Korean J Gastrointest Endosc > Volume 26(3); 2003 > Article
Korean Journal of Gastrointestinal Endoscopy 2003;26(3): 154-157.
Candida Albicans 감염에 의한 비전형적 거대 십이지장 궤양 1예
이화여자대학교 의과대학 내과학교실, *해부병리학교실
A Case of Large Duodenal Ulcer Associated with Candida Albicans
Ji-Yoon Cho, M.D., Hye-Kyung Jung, M.D., Doe-Young Kim, M.D., Il-Hwan Moon, M.D. and Min-Sun Cho, M.D.*
Departments of Internal Medicine and *Pathology, Ewha Womans University College of Medicine, Seoul, Korea
Candida can be a part of normal human flora, but can be harmful in immunocompromised patients. While oral or esophageal moniliasis can be found in healthy people or gravely ill patients, ulceration of the duodenum is far less common. Acid-reducing drugs such as H2 receptor blocker increase growth of microbes, including fungus, and candidal invasion is regarded as rare one of the factors that are associated with failure to respond to H2 receptor blocker therapy. Recently, we experienced a case of atypical duodenal ulcer which was found in a patient with iatrogenic Cushing's syndrome and diabetes mellitus and failed to respond to H2 receptor blocker therapy. Fungal spores and hyphae were histologically identified from the biopsy specimens that were obtained from the margin of the duodenal ulcer, and this fungus was confirmed as Candida albicans by blood culture. It should be considered that in immunocompromised patients, gastroduodenal ulcers can be caused by fungal infection. (Korean J Gastrointest Endosc 2003;26:154⁣157)
Key Words: Candida albicans, Duodenal ulcer
주요어: Candida albicans, 십이지장 궤양
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