Korean J Gastrointest Endosc > Volume 22(2); 2001 > Article

Korean Journal of Gastrointestinal Endoscopy 2001;22(2): 116-120.

증례 : Cyclosporine과 Azathioprine으로 관해된 스테로이드 저항성 궤양성 대장염 1예 (Steroid-resistant Ulcerative Colitis in Acute Exacervation Phase Remitted by Cyclosporine and Azathioprine - A case report - )

은수훈(Soo Hoon Eun),김은나(Eun Na Kim),김은주(Eun Joo Kim),정일권(Il Kwun Chung),김홍수(Hong Soo Kim),박상홈(Sang Heum Park),이문호(Moon Ho Lee),김선주(Sun Joo Kim)

Abstract

Ulcerative colitis is chronic inflammatory disease of bowel without definite cause. Standard therapy of ulcerative colitis consists of aminosalicylates and glucocorticoid. In recent years, the effectiveness of cyclosporine in inflammatory bowel disease has been reported. Cyclosporine is useful in inducing remission in patients with acute exacervation phase who do not achieve remission with an intensive intravenous steroid therapy. We report a case of steroid-resistnat ulcerative colitis, treated with cyclosporine in 45-year-old man. Remission was not achieved with treatment of sulfasalazine and intensive intravenous glucocorticoid therapy for 10 days. We administered cyclosporine parenterally in dose of 4 mg/kg/day for 10 days. He improved dramatically without significant side effects of drug and avoided colectomy. He was discharged with oral cyclosporine and azathioprine and has been followed up outpatients department remained in clinically remission. Cyclosporine seems to be an effective treatment for patients with steroid-resistnat severe ulcerative colitis in whom colectomy seems inevitable. (Korean J Gastrointest Endosc 2001;22:116 - 120)