Korean J Gastrointest Endosc > Volume 5(1); 1985 > Article

Korean Journal of Gastrointestinal Endoscopy 1985;5(1): 33-35.

Doxycycline 에 의한 식도궤양 5예 ( Doxycycline - Induced Esophageal Ulcers )

김재왕, 황장룡, 곽규식, 최용환, 정준모 (Jae Wang Kim, Jang Yong Hwang, Kyu Sik Kwack, Yong Hwan Choi and Joon Mo Chung)

Abstract

Esophageal ulcers induced by doxycycline is a rare complication. These patients usually complain of sudden onset of symptoms, ie acute substernal or chest pain and odynophagia without prior hietory of esophageal syraptoms. On esophagoscopic examination, there are upper or midesophageal ulcers, which heal after diseontinuation of the drug within 2 weeks. A history of ingestion of the doxycycline,with liquid jost before bedtime can be elicited. The exact eause of the xaucosal ulceration is not clear, but a direct irritant effeet on esophageal mucosa seems most likely. We report 5 cases of esophageal uleeration secondary to the ingestion of doxycydine. Esophagoscopy revealed esophageal ulcers in all patients and the patients hecame asymptomatic following stopping of tbe drugs and taking antacids.