Korean Journal of Gastrointestinal Endoscopy 1998;18(1): 11-20.
원저 : 식도 위장관 ; 기능성 소화불량증 환자에서 Helicobacter pylori 의 유형에 따른 위 조직학적 소견 및 혈청 위펩티드 농도 ( Original Articles : Esophagus , Stomach & Intestine ; Gastric Histopathology and Serum Levels of Gastric Peptides according to Types of Helicobacter Pylori in Patients with Functional Dyspepsia )
김경철, 박효진, 윤상애, 이귀순, 정준근, 이관식, 이상인, 박인서 (Kyung Chul Kim, Hyo Jin Park, Sang Ae Yoon, Kwi Soon Lee, Jun Keun Jung, Kwan Sik Lee, Sang In Lee and In Suh Park)
Abstract
Background/Aims: Clinical isolates of Helicobacter pylori(H. pylori) can be divided into at least two major types. Type I bacteria express VacA(vacuolating cytotoxin) and CagA(cytotoxin-associated antigen), type II bacteria do not exp~ress VacA or CagA. The purpose of this study is to evaluate the changes of gastric histology and serum level of gastric peptides(gastrin and pepsinogen) according to the bacteriological types in H. pylori infection. Methods: In patients with H. pylori-positive functional dyspepsia, we classified the type of infection serologically by detecting IgG antibodies to CagA and VacA. Each patient was also evaluated for the degree of gastric inflammation and serum concentrations of gastrin and pepsinogen(PG). IgG antibodies to these proteins and concentrations of gastrin and PG were detected by using a immuno-blot kit and a radioimmunoassay kit, respectively, from the sera of each patient. From endoscopically biopsied antral specimens, the degree of gastric inflammation was evaluated by scoring inflammatory changes. (Korean J Gastrointest Endosc 18: 11-20, 1998)
PDF Links
Full text via DOI 
Download Citation 
