Korean J Gastrointest Endosc > Volume 28(1); 2004 > Article
Korean Journal of Gastrointestinal Endoscopy 2004;28(1): 39-42.
십이지장 가성흑색증 1예
고려대학교 의과대학 내과학교실
A Case of Pseudomelanosis Duodeni
Sang Kyun Yu, M.D., Young Kul Jung, M.D., Jeong Han Kim, M.D., Ji Yeon Lee, M.D., Kiho Park, M.D., Kyoung Oh Kim, M.D., Hyung Joon Yim, M.D., Jin Yong Kim, M.D., Jong-Jae Park, M.D., Jae Seon Kim, M.D. and Young-Tae Bak, M.D.
Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
Pseudomelanosis duodeni is a rare benign condition in which dark pigments accumulate in macrophages located in the lamina propria of the duodenal mucosa. Most reported cases had hypertension with or without chronic renal failure, and were taking antihypertensive agents and iron supplements. Therefore, it has been assumed that pseudomelanosis duodeni is associated with these medications. Our case was a 77 year-old female patient diagnosed as having hypertension, congestive heart failure, iron deficiency anemia, and depression, who had been treated with antihypertensive agents and iron supplement. Upper gastrointestinal endoscopy revealed many tiny discrete dark macules scattered throughout the first and second portions of the duodenum. Endoscopic mucosal biopsy disclosed macrophages with Prussian blue and Fontana- Masson stain positive pigments, which suggested that the nature of pigment was iron sulfide. (Korean J Gastrointest Endosc 2004;28:39⁣42)
Key Words: Duodenum, Pseudomelanosis, Antihypertensive agents, Iron supplement
주요어: 십이지장, 가성흑색증, 항고혈압제, 철분 제제
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