Korean Journal of Gastrointestinal Endoscopy 2001;23(1): 1-6.
Helicobacter Pylori 에 대한 혈청 lgG 항체가와 내시경 및 조직병리소견과의 연관성 ( Correlation of Helicobacter pylori Serology titer with Endoscopic and Histologic Findings )
박은미(Eun Mi Park),박창영(Chang Young Park),김시영(Si Young Kim),조용균(Yong Kyun Cho),박범준(Bum Joon Park),김창섭(Chang Seop Kim),손정일(Chung Il Sohn),전우규(Woo Kyu Jeon),김병익(Byung Ik Kim),정을순(Eul Soon Jung),금주섭(Ju Sub Kemn),금동극(Dong Kug Keum),이화영(Hwa Young Lee),이상종(Sang Jong Lee)
Abstract
Baekgronnd/Alms: dinical practlce, among the technique tg defe4ed Heticobacter pylori (H. pylori) infaction IgG serological test is noninvasive, safe, quick, widely available, and inexpensive. We studied that whether the titers of anti-g. pylori IgG antibody were correla0d with endoscopic finding, and the degree of microscopic gastric damage and H. pylori density in dyspeptic patients. Methods: Gastric biopsy specimens were obtained in IGP patiens with H. pylori infec5on undergoing upper gastric endoscopy. The titers of serum IgG antibodies to H pylori were measured by enzyme immumoassay. Macrpscopic gastric damages and. Histologic pylori were scored by the Sydney system. Resnlts: Bndoscopic findings showed no significant association with H. pylori antibody titers (p=0.111). There was significant correlation between H pylori antibody titers and lymphocyte infiltration (p 0.002), neutrophil infiltration (p=0.002), H, pylori density (p=0.000I), respectively. There was no significant correlation between 8 py4ri antibody titers and atropy (p=0. 142), irrtestinal metaplasia (p=0.368), respectivelp. Conclnsions: H. pylori antibody titer has signi6cant association with the H. pylori density, neutrophil and 1ymphocyfe infiltration. The serological test using BIA method is a use5G in detecting H, pylori infection and it may be used as a predictor for the H. pylori density and degree of inflammation. (Korean J Gastrointest Eadose 2001;23:1-6)
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