Korean Journal of Gastrointestinal Endoscopy 1996;16(2): 181-190.
원저 : 식도 위장관 ; 상부 위장관 내시경 검사시 전처치로서의 Midazolam 의 효과 ( Original Articles : Esophagus , Stomach & Intestine ; Midazolam as Premedication for Upper Gastrointestinal Endoscopy )
임규성, 홍성표, 원욱희, 박필원, 차영수 (Kyu Sung Rim, Sung Pyo Hong, Wook Hee Won, Pil Won Park and Young Soo Cha)
Abstract
The intravenous administration of midazolam is widely used as sedative premedication for upper gastrointestinal endoscopy. We performed a study to evaluate the effectiveness and safety of midazoiam as premedication for upper gastrointestinal endoscopy. Between June 1995 and October 1995, 112 patients of diagnostic esophago-gastroduodenoseopy were enrolled in the study. The patients were recieved a bolus midazolam 0.~03mg/kg or placebo, followed by typical anesthesia. The blood pressure, pulse and oximeter values were monitored. The systolic blood pressure and heart rate were increased during endoscopy in compared with before premedication, and normalized immediately. There was no significant change of arterial oxygen saturation. Midazolam induced amnesia completely in 49.2% and partially in 27.2%, and all patients were recovered completely in 1 hour. The tolerance score is higher in the midazolam group as compared with the placebo group(p<0.05), and midazolam group would accept the same sedation for repeated endoscopies(p<0.01). We conclude that midazolam has beneficial effects as premedication for upper gastrointastinal endoscopy without significant altteration in cardiopulmonary parameters. This suggest that midazolam may be used more frequently as premedication, especially in the cases of repeated endoscopy. (Korean J Gastrointest Endoec 16: 181-190, 1996)
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