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Original Articles
- Bowel preparation for small bowel capsule endoscopy: standard regimen with 2 L polyethylene glycol versus 1 L polyethylene glycol plus ascorbate
- Riccardo Caccia, Alessandro Rimondi, Luca Elli, Matilde Topa, Flaminia Cavallaro, Carmine Gentile, Lucia Scaramella, Nicoletta Nandi, Reena Sidhu, Pinhas Eidler, Maurizio Vecchi, Gian Eugenio Tontini
- Clin Endosc 2025;58(2):285-290. Published online January 2, 2025
- DOI: https://doi.org/10.5946/ce.2024.097
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Graphical Abstract
Abstract
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ePub - Background
/Aims: Optimization of bowel preparation for small bowel capsule endoscopy (SBCE) is debated. Guidelines recommend 2 L of iso-osmolar polyethylene glycol (PEG) to improve SBCE visibility. We compared the efficacy of the standard 2 L PEG solution with a 1 L PEG plus ascorbate (PEG-ASC) preparation, which has already been established for large-bowel preparation.
Methods
Between October 2020 and February 2022, patients undergoing SBCE were assigned to receive 2 L PEG or 1 L PEG-ASC bowel preparation on an even- or odd-day basis. Bowel cleanliness was evaluated using the small bowel mucosal visibility scoring system (SBMVSS).
Results
Following propensity score matching using a random forest method, two comparable populations of patients treated with 2 L PEG (n=74, male 41%, 53±17 years) and 1 L PEG-ASC (n=74, male 42%, 55±21 years) were obtained from the original cohort of 221 consecutive SBCE patients. Our results showed a trend towards more frequent adequate mucosal visibility with 1 L PEG-ASC compared to 2 L PEG (small bowel mucosal visibility ≥2 in all three small bowel tertiles, p=0.07), as per the SBMVSS score. No significant differences were observed in the diagnostic yield (p=1.00), visibility score=9 (p=0.85), SBCE completeness (p=0.33), or adequate mucosal visibility in each tertile (p=0.61, p=0.74, and p=0.70 for the first, second, and third tertiles, respectively).
Conclusions
Our study suggests the non-inferiority of the 1 L PEG-ASC solution over the standard 2 L PEG for SBCE preparation.
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- 149 Download
- The Efficacy of 4 Liters of Clear Liquids for Small Bowel Preparation Prior to Video Capsule Endoscopy
- Nicholas Placone, Runalia Bahar, Surinder Mann
- Clin Endosc 2020;53(6):713-718. Published online March 31, 2020
- DOI: https://doi.org/10.5946/ce.2019.213
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Abstract
PDFPubReaderePub
- Background
/Aims: Optimal small bowel (SB) preparation for video capsule endoscopy (VCE) is controversial. Our study aimed to support the use of a specified volume of 4 liters of clear liquids for bowel preparation for VCE.
Methods
A retrospective review of 284 patients who underwent SB preparation with 2 liters of polyethylene glycol (PEG) and 284 patients who had 4 liters of clear liquid preparation. We analyzed image quality, endoscopic findings, completion rate, and transit times.
Results
The 4-liter clear liquid group had significantly higher mean image quality scores when compared to the PEG group (2.908±0.77 to 2.669±0.64, p<0.0001), as well as more studies with adequate preparation (72% to 64%, p=0.0214). Although the PEG group had more endoscopic findings on VCE (40% to 23%, p<0.0001), there was a significant difference in the indications for the procedure between the groups. There was no difference in the capsule completion rate or SB transit time.
Conclusions
Our data demonstrate significantly higher mean image quality scores when using a specified volume of 4 liters of clear liquid compared to 2 liters of PEG. This study supports the growing evidence of the effectiveness of a 4-liter clear liquid SB preparation as opposed to PEG for VCE. -
Citations
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- Small bowel cleansing for capsule endoscopy, systematic review and meta- analysis: Timing is the real issue
Clelia Marmo, Maria Elena Riccioni, Marco Pennazio, Giulio Antonelli, Cristiano Spada, Guido Costamagna
Digestive and Liver Disease.2023; 55(4): 454. CrossRef - Disease surveillance evaluation of primary small-bowel follicular lymphoma using capsule endoscopy images based on a deep convolutional neural network (with video)
Akihiko Sumioka, Akiyoshi Tsuboi, Shiro Oka, Yusuke Kato, Yuka Matsubara, Issei Hirata, Hidehiko Takigawa, Ryo Yuge, Fumio Shimamoto, Tomohiro Tada, Shinji Tanaka
Gastrointestinal Endoscopy.2023; 98(6): 968. CrossRef - A colorectal cancer missed by colon capsule endoscopy: a case report
C. MacLeod, R. Oliphant, J. G. Docherty, A. J. M. Watson
BMC Gastroenterology.2022;[Epub] CrossRef - Value of the diving method for capsule endoscopy in the examination of small-intestinal disease: a prospective randomized controlled trial
Xianhui Zeng, Liansong Ye, Jianrong Liu, Xianglei Yuan, Shan Jiang, Minghui Huang, Xiujiang Huang, Chengwei Tang, Bing Hu
Gastrointestinal Endoscopy.2021; 94(4): 795. CrossRef - Bowel Preparation for Small Bowel Capsule Endoscopy: Is There Still a Role for Polyethylene Glycol?
Paul Collins, Neil Haslam, Anthony Morris, Thomas Skouras, Ashley Bond
Journal of Digestive Endoscopy.2020; 11(03): 215. CrossRef - Capsule endoscopy – Recent developments and future directions.
Stefania Zammit Chetcuti, Reena Sidhu
Expert Review of Gastroenterology & Hepatology.2020;[Epub] CrossRef - Ideal Method for Small Bowel Preparation before Video Capsule Endoscopy
Jun Lee, Shai Friedland
Clinical Endoscopy.2020; 53(6): 631. CrossRef
- Small bowel cleansing for capsule endoscopy, systematic review and meta- analysis: Timing is the real issue
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- 101 Download
- 6 Web of Science
- 7 Crossref
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