Korean J Gastrointest Endosc > Volume 26(2); 2003 > Article
Korean Journal of Gastrointestinal Endoscopy 2003;26(2): 90-93.
제 1형 신경섬유종증에 동반된 위를 침범한 악성 림프종 1예
이덕용·정준표·지상원·김정환·박종관· 이세준·문병수·이관식·이상인·신은아*
연세대학교 의과대학 내과학교실, *진단병리학교실
A Case of Malignant B-Cell Lymphoma Involving the Stomach in a Patient with Neurofibromatosis Type 1
Dok Yong Lee, M.D., Jun Pyo Chung, M.D., Sang Won Ji, M.D., Jung Hwan Kim, M.D., Jong Kwan Park, M.D., Se Joon Lee, M.D., Byoung Soo Moon, M.D., Kwan Sik Lee, M.D., Sang In Lee, M.D. and Eun Ah Shin, M.D.*
Departments of Internal Medicine and *Diagnostic Pathology Yonsei University College of Medicine, Seoul, Korea
Abstract
Neurofibromatosis type 1, an autosomal dominant disorder, is clinically characterized by the presence of cafe-au-lait spots and cutaneous neurofibromas. Malignancy is a frequently cited and feared complication of neurofibromatosis. Neurofibromatosis has been reported to be associated with some CNS tumors, neurofibrosarcoma, pheochromocytoma, and nonlymphocytic leukemia. Also malignant lymphoma may develop in patients with neurofibromatosis. In Korea, only a case of lung cancer and a case of pheochromocytoma have been reported to develop in patients with neurofibromatosis type 1. Recently, we experienced a case of malignant lymphoma involving the stomach in a 70-year-old woman with neurofibromatosis type 1. An esophagogastroduodenoscopy revealed a 5 cm sized ulcerofungating mass on the greater curvature of the upper body. Histologic diagnosis of the biopsied specimen was B-cell diffuse small and large cell lymphoma. This case illustrates that malignant lymphoma should be included in the differential diagnosis of gastric tumors in patients with neurofibromatosis type 1. (Korean J Gastrointest Endosc 2003;26:90⁣93)
Key Words: Malignant lymphoma, Neurofibromatosis type 1, Stomach
주요어: 제 1형 신경섬유종증, 악성 림프종,
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