Korean Journal of Gastrointestinal Endoscopy 2001;22(1): 14-20.
Helicobacter pylori 감염은 상부위장관 및 대장 병변을 동시에 일으킬 수 있는가? ( Can Helicobacter pylori Infection Cause Upper Gastrointestinal and Colonic Lesions Simultaneously? )
이기성(Ki Sung Lee),김학양(Hak Yang Kim),이자영(Ja Young Lee),김성균(Seong Gyun Kim),김억(Auk Kim),서중산(Joong San Suh),이진헌(Jin Heon Lee),김종혁(Jong Hyeok Kim),장웅기(Woong Ki Chang),김용범(Yong Bum Kim),박충기(Choong Kee Park),유재영(Jae Young Yoo)
Abstract
Background/Aims: Some studies showed the higher prevalence of K. pylori infection in the patients with colon adenoma and carcinoma than control subjects. The association between H. pylori infection and colonic diseases is controversial. We evaluated K. pylori infection rate and the related upper gastrointestinal lesions in the patients with colon polyp and cancer. Methods: Ninety-four subjects, 67 with colonic lesions and 27 without colonic lesions were enrolled. Colon polyp and cancer were confirmed by colonoscopic biopsy or polypectomy. The enrolled subjects were received gastroduodenoscopic examination. K. pylori infection was evaluated serologically and/or with rapid urease test. The fasting serum gastrin level was measured. Results: H. pylori infection rates in the patients with and without colonic lesions were 67.2% and 44.4%, respectively (p<0.05). Upper gastrointestinal lesions were observed in 27 of 67 patients (40.3%) with colonic lesions and in 11 of 27 patients (40.7%) without colonic lesions (p=l.0). Mean levels of serum gastrin with and without colonic lesions were 91.7±31.1 pg/mL and 88.1±37.7 pg/mL, respectively (p=0.15). Conclusions: Our study supports the relationship between H. pylori infection, colorectal neoplasia. Although there was no significant difference, the possibility of the simultaneous presence of upper gastrointestinal lesions in the patients with colorectal polyp and cancer was suggested. But the relationship between serum gastrin and the development of colorectal polyp and cancer was not documented. (Korean J Gastrointest Endosc 2001;22:14 - 20)
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