Korean Journal of Gastrointestinal Endoscopy 2001;23(1): 7-13.
만성 신부전 환자에서 Helicobabter Pylori 감염률과 위장관 증상과의 연관성 ( The Infection Rate of Helicobacter Pylori and Its Relation to Gastrointestinal Symptoms in Patients with Chronic Renal Failure )
손혜영(Hye Young Son),김영선(Young Sun Kim),정혜경(Hye Kyung Jung),이선영(Sun Young Yi)
Abstract
Background/Aims: Helicobacter pylori (H. pylori) can survive in the add milieu of stomach by producing urease, which generates acid neutralizing ammonia by splitting gastric urea and creates a satisfactory environment for H. pylori. Thus the patients with chronic renal failure (CRF) with increased diffusion of blood urea to gastric lumen may be theoretically more susceptible to colonization with If pylori. To investigate the infection rate of H, pylori in CRF and ifs relation to gastrointestinal symptoms, we performed prospective controlled study. Methods: We performed gastroscopy in forty-two patients with CRF. Rapid urease test and histologic examination for H. pylori infection were performed, Histological gastritis was graded by updated Sydney classiflcation. Gasboinfes5nal symptoms were assessed in all CRF patients and serum blood urea nitrogen and creatinine levels were also measured. Results: Twenty-one (50.0%) demonstrated H, pylori infection in patients with CRF. H. pylori infection and major endoscopic findings were not related to the gastrointestinal symptoms in patients with CRF. In H, pyloripositive CRF patients, density of H. pylori and grade of histological gastritis were not related to the severity of gastrointestinal symptoms. Conclnsions: The infection rate of H, pylori was 50% in patients with CRF. Gastrointestinal symptoms in CRF were related to factors other than H. pylori infection. (Korean J Gastmiatest Endoec 2001;23:7-13)
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