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Korean J Gastrointest Endosc > Volume 21(1); 2000 > Article
Korean Journal of Gastrointestinal Endoscopy 2000;21(1): 518-524.
수면내시경 검사에서 Midazolam 전처치와 Flumazenil 길항작용에 대한 연구 ( Effectiveness of Flumazenil against Midazolam as Premedication for Upper Gastrointestinal Endoscopy )
윤욱돈(Uk Don Yun),최석렬(Seok Ryeol Choi),이종훈(Jong Hun Lee),최대현(Dae Hyun CHoi),신종민(Jong Min Shin),노명환(Myung Hwan Rho),한상영(Sang Young Han),신우원(Woo Won Shin)
Abstract
Background/Aims : Midazolam is utilized as a premedication for uppoer gastrointestinal endoscopy. Midazolam has a more rapid onset of reaction than that of diazepam and its duration is shorter. But the Consciousness of premedicated patients has not been regained sooner. The Purpose
of this study was to examine the effectiveness of flumazenil against midazolam as premedication for upper gastrointesinal endoscopy.
Method
: Sixty patients underwent upper gastrointestinal endoscopy. These patients were divided to three groups: Group I included twenty patients without premedication; Group Ⅱ Included twenty patients with premedication of midazolam and then were not given an antisedative agent excluign of normal saline; and Group Ⅲ included the others with midazolam and flumazenil as an antisedative agent. Results : There was no change in vital signs after midazolam and flumazenil as an antisedative agent. Results : There was no change in vital signs after midazolam injection, compared with presedation value. Modified Steward Coma Scale showed a significant increase after flumazenil injection as an antagonist of midazolam. The assessment of the endoscopist and the comfort of patients were satisfactory. When the 40 patients were asked about their willingness to undergo the same procedure in the future, thirty-four patients responded favorably.
Conclusion
: Midazolam was safe and effective for sedation for upper gastrointestinal endoscopy. There was rapid regaining of consciousness with flumazenil indection after midazolam, so the use of flumazenil against midazolam injection also appeared to be effective. ( Korean J Gastrointest Endosc 2000;21:518-524)
Key Words: Flumazenil, Midazolam, Upper gastrointestinal endoscopy
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