Clinical Endoscopy

Magnifying Endoscopy for Esophageal Ectopic Sebaceous Glands: Mu Song Jeon, Gwang Ha Kim, Dong Young Jeong, Byeong Kyu Park, Moon Won Lee, So-Jeong Lee, Do Youn Park; Clin Endosc 2018;51(5):495-497. Published online February 26, 2018; DOI: https://doi.org/10.5946/ce.2017.187

Ectopic sebaceous glands are found very rarely in the esophagus; heretofore, several cases have been reported. The sebaceous gland is originally a source of an endodermal origin; however, there have been controversies regarding whether the origin of the esophageal ectopic sebaceous gland is ectodermal or endodermal. Ectopic sebaceous glands of the esophagus usually do not cause symptoms; thus, they are often found incidentally on endoscopy for routine health screening. Endoscopic findings are characterized by single or multiple yellow patches or nodular lesions of various sizes, sometimes with small central openings. We report two cases of esophageal ectopic sebaceous glands found incidentally during endoscopy with magnifying endoscopic findings. The lesions were in the mid-esophagus and lower esophagus, respectively, and both endoscopic findings were similar as multiple yellowish patches or plaques. Magnifying endoscopy revealed the openings of the excretory ducts surrounded by circular microvessels in both cases.

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A Case of Ectopic Sebaceous Glands in the Esophagus: Hyung Bok Park, M.D., Hyeon Geun Cho, M.D., Yu Jin Kim, M.D., Kyung Suk Park, M.D., Myoung Lyeol Woo, M.D., Geun Jun Ko, M.D., Hwa Eun Oh, M.D.* and Sang Yeop Yi, M.D.*; Korean J Gastrointest Endosc 2010;41(3):155-158. Published online September 30, 2010

Abstract PDF: A 42-year-old man without any signs or symptoms of illness underwent esophago- gastroduodenoscopy (EGD) for a routine health check up. On esophagogastroduo- denoscopy, multiple small and yellowish mucosal plaques were detected in the mid to distal esophagus. These plagues proved to be ectopic sebaceous glands of the esophagus according to the histologic examination. On the immunohistochemical staining with anti-Keratin 14, the basal cells and the heterotopic sebaceous glands were immunoreactive for keratin 14. The histogenesis of this extremely rare lesion is not completely clear. There have been some reports on ectopic esophagus sebaceous glands combined with esophageal cancer or gastric cancer. However, malignant transformation of the ectopic sebaceous gland itself has not yet been reported on. This case was regularly followed up for 12 months, and no interval change or malignant transformation was found both endoscopically and histologi- cally. (Korean J Gastrointest Endosc 2010;41:155-158)

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A Case of Ectopic Sebaceous Glands in the Esophagus: Sun Moon Kim, M.D., Eui Hyeog Im, M.D., Seung Hyun Jung, M.D., Tae Hee Lee, M.D., Kyu Chan Huh, M.D., Jung Uee Lee, M.D.*, Yun Mi Kim, M.D.*, Young Woo Choi, M.D. and Young Woo Kang, M.D.; Korean J Gastrointest Endosc 2005;31(5):320-322. Published online November 30, 2005

Abstract PDF: Ectopic sebaceous glands have been reported in the organs of an ectodermal origin such as the oral cavity, genitals, eye and orbit, nipples, palm and soles, and the parotid glands. Their presence in the esophagus, which is an organ of endodermal origin, is a very rare and interesting anomaly. Whether ectopic sebaceous glands in the esophagus are the result of congenital misplacement or acquired metaplastic change remains unclear. We report here on a patient with sebaceous glands in the esophagus, and this was diagnosed by endoscopic biopsy. (Korean J Gastrointest Endosc 2005;31:320⁣322)

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