Korean J Gastrointest Endosc > Volume 21(3); 2000 > Article

Korean Journal of Gastrointestinal Endoscopy 2000;21(3): 696-703.

젊은 소화불량증 환자에서 비궤양성 소화불량증의 선별 검사로서 Helicobacter pylori 혈청학 검사가 유용한가? ( Can Helicobacter pylori Serology Predict Non-Ulcer Dyspepsia in Young Dyspeptic Patients? )

황일란(Il Ran Hwang),김진홍(Jin Hong Kim),이광재(Gwang Jae Lee),조성원(Sung Won Jo)

Abstract

Background/Aims:
In western courtry, Helicobacter pylori (H. pylori) serology is a screening test for non-ulcer dyspepsia (NUD) before endoscopy in dyspeptic patients under 45 years old without alarm symptoms The aim of this study was to determine the usefulness of H. pylori serology before endoscopy in Korea
Methods:
Six hundred and fifteen outpatients (M: F=339: 276, mean age 43.6±13.8, range 15-81) with dyspepsia performed anti-H. pylori IgG (GAP or HM-CAP) and upper gastrointestinal endoscopy with biopsy. Exclusion criteria were alarm symptoms, history of gastrectomy, NSAID use and previous anti-H. pylori treatment.
Results:
The prevalence of anti-H. pylori IgG was 61.0% in patients under and 40 years old and 63.8% in patients over 40 years old. There was no significant difference between age groups. For patients under and 40 years old, serology predicted all pathology except 5 gastric ulcer, 8 duodenal ulcer, 2 reflux esophagitis and 2 gastric submucosal tumor. The sensitivity and negative predictive value (76.7, 85.8%) in patients under and 40 years old were higher than that (61.9, 64.0%) in patients over 40 years old (p=0.037, p=0.001),
Conclusions:
H. pylori serology seems to be an acceptable screening test for NUD in dyspeptic patients under and 40 years old without alarm symptoms.

Key Words: Helicobactr pylori , Serology , Non-ulcer dyspepsia