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Remimazolam, a novel drug, for safe and effective endoscopic sedation
Jae Min Lee, Yehyun Park, Dong Won Ahn, Jun Kyu Lee, Kwang Hyuck Lee
Clin Endosc 2025;58(3):370-376.   Published online January 14, 2025
DOI: https://doi.org/10.5946/ce.2024.026
AbstractAbstract PDFPubReaderePub
Remimazolam is a novel benzodiazepine with unique pharmacokinetic and pharmacodynamic properties, making it an ideal candidate for sedation during endoscopic procedures. Distinguished by its rapid onset and short duration of action, remimazolam offers a safer and more efficient alternative to traditional sedatives, such as midazolam and propofol, with fewer side effects, such as hypotension, bradycardia, and respiratory depression. This article reviews the characteristics of remimazolam and its practical advantages, including ease of use, quick recovery time, and minimal residual sedation, emphasizing its potential to improve patient safety and procedural efficiency in clinical endoscopy settings.

Citations

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  • Remimazolam Inhibits Neuronal Apoptosis, Inflammation, and Ferroptosis in Cerebral Infarction via Promoting TRIM67‐Mediated Degradation of ACSL4
    Gaopeng Xiao, Yongqin Zhang, Ji Yang, Jigang He, Youwu Zhang, Wen Qin, Liuqiong Yu, Ling Wang, Yujin Li, Yuncheng Bai
    Journal of Biochemical and Molecular Toxicology.2026;[Epub]     CrossRef
  • Propofol Versus Remimazolam in Gastrointestinal Endoscopy: A Comprehensive Systematic Review and Meta-Analysis of Randomized Controlled Trials
    Ahmed L. Youseif, Ziad W. Elmezayen, Noha Hammad, Ahmed F. Younis, Aya M. Ramadan, Basma M. El-Khalifa, Amr R. Saleh, Karim A. Khalil, Mohamed Nabil Hamouda, Belal hamed, Alaa Ashraf Mohamed, Youssef Narouz, Doaa A. Elmarzouky, Amira A. Albawri, Yara M. H
    Digestive Diseases and Sciences.2026;[Epub]     CrossRef
  • Sedation in endoscopy: Current practices and future innovations
    Angelo Bruni, Giovanni Barbara, Alessandro Vitello, Giovanni Marasco, Marcello Maida
    World Journal of Gastrointestinal Endoscopy.2025;[Epub]     CrossRef
  • The Mechanism of Action of Remimazolam on GABAA Receptors in Painless Bronchoscopy and Its Clinical Advantages
    琪 张
    Advances in Clinical Medicine.2025; 15(10): 140.     CrossRef
  • Comparative safety and efficacy of remimazolam versus propofol for ERCP with the patient under deep sedation: a multicenter randomized controlled trial
    Sung Yong Han, Dongwook Oh, Jung Wan Choe, Jong Hyun Lee, Moon Jae Chung, Sung Ill Jang, Se Woo Park, Jin Seok Park, Min Jae Yang, Eui Joo Kim, Jae Hee Cho
    Gastrointestinal Endoscopy.2025;[Epub]     CrossRef
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