early esophageal cancer is a well-known curative modality, less invasive endoscopic methods have attracted significant attention recently on account of the fewer postoperative complications, better quality of life and preservation of the integrity of the esophagus. Among the various endoscopic techniques employed, photodynamic therapy (PDT) has been used to allow the selective destruction of malignant tissue through a photochemical effect after the administration of a photosensitizer for curative and palliative treatment purposes. This report describes a case of a 73-year-old man with early esophageal cancer, which had been diagnosed by fluorodeoxyglucose-positron emission tomography (FDG-PET) and endoscopy and a long history of chronic pulmonary diseases such as emphysema and radiation fibrosis. The patient was cured successfully with photodynamic therapy using porfimer sodium as the photosensitizer. (Korean J Gastrointest Endosc 2006;33: 37⁣41)

2,670 View
8 Download

Photodynamic Therapy for Superficial Gastrointestinal Tumors: Young Koog Cheon, M.D., Dae Hee Han, M.D., In Seop Jung, M.D., Chang Beom Ryu, M.D., Joo Young Cho, M.D., Yun Soo Kim, M.D., Joon Seong Lee, M.D., Moon Sung Lee, M.D., Chan Sup Shim, M.D. and Boo Sung Kim, M.D.; Korean J Gastrointest Endosc 2006;32(2):81-86. Published online February 27, 2006

Abstract PDF: Background
/Aims: Although photodynamic therapy (PDT) has been used for the endoscopic treatment of digestive cancer, its curative efficacy remains uncertain. This study evaluated the curative role of PDT in superficial gastrointestinal cancer. Methods: Fifteen lesions in 14 patients with a histologically proven carcinoma (early esophageal cancer 6, early gastric cancer 8, ampulla of Vater cancer 1) were injected with an intravenous hematoporphyrin derivative (2 mg/kg), and PDT was performed 48 hours later. The response to treatment was assessed by gastroscopy with biopsies. Results: The median follow-up time was 273 days (42∼1,030 days). According to the TNM stage of endoscopic ultrasonography, there were 14 T1 cases and 1 T2 case. Complete remission was observed in 13 cases after the initial and consecutive PDT. There were 2 cases of failure. The recurrence rate was 15.4% (2/13), and the median time from the initial PDT to recurrence was 349 days. Conclusions: PDT using a hematoporphyrin derivative as a photosensitizer is a safe and efficient method for treating early cancer. However, a long-term follow up period using a large population sample will be needed for confirmation. (Korean J Gastrointest Endosc 2006;32:81⁣86)

2,107 View
5 Download

상부 위장관 표재성종양에 대한 광역동 치료 효과: Korean J Gastrointest Endosc 2003;27(5):345-345. Published online November 20, 2003

PDF

1,527 View
1 Download

First
Prev
Page of 1
Next
Last

Search