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Original Articles
Impact of a simple non-invasive nasal mask device on intraprocedural hypoxemia in overweight individuals undergoing upper gastrointestinal endoscopy with sedation provided by a non-anesthesiologist provider
Jan Drews, Jonas Harder, Hannah Kaiser, Miriam Soenarjo, Dorothee Spahlinger, Peter Wohlmuth, Sebastian Wirtz, Ralf Eberhardt, Florian Bornitz, Torsten Bunde, Thomas von Hahn
Clin Endosc 2024;57(2):196-202.   Published online June 27, 2023
DOI: https://doi.org/10.5946/ce.2023.010
Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReaderePub
Background
/Aims: Hypoxemia is a common side effect of propofol sedation during endoscopy. Applying mild positive airway pressure (PAP) using a nasal mask may offer a simple way to reduce such events and optimize the conditions for diagnostic and therapeutic upper gastrointestinal endoscopies.
Methods
We compared overweight patients (body mass index >25 kg/m2) with a nasal PAP mask or standard nasal cannula undergoing upper gastrointestinal endoscopies by non-anesthesiologists who provided propofol sedation. Outcome parameters included the frequency and severity of hypoxemic episodes.
Results
We analyzed 102 procedures in 51 patients with nasal PAP masks and 51 controls. Episodes of hypoxemia (oxygen saturation [SpO2] <90% at any time during sedation) occurred in 25 (49.0%) controls compared to 8 (15.7%) patients with nasal PAP masks (p<0.001). Severe hypoxemia (SpO2 <80%) occurred in three individuals (5.9%) in both groups. The mean delta between baseline SpO2 and the lowest SpO2 recorded was significantly decreased among patients with nasal PAP mask compared to controls (3.7 and 8.2 percentage points difference, respectively). There were significantly fewer airway interventions performed in the nasal PAP mask group (15.7% vs. 41.2%, p=0.008).
Conclusions
Using a nasal PAP mask may be a simple means of increasing patient safety and ease of examination.

Citations

Citations to this article as recorded by  
  • Effects of anesthetic nasal masks on hypoxemia in overweight/obese patients undergoing gastroscopy: a randomized controlled trial
    Huan Liu, Peipei Guo, Lijian Chen, Xuesheng Liu, Huisheng Wu
    European Journal of Medical Research.2025;[Epub]     CrossRef
  • Sedation for GI Endoscopy in the Morbidly Obese: Challenges and Possible Solutions
    Lalitha Sundararaman, Basavana Goudra
    Journal of Clinical Medicine.2024; 13(16): 4635.     CrossRef
  • 4,443 View
  • 214 Download
  • 2 Web of Science
  • 2 Crossref
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Medical disputes related to advanced endoscopic procedures with endoscopic retrograde cholangiopancreatography or endoscopic ultrasonography for the management of pancreas and biliary tract diseases
Yoon Suk Lee, Jae-Young Jang, Jun Yong Bae, Eun Hye Oh, Yehyun Park, Yong Hwan Kwon, Jeong Eun Shin, Jun Kyu Lee, Tae Hee Lee, Chang Nyol Paik
Clin Endosc 2023;56(4):499-509.   Published online March 28, 2023
DOI: https://doi.org/10.5946/ce.2022.208
Graphical AbstractGraphical Abstract AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background
/Aims: This study aimed to evaluate the characteristics of endoscopic retrograde cholangiopancreatography (ERCP) or endoscopic ultrasonography (EUS)-related adverse events (AEs) that eventually lead to medical disputes or claims on medical professional liability.
Methods
Medical disputes for ERCP/EUS-related AEs filed in the Korea Medical Dispute Mediation and Arbitration Agency between April 2012 and August 2020 were evaluated using corresponding medical records. AEs were categorized into three sections: procedure-related, sedation-related, and safety-related AEs.
Results
Among a total of 34 cases, procedure-related AEs were 26 (76.5%; 12 duodenal perforations, 7 post-ERCP pancreatitis, 5 bleedings, 2 perforations combined with post-ERCP pancreatitis); sedation-related AEs were 5 (14.7%; 4 cardiac arrests, 1 desaturation), and safety-related AEs were 5 (8.8%; 1 follow-up loss for stent removal, 1 asphyxia, 1 fall). Regarding clinical outcomes, 20 (58.8%) were fatal and eventually succumbed to AEs. For the types of medical institutions, 21 cases (61.8%) occurred at tertiary or academic hospitals, and 13 (38.2%) occurred at community hospitals.
Conclusions
The ERCP/EUS-related AEs filed in Korea Medical Dispute Mediation and Arbitration Agency showed distinct features: duodenal perforation was the most frequent AE, and clinical outcomes were fatal, resulting in at least more than permanent physical impairment.

Citations

Citations to this article as recorded by  
  • Diagnostic Assessment of Endoscopic Ultrasonography–Fine Needle Aspiration Cytology in the Pancreas: A Comparison between Liquid-Based Preparation and Conventional Smear
    Jung-Soo Pyo, Dae Hyun Lim, Kyueng-Whan Min, Nae Yu Kim, Il Hwan Oh, Byoung Kwan Son
    Medicina.2024; 60(6): 930.     CrossRef
  • 2,989 View
  • 121 Download
  • 1 Web of Science
  • 1 Crossref
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A prospective study of fully covered self-expandable metal stents for refractory benign pancreatic duct strictures
Bhavik Bharat Shah, Gajanan Ashokrao Rodge, Usha Goenka, Shivaraj Afzalpurkar, Mahesh Kumar Goenka
Clin Endosc 2022;55(6):793-800.   Published online April 4, 2022
DOI: https://doi.org/10.5946/ce.2021.211
AbstractAbstract PDFPubReaderePub
Background
/Aims: Fully covered self-expanding metal stents (FCSEMSs) are a relatively novel option for treating painful main pancreatic duct refractory strictures in patients with chronic pancreatitis. Herein, we aimed to assess the efficacy, feasibility, and safety of FCSEMSs in this patient group.
Methods
This prospective single-center study included patients who underwent endoscopic retrograde pancreatography with FCSEMS placement. The primary endpoints were the technical and clinical success rates. A reduction in visual analog scale pain score of >50% compared with that before stent placement was defined as clinical success. Secondary endpoints were resolution of pancreatic strictures on fluoroscopy during endoscopic retrograde pancreatography and the development of stent-related adverse events.
Results
Thirty-six patients were included in the analysis. The technical success rate was 100% (n=36) and the clinical success rate was 86.1% (n=31). There was a significant increase in stricture diameter from 1.7 mm to 3.5 mm (p<0.001) after stent removal. The mean visual analog scale pain score showed statistically significant improvement. At 19 months of follow-up, 55.6% of the patients were asymptomatic. Stent migration (16.7%), intolerable abdominal pain (8.3%), development of de novo strictures (8.3%), and mild pancreatitis (2.8%) were the most common adverse events.
Conclusions
FCSEMS placement showed good technical and clinical success rates for achieving pain relief in patients with refractory main pancreatic duct strictures.

Citations

Citations to this article as recorded by  
  • A review on pancreatic duct stents: materials and emerging trends
    Huijuan Fan, Nan Li, Xingguang Zhang, Wei Xu, Wencheng Zhang, Yangjuan Ding, Lingjian Li, Taotao Liu, Shihai Xia
    Biomedical Materials.2025; 20(3): 032004.     CrossRef
  • Citric Acid Loaded Hydrogel-Coated Stent for Dissolving Pancreatic Duct Calculi
    Jing Li, Yanwei Lv, Zheng Chen, Jiulong Zhao, Shige Wang
    Gels.2024; 10(2): 125.     CrossRef
  • Fully Covered Self-expandable Metallic Stents for Refractory Benign Pancreatic Duct Strictures: A Systematic Review and Meta-analysis
    Gajanan Rodge, Suprabhat Giri, Kailash Kolhe, Shivaraj Afzalpurkar, Sidharth Harindranath, Sridhar Sundaram, Aditya Kale
    Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2024; 34(5): 529.     CrossRef
  • Self-expanding metallic stent for refractory pancreatic duct stricture in chronic pancreatitis: A prospective follow-up study
    Praveer Rai, Pankaj Kumar, Ashok Kumar, Sana Asari, Kartik Agarwal, Mayank, Ravi V. Krishna Kishore, Prabhaker Mishra
    Indian Journal of Gastroenterology.2023;[Epub]     CrossRef
  • Quality of life after endoscopic procedures for chronic pancreatitis: A multicentre study
    Mikael Parhiala, Camilla Nøjgaard, Andreas Bartholdy, Anne Waage, Povilas Ignatavičius, Trond Engjom, Georg Dimcevski, Ingrid Kvåle Nordaas, Evangelos Kalaitzakis, Asbjørn M. Drewes, Amer Hadi, Søren S. Olesen, Jakob L. Poulsen, Johanna Laukkarinen
    United European Gastroenterology Journal.2023; 11(9): 884.     CrossRef
  • Pancreatic duct stents
    Jin Hui Yi, Zhao Shen Li, Liang Hao Hu
    Journal of Digestive Diseases.2022; 23(12): 675.     CrossRef
  • 3,996 View
  • 293 Download
  • 6 Web of Science
  • 6 Crossref
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Focused Review Series: Future Perspectives of Fecal Microbiota Transplatation
Fecal Microbiota Transplantation: Is It Safe?
Seon-Young Park, Geom Seog Seo
Clin Endosc 2021;54(2):157-160.   Published online March 30, 2021
DOI: https://doi.org/10.5946/ce.2021.072
AbstractAbstract PDFPubReaderePub
Fecal microbiota transplantation (FMT) is an accepted procedure for the management of recurrent Clostridioides difficile infections. FMT is generally considered safe and well-tolerated - even in high-risk patients. Most short-term risks are mild and known to be associated with delivery methods. Long-term side effects have not been established, and no signs of harm have been found to date. However, causality for several microbiome-associated diseases has to be established. Even though FMT is generally considered safe with strict donor screening, serious adverse events have been recently associated with the FMT product from the stool bank, where screening for multi-drug resistant organisms is not included in protocols. Here, we discuss the adverse events associated with FMT and safety issues.

Citations

Citations to this article as recorded by  
  • Fecal microbiota transplantation, a tool to transfer healthy longevity
    Marta G. Novelle, Beatriz Naranjo-Martínez, Juan L. López-Cánovas, Alberto Díaz-Ruiz
    Ageing Research Reviews.2025; 103: 102585.     CrossRef
  • The gut-reproductive axis: Bridging microbiota balances to reproductive health and fetal development
    Bohao Li, Yan Xiong, Dong Guo, Guohong Deng, Haibo Wu
    International Immunopharmacology.2025; 144: 113627.     CrossRef
  • Bridging Microbiomes: Exploring Oral and Gut Microbiomes in Autoimmune Thyroid Diseases- New Insights and Therapeutic Frontiers
    Daliya Abubakar, Hala Abdullahi, Ibrahim Ibrahim
    Gut Microbes Reports.2025;[Epub]     CrossRef
  • The gut microbiome and cancer response to immune checkpoint inhibitors
    Francesca S. Gazzaniga, Dennis L. Kasper
    Journal of Clinical Investigation.2025;[Epub]     CrossRef
  • Gut Microbiome Modulation in Allergy Treatment: The Role of Fecal Microbiota Transplantation
    Henry Sutanto, Elisa Elisa, Betty Rachma, Deasy Fetarayani
    The American Journal of Medicine.2025; 138(5): 769.     CrossRef
  • Gut Microbiota Influences Developmental Anesthetic Neurotoxicity in Neonatal Rats
    Tomohiro Chaki, Yuri Horiguchi, Shunsuke Tachibana, Satoshi Sato, Tomoki Hirahata, Noriaki Nishihara, Natsumi Kii, Yusuke Yoshikawa, Kengo Hayamizu, Michiaki Yamakage
    Anesthesia & Analgesia.2025;[Epub]     CrossRef
  • Therapeutic role of gut microbiota in lung injury-related cognitive impairment
    Yanxia Cheng, Guangtao Hu, Lin Deng, Yalan Zan, Xia Chen
    Frontiers in Nutrition.2025;[Epub]     CrossRef
  • Five-Day Treatment with B. licheniformis Along with Classical Vancomycin Treatment Was Effective in Preserving Gut Microbiota in Patients with Clostridioides difficile Infection
    Tae-Geun Gweon, Sang-Bum Kang, Soo-Young Na, Dong Jun Oh, Sang Wook Kim, Geom Seog Seo, Joo Young Cho
    Nutrients.2025; 17(4): 641.     CrossRef
  • Interaction Between Human Microbiota, Immune System, and Hepatitis C Virus Infection: A Narrative Review
    Davide Frumento, Ștefan Țălu
    Applied Sciences.2025; 15(6): 3157.     CrossRef
  • Beyond antibiotics: exploring multifaceted approaches to combat bacterial resistance in the modern era: a comprehensive review
    Aref Yarahmadi, Hamide Najafiyan, Mohammad Hasan Yousefi, Elham Khosravi, Ehsan Shabani, Hamed Afkhami, Seyed Soheil Aghaei
    Frontiers in Cellular and Infection Microbiology.2025;[Epub]     CrossRef
  • A Novel Frontier in Gut–Brain Axis Research: The Transplantation of Fecal Microbiota in Neurodegenerative Disorders
    Majid Eslami, Zarifeh Adampour, Bahram Fadaee Dowlat, Shayan Yaghmayee, Faezeh Motallebi Tabaei, Valentyn Oksenych, Ramtin Naderian
    Biomedicines.2025; 13(4): 915.     CrossRef
  • Key Insights into Gut Alterations in Metabolic Syndrome
    Adrian Boicean, Cristian Ichim, Sabina-Maria Sasu, Samuel Bogdan Todor
    Journal of Clinical Medicine.2025; 14(8): 2678.     CrossRef
  • Probiotics as adjuvants to mitigate adverse reactions and enhance effectiveness in Food Allergy Immunotherapy
    Ingrid Lamminpää, Elena Niccolai, Amedeo Amedei
    Scandinavian Journal of Immunology.2024;[Epub]     CrossRef
  • ADS024, a single-strain live biotherapeutic product of Bacillus velezensis alleviates dextran sulfate-mediated colitis in mice, protects human colonic epithelial cells against apoptosis, and maintains epithelial barrier function
    Sophie Irwin, Andrea Chupina Estrada, Becca Nelson, Ashlen Bullock, Berkeley Limketkai, Wendy Ho, Susan Acton, Laurent Chesnel, Hon Wai Koon
    Frontiers in Microbiology.2024;[Epub]     CrossRef
  • Metabolic model predictions enable targeted microbiome manipulation through precision prebiotics
    Georgios Marinos, Inga K. Hamerich, Reena Debray, Nancy Obeng, Carola Petersen, Jan Taubenheim, Johannes Zimmermann, Dana Blackburn, Buck S. Samuel, Katja Dierking, Andre Franke, Matthias Laudes, Silvio Waschina, Hinrich Schulenburg, Christoph Kaleta, Pau
    Microbiology Spectrum.2024;[Epub]     CrossRef
  • Protective effects of fecal microbiota transplantation against ischemic stroke and other neurological disorders: an update
    Tousif Ahmed Hediyal, C. Vichitra, Nikhilesh Anand, Mahendran Bhaskaran, Saeefh M. Essa, Pravir Kumar, M. Walid Qoronfleh, Mohammed Akbar, Ruchika Kaul-Ghanekar, Arehally M. Mahalakshmi, Jian Yang, Byoung-Joon Song, Tanya M. Monaghan, Meena Kishore Sakhar
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  • Past, present, and future of microbiome-based therapies
    Pilar Manrique, Ignacio Montero, Marta Fernandez-Gosende, Noelia Martinez, Claudio Hidalgo Cantabrana, David Rios-Covian
    Microbiome Research Reports.2024;[Epub]     CrossRef
  • Changes in the Progression of Chronic Kidney Disease in Patients Undergoing Fecal Microbiota Transplantation
    Giovanna Yazmín Arteaga-Muller, Samantha Flores-Treviño, Paola Bocanegra-Ibarias, Diana Robles-Espino, Elvira Garza-González, Graciela Catalina Fabela-Valdez, Adrián Camacho-Ortiz
    Nutrients.2024; 16(8): 1109.     CrossRef
  • The Importance of Microbiota and Fecal Microbiota Transplantation in Pancreatic Disorders
    Adrian Boicean, Cristian Ichim, Samuel Bogdan Todor, Paula Anderco, Mirela Livia Popa
    Diagnostics.2024; 14(9): 861.     CrossRef
  • Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes?
    Coco M. Fuhri Snethlage, Douwe de Wit, Koen Wortelboer, Elena Rampanelli, Nordin M. J. Hanssen, Max Nieuwdorp
    Immunological Reviews.2024; 325(1): 46.     CrossRef
  • Friend or Foe: Exploring the Relationship between the Gut Microbiota and the Pathogenesis and Treatment of Digestive Cancers
    Monica Profir, Oana Roşu, Sanda Creţoiu, Bogdan Gaspar
    Microorganisms.2024; 12(5): 955.     CrossRef
  • The gut microbiota patterns of patients with COVID-19: protocol for a case-control study
    Seyed Aria Nejadghaderi, Ehsan Nazemalhosseini-Mojarad, Asra Fazlollahi, Ali Pirsadeghi, Ainaz Khalili, Rasoul Ebrahimi, Nima Rezaei
    Translational Medicine Communications.2024;[Epub]     CrossRef
  • Fecal microbiota transplantation and next-generation therapies: A review on targeting dysbiosis in metabolic disorders and beyond
    Zenawork Sahle, Getabalew Engidaye, Demissew Shenkute Gebreyes, Behailu Adenew, Tsegahun Asfaw Abebe
    SAGE Open Medicine.2024;[Epub]     CrossRef
  • Fecal microbiota transplantation: A potential novel treatment strategy for extensively drug-resistant tuberculosis
    Seyed Aria Nejadghaderi, Alexander L. Chu
    Medical Hypotheses.2024; 189: 111396.     CrossRef
  • Potential of Synbiotics and Probiotics as Chemopreventive Agent
    Kah Wei Chin, Shing Ching Khoo, Richard Paul Merisha Paul, Vijitra Luang-In, Su Datt Lam, Nyuk Ling Ma
    Probiotics and Antimicrobial Proteins.2024; 16(6): 2085.     CrossRef
  • Gut-derived immune cells and the gut-lung axis in ARDS
    Mairi Ziaka, Aristomenis Exadaktylos
    Critical Care.2024;[Epub]     CrossRef
  • Assessing the Therapeutic Potential of Fecal Microbiota Transplantation in Steatotic Liver Disease: Current Insights and Future Pathways
    Carolina Jiménez-González, Ignacio Vallejo, David Sordo, Juan Manuel Medina-Méndez, Marta Alonso-Peña, Javier Crespo
    Current Hepatology Reports.2024; 23(4): 435.     CrossRef
  • Extracellular Vesicles from Nanomedicine‐Trained Intestinal Microbiota Substitute for Fecal Microbiota Transplant in Treating Ulcerative Colitis
    Menghang Zu, Ga Liu, Haiting Xu, Zhenhua Zhu, Junfeng Zhen, Baoyi Li, Xiaoxiao Shi, Mohammad‐Ali Shahbazi, Rui L. Reis, Subhas C. Kundu, Guangjun Nie, Bo Xiao
    Advanced Materials.2024;[Epub]     CrossRef
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    Bhagyashri D. Navalkele, Teena Chopra
    Frontiers in Microbiomes.2024;[Epub]     CrossRef
  • The Impact of Infections in Patients Treated with Atezolizumab Plus Bevacizumab for Unresectable Hepatocellular Carcinoma
    Abdullah Esmail, Jiaqiong Xu, Ethan A. Burns, Karen Abboud, Ali Sheikh, Godsfavour Umoru, Kelly Gee, Catherine Wiechmann, Yuqi Zhang, Maen Abdelrahim
    Journal of Clinical Medicine.2024; 13(17): 4994.     CrossRef
  • Faecal microbiota transplantation associated adverse events
    Rafal Patryn, Natalia Kazmierczak-Wojtas, Lucyna Bulas, Olga Boretska, Monika Szkultecka-Debek, Mariola Drozd, Tomasz Blicharski
    Current Issues in Pharmacy and Medical Sciences.2024; 37(3): 171.     CrossRef
  • Gut microbe–host interactions in post-COVID syndrome: a debilitating or restorative partnership?
    Torsten P. M. Scheithauer, Roy C. Montijn, Arnout Mieremet
    Gut Microbes.2024;[Epub]     CrossRef
  • Safety and efficacy of fecal microbiota transplantation (FMT) as a modern adjuvant therapy in various diseases and disorders: a comprehensive literature review
    Mehdi Karimi, Niyousha Shirsalimi, Zahra Hashempour, Hossein Salehi Omran, Eshagh Sedighi, Farzan Beigi, Masoud Mortezazadeh
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Refractory Crohn’s Disease: Perspectives, Unmet Needs and Innovations
    Luisa Bertin, Martina Crepaldi, Miriana Zanconato, Greta Lorenzon, Daria Maniero, Caterina De Barba, Erica Bonazzi, Sonia Facchin, Marco Scarpa, Cesare Ruffolo, Imerio Angriman, Andrea Buda, Fabiana Zingone, Edoardo Vincenzo Savarino, Brigida Barberio
    Clinical and Experimental Gastroenterology.2024; Volume 17: 261.     CrossRef
  • Exploring the Frontier: The Human Microbiome’s Role in Rare Childhood Neurological Diseases and Epilepsy
    Newell Belnap, Keri Ramsey, Sophia T. Carvalho, Lexi Nearman, Hannah Haas, Matt Huentelman, Keehoon Lee
    Brain Sciences.2024; 14(11): 1051.     CrossRef
  • Gut Microbiota and New Microbiome-Targeted Drugs for Clostridioides difficile Infections
    Ahran Lee, Jung Sik Yoo, Eun-Jeong Yoon
    Antibiotics.2024; 13(10): 995.     CrossRef
  • Fecal Microbiota Transplantation: Insights into Colon Carcinogenesis and Immune Regulation
    Olga Brusnic, Danusia Onisor, Adrian Boicean, Adrian Hasegan, Cristian Ichim, Andreea Guzun, Radu Chicea, Samuel Bogdan Todor, Bogdan Ioan Vintila, Paula Anderco, Corina Porr, Horatiu Dura, Sorin Radu Fleaca, Adrian Nicolae Cristian
    Journal of Clinical Medicine.2024; 13(21): 6578.     CrossRef
  • Gut Microbiota and Immune System Dynamics in Parkinson’s and Alzheimer’s Diseases
    Natasa Kustrimovic, Sahar Balkhi, Giorgia Bilato, Lorenzo Mortara
    International Journal of Molecular Sciences.2024; 25(22): 12164.     CrossRef
  • Fecal microbiota transplantation for glaucoma; a potential emerging treatment strategy
    Rasoul Ebrahimi, Yeganeh Farsi, Seyed Aria Nejadghaderi
    Current Research in Microbial Sciences.2024; 7: 100314.     CrossRef
  • Health Benefits of Prebiotics, Probiotics, Synbiotics, and Postbiotics
    Nasser Al-Habsi, Maha Al-Khalili, Syed Ariful Haque, Moussa Elias, Nada Al Olqi, Tasnim Al Uraimi
    Nutrients.2024; 16(22): 3955.     CrossRef
  • The Microbiome–Genetics Axis in Autism Spectrum Disorders: A Probiotic Perspective
    Marija Mihailovich, Maja Tolinački, Svetlana Soković Bajić, Sanja Lestarevic, Milica Pejovic-Milovancevic, Nataša Golić
    International Journal of Molecular Sciences.2024; 25(22): 12407.     CrossRef
  • More than just a number: the gut microbiota and brain function across the extremes of life
    Nathan D. Nuzum, Clara Deady, Sarah Kittel-Schneider, John F. Cryan, Siobhain M. O'Mahony, Gerard Clarke
    Gut Microbes.2024;[Epub]     CrossRef
  • Metabolites in the Dance: Deciphering Gut-Microbiota-Mediated Metabolic Reprogramming of the Breast Tumor Microenvironment
    Afaf Altrawy, Maye M. Khalifa, Asmaa Abdelmaksoud, Yomna Khaled, Zeinab M. Saleh, Hager Sobhy, Shaimaa Abdel-Ghany, Amany Alqosaibi, Afnan Al-Muhanna, Jawaher Almulhim, Ahmed El-Hashash, Hussein Sabit, Borros Arneth
    Cancers.2024; 16(24): 4132.     CrossRef
  • Gut Microbiota-Targeted Interventions in the Management of Chronic Kidney Disease
    Keiichi Sumida, Joseph F. Pierre, Melana Yuzefpolskaya, Paolo C. Colombo, Ryan T. Demmer, Csaba P. Kovesdy
    Seminars in Nephrology.2023; 43(2): 151408.     CrossRef
  • Fecal microbiota transplantation in childhood: past, present, and future
    Xu Gu, Zhao-Hong Chen, Shu-Cheng Zhang
    World Journal of Pediatrics.2023; 19(9): 813.     CrossRef
  • Bacteria-driven bio-therapy: From fundamental studies to clinical trials
    Yuxuan Yu, Sicen Lin, Zhichao Chen, Bin Qin, Zhonggui He, Maosheng Cheng, Mengchi Sun, Jin Sun
    Nano Today.2023; 48: 101731.     CrossRef
  • Role of microbial dysbiosis in the pathogenesis of Alzheimer's disease
    Gudimetla Susmitha, Rahul Kumar
    Neuropharmacology.2023; 229: 109478.     CrossRef
  • Non-Toxigenic Clostridioides difficile Strain E4 (NTCD-E4) Prevents Establishment of Primary C. difficile Infection by Epidemic PCR Ribotype 027 in an In Vitro Human Gut Model
    Perezimor Etifa, César Rodríguez, Céline Harmanus, Ingrid M. J. G. Sanders, Igor A. Sidorov, Olufunmilayo A. Mohammed, Emily Savage, Andrew R. Timms, Jane Freeman, Wiep Klaas Smits, Mark H. Wilcox, Simon D. Baines
    Antibiotics.2023; 12(3): 435.     CrossRef
  • Discovery of Lactomodulin, a Unique Microbiome-Derived Peptide That Exhibits Dual Anti-Inflammatory and Antimicrobial Activity against Multidrug-Resistant Pathogens
    Walaa K. Mousa, Rose Ghemrawi, Tareq Abu-Izneid, Azza Ramadan, Farah Al-Marzooq
    International Journal of Molecular Sciences.2023; 24(8): 6901.     CrossRef
  • The Influence of Gut Microbial Species on Diabetes Mellitus
    Raghad Khalid AL-Ishaq, Samson Mathews Samuel, Dietrich Büsselberg
    International Journal of Molecular Sciences.2023; 24(9): 8118.     CrossRef
  • Neurodegenerative and Neurodevelopmental Diseases and the Gut-Brain Axis: The Potential of Therapeutic Targeting of the Microbiome
    Brian Bicknell, Ann Liebert, Thomas Borody, Geoffrey Herkes, Craig McLachlan, Hosen Kiat
    International Journal of Molecular Sciences.2023; 24(11): 9577.     CrossRef
  • Gut Microbiome Transplants and Their Health Impacts across Species
    Benjamin H. Levine, Jessica M. Hoffman
    Microorganisms.2023; 11(6): 1488.     CrossRef
  • Gut microbiota changes associated with Clostridioides difficile infection and its various treatment strategies
    Anne J. Gonzales-Luna, Travis J. Carlson, Kevin W. Garey
    Gut Microbes.2023;[Epub]     CrossRef
  • The Role of Gut Dysbiosis in the Loss of Intestinal Immune Cell Functions and Viral Pathogenesis
    Farzaneh Fakharian, Siva Thirugnanam, David A. Welsh, Woong-Ki Kim, Jay Rappaport, Kyle Bittinger, Namita Rout
    Microorganisms.2023; 11(7): 1849.     CrossRef
  • Swiss expert opinion: current approaches in faecal microbiota transplantation in daily practice
    Laura Rossier, Christoph Matter, Emanuel Burri, Tatiana Galperine, Petr Hrúz, Pascal Juillerat, Alain Schoepfer, Stephan R. Vavricka, Nadine Zahnd, Natalie Décosterd, Frank Seibold
    Swiss Medical Weekly.2023; 153(8): 40100.     CrossRef
  • Non-alcoholic fatty liver disease and gut microbial dysbiosis- underlying mechanisms and gut microbiota mediated treatment strategies
    Muthukumaran Jayachandran, Shen Qu
    Reviews in Endocrine and Metabolic Disorders.2023; 24(6): 1189.     CrossRef
  • Fecal Microbiota Transplantation in Liver Cirrhosis
    Adrian Boicean, Victoria Birlutiu, Cristian Ichim, Olga Brusnic, Danusia Maria Onișor
    Biomedicines.2023; 11(11): 2930.     CrossRef
  • Fecal Microbiota Transplantation in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
    Parnian Jamshidi, Yeganeh Farsi, Zahra Nariman, Mohammad Reza Hatamnejad, Benyamin Mohammadzadeh, Hossein Akbarialiabad, Mohammad Javad Nasiri, Leonardo A. Sechi
    International Journal of Molecular Sciences.2023; 24(19): 14562.     CrossRef
  • Gut microbiota of Suncus murinus, a naturally obesity-resistant animal, improves the ecological diversity of the gut microbiota in high-fat-diet-induced obese mice
    Mingshou Zhang, Ting Yang, Rujia Li, Ke Ren, Jun Li, Maozhang He, Juefei Chen, Shuang-Qin Yi, Farah Al-Marzooq
    PLOS ONE.2023; 18(11): e0293213.     CrossRef
  • New Awareness of the Interplay Between the Gut Microbiota and Circadian Rhythms
    Xiaoxiao Pang, Long Chen, Guoxin Xu
    Polish Journal of Microbiology.2023; 72(4): 355.     CrossRef
  • Clinical Practice Guidelines for Fecal Microbiota Transplantation in Korea
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FOCUSED REVIEW SERIES: Endoscopic Managements for Patients with Obesity and Its Related Comorbidities
The Efficacy and Safety of Endoscopic Sleeve Gastroplasty as an Alternative to Laparoscopic Sleeve Gastrectomy
Jin Young Yoon, Román Turró Arau, The study group for endoscopic bariatric and metabolic therapies in the Korean Society of Gastrointestinal Endoscopy
Clin Endosc 2021;54(1):17-24.   Published online January 22, 2021
DOI: https://doi.org/10.5946/ce.2021.019
AbstractAbstract PDFPubReaderePub
Endoscopic sleeve gastroplasty (ESG) is a therapeutic endoscopic technique for reducing the size of the gastric reservoir in obese patients, using a full-thickness endoscopic suturing device. The effectiveness of ESG in weight loss is significantly greater than that of high-intensity diet and lifestyle therapy and lower than that of laparoscopic sleeve gastrectomy (LSG). The efficacy at 12 months after ESG in terms of percentage of total body weight loss and excess body weight loss was approximately 16% and 60%, respectively. The well-known predictive factors for increased weight loss by ESG are good compliance with regular monitoring and post-procedure care involving a multidisciplinary team approach. Although the underlying mechanism of weight loss induced by ESG is debatable, delayed gastric emptying and early satiation are some of the proposed mechanisms. The pooled rate of adverse events after ESG reported in several meta-analysis studies ranged from 1.5% to 2.3% and the incidence of new-onset gastroesophageal reflux disease after ESG was negligible, indicating that ESG has a superior safety profile to LSG. Moreover, ESG reduced the risk of obesity-related metabolic comorbidities, evidenced by the reduction in HbA1c level, systolic blood pressure, triglyceride level, and risk of hepatic steatosis and fibrosis; it even improved the quality of life. ESG could be considered safe and qualify as an alternative treatment to LSG.

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Original Article
Colon Capsule Endoscopy: Indications, Findings, and Complications – Data from a Prospective German Colon Capsule Registry Trial (DEKOR)
Johannes Hausmann, Andrea Tal, Artur Gomer, Michael Philipper, Gero Moog, Horst Hohn, Norbert Hesselbarth, Harald Plass, Jörg Albert, Fabian Finkelmeier
Clin Endosc 2021;54(1):92-99.   Published online June 18, 2020
DOI: https://doi.org/10.5946/ce.2020.049
AbstractAbstract PDFPubReaderePub
Background
/Aims: Reliable and especially widely accepted preventive measures are crucial to further reduce the incidence of colorectal cancer (CRC). Colon capsule endoscopy (CCE) might increase the screening numbers among patients unable or unwilling to undergo conventional colonoscopy. This registry trial aimed to document and determine the CCE indications, findings, complications, and adverse events in outpatient practices and clinics throughout Germany.
Methods
Patients undergoing CCE between 2010 and 2015 were enrolled in this prospective multicenter registry trial at six German centers. Patient demographics, outcomes, and complications were evaluated.
Results
A total of 161 patients were included. Of the CCE evaluations, 111 (68.9%) were considered successful. Pathological findings in the colon (n=92, 60.1%) and in the remaining gastrointestinal tract (n=38, 24.8%) were recorded. The main finding was the presence of polyps (n=52, 32.3%). Furthermore, five carcinomas (3.1%) were detected and histologically confirmed later. Adequate bowel cleanliness was more likely to be achieved in the outpatient setting (p<0.0001). Interestingly, 85 patients (55.6%) chose to undergo CCE based on personal motivation.
Conclusions
CCE seems to be a reliable and safe endoscopic tool for screening for CRC and detecting other diseases. Its patient acceptance and feasibility seems to be high, especially in the outpatient setting.

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Reviews
Revision of Quality Indicators for the Endoscopy Quality Improvement Program of the National Cancer Screening Program in Korea
Jun Ki Min, Jae Myung Cha, Yu Kyung Cho, Jie-Hyun Kim, Soon Man Yoon, Jong Pil Im, Yunho Jung, Jeong Seop Moon, Jin-Oh Kim, Yoon Tae Jeen
Clin Endosc 2018;51(3):239-252.   Published online May 31, 2018
DOI: https://doi.org/10.5946/ce.2018.075
AbstractAbstract PDFPubReaderePub
Gastroscopy and colonoscopy are widely used for the early diagnosis of stomach and colorectal cancer. The present revision integrates recent data regarding previous quality indicators and novel indicators suggested for gastroscopy and colonoscopy procedures for the National Cancer Screening Program in Korea. The new indicators, developed by the Quality Improvement Committee of the Korean Society for Gastrointestinal Endoscopy, vary in the level of supporting evidence, and most are based solely on expert opinion. Updated indicators validated by clinical research were prioritized, but were chosen by expert consensus when such studies were absent. The resultant quality indicators were graded according to the levels of consensus and recommendations. The updated indicators will provide a relevant guideline for high-quality endoscopy. The future direction of quality indicator development should include relevant outcome measures and an evidence-based approach to support proposed performance targets.

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Quality is the Key for Emerging Issues of Population-Based Colonoscopy Screening
Jin Young Yoon, Jae Myung Cha, Yoon Tae Jeen, on behalf of Medical Policy Committee of Korean Association for the Study of Intestinal Diseases (KASID), Quality Improvement Committee of Korean Society of Gastrointestinal Endoscopy (KSGE)
Clin Endosc 2018;51(1):50-55.   Published online January 31, 2018
DOI: https://doi.org/10.5946/ce.2018.010
AbstractAbstract PDFPubReaderePub
Colonoscopy is currently regarded as the gold standard and preferred method of screening for colorectal cancer (CRC). However, the benefit of colonoscopy screening may be blunted by low participation rates in population-based screening programs. Harmful effects of population-based colonoscopy screening may include complications induced by colonoscopy itself and by sedation, psychosocial distress, potential over-diagnosis, and socioeconomic burden. In addition, harmful effects of colonoscopy may increase with age and comorbidities. As the risk of adverse events in population-based colonoscopy screening may offset the benefit, the adverse events should be managed and monitored. To adopt population-based colonoscopy screening, consensus on the risks and benefits should be developed, focusing on potential harm, patient preference, socioeconomic considerations, and quality improvement of colonoscopy, as well as efficacy for CRC prevention. As suboptimal colonoscopy quality is a major pitfall of population-based screening, adequate training and regulation of screening colonoscopists should be the first step in minimizing variations in quality. Gastroenterologists should promote quality improvement, auditing, and training for colonoscopy in a population-based screening program.

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Original Article
Considerable Variability of Procedural Sedation and Analgesia Practices for Gastrointestinal Endoscopic Procedures in Europe
Hermanus H. B. Vaessen, Johannes T. A. Knape
Clin Endosc 2016;49(1):47-55.   Published online January 28, 2016
DOI: https://doi.org/10.5946/ce.2016.49.1.47
AbstractAbstract PDFPubReaderePub
Background
/Aims: The use of moderate to deep sedation for gastrointestinal endoscopic procedures has increased in Europe considerably. Because this level of sedation is a risky medical procedure, a number of international guidelines have been developed. This survey aims to review if, and if so which, quality aspects have been included in new sedation practices when compared to traditional uncontrolled sedation practices.
Methods
A questionnaire was sent to the National Associations of Nurse Anesthetists in Europe and the National Delegates of the European Section and Board of Anaesthesiology from January 2012 to August 2012.
Results
Huge variation in practices for moderate to deep sedation were identified between and within European countries in terms of safety, type of practitioners, responsibilities, monitoring, informed consent, patient satisfaction, complication registration, and training requirements. Seventy-five percent of respondents were not familiar with international sedation guidelines. Safe sedation practices (mainly propofol-based moderate to deep sedation) are rapidly gaining popularity.
Conclusions
The risky medical procedure of moderate to deep sedation has become common practice for gastrointestinal endoscopy. Safe sedation practices requiring adequate selection of patients, adequate monitoring, training of sedation practitioners, and adequate after-care, are gaining attention in a field that is in transition from uncontrolled sedation care to controlled sedation care.

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Review
Preparation and Patient Evaluation for Safe Gastrointestinal Endoscopy
Seong Hee Kang, Jong Jin Hyun
Clin Endosc 2013;46(3):212-218.   Published online May 31, 2013
DOI: https://doi.org/10.5946/ce.2013.46.3.212
AbstractAbstract PDFPubReaderePub

Patient evaluation and preparation is the first and mandatory step to ensure safety and quality of endoscopic procedures. This begins and ends with identifying the patient, procedure type, and indication. Every patient has the right to be fully informed about risks and benefits of what is to be performed on them, and the medical personnel should respect the decision made by the patients. Thoroughly performed history taking and physical examination will guide the endoscopists to better stratify risk and plan sedation. Special attention should be given to higher-risk patients with higher-risk condition undergoing higher-risk procedures. Making preparations to monitor the patients and being ready to handle emergency situations throughout the endoscopic procedure are sine qua non to warrant safe endoscopy.

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The Efficacy and Safety of Performing Colonoscopy in Patients 80 Years of Age and Older
Yeun Jung Lim, M.D., Young-Ho Kim, M.D., Dong Kyung Chang, M.D., Hee Jung Son, M.D., Poong-Lyul Rhee, M.D., Jae J. Kim, M.D. and Jong Chul Rhee, M.D.
Korean J Gastrointest Endosc 2009;38(3):128-132.   Published online March 30, 2009
AbstractAbstract PDF
Background
/Aims: Optical colonoscopy is considered the gold standard for conducting a colorectal examination. Yet clinicians are often reluctant to refer elderly patients for colonoscopy because of their perception that it is a risky procedure. The aim of this study was to establish the efficacy and safety of performing colonoscopy in patients 80 years of age and older.
Methods
The study data was retrospectively collected from January 2000 to April 2007. Comparisons were made between two groups: The patients were classified based on age: 50~69 years and ≥80 years of age. We collected data on sedation, the total colonoscopy rates, the indication, the colonoscopic findings and the complications.
Results
Three hundred and forty-nine patients (170 elderly patients and 179 patients aged 50~69 years) were enrolled. Compared to the patients aged 50~69 years, the elderly patients had more clinically significant findings (55.9% for the elderly patient and 37.4% for the patients aged 50~80 years). Cecal intubation was done at a similar rate for both groups (94.7% and 96.6%, respectively). Although the elderly patients usually had one or more co-morbid illnesses (p<0.001), the complication rate was not different between the 2 groups.
Conclusions
Colonoscopy in the elderly is safe and effective and it allows physicians to discover many significant findings. (Korean J Gastrointest Endosc 2009;38:128-132)
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Clinical Application and Safety of Endoscopic Pancreatic Sphincterotomy in 339 Cases
Hyun Young Son, M.D., Sung Koo Lee, M.D., Moon Hee Song, M.D., Ji Min Han, M.D., Eun Kwang Choi, M.D., Jong Cheol Kim, M.D., Sang Soo Lee, M.D., Dong Wan Seo, M.D. and Myung-Hwan Kim, M.D.
Korean J Gastrointest Endosc 2005;31(3):155-160.   Published online September 30, 2005
AbstractAbstract PDF
Background
/Aims: Endoscopic pancreatic sphincterotomy (EPST) has been performed more frequently in recent years. However, it is less widely practiced than biliary sphincterotomy due to lack of firm scientific data regarding its indication and safety. The aims of this study are to evaluate EPST with regard to indications, complications, and safety. Methods: We retrospectively reviewed and analyzed the results of EPST performed in three hundred thirty nine patients from January 2000 to April 2004. Results: Complications occurred in 37 patients (10.7%) which included pancreatitis, hemorrhage, perforation, cholangitis, sepsis, and stenosis of sphincterotomy site. They were successfully managed by medical treatment. No mortalities were reported. Conclusions: EPST is a relatively safe procedure in various pancreatic diseases. Incidence of long-term complications awaits further investigations. EPST enlarges our endotherapeutic armamentarium and deserves additional evaluation. (Korean J Gastrointest Endosc 2005;31:155⁣160)
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Clinical Application and Safety of Endoscopic Pancreatic Sphincterotomy in 339 Cases
Hyun Young Son, M.D., Sung Koo Lee, M.D., Moon Hee Song, M.D., Ji Min Han, M.D., Eun Kwang Choi, M.D., Jong Cheol Kim, M.D., Sang Soo Lee, M.D., Dong Wan Seo, M.D. and Myung-Hwan Kim, M.D.
Korean J Gastrointest Endosc 2005;31(3):155-160.   Published online September 30, 2005
AbstractAbstract PDF
Background
/Aims: Endoscopic pancreatic sphincterotomy (EPST) has been performed more frequently in recent years. However, it is less widely practiced than biliary sphincterotomy due to lack of firm scientific data regarding its indication and safety. The aims of this study are to evaluate EPST with regard to indications, complications, and safety. Methods: We retrospectively reviewed and analyzed the results of EPST performed in three hundred thirty nine patients from January 2000 to April 2004. Results: Complications occurred in 37 patients (10.7%) which included pancreatitis, hemorrhage, perforation, cholangitis, sepsis, and stenosis of sphincterotomy site. They were successfully managed by medical treatment. No mortalities were reported. Conclusions: EPST is a relatively safe procedure in various pancreatic diseases. Incidence of long-term complications awaits further investigations. EPST enlarges our endotherapeutic armamentarium and deserves additional evaluation. (Korean J Gastrointest Endosc 2005;31:155⁣160)
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원저 : 담도 췌장 ; 내시경적 유두괄약근절개술과 담췌관조영술시 침형절개도의 효율성과 안전성 ( Original Articles : Biliary Tract & Pancreas ; The Efficacy and Safety of Needle-Knife Papillotomy for Endoscopic Sphincterotomy and Cholangiography )
Korean J Gastrointest Endosc 1997;17(3):380-389.   Published online November 30, 1996
AbstractAbstract PDF
Background
Conventional endoscopic sphincterotomy with papillotome(CES) is an established method of management for patients with biliary obstruction from various causes. However, an alternative treatment to CES must be considered when antecedent cholangiagraphy is unsuccessful or when cannulatian with the conventional papillotome fails. The needle-knife papillotomy(NKP) is one of the alternative methods to CES. Recently, it has been suggested that NKP can be used to achieve diagnostic cholangiography. But NKP is controversial because results from studies assessing its efficacy and safety are conflicting. The current study was undertaken to assess retrospectively the efficacy and safety of NKP and CES. Methods: All enrolled patients(CES group 113, NKP group 105) underwent ERCP between September 1993 and August 1996 at Korea Univeisity Guro Hospital. NKP for cannulation was used only when biliary tract disease was suspected but deep canulation failed inspite of several attempts. The efficacy and safety of NKP and CES were evaluated according to the rate of success of performing purposes(removal of common bile duct stones, inser tion of endoscopic nasobiliary drainage or endoprosthesis, treatment of sphincter of Oddi dysfunction, and cannulation) and complications(bleeding, perforation, pancreatitis). (Korean J Gastrointest Endosc 17: 380-389, 1997) (continue)
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